Vancomycin-resistant enterococci. Mechanism and clinical relevance

Infectious Disease Clinics of North America

Volumn 11, Issue 4, 1997, Pages 851-865

  Eliopoulos, G M ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; DRUG CHOICE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; GENOTYPE; HEALTH CARE COST; HUMAN; INFECTION CONTROL; REVIEW; UNITED STATES;

EID: 0031454375     PISSN: 08915520     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5520(05)70393-7     Document Type: Article

References (81)

1. Aarestrup FM, Bager F, Madsen M, et al: The effect of avoparcin as a feed additive on the occurrence of vancomycin resistant Enterococcus faecium in pig and poultry production. Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Abstract No. LB-27, September 1995.
2. M. Arthur F. Depardieu G. Gerbaud The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn 1546 and related elements in the absence of induction J Bacteriol 179 1997 97 106
3. M. Arthur F. Depardieu C. Molinas The vanZ gene of Tn 1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin Gene 154 1995 87 92
4. M. Arthur F. Depardieu P. Reynolds Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci Molec Microbiol 21 1996 33 44
5. M. Arthur C. Molinas S. Dutka-Malen Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases Gene 103 1991 133 134
6. M. Baptista F. Depardieu P. Courvalin Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis Antimicrob Agents Chemother 40 1996 2291 2295
7. J. Bates J.Z. Jordens D.T. Griffiths Farm animals as a putative reservoir for vancomycin-resistant enterococcal infection in man J Antimicrob Chemother 34 1994 507 516
8. D.A. Beauregard D.H. Williams M.N. Gwynn Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics Antimicrob Agents Chemother 39 1995 781 785
9. D. Billot-Klein L. Gutmann S. Sable Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type enterococcus D366 and the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides , and Enterococcus gallinarum J Bacteriol 176 1994 2398 2405
10. J.M. Boyce L.A. Mermel M.J. Zervos Controlling vancomycin-resistant enterococci Infect Control Hosp Epidemiol 16 1995 634 637
11. C.M. Brandt M.S. Rouse N.W. Laue Effective treatment of multidrug-resistant enterococcal experimental endocarditis with combinations of cell-wall active agents J Infect Dis 173 1996 909 913
12. T.D.H. Bugg S. Dutka-Malen M. Arthur Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity Biochemistry 30 1991 2017 2021
13. T.D.H. Bugg G.D. Wright S. Dutka-Malen Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: Biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA Biochemistry 30 1991 10408 10415
14. F. Caron M. Pestel M.D. Kitzis Comparison of different β-lactam-glycopeptide-gentamicin combinations for an experimental endocarditis caused by a highly β-lactam-resistant and highly glycopeptide-resistant isolate of Enterococcus faecium J Infect Dis 17 1995 106 112
15. Centers for Disease Control and Prevention Nosocomial enterococci resistant to vancomycin—United States, 1989–1993 MMWR 42 1993 597 599
16. Centers for Disease Control and Prevention Preventing the spread of vancomycin resistance Federal Register 59 1994 25758 25763
17. P.R. Chadwick N. Woodford E.B. Kaczmarski Glycopeptide-resistant enterococci isolated from uncooked meat J Antimicrob Chemother 38 1996 908 909
18. J.K.S. Chia M.M. Nakata S.S. Park Use of bacitracin therapy for infection due to vancomycin-resistant Enterococcus faecium Clin Infect Dis 21 1995 1520
19. J.W. Chow A. Davidson Sanford E. III Superinfection with Enterococcus faecalis during quinupristin/dalfopristin therapy Clin Infect Dis 24 1997 91 92
20. J.W. Chow S.M. Donabedian M.J. Zervos Emergence of increased resistance to quinupristin/dalfopristin during therapy for Enterococcus faecium bacteremia Clin Infect Dis 24 1997 90 91
21. P. Courvalin Resistance of enterococci to glycopeptides Antimicrob Agents Chemother 34 1990 2291 2296
22. de Jonge B.L.M. S. Handwerger D. Gage Altered peptidoglycan composition in vancomycin-resistant Enterococcus faecalis Antimicrob Agents Chemother 40 1996 863 869
23. L.A. Devriese M. Ieven H. Goossens Presence of vancomycin-resistant enterococci in farm and pet animals Antimicrob Agents Chemother 40 1996 2285 2287
24. S. Dutka-Malen B. Blaimont G. Wauters Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus Antimicrob Agents Chemother 38 1994 1675 1677
25. M.B. Edmond J.F. Ober J.D. Dawson Vancomycin-resistant enterococcal bacteremia: Natural history and attributable mortality Clin Infect Dis 23 1996 1234 1239
26. M.B. Edmond J.F. Ober D.L. Weinbaum Vancomycin-resistant Enterococcus faecium bacteremia: Risk factors for infection Clin Infect Dis 20 1995 1126 1133
