Effect of temperature and cardiopulmonary bypass on the pharmacokinetics of remifentanil

British Journal of Anaesthesia

Volumn 79, Issue 4, 1997, Pages 456-459

  Russell, D ^a   Royston, D ^b   Rees, P H ^c   Gupta, S K ^d   Kenny, G N C ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b HAREFIELD HOSPITAL   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Analgesics opioid, remifentanil; Heart, cardiopulmonary bypass; Pharmacokinetics, remifentanil; Surgery, cardiovascular; Temperature, effect

Indexed keywords

ESTERASE; NARCOTIC ANALGESIC AGENT; REMIFENTANIL;

ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CLEARANCE; ENZYME ACTIVITY; FEMALE; HEART MUSCLE REVASCULARIZATION; HUMAN; INDUCED HYPOTHERMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; STERNOTOMY; TEMPERATURE SENSITIVITY; WARMING;

EID: 0030822155     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/79.4.456     Document Type: Article

References (15)

1. Bovill JG, Sebel PS, Stanley TH. Opioid analgesics in anaesthesia: with special reference to their use in cardiovascular anesthesia. Anesthesiology 1984; 61: 731-755.
2. Hug CG. Does opioid "anesthesia" exist? Anesthesiology 1990; 73: 1-4.
3. Bovill JG, Warren PJ, Schuller JL, van Wezel HB, Hoeneveld MH. Comparison of fentanyl, sufentanil and alfentanil anesthesia in patients undergoing valvular heart surgery. Anesthesia and Analgesia 1984; 63: 1081-1086.
4. Marton JP, Hardman HD, Kamiyama Y, Donn KH, Glass PSA. Analgesic efficacy of single escalating doses of GI87084B administered intravenously to healthy male adult volunteers. Anesthesiology 1991; 75: A378.
5. Westmoreland CL, Hoke JF, Sebel PS, Hug CC jr, Muir KT. Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. Anesthesiology 1993; 79: 893-903.
6. Cunningham FE, Hoke JF, Muir KT, James MK, Hoffman WE. Pharmacokinetic/pharmacodynamic evaluation of remifentanil, GR90291 and alfentanil. Anesthesiology 1995; 83: A376.
7. Dershwitz M, Randel G, Rosow CE, Fragen R, DiBiase PM, Librojo ES, Jamerson B, Shaw DL, Batenhorst R. Dose-response relationship of GI87084B, a new ultra-short acting opioid. Anesthesiology 1992; 77: A396.
8. Dershwitz M, Rosow CE, Michalowski P, Connors PM, Hoke JF, Muir KT, Dienstag JL. Pharmacokinetics and pharmacodynamics of remifentanil in volunteer subjects with severe liver disease compared with normal subjects. Anesthesiology 1994; 81: A377.
9. Navapurkar VU, Archer S, Frazer NM, Gupta SK, Muir KT, Park GR. Pharmacokinetics of remifentanil during hepatic transplantation. Anesthesiology 1995; 83: A382.
10. Shlugman D, Dufore S, Dershwitz M, Michalowski P, Hoke J, Muir KT, Rosow C, Glass PSA. Respiratory effects of remifentanil in subjects with severe renal impairment compared to matched controls. Anesthesiology 1994; 81: A1417.
11. Turlapaty P, Laddu A, Murthy VS, Singh B, Lee R. Esmolol: a titratable short-acting intravenous beta blocker for acute critical care settings. American Heart Journal 1987; 114: 866-885.
12. Kramer TH, Cork RC, DiNardo JA, Dreischmeier B, Vranas R. Temperature dependent pharmacokinetics of esmolol demonstrated during hypothermie cardiopulmonary bypass. Anesthesiology 1992; 77: A455.
13. Metzler CM, Weiner DL. PCNONLIN User's Guide, version 4.1. Lexington, KY: Statistical Consultants Inc.
14. Yamaoka K, Nakagawa T, Uno T. Application of Akaike's information criteria (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 1978; 6: 165-175.
15. Egan TD, Lemmens HJM, Fiset P, Hermann DJ, Muir KT, Stanski DR, Shafer SL. The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers. Anesthesiology 1993; 79: 881-892.