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Appelt, K.; Bacquet, R. J.; Bartlett, C.; Booth, C. L. J.; Freer, S. T.; Fuhry, M. M.; Gehring, M. R.; Herrmann, S. M.; Rowland, E. F.; Janson, C. A.; Jones, T. R.; Kan, C. C.; Kathardekar, V.; Lewis, K. K.; Marzoni, G. P.; Mathews, D. A.; Mohr, C.; Moomaw, E. W.; Oatley, S. J.; Ogden, R. C.; Reddy, M. R.; Reich, S. H.; Schoettlin, W. S.; Smith, W. W.; Varney, M. D.; Villafranca, J. E.; Ward, R. W.; Webber, S.; Webber, S. E.; Welsh, K. M.; White, J. J. Med. Chem. 1991, 34, 1925. Patick, A.; Hongmei, M.; Markowitz, M.; Ho, D.; Webber, S. Proc. 2nd Nat. Conf. Human Retroviruses and Related Infections 1995, abstr. 184, 88. Shetty, B. V.; Kosa, M. B.; Khalil, D. A.; Webber, S. Antimicrob. Agents Chemother. 1996, 40, 110.
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abstr. 184
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Appelt, K.; Bacquet, R. J.; Bartlett, C.; Booth, C. L. J.; Freer, S. T.; Fuhry, M. M.; Gehring, M. R.; Herrmann, S. M.; Rowland, E. F.; Janson, C. A.; Jones, T. R.; Kan, C. C.; Kathardekar, V.; Lewis, K. K.; Marzoni, G. P.; Mathews, D. A.; Mohr, C.; Moomaw, E. W.; Oatley, S. J.; Ogden, R. C.; Reddy, M. R.; Reich, S. H.; Schoettlin, W. S.; Smith, W. W.; Varney, M. D.; Villafranca, J. E.; Ward, R. W.; Webber, S.; Webber, S. E.; Welsh, K. M.; White, J. J. Med. Chem. 1991, 34, 1925. Patick, A.; Hongmei, M.; Markowitz, M.; Ho, D.; Webber, S. Proc. 2nd Nat. Conf. Human Retroviruses and Related Infections 1995, abstr. 184, 88. Shetty, B. V.; Kosa, M. B.; Khalil, D. A.; Webber, S. Antimicrob. Agents Chemother. 1996, 40, 110.
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Appelt, K.; Bacquet, R. J.; Bartlett, C.; Booth, C. L. J.; Freer, S. T.; Fuhry, M. M.; Gehring, M. R.; Herrmann, S. M.; Rowland, E. F.; Janson, C. A.; Jones, T. R.; Kan, C. C.; Kathardekar, V.; Lewis, K. K.; Marzoni, G. P.; Mathews, D. A.; Mohr, C.; Moomaw, E. W.; Oatley, S. J.; Ogden, R. C.; Reddy, M. R.; Reich, S. H.; Schoettlin, W. S.; Smith, W. W.; Varney, M. D.; Villafranca, J. E.; Ward, R. W.; Webber, S.; Webber, S. E.; Welsh, K. M.; White, J. J. Med. Chem. 1991, 34, 1925. Patick, A.; Hongmei, M.; Markowitz, M.; Ho, D.; Webber, S. Proc. 2nd Nat. Conf. Human Retroviruses and Related Infections 1995, abstr. 184, 88. Shetty, B. V.; Kosa, M. B.; Khalil, D. A.; Webber, S. Antimicrob. Agents Chemother. 1996, 40, 110.
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(a) Sibi, M. P. Org. Prep. Proc. Int. 1993, 25, 15. Nahm, S.; Weinreb, S. M. Tetrahedron Lett. 1981, 22, 3815.
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(3) (a) Sibi, M. P. Org. Prep. Proc. Int. 1993, 25, 15. Nahm, S.; Weinreb, S. M. Tetrahedron Lett. 1981, 22, 3815.
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7
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15144339457
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note
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(b) The author would like to thank Mr. M. Shore for development of this conversion.
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8
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15144348961
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note
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The ratio was determined by isolation of 4 and its diastereomer at the carbinol center.
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9
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15144361390
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note
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Quenching of the reaction under two-phase conditions (2 N aqueous HCl) resulted in 4 (after reduction) that was racemic.
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15144341865
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2/hexane. Flow: 1.5 mL/ min. Detector: 254 nm. Retention times: 4, 53 min; ent-4, 57 min; diastereomer 1, 37 min; diastereomer 2, 48 min.
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0027474335
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Houpis, I. N.; Molina, A.; Reamer, R. A.; Lynch, J. E.; Volante, R. P.; Reider, P. J. Tetrahedron Lett. 1993, 34, 2593. Gohring, W.; Gokhale, S.; Hilpert, H.; Roessler, F.; Schlageter, M.; Vogt, P. Chimica 1996, 50, 532. Allen, D. R.; Jenkins, S.; Klein, L.; Erickson, R.; Froen, D. U.S. Patent 5,587,481, 1996 (The Monsanto Company).
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Houpis, I. N.; Molina, A.; Reamer, R. A.; Lynch, J. E.; Volante, R. P.; Reider, P. J. Tetrahedron Lett. 1993, 34, 2593. Gohring, W.; Gokhale, S.; Hilpert, H.; Roessler, F.; Schlageter, M.; Vogt, P. Chimica 1996, 50, 532. Allen, D. R.; Jenkins, S.; Klein, L.; Erickson, R.; Froen, D. U.S. Patent 5,587,481, 1996 (The Monsanto Company).
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