Human T cell lymphotropic retroviruses: Association with diseases of the nervous system

Intervirology

Volumn 40, Issue 2-3, 1997, Pages 132-142

  Kitze, Bernd ^a   Brady, John N ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antiviral immune response; Human T cell lymphotropic virus; Myelopathy tropical spastic; Paraparesis Viral persistence; Transactivation; Type I HTLV I associated

Indexed keywords

CD4 ANTIGEN; TAX PROTEIN; VIRUS PROTEIN;

BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REVIEW; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; T LYMPHOCYTE; VIRUS IMMUNITY;

ANIMALS; GENOME, VIRAL; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; PARAPARESIS, TROPICAL SPASTIC; VARIATION (GENETICS);

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T CELL LYMPHOTROPIC VIRUS TYPE I; HUMAN T-LYMPHOTROPIC VIRUS 1; RNA VIRUSES;

EID: 0031466206     PISSN: 03005526     EISSN: 14230100     Source Type: Journal    
DOI: 10.1159/000150540     Document Type: Article

References (118)

1. Kaplan JE, Osame M, Kubota H, Igata A, Nishitani H, Maeda Y, Khabbaz RF, Janssen RS: The risk of development of HTLV-I-asso-ciated myelopathy/tropical spastic paraparesis among persons infected with HTLV-1. J Aequir Immune Dcfic Syndr 1990:3:1096-1101.
2. Takatsuki K, Yamaguchi K, Watanabc T, Mo-chizuki M, Kiyokawa T, Mori S, Mivata N: Adult T-cell leukemia and I1TLV-I related diseases; in Takatsuki K, Hinuma Y, Yoshida M (cds): Advances in Adult T-Cell Leukemia and HTLV-I Research, Gann Monograph on Cancer Research, Tokyo, Japan Scientific Societies Press, 1992. vol 39. pp 1-15.
3. Poicsz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proc Natl Acad Sci 1980:77:7415-7419.
4. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease, Proc Natl Acad Sci 1982:79:2031.
5. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calander A, de The G: Antibodies to human T-lymphotopic virus type I in patients with tropical spastic paraparesis, Lancet 1985;2:407-410.
6. Osame M, Janssen R, Kubote H, Nishitani H, Igata A, Nagataki S, Mori M, Goto I, Shimabu-kuro H, Khabbaz R, et al: Nationwide survey of HTLV-I-associated myelopathy/tropical spastic paraparesis in Japan: Association with blood transfusion, Ann Neurol 1990:28:50-56.
7. Iljichi S, Matsuda T, Marayuma I, et al: Arthritis in a human T lymphotropic virus type I (HTVL-I) carrier, Ann Rheumatol Dis 1991: 162:435.
8. Sasaki K, Morooka I, lnomata H, Kashio N, Akamine T, Osame M: Retinal vasculitis in human T-lvmphotropic virus type I associated myelopathy, Br J Ophthalmol 1989:73:812.
9. LaGrande L, Hanchard B, Fletcher V, Cranston B, Blattner WA: Infective dermatitis of Jamaican children: A marker of HTLV-I infection, Lancet 1991:336:1345.
10. Katsuki T, Katski K, Imai J, Hinuma Y: Immune suppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-I): impairment of T-cell control of Epstein-Barr virus-infected B-cclls, Jpn J Cancer Res 1987:78: 639.
11. Kalvanaraman VS, Samgadharan MG, Robert-Guroff M, Miyoshi I, Golde D, Gallo RC: A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia, Science 1982:218:571.
12. Reitz MS, Popovic M, Haynes BF, Clark SC, Gallo RC: Relatedness by nucleic acid hybridization of new isolates of human T-cell leukc-mia-lymphoma virus (FITLV) and demonstration of provirus in uncultured leukemic blood cells, Virology 1983:126:688.
13. Hollsbcrg P, Haller DA: Pathogenesis of diseases induced by human lymphotropic virus type I infection, N Engl J Med 1993:328:1173.
14. Tajima K, Ito SI, Tsushima ATL study group: Prospective studies of HTLV-I and associated diseases in Japan: in Blattner WA (ed): Human Retrovirology: HTLV, Raven Press, 1990. p 267.
