Inhibitors of the cytochrome P450-mono-oxygenase and endothelium-dependent hyperpolarizations in the guinea-pig isolated carotid artery

British Journal of Pharmacology

Volumn 117, Issue 4, 1996, Pages 607-610

  Corriu, Catherine ^a   Félétou, Michel ^a   Canet, Emmanuel ^a   Vanhoutte, Paul M ^b  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Clotrimazole; Cytochrome P450; EDHF; Electrophysiology; Endothelium; Hyperpolarization; Metyrapone; Quinacrine; SKF525a; Smooth muscle cells

Indexed keywords

ACETYLCHOLINE; ATROPINE; CLOTRIMAZOLE; CYTOCHROME P450; ICOSATETRAYNOIC ACID; INDOMETACIN; MEPACRINE; METHOXSALEN; METYRAPONE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM; PROADIFEN; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY MUSCLE; ARTICLE; CAROTID ARTERY; GUINEA PIG; HYPERPOLARIZATION; ISOLATED ARTERY; MALE; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL;

EID: 0030068066     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15233.x     Document Type: Article

References (18)

1. BAUERSACHS, J., HECKER, M. & BUSSE, R. (1994). Display of characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br. J. Pharmacol., 113, 1548-1553.
2. CHEN, G., SUZUKI, H. & WESTON, AH. (1988). Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol., 95, 1165-1174.
3. CHEN, G., YAMAMOTO, Y., MIWA, K. & SUZUKI, H. (1991). Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. Am. J. Physiol., 260, H1888-H1892.
4. FELETOU, M. & VANHOUTTE, PM. (1988). Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br. J. Pharmacol., 93, 515-524.
5. FULTON, D., MAHBOUDI, K., MCGIFF, J. & QUILLEY, J. (1995). Cytochrome P450-dependent effects of bradykinin in the rat heart. Br. J. Pharmacol., 114, 99-102.
6. FURCHGOTT, R. & VANHOUTTE, PM. (1989). Endothelium-derived relaxing and contracting factors. FASEB J., 3, 2007-2018.
7. GEBREMEDHIN, D., YUNN-HWA, A., FALCK, J.R, ROMAN, R.J., VANROLLINS, M. & HARDER, D. (1992). Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am. J. Physiol., 263, H519-H525.
8. HARDER, D.R., CAMPBELL, W.B. & ROMAN, R.J. (1995). Role of the cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J. Vasc. Res., 32, 79-92.
9. HECKER, M., BARA, A.T., BAUERSACHS, J. & BUSSE, R. (1994). Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol., 481, 407-414.
10. HU, S. & KIM, H.S. (1993). Activation of K + channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid. Eur. J. Pharmacol., 230, 215-221.
11. KOMORI, K. & VANHOUTTE, P.M. (1990). Endothelium-derived hyperpolarzing factor. Blood Vessels, 27, 238-245.
12. NAGAO, T. & VANHOUTTE, P.M. (1992). Hyperpolarization as a mechanism for endothelium-dependent relaxations in porcine coronary arteries. J. Physiol., 445, 355-368.
13. OYEKAN, A., MCGIFF, J.C., ROSENCRANTZ-WEISS, P. & QUILLEY, J. (1994). Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors. J. Pharmacol. Exp. Ther., 268, 262-269.
14. PALMER, R.J.M., FERRIDGE, A.G. & MONCADA, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524-526.
15. RAPPOPORT, R.M. & MURAD, F. (1983). Agonist-induced endothelium-dependent relaxations in rat thoracic aorta may be mediated through cGMP. Circ. Res., 52, 352-357.
16. SUZUKI, H., CHEN, G., YAMAMOTO, M. & MIWA, K. (1992). Nitroarginine-sensitive and -insensitive components of the endothelium-dependent relaxation in the guinea-pig carotid artery. Jpn. J. Pharmacol., 42, 335-347.
17. WEINTRAUB, N.L., JOSHI, S.N., BRANCH, C.A., STEPHENSON, A.H., SPRAGUE, R.S. & LONIGRO, A.J. (1994). Relaxation of porcine coronary artery to bradykinin. Role of arachidonic acid. Hypertension, 23, 976-981.
18. ZHANG, G., YAMAMOTO, Y., MIWA, K. & SUZUKI, H. (1994). Vasodilation induced by substance P in guinea-pig carotid arteries. Am. J. Physiol., 266, H1132-H1137.