Ca2+ regulation of gelsolin activity: Binding and severing of F-actin

Biophysical Journal

Volumn 75, Issue 6, 1998, Pages 3101-3109

  Kinosian, Henry J ^a   Newman, Jay ^c   Lincoln, Bryan ^c   Selden, Lynn A ^b   Gershman, Lewis C ^a,b   Estes, James E ^a,b  

^a ALBANY MEDICAL COLLEGE   (United States)

^b STRATTON VA MEDICAL CENTER   (United States)

^c UNION COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; CALCIUM ION; EGTAZIC ACID; F ACTIN; GELSOLIN; PHALLOIDIN; ACTIN; CALCIUM; POLYMER; TRYPTOPHAN;

ACTIN FILAMENT; ANIMAL TISSUE; ARTICLE; DEPOLYMERIZATION; DIFFUSION COEFFICIENT; LIGHT SCATTERING; NONHUMAN; RABBIT; SKELETAL MUSCLE; ANIMAL; BINDING SITE; BIOPHYSICS; CHEMISTRY; DRUG STABILITY; HUMAN; IN VITRO STUDY; KINETICS; LIGHT; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; RADIATION SCATTERING; SPECTROFLUOROMETRY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ACTINS; ANIMALS; BINDING SITES; BIOPHYSICS; CALCIUM; DRUG STABILITY; GELSOLIN; HUMANS; KINETICS; LIGHT; PHALLOIDINE; POLYMERS; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 0031593377     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(98)77751-3     Document Type: Article

References (41)