15. Hino S: Maternal-infant transmission of HTLV-I: Implication for disease: in Blattner WA (cd): Human Retrovirology, New York, Raven Press, 1990. p 363.
16. Kajiyama W, Kashiwaga S, lkematsu H, Haya-shi J, Normura H, Okochi K: Intrafamilial transmission of adult T-cell leukemia virus, J Infect Dis 1986; 154:851.
17. Murphy EL, Figueroa JP, Gibbs WN, Brath-waite A, Holding-Cobham M, Waters D, Cranston B, Hanchard B, Blattner WA: Sexual transmission of human T-lymphotropic virus, Ann Intern Med 1989:111:555-560.
18. Take H, Umemoto M, Kushuara K, Kuraya K: Transmission routes of HTLV-1: An analysis of 66 families, Jpn J Cancer Res 1993:84:1265.
19. Inaba S, Sato H, Okochi K, Fukada K, Takaku-ra F, Tokunaga K, Kiyohawa H, Maeda Y: Prevention of transmission of human T-lymphotropic virus type I (HTLV-I) through transfusion, by donor screening with antibody to the virus, One-year experience, Transfusion 1989: 29:7-11.
20. Sandler SG, Fang CT, Williams AE: Human T-cell lymphotropic virus type I and II in transfusion medicine, Transfus Med Rev 1991:5:93.
21. Schwebkc J, Calsyn D, Shriver K, Saxon A, Kleyn J, Oluoch Mitchell E, Olmstcad L, Fisher LD, Krone M, Ashley R, Stamm W, Swenson P, Holmes KK: Prevalence and epidemiologic correlates of human T cell lymphotropic virus infection among intravenous drug users, J Infect Dis 1994:169:962-967.
22. Coffin JM: RNA tumor viruses (and related agents) - Retroviridae; in Francki RIB, Fau-quet CM, Knudson DL, Brown F (cds): Classification and Nomenclature of Viruses, Arch Virol Suppl, Wien, Springer, 1991. vo! 2. pp 290-299.
23. Koralnik LL: Structure of HTLV-I: in Hollsbcrg P, Hafler DA (cds): Human T-Cell Lymphotropic Virus Type I, Chichester, Wiley, 1996. pp 65-78.
24. m, proteins encoded by the pX sequence of human T-cell leukemia virus type I, Proc Natl Acad Sci 1985:82:8359.
25. Nagashima K, Yoshida M, Seiki M: A single species ofp, YmRNA of human T-cell leukemia virus type I encodes /ram-aclivator p40' and two other phosphoprotcins, J Virol 1986:60: 394.
26. Furukawa K, Furukawa K, Shiku H: Alternatively spliced mRNA of the pX region of human T lymphotropic virus type I proviral genome, FEBS Lett 1991:295:141.
27. Ciminale V, Pavlakis GN, Dersc D, Cunningham CP, Fclber BK: Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: Novel mRNAs and proteins produced by HTLV type I, J Virol 1992:66:1737.
28. Bememan ZN, Gartcnhaus RB, Reitz MS Jr, Blattncr WA, Manns A, Hanchard B, Ikchara O, Gallo RC, Klotman ME: Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers, Proc Natl Acad Sci 1992:89:3005.
29. M proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments, J Virol 1993: 67:2360.
30. 1 protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodallon subunit of the vacuolar H* ATPase, J Virol 1993:67:7701.
31. Mulloy JC, Bocri E, Gallo RC, Leonard WJ, Franchini G: Association of the HTLV-I pl2l protein with immature forms of the IL-2R p and Yc chains: Implications forleukemogenesis, Submitted.
32. Paine E, Garcia J, Philpotl TC, Shaw G, Rainer L: Limited sequence variation in human T-lymphotropic virus type I isolates from North American and African patients, Virology 1991; 182:111.
33. Komurian F, Pelloquin F, deThe G: In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies, J Virol 1991:65:3770.
34. Gessain A, Saal F, Morozov V, Lasnerct J, Vilctte D, Gout O, Entanoil-Ravier R, Sigaux F, dc The G, Perics J: Characterization of HTLV-I isolates and T lymphoid cell lines derived from French West Indian patients with tropical spastic paraparesis, Int J Cancer 1989; 43:327.
