Spontaneous metastasis of rat liver epithelial cells transformed with v-raf and v-raf/v-myc: Association with different phenotypic properties

Invasion and Metastasis

Volumn 17, Issue 5, 1997, Pages 240-250

  Bisgaard, Hanne Cathrine ^a   Mackay, Andrew R ^b   Gomez, Daniel E ^c   Ton, Phuongnga T ^c   Thorgeirsson, Snorri S ^c   Thorgeirsson, Unnur P ^c  

^a ROSKILDE UNIVERSITY   (Denmark)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Liver epithelial cells, rat; Myc; Raf

Indexed keywords

COLLAGEN TYPE 1; CYTOKERATIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RAF PROTEIN; RNA; UROKINASE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSKELETON; EPITHELIUM CELL; LIVER; LUNG METASTASIS; MARKER GENE; METASTASIS; MOLECULAR CLONING; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE MYC; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; XENOGRAFT;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; COLLAGEN; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; KERATIN-14; KERATINS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOGENE PROTEINS V-RAF; PHENOTYPE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, INBRED F344; RECEPTORS, CELL SURFACE; RETROVIRIDAE PROTEINS, ONCOGENIC; RNA, MESSENGER;

EID: 0031544229     PISSN: 02511789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Fidler IJ: Critical factors in the biology of human cancer metastasis: Twenty-eight G.H.A. Clowes Memorial Award Lecture. Cancer Res 1990;50:6130-6138.
2. Crissman JD, Hatfield J, Schaldenbrand J, Sloane BF, Honn KV: Arrest and extravasation of B16 amelanotic melanoma in murine lungs. Lab Invest 1985;53:470-478.
3. Lindsay CK, Sinha CC, Thorgeirsson UP: Morphological study of vascular dissemination in a metastatic hepatocellular carcinoma model. Hepatology 1997;26:1209-1215.
4. Marceau N: Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms. Lab Invest 1990; 63:4-20.
5. Grisham JW, Thorgeirsson SS: Liver stem cells; in Potter CS (ed): Stem Cells. London, Academic Press, 1997, pp 233-282.
6. Shiojiri N, Lemire JM, Fausto N: Cell lineages and oval cell progenitors in rat liver development. Cancer Res 1991;51:2611-2620.
7. Mareel MM, De Baetselier P, Van Roy FM: Oncogenes and malignancy in experimental tumor progression systems; in Mareel MM, DeBaetselier P, Van Roy FM (eds): Mechanisms of Invasion and Metastasis. Boca Raton, CRC Press, 1991, pp 327-359.
8. Brown K, Kemp C, Burns P, Balmain A: Importance of genetic alterations in tumor development. Arch Toxicol Suppl 1994;16:253-260.
9. Thorgeirsson UP, Turpeenniemi-Hujanen T, Williams JE, Westin EH, Heilman CA, Talmadge JE, Liotta LA: NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol 1985;5: 259-262.
10. Egan SE, Wright JA, Jarolim J, Yanagihara K, Bassin RH, Greenberg AH: Transformation by oncogenes encoding protein kinases induces the metastatic phenotype. Science 1987;238:202-205.
11. Vousden KH, Eccles SA, Purvies H, Marshall CJ: Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c-Haras-1 gene. Int J Cancer 1986;37: 425-433.
12. Ura H, Bonfil RD, Reich R, Reddel R, Pfeifer A, Harris CC, Klein-Szanto AJP: Expression of type IV collagenase and procollagen genes and its correlation with tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res 1989;49:4615-4621.
13. Yanagihara K, Nu M, Tsumuraya M, Numoto M, Seito T, Seyama T: A radiation-induced murine ovarian granulosa cell tumor line: Introduction of v-ras gene potentiates a high metastatic ability. Jpn J Cancer Res 1995;86:347-356.
14. Tiniakos D, Spandidos DA, Yiagnisis M, Tiniakos G: Expression of ras and c-myc oncoproteins and hepatitis B surface antigen in human liver disease. Hepatogastroenterol 1993; 40:37-40.
15. Shen HM, Ong CN: Mutations of the p53 tumor suppressor gene and ras oncogene in aflatoxin hepatocarcinogenesis. Mutat Res 1996;366: 23-44.
16. Giri RK, Das BR: Differential expression of c-jun and c-myc in N-nitrosodiethylamine-induced hepatic oncogenesis in AKR mice. Cancer Lett 1996;109:121-127.
17. Abou-Elella A, Gramlich T, Fritsch C, Gansler T: c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis. Mol Pathol 1996;9:95-98.
