Applications of small-molecule combinatorial chemistry to drug discovery

Drug Discovery Today

Volumn 1, Issue 4, 1996, Pages 134-144

  Patel, Dinesh V ^a   Gordon, Eric M ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000122370     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/1359-6446(96)89062-3     Document Type: Review

References (67)

1. Gallop, M.A. et al. (1994) J. Med. Chem. 37, 1233-1251
2. Gordon, E.M. et al. (1994) J. Med. Chem. 37, 1385-1401
3. Terrett, N.K. et al. (1995) Tetrahedron 51, 8135-8173
4. Gordon, E.M. (1995) Curr. Opin. Biotechnol. 6, 624-631
5. Morin, R.B. and Gorman, M. (eds) (1982) Beta-Lactam Antibiotics, Chemistry and Biology, Vols 1-3. Academic Press, New York
6. Hirschmann, R. (1991) Angew. Chem. 1278-1301
7. Patchett, A.A. (1993) J. Med. Chem. 36, 2051-2058
8. Petrillo, E.W. and Ondetti, M.A. (1982) Med. Res. Rev. 2, 1-41
9. Wiley, R.A. and Rich, D.H. (1993) Med. Res. Rev. 13, 327-384
10. Gordon, E.M., Gallop, M.A. and Patel, D.V. (1995) Account. Chem. Res. (in press)
11. Baldwin, J.J. et al. (1995) J. Am. Chem. Soc. 117, 5588-5589
12. Pei, Y. and Moos, W.H. (1994) Tetrahedron Lett. 35, 5825-5828
13. Forman, F.W. and Sucholeiki, I. (1995) J. Org. Chem. 60, 523-528
14. Chen, C. et al. (1994) J. Am. Chem. Soc. 116, 2661-2662
15. Carell, T., Wintner, E.A. and Rebek, Jr, J. (1994) Angew. Chem. Int. Ed. 33, 2061-2064
16. Carell, T. et al. (1994) Angew. Chem. Int. Ed. 33, 2059-2061
17. Carell, T. et al. (1995) Chem. Biol. 2, 171-183
18. Terrett, N.K. et al. (1995) Bioorg. Medicinal Chem. Lett. 5, 917-922
19. Pirrung, M.C. and Chen, J. (1995) J. Am. Chem. Soc. 117, 1240-1245
20. Moran, E.J. et al. (1995) Biopolymers 37, 213-220
21. Green, J. (1995) J. Org. Chem. 60, 4287-4290
22. Sundram, U.N. and Griffin, J.H. (1995) J. Org. Chem. 60, 1102-1103
23. Rano, T.A. and Chapman, K.T. (1995) Tetrahedron Lett. 36, 3789-3792
24. Burbaum, J.J. et al. (1995) Proc. Natl Acad. Sci. USA 92, 6027
25. Beebe, X., Schore, N.E. and Kurth, M.J. (1995) J. Org. Chem. 60, 4196-4203
26. Beebe, X. et al. (1995) J. Org. Chem. 60, 4204-4212
27. Furka, A. et al. (1988) Abstracts 14th International Congress Biochemistry, Prague, Vol. 5, p. 47
28. Furka, A. et al. (1988) Abstracts 10th International Symposium Med. Chemistry, Budapest, p. 288
29. Furka, A. et al. (1991) Int. J. Peptide Protein Res. 37, 487-493
30. Houghten, R.A. (1985) Proc. Natl Acad. Sci. USA 82, 5131-5135
31. Houghten, R.A. et al. (1986) Int. J. Peptide Protein Res. 27, 673-678
32. Geysen, H.M., Meloen, R.H. and Barteling, S.J.(1984) Proc. Natl. Acad. Sci. USA 81, 3998-4002
33. Valerio, R.M. et al. (1993) Int. J. Peptide Protein Res. 42, 1-9
34. Bray, A.M., Maeji, N.J. and Geysen, H.M. (1990) Tetrahedron Lett. 31, 5811-5814
35. Fodor, S.P.A. et al. (1991) Science 251, 767
36. Jacobs, J.W. and Fodor, S.P.A. (1994) Trends Biotechnol. 12, 19-26
37. Cho, C.Y. et al. (1993) Science 261, 1303-1305
38. Simon, R.J. et al (1992) Proc. Natl Acad. Sci. USA 89, 9367-9371
39. Zuckermann, R.N. et al. (1992) J. Am. Chem. Soc. 114, 10646-10647
40. Zuckermann, R.N. et al. (1994) J. Med. Chem. 37, 2678-2685
41. Bartlett, P.A. and Marlowe, C.K. (1987) Biochemistry 26, 8553-8561
42. Morgan, B.R et al. (1991) Am. Chem. Soc. 113, 297-307
43. Karanewsky, D.S. et al. (1988) J. Med. Chem. 31, 204
44. Campbell, D.A. (1992) J. Org. Chem. 57, 6331-6335
45. Campbell, D.A. and Bermak, J.C. (1994) J. Org. Chem. 59, 658-660
46. Campbell, D.A. and Bermak, J.C. (1994) J. Am. Chem. Soc. 116, 6039-6040
47. Campbell, D.A. et al. (1995) J. Am. Chem. Soc. 117, 5381-5382
48. Bunin, B.A. and Ellman, J.A. (1992) J. Am. Chem. Soc. 114, 10997-10998
49. Bunin, B.A., Plunkett, M.J. and Ellman, J.A. (1996) Methods Enzymol. (in press)
50. Plunkett, M.J. and Ellman, J.A. (1995) J. Am. Chem. Soc. 117, 3306-3307
51. Bunin, B.A., Plunkett, M.J. and Ellman, J.A. (1994) Proc. Natl Acad. Sci. USA 91, 4708-4712
52. DeWitt, S.H. et al. (1993) Proc. Natl Acad. Sci. USA 90, 6909-6913
53. Murphy, M.M. et al. (1995) J. Am. Chem. Soc. 117, 7029-7030
54. Look, G.C. et al. (1994) J. Org. Chem. 59, 7588-7590
55. Gordon, D.W. and Steele, J. (1995) Bioorg. Medicinal Chem. Lett. 5, 47-50
56. Wang, G.T. et al. (1995) J. Med. Chem. 38, 2995-3002
57. Kick, E.K. and Ellman, J.A. (1995) J. Med. Chem. 38, 1427-1430
58. Kurth, M.J. et al. (1994) J. Org. Chem. 59, 5862-5864
59. Williard, R. et al. (1995) Chem. Biol 2, 45-51
60. Holmes, C.P. et al. (1995) J. Org. Chem. 60, 7328-7333
61. Ruhland, B. et al. (1995) J. Am. Chem. Soc. (in press)
62. Boojamra, C.G., Burow, K.M. and Ellman, J.A. (1995) J. Org. Chem. 60, 5742-5743
63. Goff, D.A. and Zuckermann, R.N. (1995) J. Org. Chem. 60, 5744-5745
64. Gordeev, M.F., Patel, D.V. and Gordon, E.M. (1995) J. Org. Chem. (in press)
65. Wipf, P. and Cunningham, A. (1995) Tetradedron. Lett. 36, 7819-7822
66. Yu, K-L., Deshpande, M.S. and Vyas, D.M. (1994) Tetrahedron Lett. 35, 8919-8972
67. Goff, D.A. and Zuckermann, R.N. (1995) J. Org. Chem. 60, 5748-5749