35. Shimotohno K, Takahashi Y, Shimizu N, Go-jobori T, Golde DW, Chen IS, Miwa M, Sugi-ntura T: Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the pro-tease gene, Proc Natl Acad Sci USA 1985:82: 3101-3105.
36. Gessain A, Yanagihara R, Franchini G, Garru-to RM, Jenkins CL, Ajdukicwicz AB, Gallo RC, Gajdusek DC: Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands, Proc Nall Acad Sci USA 1991:88:7694-7698.
37. Gessain A, Gallo RC, Franchini G: Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations, J Virol 1992:66: 2288.
38. Franchini G, Reitz MS Jr.: Phylogenesis and genetic complexity of the nonhuman primate Retroviridae, AIDS Res Hum Retroviruses 1994:10:1047.
39. r HTLV-I variant from Papua New Guinea, J Virol 1992:144:59.
40. Vidal All, Gessain A, Yoshida M, Tckaia F, Garin B, Guillcrmain B, Schulz T, Farid R, dc The G: Phylogenetic classification of human T cell leukacmia/lvmphoma virus type I genotypes in five major molecular and geographical subtypes, J Gen Virol 1994:75:3655-3666.
41. Voevodin A, al-Mufti S, Farah S, Khan R, Miu-ra T: Molecular characterization of human T-lvmphotropic virus, type 1 (HTLV-I) found in Kuwait: Close similarity with HTLV-I isolates originating from Mashhad, Iran, AIDS Res Hum Retroviruses 1995; 11:1255.
42. Safai B, Huang J-L, Boeri E, Farid R, Raafat J, Schutzcr P, Akhami R, Franchini G: Prevalence of HTLV type I infection in Iran: A serological and genetic study, AIDS Res Hum Retroviruses 1996:12:1185.
43. Yamashita M, Kitzc B, Miura T, Weber T, Fujiyoshi T, Takehisa J, Chen J, Sonoda S, Hayarni M: The phylogenetic relationship of HTLV type I from non-Mashadi Iranians to that from Mashadi Jews, AIDS Res Hum Retroviruses 1991;11:1533-1535.
44. Constantine NT, Callahan JD, Watts DM: Retroviral Testing: Essentials for Quality Control and Laboratory Diagnosis, Boca Raton, CRC Press, 1992.
45. Lai RB, Hencine W: Testing of human T-lvm-photropic virus types I and II: Serologic, viro-logic and molecular detection: in Hollsbcrg P, Haller DA (cds): Human T-Cell Lymphotropic Virus Type 1. Chichester, Wilev, 1996. pp 167-195.
46. Molgaard CA, Eisenman PA, Ryden LA, Gol-bcck AL: Neuroepidcmiology of human T-Ivmphotrophic virus type-I-associatcd tropical spastic paraparesis, Neuroepidemiologv 1989; 8:109.
47. Larkin J, Sinnott JT, Weiss J, Holt DA: Human T-cdl lymphotropic virus-type I, Infect Control Hosp Epidemiol 1990:11:314.
48. Nakagawa M, Izumo S, Ijichi S, Kubota H, Ari-mura K, Kawabata M, Osame M: HTLV-I-associatcd myelopathy: Analysis of 213 patients based on clinical features and laboratory findings, J Neuroviroi 1995:1:50-61.
49. Manns A, Blattncr WA: The epidemiology of the human T-cell lymphotrophic virus type 1 and type II: Etiologic role in human disease, Transfusion 1991:31:67.
50. Janssen RS, Kaplan JE, Khabbaz RF, Hammond R, Lechtenberg R, Lairmorc M, Chias-son MA, Punsalang A, Roberts B, McKendall RR: HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States, Neurology 1991:41:1355.
51. Gessain A, Barin F, Vemant JC, Gout O, Maurs L, Calender A, de The G: Antibodies to human T-lvmphotropic virus typc-I in patients with tropical spastic paraparesis, Lancet 1985: 2:407.
52. Wattel E, Vartanian JP, Pannetier C, Wain-Hobson S: Clonal expansion of human T-cell leukemia virus type 1-infectcd cells in asymptomatic carriers without malignancy, J Virol 1995:69:2863-2868.