27. G.M. Eliopoulos Antibiotic resistance in Enterococcus species: An update Remington J.S. Swartz M.N. Current Clinical Topics in Infectious Diseases, Vol 16 1996 Blackwell Science Cambridge 21 51
28. B two-component regulatory system in Enterococcus faecalis V583 J Bacteriol 178 1996 1302 1309
29. S. Evers D.F. Sahm P. Courvalin The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala, D-Ala ligases and glycopeptide-resistance proteins VanA and VanC Gene 124 1993 143 144
30. T.R. Frieden S.S. Munsiff D.E. Low Emergence of vancomycin-resistant enterococci in New York City Lancet 342 1993 76 79
31. Gordts B. van Landuyt H. M. Ieven Vancomycin-resistant enterococci colonizing the intestinal tracts of hospitalized patients J Clin Microbiol 33 1995 2842 2846
32. S. Handwerger M.J. Pucci K.J. Volk Vancomycin-resistant Leuconostoc mesenteroides and Lactobacillus casei synthesize cytoplasmic peptidoglycan precursors that terminate in lactate J Bacteriol 176 1994 260 264
33. S. Handwerger J. Skoble Identification of chromosomal mobile element conferring high-level vancomycin resistance in Enterococcus faecium Antimicrob Agents Chemother 39 1995 2446 2453
34. S. Handwerger J. Skoble L.F. Discotto Heterogeneity of the VanA gene in clinical isolates of enterococci from the northeastern United States Antimicrob Agents Chemother 39 1995 362 368
35. M.K. Hayden G.M. Trenholme J.E. Schultz In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate J Infect Dis 167 1993 1224 1227
36. Centers for Disease Control and Prevention Recommendations for preventing the spread of vancomycin resistance Infect Control Hosp Epidemiol 16 1995 106 113
37. R.N. Jones H.S. Sader M.E. Erwin Emerging multiply resistant enterococci among clinical isolates. I. Prevalence data from 97 medical center surveillance study in the United States Diagn Microbiol Infect Dis 21 1995 85 93
38. I. Klare H. Heier H. Claus Enterococcus faecium strains with vanA -mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community Microb Drug Resis 1 1995 265 272
39. I. Klare H. Heier H. Claus vanA -mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry FEMS Microb Lett 125 1995 165 172
40. S. Lam C. Singer V. Tucci The challenge of vancomycin-resistant enterococci: A clinical and epidemiologic study Am J Infect Control 23 1995 170 180
41. R. Leclercq Enterococci acquire new kinds of resistance Clin Infect Dis 24 Suppl 1 1997 S80 S84
42. P.K. Linden A.W. Pasculle R. Manez Differences in outcomes for patients with bacteremia due to vancomycin-resistant Enterococcus faecium or vancomycin-susceptible E. faecium Clin Infect Dis 22 1996 663 670
43. A.D. Luber R.A. Jacobs M. Jordan Relative importance of oral versus intravenous vancomycin exposure in the development of vancomycin-resistant enterococci J Infect Dis 173 1996 1292 1293
44. E.T. Mekonen G.A. Noskin D.M. Hacek Successful treatment of persistent bacteremia due to vancomycin-resistant, ampicillin-resistant Enterococcus faecium Microbial Drug Resis 1 1995 249 253
45. Montecalvo M.A. de Lencastre H. M. Carraher Natural history of colonization with vancomycin-resistant Enterococcus faecium Infect Control Hosp Epidemiol 16 1995 680 685
46. M.A. Montecalvo K. Seiter C.A. Carbonaro Effect of novobiocin-containing antimicrobial regimens on infection and colonization with vancomycin-resistant Enterococcus faecium Antimicrob Agents Chemother 39 1995 794
47. F. Moreno P. Grota C. Crisp Clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium during its emergence in a city in southern Texas Clin Infect Dis 21 1995 1234 1237
48. Morris J.G. Jr D.K. Shay J.N. Hebden Enterococci resistant to multiple antimicrobial agents, including vancomycin: Establishment of endemicity in a university medical center Ann Intern Med 123 1995 250 259
49. B.E. Murray Editorial response: What can we do about vancomycin-resistant enterococci? Clin Infect Dis 20 1995 1134 1136
50. F. Navarro P. Courvalin Analysis of genes encoding D-alanine-D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens Antimicrob Agents Chemother 38 1994 1788 1793
51. W.C. Noble K. Virani R.G.A. Cree Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus FEMS Microbiol Lett 93 1992 195 198
52. A.H. Norris J.P. Reilly P.H. Edenstein Chloramphenicol for the treatment of vancomycin-resistant enterococcal infections Clin Infect Dis 20 1995 1137 1144
53. G.A. Noskin V. Stosor I. Cooper Recovery of vancomycin-resistant enterococci on fingertips and environmental surfaces Infect Control Hosp Epidemiol 16 1995 577 581
54. C.A. O'Donovan P. Fan-Havard F.T. Tecson-Tumang Enteric eradication of vancomycin-resistant Enterococcus faecium with oral bacitracin Diagn Microbiol Infect Dis 18 1994 105 109
55. G.A. Papanicolaou B.R. Meyers J. Meyers Nosocomial infections with vancomycin-resistant Enterococcus faecium in liver transplant recipients: Risk factors for acquisition and mortality Clin Infect Dis 23 1996 760 766
