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of outstanding interest. The discovery of mitochondrial cpn genes reported here as well as those cited below [46, 49, 50] lead to the conclusion that hydrogenosomes in Trichomonads are the descendants of ancestral endosymbionts that gave rise to mitochondria.
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Bui ETN, Bradley PJ, Johnson PJ. A common evolutionary origin for mitochondria and hydrogenosomes. of outstanding interest Proc Natl Acad Sci USA. 93:1996;9651-9656 The discovery of mitochondrial cpn genes reported here as well as those cited below [46, 49, 50] lead to the conclusion that hydrogenosomes in Trichomonads are the descendants of ancestral endosymbionts that gave rise to mitochondria.
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46
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Evidence for loss of mitochondria in microsporidia from a mitochondrial-type HSP70 in Nosema locustae
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A possible mitochondrial gene in the early-branching amitochondriate protist Trichomonas vaginalis
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of outstanding interest. One parsimonious interpretation of cpn60 genes in the Trichomonad genome is that hydrogenosomes are descendants of mitochondria. It is impossible, however, to rule out other scenarios. The cpn60 gene might have come form an endosymbiont in Trichomonads that was ancestral to hydrogenosomes but not the progenitor of mitochondria. Alternatively, the cpn60 gene in Trichomonads may have been acquired by lateral transfer from another organism with which the ancestral trichomonad formed a transient symbiosis that did not result in the formation of an endosymbiotic organelle. Yet both of these more complicated but feasible explanations imply that the cpn60 gene would have come from an ancestral symbiont that was closely related to the α-proteobacterial relatives of mitochondria.
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Roger AJ, Clark CG, Doolittle WF. A possible mitochondrial gene in the early-branching amitochondriate protist Trichomonas vaginalis. of outstanding interest Proc Natl Acad Sci USA. 93:1996;14618-14622 One parsimonious interpretation of cpn60 genes in the Trichomonad genome is that hydrogenosomes are descendants of mitochondria. It is impossible, however, to rule out other scenarios. The cpn60 gene might have come form an endosymbiont in Trichomonads that was ancestral to hydrogenosomes but not the progenitor of mitochondria. Alternatively, the cpn60 gene in Trichomonads may have been acquired by lateral transfer from another organism with which the ancestral trichomonad formed a transient symbiosis that did not result in the formation of an endosymbiotic organelle. Yet both of these more complicated but feasible explanations imply that the cpn60 gene would have come from an ancestral symbiont that was closely related to the α-proteobacterial relatives of mitochondria.
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Proc Natl Acad Sci USA
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Roger, A.J.1
Clark, C.G.2
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50
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Molecular data suggest an early acquisition of the mitochondrion endosymbiont
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51
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Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes
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Germot A, Philippe H, Guyader HL. Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes. Proc Natl Acad Sci USA. 93:1996;14614-14617.
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A mitochondrial-like chaperonin 60 gene in Giardia lamblia: Evidence that diplomonads once harbored an endosymbiont related to the progenitor of mitochondria
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of outstanding interest
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Roger AJ, Svard SG, Tovar J, Clark CG, Gillin FD, Sogin ML, Morrison HG. A mitochondrial-like chaperonin 60 gene in Giardia lamblia: evidence that diplomonads once harbored an endosymbiont related to the progenitor of mitochondria. of outstanding interest Proc Natl Acad Sci USA. 95:1997; In contrast to microsporidia and trichomonads, the diplomonads are consistently basal to other eukaryotes in most gene trees. The discovery of cpn60 in G. lamblia was the final demonstration that amitochondriate early branching eukaryotes can harbor coding regions which define proteins normally associated with the mitochondria. This manuscript demonstrates the phylogenetic placement of the Giardia mitochondrial-like cpn60 within the mitochondrial/α-proteobacterial clade and even suggests a modified function as evidenced by an accelerated rate of evolution. The temporal expression patterns of cpn60 in Giardia does not appear to reflect a normal heatshock response. The possibility of distinct α-proteobacterial endosymbionts forming transient endosymbioses in these early branching amitochondriate lineages and their potential to contribute cpn genes is discussed.
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Protemozoic and early Cambrian protists: Evidence for accelerating evolutionary tempo
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