53. Yoshida M, Osame M, Kawai H, Toita M, Kuwasaki N, Nishida Y, Hiraki Y, Takahashi K, Nomura K, Sonoda S, Eiraku N, Ijichi S, Usuku K: Increased replication of HTLV-I in HTLV-I-associated myelopathy, Ann Neurol 1989:26:331-335.
54. Kubota R, Fujiyoshi T, Izumo S, Yashiki S, Maruyama I, Osame M, Sonoda S: Fluctuation of HTLV-I proviral DN'A in peripheral blood mononucear cells of HTLV-I-associated myelopathy, J Neuroimmunol 1993:42:147-154.
55. Niewicsk S, Daenke S, Parker CE, Taylor G, Weber J, Nightingale S, Bangham CRM: The transactivator gene of human T-cell leukemia virus type 1 is more variable within and between healthy carriers than patients with tropical spastic paraparesis, J Virol 1994:68:6778-6781.
56. Tendler CL, Greenberg SJ, Blattner WA, Manns A, Murphy E, Fleisher T, Hanchard B, Morgan O, Burton JD, Nelson DL: Transacti-vation of interleukin 2 and its receptor induces immune activation in human T-cell lympho-tropic virus type I-associated myelopathy: Pathogenic implications and a rationale for immunotherapy, Proc Natl Acad Sci USA 1990: 87:5218.
57. Lehkv TJ, Fox CH, Koenig S, Levin MC, Fler-lage N, Izumo S, Sato E, Raine CS, Osante M, Jacobson S: Detection of human T-Iympho-tropic virus type I (HT1.V-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization, Ann Neurol 1995:37:167.
58. Hara H, Morita M, Iwaki T, Hatac T, Itoyama Y, Kitamoto T, Akizuki S, Goto 1. WatanabeT: Detection of human T lymphotropic vims type I (HTLV-1) proviral DNAand analysis of T cell receptor V beta CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/ tropical spastic paraparesis, J Exp Med 1994: 180:831-839.
59. Moritoyo T, Reinhart TA, Moritoyo H, Sato E, Izumo S, Osame M, Haase AT: Human T-lvm-photropic vims type l-associatcd myelopathy and tax gene expression in CD4+ T lymphocytes, Ann Neurol 1996:40:84-90.
60. Koyanagi Y, Itoyama Y, Nakamura N, Takamatsu K, Kira J, Iwamasa T, Goto I, Yamamoto N: In vivo infection of human T-ccll leukemia vims type I in non-T cells, Virology 1993; 196:25.
61. Fanauchi M, Saida T, Saida M, Makajima M, Matsuda S, Nishiguchi E, Nishitani H: Cvto-pathic effects of HTLV-I infection in human neural cell lines: in Roman GC, Vcmant J-C, Osame M (eds): HTLV-1 in the Nervous System, New York, Liss, 1989. pp 333.
62. Hiravama M, Miyadai T, Yokochi T, Sato K, Kubota M, lida M, Fujiki N: Infection of human T-lvmphoiropic virus type I to astrocytes in vitro with induction of the class II major histocompatibility complex, Neurosci Lett 1988; 92:34.
63. Hayami M, Tsujimoto H, Komuro A, Hinuma Y, Fujiwara K: Transmission of adult T-cell leukemia vims from lymphoid cells to non-lvmphoid cells associated with cell membrane fusion, Gann 1984:75:99.
64. Watanabc H, Nakamura T, Nagasato K, Shi-rabe S, Ohishi K, Ichinose K, Nishiura Y, C'hiyoda S, Tsujihata M, Nagataki S: Exaggerated messenger RNA expression of inflammatory cytokines in human T-cell lymphotropic vims type I-associated myelopathy, Arch Neurol 1995;52:276-280.
65. Nishiura Y, Nakamura T, Takino H, Ichinose K, Nagasato K, Ohishi K, Tsujihata M, Nagataki S: Production of granulocytc-macrophage colony stimulating factor by human T-lympho-tropic virus type 1-infected human glioma cells, J Neurol Sci 1994:121:208-214.
66. Nagai M, Yashiki S, Fujiyoshi T, Fujiyama C, Kitze B, Izumo S, Osame M, Sonoda S: Characterization of a unique T-ccll clone established from a patient with HAM/TSP which recognized HTLV-l-infeeted T-cell antigens as well as spinal cord tissue antigens, J Neuroimmunol 1996;65:97-105.
