Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiation

International Journal of Cancer

Volumn 73, Issue 5, 1997, Pages 757-762

  Sheard, Michael A ^a   Vojtesek, Borek ^a   Janakova, Libuse ^a   Kovarik, Jan ^a   Zaloudik, Jan ^a  

^a MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; PROTEIN P53;

ARTICLE; BREAST TUMOR; CELL CULTURE; CELL CYCLE; FEMALE; GAMMA RADIATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE; TUMOR SUPPRESSOR GENE; UPREGULATION;

ANTIGENS, CD95; BREAST NEOPLASMS; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0031588408     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19971127)73:5<757::AID-IJC24>3.0.CO;2-1     Document Type: Article

References (20)

1. BOEHME, S.A. and LENARDO, M.J., TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J. Immunol., 156, 4075-4078 (1996).
2. CONEY, L.R., DANIEL, P.T., SANBORN, D., DHEIN, J., DEBATIN, K-M., KRAMMER, P.H. and ZURAWSKI, V.R., Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression. Int. J. Cancer, 58, 562-567 (1994).
3. KASTAN, M.B., ZHAN, Q., EL-DIERY, W.S., CARRIER, F., JACKS, T., WALSH, W.V., PLUNKETT, B.S., VOGELSTEIN, B. and FORNACE, A.J., A mammalian cell-cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71, 587-597 (1992).
4. KO, L.J. and PRIVES, C., p53: puzzle and paradigm. Genes Dev., 10, 1054-1072 (1996).
5. LEITHÄUSER, F., DHEIN, J., MECHTERSHEIMER, G., KORETZ, K., BRUDERLEIN, S., HENNE, C., SCHMIDT, A., DEBATIN, K.-M., KRAMMER, P.H. and MOLLER, P., Constitutive and induced expression of APO-1, a new member of the nerve-growth-factor/tumor-necrosis-factor-receptor superfamily, in normal and neoplastic cells. Lab. Invest., 69, 415-429 (1993).
6. LINKE, S.P., CLARKIN, K.C. and WAHL, G.M., p53 mediates permanent arrest over multiple cell cycles in response to γ-irradiation. Cancer Res., 57, 1171-1179 (1997).
7. LU, X. and LANE, D., Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell, 75, 765-778 (1993).
8. MIDGLEY, C.A., FISHER, C.J., BARTEK, J., VOJTESEK, B. and LANE, D., Analysis of p53 expression in human tumors: an antibody raised against human p53 expressed in E. coli. J. Cell Sci., 101, 183-187 (1992).
9. NAGATA, S. and GOLSTEIN, P., The Fas death factor. Science, 267, 1449-1456 (1995).
10. NIEWOLIK, D., VOJTESEK, B. and KOVARIK, J., p53 derived from human tumour cell lines and containing distinct point mutations can be activated to bind its consensus target sequence. Oncogene, 10, 881-890 (1995).
11. OWEN-SCHAUB, L.B., RADINSKY, R., KRUZEL, E., BERRY, K. and YONEHARA, S., Anti-Fas on non-hematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responses. Cancer Res., 54, 1580-1586 (1994).
12. OWEN-SCHAUB, L.B., ZHANG, W., CUSACK, J.C., ANGELO, L.S., SANTEE, S.M., FUJIWARA, T., ROTH, J.A., DEISSEROTH, A.B., ZHANG, W.-W., KRUZEL, E. and RADINSKY, R., Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. cell. Biol., 15, 3032-3040 (1995).
13. RADFORD, I.R., The level of induced DNA-double-strand breakage correlates with cell killing after X-irradiation. Int. J. Radiat. Biol., 48, 45-54 (1986).
14. STRASSER, A., HARRIS, A.W., HUANG, D.C., KRAMMER, P.H. and CORY, S., bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J., 14, 6136-6147 (1995).
15. TRAUTH, B.C., KLAS, C., PETERS, A.M.J., MATZKU, S., MOLLER, P., FALK, W., DEBATIN, K.-M. and KRAMMER, P.H., Monoclonal-antibody-mediated tumor regression by induction of apoptosis. Science, 245, 301-305 (1989).
16. VOJTESEK, B., BARTEK, J., MIDGLEY, C.A. and LANE, D.P., An immunochemical analysis of the human nuclear phosphoprotein p53: new monoclonal antibodies and epitope mapping using recombinant p53. J. immunol. Methods, 151, 237-244 (1992).
17. VOJTESEK, B., FISHER, C.J., BARNES, D.M. and LANE, D.P., Comparison between p53 staining in tissue sections and p53 protein levels measured by an ELISA technique. Brit. J. Cancer, 67, 1254-1258 (1993).
18. VOJTESEK, B. and LANE, D.P., Regulation of p53 protein expression in human breast-cancer cell lines. J. Cell Sci., 105, 607-612 (1993).
19. WASEEM, N.H. and LANE, D.P., Monoclonal-antibody analysis of the proliferating-cell nuclear antigen. J. Cell Sci., 96, 121-129 (1990).
20. L depends on normal p53 function. Oncogene, 13, 2287-2293 (1996).