1. 2+ affect the rate at which gelsolin severs F-actin. J. Biol. Chem. 269:32916-32923.
2. Arcaro, A. 1998. The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils. J. Biol. Chem. 273:805-813.
3. Asch, H. L., K. Head, Y. Dong, F. Natoli, J. S. Winston, J. L. Connolly, and B. B. Asch. 1996. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Cancer Res. 56:4841-4845.
4. Baldassare, J. J., P. A. Henderson, A. Tarver, and G. J. Fisher. 1997. Thrombin activation of human platelets dissociates a complex containing gelsolin and actin from phosphatidylinositide-specific phospholipase Cgammal. Biochem. J. 324:283-287.
5. Bryan, J., and M. C. Kurth. 1984. Actin-gelsolin interactions. Evidence for two actin-binding sites. J. Biol. Chem. 259:7480-7487.
6. Burtnick, L. D., E. K. Koepf, J. Grimes, E. Y. Jones, D. I. Stuart, P. J. McLaughlin, and R. C. Robinson. 1997. The crystal structure of plasma gelsolin: implications for actin severing, capping and nucleation. Cell. 90:661-670.
7. Davoodian, K., B. W. Ritchings, R. Ramphal, and M. R. Bubb. 1997. Gelsolin activates DNase I in vitro and cystic fibrosis sputum. Biochemistry. 36:9637-9641.
8. 2+-binding sites of gelsolin that regulate association with actin. Eur. J. Biochem. 229: 512-516.
9. Estes, J. E., L. A. Selden, and L. C. Gershman. 1981. Mechanism of action of phalloidin on the polymerization of muscle actin. Biochemistry. 20:708-712.
10. Hartwig, J. H. 1992. Mechanisms of actin rearrangements mediating platelet activation. J. Cell Biol. 118:1421-1441.
11. Hartwig, J. H., G. M. Bokoch, C. L. Carpenter, P. A. Janmey, L. A. Taylor, A. Toker, and T. P. Stossel. 1995. Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 82:643-653.
12. 2+-induced conformational change of gelsolin is located in the carboxyl-terminal half of the molecule. Biophys. J. 65:499-805.
13. Ismailov, I. I., B. K. Berdiev, V. G. Shlyonsky, C. M. Fuller, A. G. Prat, B. Jovov, H. F. Cantiello, D. A. Ausiello, and D. J. Benos. 1997. Role of actin in regulation of epithelial sodium channels by CFTR. Am. J. Physiol. 272:C1077-C1086.
14. Janmey, P. A., C. Chaponnier, S. E. Lind, K. S. Zaner, T. P. Stossel, and H. L. Yin. 1985. Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry. 24:3714-3723.
15. Janmey, P. A., K. Iida, H. L. Yin, and T. P. Stossel. 1987. Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J. Biol. Chem. 262:12228-12236.
16. Kinosian, H. J., L. A. Selden, J. E. Estes, and L. C. Gershman. 1996. Kinetics of gelsolin interaction with phalloidin-stabilized F-actin. Rate constants for binding and severing. Biochemistry. 35:16550-16556.
17. Kothakota, S., T. Azuma, C. Reinhard, A. Klippel, J. Tang, K. Chu, T. J. McGarry, M. W. Kirschner, K. Koths, D. J. Kwiatkowski, and L. T. Williams. 1997. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science. 278:294-298.
18. Kouyama, T., and K. Mihashi. 1981. Fluorometry study of N-(1-pyrenyl) iodoacetamide-labeled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin. Eur. J. Biochem. 114:33-36.
19. Kurokawa, H., W. Fujii, K. Ohmi, T. Sakurai, and Y. Nonomura. 1990. Simple and rapid purification of brevin. Biochem. Biophys. Res. Commun. 168:451-457.
20. Kwiatkowski, D. J., P. A. Janmey, and H. L. Yin. 1989. Identification of critical functional and regulatory domains in gelsolin. J. Cell Biol. 108:1717-1726.
21. 2+ requirement. J. Biol. Chem. 268:8999-9004.
22. Lin, K.-M., E. Wenegieme, P.-J. Lu, C.-S. Chen, and H. L. Yin. 1997. Gelsolin binding to phosphatidyl 4,5-bisphosphate is modulated by calcium and pH. J. Biol. Chem. 272:20443-20450.
23. Lind, S. E., P. A. Janmey, C. Chaponnier, T. J. Herbert, and T. P. Stossel. 1987. Reversible binding of actin to gelsolin and profilin in human platelet extracts. J. Cell Biol. 105:833-842.
24. Lu, M., W. Witke, D. J. Kwiatkowski, and K. S. Kosik. 1997. Delayed retraction of filopodia in gelsolin null mice. J. Cell Biol. 138: 1279-1287.
25. +-selective channels via actin cytoskeleton modification in leukemia cells. FEBS Lett. 412:94-96.
26. McGough, A., W. Chiu, and M. Way. 1998. Determination of the gelsolin binding site on F-actin: implications for severing and capping. Biophys. J. 74:764-772.
27. McLaughlin, P. J., J. T. Gooch, H. G. Mannherz, and A. G. Weeds. 1993. Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature. 364:685-692.
28. Newman, J., L. A. Day, G. W. Dalack, and D. Eden. 1982. Hydrodynamic determination of molecular weight, dimensions, and structural parameters of Pf3 virus. Biochemistry. 21:3352-3358.
29. Ohtsu, M., N. Sakai, H. Fujita, M. Kashiwagi, S. Gasa, S. Shimizu, Y. Eguchi, Y. Tsujimoto, Y. Sakiyama, K. Kobayashi, and N. Kuzumaki. 1997. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 16:4650-4656.
30. Perrin, D. D., and I. G. Sayce. 1967. Computer calculation of equilibrium concentrations in mixtures of metal ions and complexing species. Talanta. 14:833-842.
31. Pope, B. J., J. T. Gooch, and A. G. Weeds. 1997. Probing the effects of calcium on gelsolin. Biochemistry. 36:15848-15855.
32. Pope, B., S. Maciver, and A. G. Weeds. 1995. Localization of the calcium-sensitive actin monomer binding site in gelsolin to segment 4 and identification of calcium binding sites. Biochemistry. 34:1583-1588.
33. Selden, L. A., H. J. Kinosian, J. Newman, B. Lincoln, C. Hurwitz, L. C. Gershman, and J. E. Estes. 1998. Severing of F-actin by the N-terminal half of gelsolin suggests internal cooperativity in gelsolin. Biophys. J. 75: (in press).
34. Selve, N., and A. Wegner. 1986. Rate constants for capping of the barbed ends of actin filaments by the gelsolin-actin complex. Eur. J. Biochem. 155:397-401.
35. Singh, S. S., A. Chauhan, N. Murakami, and V. P. Chauhan. 1996. Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity. Biochemistry. 35:16544-16549.
36. Steed, P. M., S. Nagar, and L. P. Wennogle. 1996. Phospholipase D regulation by a physical interaction with the actin-binding protein gelsolin. Biochemistry. 35:5229-5237.
37. Way, M., J. Gooch, B. Pope, and A. G. Weeds. 1989. Expression of human plasma gelsolin in Escherichia coli and dissection of actin binding sites by segmental deletion mutagenesis. J. Cell Biol. 109:593-605.
38. Weeds, A. G., J. Gooch, P. McLaughlin, B. Pope, M. Bengtsdotter, and R. Karlsson. 1995. Identification of the trapped calcium in the gelsolin segment 1-actin complex: implications for the role of calcium in the control of gelsolin activity. FEBS Lett. 360:227-230.
39. Wegner, A., K. Aktories, A. Ditsch, I. Just, B. Schoepper, N. Selve, and M. Wille. 1994. Actin-gelsolin interaction. Adv. Exp. Med. Biol. 358: 97-104.
40. Witke, W., A. H. Sharpe, J. H. Hartwig, T. Azuma, T. P. Stossel, and D. J. Kwiatkowski. 1995. Hemostatic, inflamatory, and fibroblast reponses are blunted in mice lacking gelsolin. Cell. 81:41-51.
41. Yin, H., and T. P. Stossel. 1979. Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature. 281:583-586.