Involvement of nitric oxide synthesis in hepatic perturbations induced in rats by a necrogenic dose of thioacetamide

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 820-826

  Díez Fernández, Carmen ^a   Sanz, Nuria ^a   Boscá, Lisardo ^a   Hortelano, Sonsoles ^a   Cascales, María ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Necrosis; Nitric oxide; Nitric oxide synthase; Regeneration; Thioacetamide

Indexed keywords

ACONITATE HYDRATASE; CYCLIC GMP; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; KUPFFER CELL; LIVER CELL; LIVER HOMOGENATE; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER REGENERATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACONITATE HYDRATASE; ANIMALS; CARCINOGENS; CYCLIC GMP; KUPFFER CELLS; LIVER; MALE; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; RATS; RNA, MESSENGER; THIOACETAMIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031011058     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701191     Document Type: Article

References (60)

1. AKERMAN, P., COTE, P., YANG, S.Q., MCLAIN, C., NELSON, S., BAGBY, G.J. & DIEHL, A.M. (1992). Antibodies to tumor necrosis factor inhibit liver regeneration after partial hepatectomy. Am. J. Physiol., 263, G579-G585.
2. ALESSENKO, A., KHAN, W.A., WETSEL, W.C. & HANNUN, Y.A. (1992). Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem. Biophys. Res. Commun., 182, 1333-1339.
3. ARTHUR, M.J.P., BENTLEY, I.S., TANNER, A.R., KOWALSKI, SAUNDERS, P., MILLWARD-SADLER, G.H. & WRIGHT, R. (1985). Oxygen derived free radicals promote hepatic injury in the rat. Gastroenterology, 89, 1114-1122.
4. BILLIAR, T.R., CURRAN, R.D., FERRARI, F.K., WILLIAMS, D.L. & SIMMONS, R.L. (1990a). Kupffer cell: Hepatocyte cocultures release nitric oxide in response to bacterial endotoxin. J. Surg. Res., 48, 349-353.
5. BILLIAR, T.R., CURRAN, R.D., HARBRECHT, B.C., STADLER, J., WILLIAMS, D.L. OCHOA, J.B., DI SILVIO, M., SIMMONS, R.L. & MURRAY, S.A. (1992). Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes. Am. J. Physiol., 262, C1077-C1082.
6. BILLIAR, T.R., CURRANT, R.D., STUEHR, D.J., STRADLER, J. & MURRAY, R.L. (1990b). Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes. Biochem. Biophvs. Res. Commun., 168, 1034-1040.
7. BRADFORD, M.M. (1975). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
8. BRAUN, L., MEAD, J.E., PANZICA, M., MIKUMO, R., BELL, G.I. & FAUSTO, N. (1988). Elevation of transforming growth factor-beta mRNA during liver regeneration: A possible paracrine mechanism of growth regulation. Proc. Natl. Acad. Sci. U.S.A., 85, 1534-1538.
9. BREDT, D.S., FERRIS, C.D. & SNYDER, S.H. (1992). Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C and calcium/ calmodulin protein kinase; identification of flavin and calmodulin binding sites. J. Biol. Chem., 267, 10976-10981.
10. BREDT, D.S. & SNYDER, S.H. (1990). Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A., 87, 682-685.
11. CASCALES, M., ALVAREZ, A., GASCO, P. FERNANDEZ-SIMON, L., SANZ, N. & BOSCA, L. (1994). Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed death of hepatocytes. Hepatology, 20, 992-1001.
12. CASTRO, L., RODRIGUEZ, M. & RADI, R. (1994). Aconitase is readily inactivated by peroxynitrite but not by its precursor, nitric oxide. J. Biol. Chem., 269, 29409-29415.
13. CHIELI, E. & MAVALDI, G. (1984). Role of microsomal FAD-containing monooxygenase in liver toxicity of thioacetamide-S-oxide. Toxicology, 31, 41-52.
14. CHIRGWIN, J.M., PRZYBYLA, A.E., MACDONALD, R.J. & RUTTER, W.J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
