Effects of EGb 761 on fatty acid reincorporation during reperfusion following ischemia in the brain of the awake gerbil

Molecular and Chemical Neuropathology

Volumn 34, Issue 1, 1998, Pages 79-101

  Rabin, Olivier ^a   Drieu, Katy ^b   Grange, Eric ^a   Chang, Michael C J ^a   Rapoport, Stanley I ^a   Purdon, A David ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Institut Henri Beaufour   (France)

Author keywords

Arachidonic acid; Brain; Damage; Fatty acid metabolism; Gerbil; Ginkgo biloba extract (EGb 761); Ischemia; Phospholipid metabolism; Recovery; Reincorporation

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; BRAIN LEVEL; DRUG EFFECT; FATTY ACID METABOLISM; GERBIL; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ANIMALIA; GERBILLINAE; GINKGO BILOBA;

EID: 0031659659     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815137     Document Type: Article

References (54)

1. Abe K., Araki T., Kawagoe J., Aoki M., and Kogure K. (1992) Phospholipid metabolism and second messenger system after brain ischemia, in Advances in Experimental Biology: Neurobiology of Essential Fatty Acids (Bazan N. G., Murphy M. G., and Toffano G., eds.), pp. 183-196, Plenum, New York.
2. Barbour B., Szatkowski M., Ingledew N., and Attwell D. (1989) Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 342, 918-920.
3. Bazan, N. G. (1970) Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta 218, 1-10.
4. Bazan N. G., Squinto S. P., Braquet P., Panetta T., and Marcheselli V. L. (1991) Plateletactivating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: intracellular PAF-binding sites and activation of a Fos/Jun/AP-1 transcriptional signaling system. Lipids 26, 1236-1242.
5. Bazan N. G. and Rodriguez de Turco E. B. (1992) Accumulation of lipid-derived second messengers during seizures and ischemia: decreased seizure-induced phospholipase C activation in the hippocampus by EGb 761, in Effects of Ginkgo biloba Extract (ECb 761) on the Central Nervous System (Christen Y, Costentin J., and Lacour M., eds.), pp. 159-169, Elsevier, Paris.
6. 2 and membrane derived lipid second messengers in membrane function and transcriptional activation of genes: implications in cerebral ischemia and neuronal excitability, in Prog. Brain Res. (Kogure K., Hossmann K. A., and Siesjö B. K., eds), pp. 247-257, Elsevier, Paris.
7. Birkle D. L., Kurian P., Braquet P., and Bazan N. G. (1988) Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. J. Neurochem. 51, 1900-1905.
8. Chan P. H., Yurko M., and Fishman R. A. (1982) Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices. J. Neurochem. 38, 525-531.
9. Deutsch J., Grange E., Rapoport S. I., and Purdon A. D. (1994) Isolation and quantitation of acyl-CoA esters in brain tissue by solid phase extraction. Anal. Biochem. 220, 321-323.
10. Deutsch J., Rapoport S. I., and Purdon A. D. (1996) Isolation and HPLC separation of polyunsaturated species of rat brain acyl-CoA produced during decapitationischemia. Phosphorus, Sulfur, and Silicon 109-110, 389-392.
11. Deutsch J., Rapoport S. I., and Purdon A. D. (1997) Relation between free fatty acid and acylCoA concentrations in rat brain following decapitation. Neurochem. Res. 22(7), 759-765.
12. Doucet J. P. and Bazan N. G. (1993) Excitable membranes, lipid messengers and immediate early genes. Alteration of signal transduction in neuromodulation and neurotrauma. Mol. Neurobiol. 6, 407-424.
13. Dumuis A., Pin J. P., Oomagari K., Sebben M., and Bockaert J. (1990) Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature 347, 182-184.
