Ring-closing olefin metathesis for the synthesis of 1,8-diazabicyclo[4.3.0]non-3-ene-7,9-diones

Tetrahedron Letters

Volumn 38, Issue 12, 1997, Pages 2065-2066

  Dyatkin, Alexey B ^a,b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDANTOIN DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0031585082     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00286-4     Document Type: Article

References (19)

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11. 6. The catalyst 4 was purchased from Strem Chemicals, Inc.
12. 7. Lopez-Rodriguez, M.L.; Morcillo, M.J.; Garrido, M.; Banhamu, B.; Perez, V.; de la Campa, J.G. J. Org. Chem. 1994, 59, 1583
13. (b) Winterfeld, K.; Schuler, H.; Arch. der Pharm. 1960, 293, 203
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18. 2 was added by syringe in one portion. The reaction mixture was refluxed overnight, evaporated and the remaining brown residue was subjected to column chromatography (silica, hexanes-ethyl acetate mixture as eluent).
19. 2: C, 75.55; H, 5.83; N, 10.57. Found: C, 75.29; H, 5.89; N, 10.49.