Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes

Cancer Letters

Volumn 112, Issue 1, 1997, Pages 33-45

  Masui, Tsuneo ^a   Nakanishi, Hayao ^a   Inada, Ken Ichi ^a   Imai, Toshio ^a   Mizoguchi, Yasumoto ^b   Yada, Hideaki ^b   Futakuchi, Mitsuru ^b   Shirai, Tomoyuki ^b   Tatematsu, Masae ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Growth factor; Lung metastasis; N nitrosomorpholine; p53; Rat hepatocarcinogenesis model

Indexed keywords

ALPHA FETOPROTEIN; CARCINOGEN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; NITROSOMORPHOLINE; PROTEIN P53; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LUNG METASTASIS; MALE; METASTASIS POTENTIAL; MUTATION RATE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; POINT MUTATION; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; GENES, P53; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MALE; MUTATION; NITROSAMINES; ONCOGENES; RATS; RATS, INBRED F344; RNA, MESSENGER;

ANIMALIA;

EID: 0031032172     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04543-0     Document Type: Article

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