Glutamine substitution at Alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel

Journal of General Physiology

Volumn 111, Issue 5, 1998, Pages 639-652

  Tang, Lihui ^a   Chehab, Nabil ^a   Wieland, Steven J ^b   Kallen, Roland G ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Activation inactivation coupling; Gating; S4 S5 segment; Sodium channels

Indexed keywords

ALANINE; GLUTAMINE; METHIONINE; SODIUM CHANNEL; SODIUM ION;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HUMAN; HUMAN CELL; HYDROPHOBICITY; PROTEIN DOMAIN; CYTOPLASM; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GENETICS; HEART MUSCLE; HOMEOSTASIS; METABOLISM; PHYSIOLOGY; TIME;

AMINO ACID SUBSTITUTION; CYTOPLASM; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; HOMEOSTASIS; HUMANS; ION CHANNEL GATING; MYOCARDIUM; SODIUM CHANNELS; TIME FACTORS;

EID: 0031594876     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.111.5.639     Document Type: Article

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