67. Jacobson S, Shida H, McFarlin DE, Fauci AS, Koenig S: Circulating CD8+ cytotoxic lymphocytes specific for HTLV-I in patients with HTLV-1 associated neurological disease, Nature 1990:348:245-248.
68. Jacbson S, McFarlin D, Robinson S, Voskuhl R, Martin R, Brewah A, Newell AJ, Koenig S: Demonstration of HTLV-I specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-1 associated neurologic disease, Ann Neurol 1992:32:651-657.
69. Elovaara I, Koenig S, Brewah A, Jacobson S: High HTLV-I specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I associated neurological disease, J Exp Med 1993;177:1567-1573.
70. Koenig S, Woods R, Brewah AH, ct al: Characterization of major histocompatibility com-plcx-(MHC) class I restricted cytotoxic T cells (CTL) responses to Tax in HTLV-I infected patients with neurologic disease, J Immunol 1993:156:3874-3883.
71. Kannagi M, Harada S, Maruyama I, Inoko H, lgarashi H, Kuwashima G, Sato S, Morita M, Kidokoro M, Sugimoto M, et al: Predominant recognition of HTLV-I pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I infected cells, Ini Immunol 1991:3: 761-767.
72. Parker CE, Daenkc S, Nightingale S, Bangham CR: Activated, HTLV-I specific cytotoxic T lymphocytes are found in healthy seropositive as well as patients with tropical spastic paraparesis, Virology 1992:188:628-636.
73. Kannagi M, Matsushita S, Shida H, Harada S: Cytotoxic T cell response and expression of the target antigen in HTLV-infection, Leukemia 1994;8(suppl l):S54-59.
74. Daenkc S, Kcrmodc AG, Hall SE, Taylor G, Weber J, Nightingale S, Bangham CR: High activated and memory cytotoxic T-cell responses to HTLV-I in healthy carriers and patients with tropical spastic paraparesis, Virology 1996;217:139-146.
75. Niewiesk S, Daenke S, Parker CE, Taylor G, Weber J, Nightingale S, Bangham CR: Naturally occurring variants of human T-cell leukemia virus type I tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax, J Virol 1995:69:2649-2653.
76. Jacobson S: Immune response to retroviruses in the central nervous system: Role in the neuropathology of HTLV-1 associated neurologic disease, Semin Neurosci 1992:4:285-290.
77. Iwasaki Y, Tsukamoto T, Terunuma IT, Osame M: Mechanisms of neural tissue damage in human retrovirus infections: Cytopathic activity in CSF of patients with HTLV-l-associaicd myelopathy: in Roman GC, Vcmant J-C, Osame M (eds): HTLV-I and the Nervous System, New York, Liss, 1989. pp 325.
78. Terunuma H, Iwasaki Y, Tsukamoto T, Konno H, Ykamamoto T, Ohara Y: Neurotoxic activity in HTLV-I carrier lymphocyte culture, J Neurol Sci 1989:92:169.
79. Hollsberg P, Haller DA: Pathogenesis of diseases induced by human lymphotropic virus type I infection, N Engl J Med 1993:328:1173-1182.
80. IJichi S, Izumo S, Eiraku N, et al: An autoag-grcssivc process against bystander tissues in HTLV-I infected individuals: A possible mechanism of HAM/TSP, Med Hypotheses 1993; 41:542-547.
81. Sonoda S, Fujiyoshi T, Yashiki S: Immunoge-neticsof HTLV-I/II and associated diseases, J Acquir Immune Dcfic Syndr 1996:13(suppl 1): 119-123.
82. Akari H, Goto Y, Shinjo T: Detection of the cellular membrane proteins on human T cell leukemia virus type I, Arch Virol 1995:140: 375-382.
83. Lchky TJ, Jacobson S: Induction of HLA class II in HTLV-I infected neuronal cell lines, J Neurovirol 1995; 1:157.
84. Noraz N, Verricr B, Fraisier C, Desgrangcs C: Cell surface phenotype changes induced in H9 T cells chronically infected with HTLV type 1 or type I or coinfected with the two viruses, AIDS Res Hum Retroviruses 1995:11:145-154.
