T helper type 1/T helper type 2 cytokines and T cell death: Preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

Journal of Experimental Medicine

Volumn 182, Issue 6, 1995, Pages 1759-1767

  Estaquier, Jérôme ^a   Idziorek, Thierry ^a   Zou, Weiping ^a   Emilie, Dominique ^a   Farber, Claire Michelle ^b   Bourez, Jean Michel ^c   Ameisen, Jean Claude ^a  

^a INSERM   (France)

^b ERASME HOSPITAL   (Belgium)

^c Hopital Dron   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12; T LYMPHOCYTE ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; CELL DEATH; CELLULAR IMMUNITY; CELLULAR IMMUNODEFICIENCY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ANTIGENS, CD95; APOPTOSIS; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DNA PRIMERS; GENE EXPRESSION; HIV INFECTIONS; HUMAN; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TH1 CELLS; TH2 CELLS;

EID: 0028839280     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.6.1759     Document Type: Article

References (50)

1. Miedema, F., A.J.C. Petit, F.G. Terpestra, J.K.M. Eeftinck, F. Dewolf, B.J.M. Al, M. Roos, J.M.A. Lange, S.A. Danner, J. Goudsmit, and P.T.A. Schellkens. 1988. Immunological abnormalities in HIV-infected asymptomatic homosexual men. J. Clin. Invest. 82: 1908-1914.
2. Clerici, M., N.I. Stocks, R.A. Zajac, R.N. Boswell, D.R. Lucey, C.S. Via, and G.M. Shearer. 1989. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV-seropositive patients. J. Clin. Invest. 84: 1892-1899.
3. Fauci, A.S. 1993. Multifactorial nature of HIV disease: implications for therapy. Science (Wash. DC). 262: 1011-1018.
4. Ameisen, J.C., and A. Capron. 1991. Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol. Today. 12: 102-105.
5. + T Cells from HIV-infected asymptomatic individuals. J. Exp. Med. 175: 331-340.
6. Meyaard, L., S.A. Otto, R.R. Jonker, M.J. Mijnster, I.P.M. Keet, and F. Miedema. 1992. Programmed cell death of T cells in HIV-1 infection. Science (Wash. DC). 257: 217-219.
7. Gougeon, M.-L., S. Garcia, J. Heeney, R. Tschopp, H. Lecoeur, D. Guétard, V. Rame, C. Dauguet, and L. Montagnier. 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retrovir. 9: 553-563.
8. Oyaizu, N., T.W. McCloskey, M. Coronesi, N. Chirmule, and S. Pahwa. 1993. Accelerated apoptosis in PBMCs from HIV-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood. 82: 3392-3400.
9. + T cells from HIV-infected persons. J. Immunol. 153: 412-420.
10. Sarin, A., M. Clerici, S.P. Blatt, C.W. Hendrix, G.M. Shearer, and P.A. Henkart. 1994. Inhibition of activationinduced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J. Immunol. 153: 862-872.
11. Estaquier, J., T. Idziorek, F. De Bels, F. Barre-Sinoussi, B. Hurtrel, A.M. Aubertin, A. Venet, M. Mehtali, E. Muchmore, P. Michel, et al. 1994. Programmed cell death and AIDS: the significance ofT cell apoptosis in pathogenic and non pathogenic primate lentiviral infections. Proc. Natl. Acad. Sci. USA. 91: 9431-9435.
12. Terai, C., R.S. Kornbluth, C.D. Pauza, D.D. Richman, and D.A. Carson. 1991. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. Clin. Invest. 87: 1710-1715.
13. Laurent-Crawford, A.G., B. Krust, S. Muller, Y. Rivière, M.A. Rey-Cuillé, J.M. Béchet, L. Montagnier, and A.G. Hovanessian. 1991. The cytopathic effect of HIV is associated with apoptosis. Virology. 185: 829-839.
14. Banda, N.K., J. Bernier, D.K. Kurahara, R. Kurrle, N. Haigwood, R.P. Sekaly, and T.H. Finkel. 1992. Crosslinking CD4 by HIV gpl20 primes T cells for activation-induced apoptosis. J. Exp. Med. 176: 1099-1106.