18. Masui T, Nakanishi H, Inada K, Imai T, Mizoguchi Y, Yada H, Futakuchi M, Shirai T, Tatematsu M: Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Cancer Lett 1997;112: 33-45.
19. Tabor E: Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus-associated hepatocellular carcinoma. J Med Virol 1994;42:357-365.
20. Deguchi T, Pilot HC: Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital. Mol Carcinog 1995;14:152-159.
21. Neumann U, Eisenmann-Tappe I, Rapp UR: The role of Raf kinases in development and growth of tumors. Recent Results Cancer Res 1997; 143:237-244.
22. Huber BE, Heilman CA, Thorgeirsson SS: Poly (A+) RNA levels of growth: Differentiation- and transformation-associated genes in the progressive development of hepatocellular carcinoma in the rat. Hepatology 1989;9:756-762.
23. Storm SM, Rapp UR: Oncogene activation: c-raf-1 gene mutations in experimental naturally occurring tumors. Toxicol Lett 1993;67:201-210.
24. Cleveland JL, Jansen HW, Bister K, Frederickson TN, Morse HC III, Ihle JN, Rapp UR: Interaction between raf and myc oncogenes in transformation in vivo and in vitro. J Cell Biochem 1986;30:195-218.
25. Garfield S, Huber BE, Nagy P, Cordingley MG, Thorgeirsson SS: Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus-associated oncogenes. Mol Carcinog 1988;189-195.
26. Huber BE, Cordingley MG: Expression and phenotypic alterations caused by an inducible transforming ras oncogene introduced into rat liver epithelial cells. Oncogene 1988;3: 245-256.
27. Hampton LL, Worland PJ, Yu B, Thorgeirsson SS, Huggett AC: Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells. Cancer Res 1990;50:7460-7467.
28. Worland PJ, Hampton LL, Thorgeirsson SS, Huggett AC: Development of an in vitro model of tumor progression using v-raflv-myc transformed rat liver epithelial cells: Correlation of tumorigenicity with the downregulation of specific proteins. Mol Carcinog 1990;3:20-29.
29. Williams AO, Huggett AC, Thorgeirsson SS: Pathology of spontaneous and oncogene transformed rat liver epithelial cells and derived tumours in nude mice. Int J Exp Pathol 1992;73:99-114.
30. Price J, Turner D, Cepko C: Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA 1987;84:156-160.
31. Mackay AR, Corbitt RH, Hartzler JL, Thorgeirsson UP: Basement membrane type IV collagen degradation: Evidence for a proteolytic cascade independent of metalloproteinases. Cancer Res 1990;50:5997-6001.
32. Ballin M, Gomez DE, Sinha CC, Thorgeirsson UP: Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype. Biochem Biophys Res Commun 1988;154: 832-838.
33. Zeheb R, Gelehrter TD: Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1. Gene 1988;73:459-469.
34. Bisgaard HC, Ton PT, Nagy P, Thorgeirsson SS: Phenotypic modulation of keratins, vimentin, and α-fetoprotein in cultured rat liver epithelial cells after chemical, oncogene, and spontaneous transformation. J Cell Physiol 1994;159:485-494.
35. Santoni-Rugiu E, Nagy P, Jensen MR, Factor VM, Thorgeirsson SS: Evolution of neoplastic development in the liver of transgenic mice coexpressing c-myc and transforming growth factor-α. Am J Pathol 1996;149:407-428.
36. Lin W-C, Pretlow TP, Pretlow TG, Culp LA: Bacterial lacZ gene as a highly sensitive marker to detect micrometastasis formation during tumor progression. Cancer Res 1990; 50:2808-2817.
37. Mignatti P, Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993;73: 161-195.
38. Bernard EJ, Muschel RJ, Hughes EN: Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells. Cancer Res 1990;50:3872-3877.
39. Ballin M, Mackay AR, Hartzler JL, Nason A, Pelina MD, Thorgeirsson UP: Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues. Clin Exp Metastasis 1991;9:179-189.
40. Bisgaard HC, Santoni-Rugiu E, Nagy P, Thorgeirsson SS: Modulation of the plasminogen activator/ plasmin system in rat liver regenerating by recruitment of oval cells. Lab Invest 1998;78:237-246.
41. Bisgaard HC, Thorgeirsson SS: Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas. J Cell Physiol 1991;147:333-343.