15. CURRAN, R.D., BILLIAR, T.R., STUEHR, D.J., HOFMANN, K. & SIMMONS, R.L. (1989). Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. Exp. Med., 170, 1769-1774.
16. DIEZ-FERNANDEZ, C., BOSCA, L., FERNANDEZ-SIMON, L., ALVAREZ, A. & CASCALES, M. (1993). Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide. Hepatology, 18, 912-918.
17. 2+ dependent enzymes. J. Hepatol., 24, 460-467.
18. DECKER, K. & OBOLENSKAYA, M.Y. (1995). Cytokines, nitric oxide synthesis and liver regeneration. J. Gastroenterol. Hepatol., 10, S12-S17.
19. DING, A.H., NATHAN, C.F. & STUEHR, D.J. (1988). Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol., 141, 2407-2412.
20. DYROFF, M.C. & NEAL, R.A. (1983). Studies of metabolism of thioacetamide-S-oxide by rat liver microsomes. Mol. Pharmacol., 23, 219-227.
21. FAUSTO, N., LAIRD, A.D. & WEBBER, E.M. (1995) Role of growth factors and cytokines in hepatic regeneration. FASEB J., 9, 1527-1536.
22. FRIEDMAN, S.L. (1993). Isolation and culture of hepatic nonparenchymal cells. In Methods in Toxicology, ed Tyson, C.A. & Frazier, J.M. Vol 1A pp. 292-310. New York: Academic Press.
23. GELLER, D.A., NUSSLER, A.K., DI SILVIO, M., LOWENSTEIN, C.J., SHAPIRO, R.A., WANG, S.C., SIMMONS, R.L. & BILLIAR, T.R. (1993). Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. U.S.A., 90, 522-526.
24. GOPALAKRISNA, R., CHEN, Z.H. & GUNDIMEDA, U. (1993). Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J. Biol. Chem., 268, 27180-27185.
25. 15N] nitrate in biological fluids. Anal. Biochem., 126, 131-138.
26. GRYGLEWSKI, R.J., PALMER, R.M.J. & MONCADA, S. (1986). Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature, 320, 454-456.
27. HASSELGREN, H. (1993). Nitric oxide may upregulate in vivo hepatic protein synthesis during endotoxemia. Arch. Surg., 128, 152-157.
28. HAUSLADEN, A. & ERIDOVICH, I. (1994). Superoxide and peroxynitrite inactivate aconitases, but nitric oxide not. J. Biol. Chem., 269, 29405-29408.
29. HORTELANO, S., DEWEZ, B., GENARO, A.M., DIAZ-GUERRA, M.J.M. & BOSCÁ, L. (1995). Nitric oxide is released in regenerating liver after partial hepatectomy. Hepatology, 21, 776-786.
30. HORTELANO, S., GENARO, A.M. & BOSCA, L. (1992). Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. J. Biol. Chem., 267, 24937-24940.
31. HOUWELING, M., VAARTJES, W.J. & VAN GOLDE, L.M.G. (1989). Metabolic responsiveness to phorbol esters and activity of protein kinase C in isolated hepatocytes from partially hepatectomyzed rats. Biochem. Biophys. Res. Commun., 158, 294-301.
32. KIKKAWA, U., TAKAI, Y., MINAKUCHI, R. & NISHIZUKA, Y. (1982). Calcium-activated phospholipid-dependent protein kinase from rat brain. J. Biol. Chem., 257, 13241-13248.
33. KNOWLES, R.G., MERRET, M., SALTER, M. & MONCADA, S. (1990). Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J., 270, 833-836.
34. KUBES, P. (1992). Nitric oxide modulates epithelial permeability in the feline small intestine. Am. J. Physiol., 262, G1138-G1142.
35. LASKIN, D.L. (1990). Non parenchymal cells in hepatotoxicity. Semin. Liver Dis., 10, 293-304.
36. LASKIN, D.L. (1992). Role of macrophages and endothelian cells in hepatotoxicity. In Kupffer Hepatocyte Interactions, ed. Billiar, T. & Curran, R. pp. 147-168. Boca Raton, FL: CRC Press.
37. LASKIN, D.L., GARDNER, C.R., PRICE, V.F. & JOLLOW, D.J. (1995). Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology, 21, 1045-1050.
38. MANGIPUDY, R.S., CHANDA, S. & MEHENDALE, H.M. (1995). Hepatocellular regeneration: Key to thioacetamide autoprotection. Pharmacol. Toxicol., 77, 182-188.