85. Zhao TM, Robinson MA, Bowers FS, Kindt TJ: Characterization of an infectious molecular clone of human T-cell leukemia virus type I, J Virol 1995:69:2024-2030.
86. Sawada M, Suzumura A, Yoshida M, Maru-nouchi T: Human T-cell leukemia virus type I transactivator induced class I major histocompatibility complex antigen expression in glial cells, J Virol 1990:64:4002.
87. Stone DM, Hof AJ, Davis WC: Up-rcgulation of IL-2 receptor alpha and MHC class II expression on lymphocyte subpopulations from bovine leukemia virus infected lymphocytotic cows, Vet Immunol lmmunopatho! 1995:48: 65-76.
88. Iwakura YS, Saijo S, Kioka Y, Nakayanta-Yamada J, Itagaki K, Tosu M, Asano M, Kanai Y, Kaikimoto K: autoimmunity induction by human T cell leukemia virus type I in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans, J Immunol 1995:155:1588-1598.
89. Grcgersen PK: HLA class II polymorphism: Implications for genetic susceptibility to autoimmune disease, Lab Invest 1989;61:6-19.
90. Hasunuma T, Nakajima T, Aono II, Sato K, Malsubara T, Yamamoto K, Nishioka K: Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus type-1. Clin Immunol Immunopathol 1994;72:90-97.
91. Gessain A, Saal F, Gout O, Daniel MT, Flan-drin G, de The G, Perics J, Sigaux F: High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis, Blood 1990; 75:428-433.
92. Kira J, Itoyama Y, Koyanagi Y, Tatcishi J, Kishikawa M, Akizuki S, Kobayashi I, Toki N, Sucishi K, Sato H, et al: Presence of HTLV-I proviral DNA in central nervous system of patients with HTLV-I-associated myelopathy, Ann Neurol 1992:31:39-45.
93. Jacobosn S, Reuben JS, Streilein RD, Palker TJ: Induction of CD4+, human T lympho-tropic type-l-speciftc cytotoxic T lymphocytes from patients with HAM/TSP, Recognition of an immunogenic region of the gp46 evel-opc glycoprotein of human T lymphotropic virus typc-l, J Immunol 191:146:1155-1162.
94. Pise Masison CA, Dittmer J, Clemens KE, Brady JN: Physical and functional interaction between the human T-cell lymphotropic virus type I Taxi protein and theCCAAT binding protein NF-Y, Mol Cell Biol 1997; 17:1236-1243.
95. Hooft van Huijsduijncn RA, Bollekens J, Dorn A, Benoist C, Mathis D: Properties of a CCAAT box-binding protein, Nucleic Acids Res 1987;15:7265-7282.
96. Mantovani R, Pessara U, Tranche F, Li XY, Knapp AM, Pasquali JL, Benoist C, Mathis D: Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription, EMBO J 1992:11:3315-3322.
97. Ting JP, Baldwin AS: Regulation of MHC gene expression, CurrOpin Immunol 1993:5: 8-16.
98. Kitze B, Usuku K, Izumo S, Nakamura M, Shiraki H, Ijichi S, Yashiki S, Fujiyoshi T, Sonoda S, Osame M: Diversity of intrathecal antibody synthesis against HTLV-I and its relation to HTLV-1 associated myelopathy, J Neurol 1996;243:393-400.
99. Kitze B, Usuku K, Yashiki S, Ijichi S, Fujiyoshi T, Nakamura M, izumo S, Osame M, Sonoda S: Intrathecal humoral immune response in HAM/TSP in relation to HLA haplotype analysis, Acta Neurol Scand 1996:94:87-93.
100. Izumo S, Goto I, Itoyama Y, Okajima T, Watanabe S, Kuroda Y, Araki S, Mori M, Nagataki S, Matsukura S, Akamine T, Naka-gawa M, Yamamoto I, Osame M: Interferon-alpha is effective in HTLV-I-associated myelopathy: A multicenter randomized, doubleblind, controlled trial, Neurology 1996:46: 103-123.
101. Iwasaki Y: Pathology of chronic myelopathy associated with HTLV-I infection (HAM/ TSP), J Neurol Sci 1990:96:103-123.
