Population pharmacodymics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery

Anesthesiology

Volumn 89, Issue 4, 1998, Pages 869-877

  Drover, David R ^a   Lemmens, Harry J M ^b  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

CACI; Covariates; Gender; NONMEM

Indexed keywords

NITROUS OXIDE; REMIFENTANIL; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT; PIPERIDINE DERIVATIVE;

ABDOMINAL SURGERY; ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG EFFECT; ELECTIVE SURGERY; FEMALE; HUMAN; INFUSION PUMP; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLIC CLEARANCE RATE; POPULATION RESEARCH; PRIORITY JOURNAL; STIMULUS RESPONSE; ABDOMEN; BLOOD; CLINICAL TRIAL; COMPUTER ASSISTED DRUG THERAPY; GENERAL ANESTHESIA; MIDDLE AGED;

ABDOMEN; ADULT; ANALGESICS, OPIOID; ANESTHESIA, GENERAL; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMPUTER-ASSISTED; FEMALE; HUMANS; INFUSION PUMPS; MALE; MIDDLE AGED; NITROUS OXIDE; PIPERIDINES;

EID: 0031595342     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199810000-00011     Document Type: Article

References (16)

1. Ausems ME, Hug CC, Stanski DR, Burm AG: Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery. ANESTHESIOLOGY 1986; 65:362-73
2. Lemmens HJM, Burm AGL, Bovill JG, Hennis PJ, Gladines MPRR: Pharmacodynamics of alfentanil. The role of plasma protein binding. ANESTHESIOLOGY 1992; 76:65-70
3. Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJM, Gambus PL, Billard V, Hoke JF, Moore KHP, Hermann DJ, Muir KT, Mandema JW, Shafer SL: Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. ANESTHESIOLOGY 1997; 86:10-23
4. Egan TD, Minto CF, Herman DJ, Barr J, Muir KT, Shafer SL: Remifentanil versus alfentanil. Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. ANESTHESIOLOGY 1996; 84:821-33
5. Glass PSA, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D: Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: Remifentanil (GI87084B). Anesth Analg 1993; 77:1031-40
6. Egan TD, Lemmens HJM, Fiset P, Hermann DJ, Muir KT, Stanski DR, Shafer SL: The Pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers. ANESTHESIOLOGY 1993; 79:881-92
7. Westmoreland CL, Hoke JF, Sebel PS, Hug CC, Muir KT: Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. ANESTHESIOLOGY 1993; 79:893-903
8. Selinger K, Lanzo C, Sekut A: Determination of remifentanil in human and dog blood by HPLC with UV detection. J Pharm Biomed Anal 1994: 12:243-8
9. Mandema JW, Verotta D, Sheiner LB: Building population pharmacokinetic-pharmacodynamic models. J. Pharmacokinet Biopharm 1992; 20:511-28
10. Varvel JR, Donoho DL, Shafer SL: Measuring the predictive performance of computer-controlled infusion pumps. J Pharmacokin Biopharm 1992; 20:63-94
11. Meuldermans WEG, Hurkmans RMA, Heykants JJP: Plasma protein binding distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Arch Int Pharmacodyn 1982; 257:4-19
12. Jhaveri R, Joshi P, Batenhorst R, Baughman V, Glass PSA: Dose comparison of remifentanil and Alfentanil for loss of consciousness. ANESTHESIOLOGY 1997; 87:253-9
13. Lemmens HJM, Bovill JG, Hennis PJ, Burm AGL: Age has no Effect on the pharmacodynamics of alfentanil. Anesth Analg 1988; 67:956-60
14. Scott JC, Stanski DR: Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987; 240:159-66
15. Lang E, Kapila A, Shlugman D, Hoke JF, Sebel PS, Glass PSA: Reduction of isoflurane minimal alveolar concentration by remifentanil. ANESTHESIOLOGY 1996; 85:721-8
16. Russell D, Royston D, Rees PH, Gupta SK, Kenny GNC: Effect of temperature and cardiopulmonary bypass on the pharmacokinetics of remifentanil. Br J Aneasth 1997; 79:456-9