[3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: Effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding

Prostaglandins

Volumn 53, Issue 1, 1997, Pages 21-35

  Seiler, Steven M ^a   Brassard, Catherine L ^a   Federici, Marianne E ^a   Romine, Jeffrey ^a   Meanwell, Nicholas A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

BMY 45778; cyclic AMP; partial agonist; platelet; prostacyclin; prostacyclin agonist

Indexed keywords

[3 [4 (4,5 DIPHENYL 2 OXAZOLYL) 5 OXAZOLYL]PHENOXY]ACETIC ACID; ADENYLATE CYCLASE; CYCLIC AMP; GUANOSINE TRIPHOSPHATASE; ILOPROST; PROSTACYCLIN DERIVATIVE; PROSTACYCLIN RECEPTOR; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; MEMBRANE BINDING; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE MEMBRANE;

ACETATES; ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CYCLIC AMP; EPOPROSTENOL; GTP PHOSPHOHYDROLASES; HUMANS; ILOPROST; IMIDAZOLES; OXAZOLES; PHENOXYACETATES; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASES; RABBITS; RATS;

EID: 0031050332     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(96)00138-4     Document Type: Article

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