Menadione (vitamin K3) enhances the mitogenic signal of epidermal growth factor via extracellular signal-regulated kinases

International Journal of Oncology

Volumn 13, Issue 6, 1998, Pages 1163-1170

  Markovits, Judith ^a,b   Sun, Te Ping ^a   Juan, Chung Ching ^a,c   Ju, Gloria Chia Cheng ^a,d   Wu, Felicia Ying Hsiueh ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^d New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Epidermal growth factor; Extracellular signal regulated kinases; Menadione; Oxidant; Protein tyrosine phosphatases; Vitamin K3

Indexed keywords

CYSTEINE; DNA; EPIDERMAL GROWTH FACTOR; MENADIONE; 3CH134 PROTEIN; CELL CYCLE PROTEIN; IMMEDIATE EARLY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGENIC AGENT; PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN TYROSINE PHOSPHATASE; VITAMIN K GROUP;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; DATA ANALYSIS; DNA SYNTHESIS; DRUG CYTOTOXICITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; BIOSYNTHESIS; CELL DIVISION; CELL STRAIN 3T3; CELL SURVIVAL; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIME;

3T3 CELLS; ANIMALS; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE PROTEINS; CELL DIVISION; CELL SURVIVAL; DNA; EPIDERMAL GROWTH FACTOR; IMMEDIATE-EARLY PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGENS; PEPTIDES; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; TIME FACTORS; VITAMIN K;

EID: 0031593362     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.13.6.1163     Document Type: Article

References (44)