56. Pegues DA, Pegues CF, Hooper DC: Emergence of a highly resistant strain of vanA Enterococcus faecium at a large teaching hospital. Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Abstract No. J1, September, 1996.
57. Perichon B, Reynolds PE, Courvalin P: A VanD-type glycopeptide-resistant Enterococcus faecium . Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Abstract No. LB12, September, 1996.
58. E.G.M. Power Y.H. Abdulla H.G. Talsania vanA genes in vancomycin-resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Corynebacterium) haemolyticum J Antimicrob Chemother 36 1995 595 606
59. C. Poyart C. Pierre G. Quesne Emergence of vancomycin resistance in the genus Streptococcus : Characterization of a vanB transferable determinant in Streptococcus bovis Antimicrob Agents Chemother 41 1997 24 29
60. J. Quale D. Landman G. Saurina Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci Clin Infect Dis 23 1996 1020 1025
61. Quintiliani R. Jr Courvalin P. Conjugal transfer of the vancomycin resistance determinant vanB between enterococci involves the movement of large genetic elements from chromosome to chromosome FEMS Microbiol Lett 119 1994 359 364
62. Quintiliani R. Jr Evers S. Courvalin P. The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci J Infect Dis 167 1993 1220 1223
63. P.E. Reynolds F. Depardieu S. Dutka-Malen Glycopeptide resistance mediated by enterococcal transposon Tn 1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine Molec Microbiol 13 1994 1065 1070
64. P.E. Reynolds H.A. Snaith A.J. Maguire Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarium BM4174 Biochem J 301 1994 5 8
65. A. Rosato J. Pierre D. Billot-Klein Inducible and constitutive expression of resistance to glycopeptides and vancomycin dependence in glycopeptide-resistant Enterococcus avium Antimicrob Agents Chemother 39 1995 830 833
66. D.F. Sahm L. Free S. Handwerger Inducible and constitutive expression of vanC-1 -encoded resistance to vancomycin in Enterococcus gallinarum Antimicrob Agents Chemother 39 1995 1480 1484
67. D.K. Shay S.A. Maloney M. Montecalvo Epidemiology and mortality risk of vancomycin-resistant enterococcal bloodstream infections J Infect Dis 172 1995 993 1000
68. R. Shekar G. Chico S.N. Bass Household transmission of vancomycin-resistant Enterococcus faecium Clin Infect Dis 21 1995 1511 1512
69. R.S. Schwalbe A.C. McIntosh S. Qaiyumi In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci Antimicrob Agents Chemother 40 1996 2416 2419
70. S. Slaughter M.K. Hayden C. Nathan A comparison of the effect of universal use of gloves and gowns with that of glove use alone on acquisition of vancomycin-resistant enterococci in a medical intensive care unit Ann Intern Med 125 1996 448 456
71. N.G. Tornieporth R.B. Roberts J. John Risk factors associated with vancomycin-resistant Enterococcus faecium infection or colonization in 145 matched case patients and control patients Clin Infect Dis 23 1996 767 772
72. C. Torres J.A. Reguera M.J. Sammartin vanA -mediated vancomycin-resistant Enterococcus spp sewage J Antimicrob Chemother 33 1994 553 561
73. Van der Auwera P. N. Pensart V. Korten Influence of oral glycopeptides on the fecal flora of human volunteers: Selection of highly glycopeptide-resistant enterococci J Infect Dis 173 1996 1129 1136
74. J.J. Wade The emergence of Enterococcus faecium resistant to glycopeptides and other standard agents—a preliminary report J Hosp Infect 30 Suppl 1995 483 493
75. R. Washko A. Dow K.J. Henning A citywide survey of vancomycin-resistant Enterococcus —New York City, 1993 Clin Infect Dis 22 1996 136 137
76. Weinstein MR, Brunton J, Campbell I, et al: Oral bacitracin and doxycycline for the eradication of stool colonization by vancomycin-resistant Enterococcus faecium . Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Abstract No. J10, September, 1996.
77. C.L. Wells B.A. Juni S.B. Cameron Stool carriage, clinical isolation, and mortality during an outbreak of vancomycin-resistant enterococci in hospitalized medical and/or surgical patients Clin Infect Dis 21 1995 45 50
78. M.S. Whitman P.G. Pitsakis E. DeJesus Gastrointestinal tract colonization with vancomycin-resistant Enterococcus faecium in an animal model Antimicrob Agents Chemother 40 1996 1526 1530
79. W. Witte I. Klare Glycopeptide-resistant Enterococcus faecium outside hospitals: A commentary Microb Drug Resis 1 1995 259 263
80. Z. Wu G.D. Wright C.T. Walsh Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147 Biochemistry 34 1995 2455 2463
81. M.M. Zaman D. Landman S. Burney Treatment of experimental endocarditis due to multidrug-resistant Enterococcus faecium with clinafloxacin and penicillin J Antimicrob Chemother 37 1996 127 132