102. Umchara F, Izumo S, Nakagawa M, Ronquil-lo AT, Takahashi K, Matsumuro K, Sato E, Osame M: Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy, J Ncuro-pathol Exp Neurol 1993;52:424-430.
103. Kubota R, Umchara F, Izumo S, Ijichi S, Matsumuro K, Yashiki S, Fujiyoshi T, Sonoda S, Osame M: HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy, J Neuroimmunol 1994;53:23-29.
104. Levin MC, Lchky TJ, Flcrlage AN, Katz D, Kingma DW, Jaffc ES, Heiss JD, Patronas N, McFarland HF, Jacobson S: Immunologic analysis of a spinal cord-biopsy specimen from a patient with human T-cell lymphotropic virus type I-associated neurological disease, N Engi J Med 1997;336:839-845.
105. Arimura K, Arimura Y, Yoncnaga Y, Rosales RL, Osame M: Clinical electrophysiological findings in patient with HTLV-I-associated myelopathy (HAM): in Roman DC, Vernant JC, Osame M (eds): HTLV-I and the Nervous System, Neurology and Ncurobiology, New York, Liss, 1989. vol 51. pp 245-250.
106. Morgan OS, Rodgers Johnson P, Mora C, CharG: IITLV-I and polymyositis in Jamai-ka, Lancet 1989;ii: 1 184-1187.
107. Takatsuki K, Yamaguchi K, Matsuoka M: Adult T-cell leukemia: in Hollsbcrg P, Haller DA (eds): Human T-Cell Lymphotropic Virus Type I, Chichester, Wiley, 1996. pp 219-246.
108. Lehky TJ, Flerlage N, Katz D, Houff S, Hall WH, Ishii K, Monken C, Dhib-Jalbut S, McFarland HF, Jacobson S: Human T-cell lymphotropic virus type ll-associated myelopathy: Clinical and immunological profiles, Ann Neurol 1996:40:714-723.
109. Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F: Tat protein of HIV-I stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients, Nature 1990;345:84.
110. Lindholm PF, Marriott SJ, Gitlin SD, Bohan CA, Brady JN: Induction of nuclear NF-kB DNA binding activity after exposure of lymphoid cells to soluble Taxi protein, New Biol 1990:2:1034.
111. Marriott SJ, Lindholm PF, Reid RL, Brads JN: Soluble HTLV-I Taxi protein stimulates proliferation of human peripheral blood lymphocytes, New Biol 1991:3:678.
112. Lindholm PF, Reid RL, Brady JN: Extracellular Taxi stimulates tumor necrosis factor-u and immunoglobulin kappa light chain expression in lymphoid cells, J Virol 1992:66: 1294.
113. Marriott SJ, Trinh D, Brady JN: Activation of interleukin 2 receptor alpha expression by extracellular HTLV-1 Taxi protein: A potential role in HTLV-I pathogenesis, Oncogene 1992:7:1749.
114. Lindholm PF, Tamami M, Makowski J, Brady JN: Human T-cell lymphotropic virus type I Tax activation of iiI-kB: Involvement of the protein kinase C pathway, J Virol 1996:70: 2525.
115. Ensoli B, Gcndelman R, Markham P, Florclli V, Columbini S, Raffeld M, Cafaro A, Chang H-S, Brady JN, Gallo RC: Evidence that basic fibroblast growth factor and HIV typc-l Tat protein syncrgize in inducing Kaposi’s sarcoma development, Nature 1994:371:674.
116. Cowan EP, Alexander RK, Daniel S, Kashanchi F, Brady JN: Induction of TNF-a in human neuronal cells by extracellular Tax, Submitted.
117. Dhib-Jalbut S, Hoffman PM, Yarnabe T, Sun D, Xia J, Eisenberg H, Bergev G, Ruscetti FW: Extracellular human T-cell lymphotropic virus type I Tax protein induces cytokine production in adult human microglial cells, Anr, Neurol 1994:36:787.
118. Lai RB, Giam C, Coligan JE, Rudolph DL: Differential immune responsiveness to the immunodominant epitopes of regulatory proteins (lax and rex) in human T cell lymphotropic virus type 1-associated myelopathy, J Infect Dis 1994:169:496-503.