15. Bonyhadi, M.L., L. Rabin, S. Salimi, D.A. Brown, J. Kosek, J.M. McCune, and H. Kaneshima. 1993. HIV induces thymus depletion in vivo. Nature (Lond.). 363: 728-732.
16. Schuitemaker, H., L. Meyaard, N.A. Kootstra, S.A. Otto, R. Dubbes, M. Tersmette, J.L. Heeney, and F. Miedema. 1993. Lack of T-cell dysfunction and programmed cell death correlates with inability of HIV-1 to infect chimpanzee monocytes. J. Infect. Dis. 168: 1140-1147.
17. Zauli, G., M. Vitale, M.C. Re, G. Furlini, L. Zamai, E. Falcieri, D. Gibellini, G. Visani, B.R. Davis, S. Capitani, and M. La Placa. 1994. In vitro exposure to HIV-1 induces apoptotic cell death of the factor-dependent TF-1 hematopoietic cell line. Blood. 83: 167-175.
18. Cameron, P.U., M. Pope, S. Gezelter, and R.M. Steinman. 1994. Infection and apoptotic cell death of CD4 T cells during an immune response to HIV-l-pulsed dendritic cells. AIDS Res. Hum. Retrovir. 10: 61-71.
19. Martin, S.J., P. Matear, and A. Vyakamam. 1994. HIV-1 infection of human CD4 T cells in vitro. Differential induction of apoptosis in these cells. J. Immunol. 152: 330-342.
20. Su, L., H. Kaneshima, M. Bonyhadi, S. Salimi, D. Kraft, L. Rabin, and J.M. McCune. 1995. HIV-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity. 2: 25-36.
21. Dhein, J., H. Walczak, C. Baumier, K.-M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by Apo-1 (Fas/CD95). Nature (Lond.). 373: 438-441.
22. Brunner, T., R.J. Mogil, D. LaFace, N.J. Yoo, A. Mahboubi, F. Echeverri, S.J. Martin, W.R. Force, D.H. Lynch, C.F. Ware, and D.R. Green. 1995. Cell-autonomous Fas (CD95)/Fasligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (Lond.). 373: 441-444.
23. Ju, S.T., D.J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D.H. Sherr, B.Z. Stanger, and A. Marshak-Rothstein. 1995. Fas (CD95)/Fas-L interactions required for programmed cell death after T-cell activation. Nature (Lond.). 373: 444-448.
24. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S.-I. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66: 233-243.
25. Oehm, A., I. Behrmann, W. Falk, M. Pawlita, G. Maier, C. Klas, M. Li-Weber, S. Richards, J. Dhein, and B.C.X. Trauth. 1992. Purification and molecular cloning of APO-1 cell surface antigen, a member of the TNF/NGF receptor superfamily. Sequence similarity with the Fas antigen. J. Biol. Chem. 267: 10709-10708.
26. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen codownregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169: 1747-1756.
27. Trauth, B.C., C. Klas, A.M.J. Peters, S. Matzku, P. Moller, W. Falk, K.-M. Debatin, and P.H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science (Wash. DC). 245: 301-305.
28. Miyawaki, T., T. Uehara, R. Nibu, T. Tsuji, A. Yachie, S. Yonehara, and N. Taniguchi. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149: 3753-3758.
29. Sato, T., S. Irie, S. Kitado, and J. Reed. 1995. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (Wash. DC). 268: 411-415.
30. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R.L. Modlin, and B.R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science (Wash. DC). 254: 279-282.
31. Yamamura, M., K. Uyemura, R.J. Deans, K. Weinberg, T.H. Rea, B.R. Bloom, and R.L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science (Wash. DC). 25: 277-279.