1. 3 inhibition of malignant murine cell growth and human tumor colony formation. Cancer Treat Rep 69: 527-532, 1985.
2. 3 on human tumor cells by two (MTT and SRB) cell viability assays. Life Sci 52: 1797-1804, 1993.
3. 3) against rat transplantable hepatoma induced by 3′-methyl-4-dimethyl-aminoazobenzene. Kaohsiung J Med Sci 7:454-459, 1991.
4. Tetef M, Margolin K, Ahn C, Akman S, Chow W, Leong L, Morgan R Jr, Raschko J, Somlo G and Doroshow H: Mitomycin C and menadione for the treatment of lung cancer: a phase II trial. Invest New Drug 13: 157-162, 1995.
5. Hu OYP, Wu CY, Chan WK, Wu FYH and Whang-Peng J: A pharmacokinetic study with the high-dose anticancer agent menadione in rabbits. Biopharm Drug Disposition 17: 493-499, 1996.
6. Cantoni O, Fiorani M, Cattabeni F and Bellomo G: DNA breakage caused by hydrogen peroxide produced during the metabolism of 2-methyl-1,4-naphthoquinone. Biochem Pharmacol 42 (Suppl): 220-222, 1991.
7. 3 (or menadione). J Chinese Oncol Soc 8: 105-106, 1992.
8. Nutter LM, Ngo EO, Fisher GR and Gutierrez PL: DNA strand scission and free radical production in menadione-treated cells. J Biol Chem 267: 2474-2479, 1992.
9. cdc2 kinase and phosphatase. Biochem Biophys Res Commun 190: 907-913, 1993.
10. 3-induced cell cycle arrest and apoptotic cell death are accompanied by altered expression of c-fos and c-myc in nasopharyngeal carcinoma cells. Oncogene 8: 2237-2244, 1993.
11. 3 induces cell death via apoptosis in human cervical carcinoma TSGH8302 cells. Oncol Rep 1: 53-58, 1994.
12. 3 in human hepatoma HepG2 cells is accompanied by down-regulation of proliferating cell nuclear antigen expression. Int J Oncol 10: 1015-1019, 1997.
13. Nishikawa Y, Carr BL, Wang M, Kar S, Finn F, Dowd P, Kerns J and Naganathan S: Growth inhibition of hepatoma cells induced by vitamin K and its analogs. J Biol Chem 270: 28304-28310, 1995.
14. 2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity. Cell Physiol 37: C227-C236, 1995.
15. 3. Biochim Biophys Acta 888: 176-183, 1986.
16. 3 (menadione) and related quinones, like tumor-promoting phorbol esters, alter the affinity of epidermal growth factor for its membrane receptors. J Biol Chem 255: 8735-8739, 1980.
17. Chai YC, Hendrich S and Thomas JA: Protein S-thiolation in hepatocytes stimulated by t-butyl hydroperoxide, menadione, and neutrophils. Arch Biochem Biophys 310: 264-272, 1994.
18. Vallis KA, Reglinski J, Garner M, Bridgeman MM and Wolf CR: Menadione-resistant chinese hamster ovary cells have an increased capacity for glutathione synthesis. Br J Cancer 76: 870-877, 1997.
19. Sun H, Charles CH, Lau LF and Tonks NK: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487-493, 1993.
20. Rossomando AJ, Payne DM, Weber MJ and Sturgill TW: Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc Natl Acad Sci USA 86: 6940-6943, 1989.
21. Cano E and Mahadevan LC: Parallel signal processing among mammalian MAPKs. Trends Biol Sci 20: 117-122, 1995.
22. Markovits J, Pommier Y, Kerrigan D, Covey JM, Tilchen EJ and Kohn KW: Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells. Cancer Res 47: 2050-2055, 1987.
23. 1 progression in NIH 3T3 cells. Mol Cell Biol 15:3654-3663, 1995.
24. Skehan P, Storeng RD, Scudiero A, Monks J, McMahon D, Vistica JT, Warren H, Bokesch H, Kenney S and Boyd MR: New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82: 1107-1112, 1990.
25. 2 stimulate mitogen-activated protein kinase activity in NIH 3T3 cells through the formation of reactive oxygen intermediates. Cancer Res 54: 12-15, 1994.
26. Waskiewicz AJ and Cooper JA: Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 7: 798-805, 1995.
27. Ghosh S, Xie WQ, Quest AFG, Mabrouk GM, Strum JC and Bell RM: The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras. J Biol Chem 269: 10000-10007, 1994.
28. Burgering BMT and Bos JL: Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends Biol Sci 20: 18-22, 1995.
29. Pumiglia KM and Decker SJ: Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94: 448-452, 1997.
30. 2 and vanadate in vitro. Biochem Biophys Res Commun 188: 773-779, 1992.
31. Nickerson AJ, Falcone G and Strauss G: Studies on quinonethioethers. I. Mechanism of formation and properties of thiodione. Biochemistry 2: 537-543, 1963.
32. 3 oxide inhibit growth of Hep3B and HepG2 cells. Bioorg Chem 23: 101-108, 1995.
33. Yuvaniyama J, Denu JM, Dixon JE and Saper MA: Crystal structure of the dual specificity protein phosphatase VHR. Science 272: 1328-1331, 1996.
34. Denu JM, Lohse DL, Vijayalakshmi J, Saper MA and Dixon JE: Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis. Proc Natl Acad Sci USA 93: 2493-2498, 1996.
35. Chen Y and Chan TM: Orthovanadate and 2,3-dimethoxy-1,4-naphthoquinone augment growth factor-induced cell proliferation and c-fos gene expression in 3T3-L1 cells. Arch Biochem Biophys 305: 9-16, 1993.
36. Carpenter G and Cohen S: Epidermal growth factor. J Biol Chem 265: 7709-7712, 1990.
37. 3). Mol Pharmacol 42: 917-921, 1992.
38. Frydman B, Marton LJ, Sun JS, Neder K, Witiak DT, Liu AA, Wang HM, Mao Y, Wu HY, Sanders MM and Liu LF: Induction of DNA topoisomerase II-mediated DNA cleavage by B-lapachone and related naphthoquinones. Cancer Res 57: 620-627, 1997.
39. Galaktionov K, Lee AK, Eckstein J, Draetta J, Meckler J, Loda M and Beach D: CDC25 phosphatases as potential human oncogenes. Science 269: 1575-1577, 1995.
40. Ham SW, Park HJ and Lim DH: Studies on menadione as an inhibitor of the cdc25 phosphatase. Bioorganic Chem 25: 33-16, 1997.
41. cdc2. Cell 67: 197-211, 1991.
42. Rossomando AJ, Dent P, Sturgill TW and Marshak DR: Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation. Mol Cell Biol 14: 1594-1602, 1994.
43. Cans C, Baldin V, Mils V and Ducommun B: Les phosphatases CDC25: régulateurs du cycle cellulaire et oncogènes potentiels. Med Sci 14: 269-274, 1998.
44. Galaktionov K, Jessus C and Beach D: Raf-1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Develop 9: 1046-1058, 1995.