14. Folch J., Lees M., and Sloane Stanley G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
15. Gaudet R. J., Alam I., and Levine L. (1980) Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J. Neurochem. 35, 653-658.
16. 3H]-palmitic acid in plasma and brain precursor pools. J. Neurochem. 65, 2290-2298.
17. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
18. Huang S. F. L. and Sun G. Y. (1987) Acidic phospholipids, diacylglycerols, and free fatty acids in gerbil brain: a comparison of ischemic changes resulting from carotid ligation and decapitation. J. Neurosci. Res. 17, 162-167.
19. Ikeda M., Yoshida S., Busto R., Santiso M., and Ginsberg M. D. (1986) Polyphosphoinositides as a probable source of brain free fatty acids accumulated at the onset of ischemia. J. Neurochem. 47, 123-132.
20. Janssens D., Michiels C., Delaive E., Eliaers F., Drieu K., and Remacle J. (1995) Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem. Pharmacol. 50, 991-999.
21. 2 and C activation during ischemia. J. Neurochem. 61, 1677-1684.
22. Kirino T. (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239, 57-69.
23. Kriegelstein J., Ausmeier F., El-Abhar H., Lippert K., Welsch M., Rupalla K., et al. (1995) Neuroprotective effects of Ginkgo biloba constituents. Eur. J. Pharmacol. Sci. 3, 39-48.
24. Lazarewicz J. W., Wroblewski J. T, Palmer M. E., and Costa E. (1988) Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells. Neuropharmacology 27, 765-769.
25. Le Poucin-Lafitte M., Rapin J., and Rapin J. R. (1980) Effects of Ginkgo biloba on changes induced by quantitative cerebral microembolization in rats. Arch. Int. Pharmacodyn. Ther. 243, 236-244.
26. Loskota W. J., Lomax P., and Verity M. A. (1974) A Stereotaxic Atlas of the Mongolian Gerbil Brain (Meriones unguicularus), Ann Arbor Science Publishers, Ann Arbor, MI.
27. Lynch M. A. and Voss K. L. (1990) Arachidonic acid increases inositol phospholipid metabolism and glutamate release in synaptosomes prepared from hippocampal tissue. J. Neurochem. 55, 215-221.
28. Matsumiya N., Koehler R. C., Kirsch J. R., and Traystman R. J. (1991) Conjugated superoxide dismutase reduces extent of caudate injury after transient focal ischemia in cats. Stroke 22, 1193-1200.
29. Miller B., Sarantis M., Traynelis S., and Attwell D. (1992) Potentiation of NMDA receptor currents by arachidonic acid. Nature 355, 722-725.
30. Moskowitz M. A., Kiwak K. J., Hekimian K., and Levine L. (1984) Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion. Science 224, 886-889.
31. Nakagomi T., Sasaki T, Kirino T., Tamura A., Noguchi M., Saito I, and Takakura K. (1989) Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Stroke 20, 925-929.
32. Nakano S., Kogure K., Abe K., and Yae T. (1990) Ischemia-induced alterations in lipid metabolism of the gerbil cerebral cortex: changes in free fatty acid liberation. J. Neurochem. 54, 1911-1916.
33. H]palmitic acid incorporation into brain Upids. J. Neurol. Res. 26, 196-208.
34. O'Regan M. H., Smith-Barbour M., Perkins L. M., and Phillis J. W. (1995) A possible role for phospholipases in the release of neurotransmitter amino acids from the ischemic rat cerebral cortex. Neurosci. Lett. 185, 191-194.
35. Pace-Asciak C. R. (1989) One-step rapid extractive methylation of plasma nonesterified fatty acids for gas Chromatographic analysis. J. Lipid Res. 30, 196-208.
36. Panetta T, Marcheselli V. L., Braquet P., Spinnewyn B., and Bazan N. G. (1987) Effects of a platelet-activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemiareperfusion induced cerebral injury. Biochem. Biophys. Res. Commun. 149, 580-587.
37. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd ed., Academic Press, New York.
38. Pickard J. D. (1981) Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to cerebral metabolism. J. Cereb. Flow Metab. 1, 361-384
39. Pietri S., Maurelli E., Drieu K., and Culcase M. (1997) Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo Biloba extract (EGb 762). J. Mol Cell. Cardiol. 29(2), 733-742.
40. Rabin O., Chang M. C., Grange E., Bell J. M., Drieu K., and Rapoport S. I. (1995) Effect of Ginkgo biloba extract (EGb 761) on brain incorporation of radiolabeled fatty acids following global cerebral ischemia, in Fatty Acids and Lipids from Cell Biology to Human Disease, International Society for the Study of Fatty Acids and Lipids #176 (Abstract).
41. Rabin O., Deutsch J., Grange E., Pettigrew K. D., Chang M. C. J., Rapoport S. I., et al. (1997) Changes in cerebral acyl-CoA concentrations following ischemia-reperfusion in awake gerbils. J. Neurochem. 68, 2111-2118.
42. Rabin O., Chang M. C. J., Grange E., Bell J., Rapoport S. I., Deutsch J., et al. (1998) Selective acceleration of arachidonic acid reincorporation into brain membranes following transient ischemia in awake gerbil. J. Neurochem. 70, 325-334.
43. Rehncrona S., Westerberg E., Åkesson B., and Siesjö B. K. (1982) Brain cortical fatty acids and phospholipids during and following complete and severe incomplete ischemia. J. Neurochem. 38, 84-93.
44. Robinson P. J., Noronha J., DeGeorge J. J., Freed L. M., Nariai T., and Rapoport S. I. (1992) A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Rev. 17, 187-214.
45. Rodriguez de Turco E. B., Droy-Lefaix M. T., and Bazan N. G. (1993) Decreased electroconvulsive shock-induced diacylglycerols and free fatty acid accumulation in the rat brain by Ginkgo biloba extract (EGb 761): selective effect in hippocampus as compared with cerebral cortex. J. Neurochem. 61, 1438-1444.
46. Spinnewyn B. (1992) Ginkgo biloba extract (EGb 761) protects against delayed neuronal death in gerbils, in Effects of Ginkgo biloba Extract (EGb 761) on the Central Nervous System (Christen Y, Costentin J., Lacour M., eds.), pp. 113-118, Elsevier, Paris.
47. Takemodo O., Tomimoto H., and Yanagihara T. (1995) Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils. Stroke 26, 1639-1648.
48. Tone O., Miller J. C, Bell J. M., and Rapoport S. I. (1987) Regional cerebral palmitate incorporation following transient bilateral carotid occlusion in awake gerbils. Stroke 18. 1120-1127.
49. Volterra A. (1994) Inhibition of high-affinity glutamate transport in neuronal and glial cells by arachidonic acid and oxygen-free radicals. Renal Physiol. Biochem. 17, 165-167.
50. 3H]arachidonate in the anesthetized rat. J. Neurochem. 63, 727-736.
51. Watanabe T. and Egawa M. (1994) Effects of an antistroke agent MCI-186 on the cerebral arachidonate cascade. J. Pharmacol. Exp. Ther. 271, 1624-1629.
52. Woldegiorgis G., Spennetta T., Corkey B. E., Williamson J. R., and Shrago E. (1985) Extraction of tissue long-chain acyl-CoA esters and measurement by reverse-phase high performance liquid chromatography. Anal. Biochem. 150, 8-12.
53. Yamazaki S., DeGeorge J. J., Bell J. M., Rapoport S. I. (1994) Effects of pentobarbital on incorporation of plasma palmitate into rat brain. Anesthiology 80(1), 151-158.
54. Yoshida S., Ikeda M., Busto R., Santiso M., Martinez E., and Ginsberg M. D. (1986) Cerebral phosphoinositide, triacylglycerol, and energy metabolism in reversible ischemia: origin and fate of free fatty acids. J. Neurochem. 47, 744-757.