32. Gazzinelli, R.T., M. Makino, S.K. Chattopadhyay, C.M. Snapper, A. Sher, A.W. Hügin, and H.C. Morse III. 1992. CD4 subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J. Immunol. 148: 182-188.
33. Sher, A., and R.L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10: 385-409.
34. Clerici, M., and G.M. Shearer. 1993. A TH1/TH2 switch is a critical step in the etiology of HIV infection. Immunol. To day. 14: 107-111.
35. Trinchieri, G. 1993. IL-12 and its role in the generation of TH1 cells. Immunol. Today. 14: 335-337.
36. Paul, W.E., and R.A. Seder. 1994. Lymphocyte responses and cytokines. Cell. 76: 241-251.
37. Clerici, M., D.R. Lucey, J.A. Berzofsky, L.A. Pinto, T.A. Wynn, S.P. Blatt, M.J. Dolan, C.W. Hendrix, S.F. Wolf, and G.M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune response by IL-12 in vitro. Science (Wash. DC). 262: 1721-1724.
38. Clerici, M., T.A. Wynn, J.A. Berzofsky, S.P. Blatt, C.W. Hendrix, A. Sher, R.L. Coffman, and G.M. Shearer. 1994. Role of IL-10 in T helper cell dysfunction in asymptomatic individuals infected with HIV. J. Clin. Invest. 93: 768-775.
39. Shire, D. 1993. An invitation to an open exchange of reagents and information useful for the measurement of cytokine mRNA levels by PCR. Eur. Cytokine Netw. 4: 161-162.
40. Bouabouloa, M., P. Legoux, B. Pessegue, B. Delpech, X. Dumont, M. Piechaczyk, P. Casellas, and D. Shire. 1992. Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control. J. Biol. Chem. 267: 21830-21838.
41. Graziosi, C., G. Pantaleo, K.R. Gantt, J.P. Fortin, J.F. Demarest, O.J. Cohen, R. Sekaly, and A.S. Fauci. 1994. Lack of evidence for the dichtomy of Thl and Th2 predominance in HIV-infected individuals. Science (Wash. DC). 265: 248-252.
42. D’Andrea, A., M. Aste-Amezaga, N.M. Valiante, X.J. Ma, M. Kubin, and G. Trinchieri. 1993. IL-10 inhibits human lymphocyte IFNy production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 9: 1041-1048.
43. Chehimi, J., S.E. Starr, I. Frank, A. D’Andrea, X. Ma, R.R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired IL-12 production in HIV-infected patients. J. Exp. Med. 179: 1361-1366.
44. Powrie, F., and R.L. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today. 14: 270-274.
45. Clerici, M., A. Sarin, R.L. Coffman, T.A. Wynn, S.P. Blatt, C.W. Hendrix, S.F. Wolf, G.M. Shearer, and P.A. Henkart. 1994. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for HIV pathogensis. Proc. Natl. Acad. Sci. USA. 91: 11811-11815.
46. Maggi, E., M. Mazzetti, A. Ravina, F. Annunziato, M. De Carli, M.P. Piccinni, R. Manetti, M. Carbonari, A.M. Pesce, G. Del Prete, and S. Romagnani. 1994. Ability of HIV to promote a Thl to ThO shift and to replicate preferentially in Th2 and ThO cells. Science (Wash. DC). 265: 244-248.
47. Klas, C., K.M. Debatin, R.R. Jonker, and P.H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5: 625-630.
48. Ramsdell, F., M.S. Seaman, R.E. Miller, K.S. Picha, M.K. Kennedy, and D.H. Lynch. 1994. Differential ability of Thl and Th2 cells to express Fas ligand and to undergo activationinduced cell death. Int. Immunol. 6: 1545-1553.
49. Rothstein, T.L., J.K.M. Wang, D.J. Panka, L.C. Foote, Z. Wang, B. Stanger, H. Cui, S.T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells. Nature (Lond.). 374: 163-165.
50. Idziorek, T., J. Estaquier, F. De Bels, and J.C. Ameisen. 1995. YOPRO-1 permits cytofluorometric analysis of apoptosis without interfering with cell viability. J. Immunol. Methods. 185: 249-258.