39. MEHENDALE, H.M. (1991). Role of hepatocellular regeneration and hepatocellular healing in final outcome of liver injury. A two stage models of toxicity. Biochem. Pharmacol., 42, 1155-1162.
40. MEHENPALE, H.M. ROTH, R.A. GANDOLFO, A.J., KLAUNIG, J.E., LEMASTERS, J.J. & CURTIS, R.L. (1994). Novel mechanisms in chemically induced hepatotoxicity. FASEB J., 8, 1285-1295.
41. MILBOURNE, E. & BYGRAVE, F. (1995). Does nitric oxide play a role in liver function? Cellular Signaling, 7, 313-318.
42. MONCADA, S., PALMER, R.M.J. & HIGGS, H.A. (1991). Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
43. MOY, J.A., BATES, J.N. & FISHER, R.A. (1992). Effects of nitric oxide on platelet-activating factor- and 2-adrenergic-stimulated vasoconstriction and glycogenolysis in the perfused rat liver. J. Biol., Chem., 266, 8092-8096.
44. NATHAN, C. & HIBBS, J.B. (1991). Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol., 3, 65.
45. NISHIZUKA, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. J. Biol. Chem., 268, 5063-5068.
46. OBOLENSKAYA, M.Y., SCHULZE-SPECKING, A., PLAUMANN, B., FRENZER, K., FREUDENBERG, N. & DECKER, K. (1994a). Nitric oxide production by production by cell isolated from regenerating liver. Biochem. Biophys. Res. Commun., 204, 1305-1311.
47. OBOLENSKAYA, M.Y., VANIN, A.F., MORDVINTCEV, P.I., MÜLSCH, A. & DECKER, K. (1994b). EPR evidence of nitric oxide production by the regenerating rat liver. Biochem. Biophys. Res. Commun., 202, 571-576.
48. RICHTER, C., GODVADZE, V., SCHLAPBACH, R., SCHWEIZER, M. & SCHLEGEL, J. (1994). Nitric oxide kills hepatocytes by mobilizing mitochondrial calcium. Biochem. Biophys. Res. Commun., 205, 539-541.
49. RODENAS, J., MITJAVILLA, M.T. & CARBONELL, R. (1995). Simultaneous generation of nitric oxide and Superoxide by inflammatory cells in rats. Free Rad. Biol. Med., 18, 869-875.
50. ROSE, I.A. & O-CONNEL, E.L. (1967). Mechanism of aconitase action. The hydrogen transfer reaction. J. Biol. Chem., 242, 1870-1879.
51. SCHMIDT, H.H.H.W., WARNER, T.D., NAKANE, M., FORSTERMANN, U. & MURAD, F. (1992). Regulation and subcellular location of nitrogen oxide synthesis in RAW 2647 macrophages. Mol. Pharmacol., 41, 615-624.
52. SCHNEIDER, F., LUTUN, P., BOUDJEMA, K., WOLF, P. & TEMPE, J.-D. (1994). In vivo evidence of enhanced guanylyl cyclase activation during hyperdinamic circulation of acute liver failure. Hepatology, 19, 38-44.
53. SEGLEN, P.O. (1993). Isolation of hepatocytes by collagenase perfussion. In Methods in Toxicology. In vitro biological systems. ed. Tyson, C.A. & Frazier, J.M. pp. 231-243. New York, London: Academic Press.
54. SHIRATORI, Y., KAWASE, T., SHINA, S., OKANO, K., SUGIMOTO, T., TERAOKA, H. & MATANOS, H. (1988). Modulation of hepatotoxicity by macrophages in the liver. Hepatology, 8, 815-821.
55. SPITZER, J. A. (1994). Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats. Hepatology, 19, 217-228.
56. STEER, C.J. (1995). Liver regeneration. FASEB J., 9, 1396-1400.
57. WANG, G.S. & LIU, G.T. (1995). Role of nitric oxide in immunological liver damage in mice. Biochem. Pharmacol., 49, 1277-1281.
58. WEBBER, E.M., GODOWSKI, P.J. & FAUSTO, N. (1994). In vivo response of hepatocyte to growth factors requires an initial priming stimulus. Hepatology, 19, 1521-1527.
59. XIE, Q.-W., CHO, H.J., CALAYCAY, J., MUMFORD, R.A., SWDEREK, K.M., LEE, T.D., DING, A., TROSO, T. & NATHAN, C.F. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science, 256, 225-228.
60. YUI, Y., HATTORI, R., KONIGA, K., EIZAWA, H., HIKO, K. & KAWAI, C. (1991). Purification of nitric oxide synthesis from rat macrophages. J. Biol. Chem., 266, 12544-12547.