Immunological aspects of aging and malnutrition: Consequences and intervention with nutritional immunomodulators

Clinics in Geriatric Medicine

Volumn 13, Issue 4, 1997, Pages 697-715

  Heuser, M D ^a   Adler, W H ^a  

^a BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANTIBODY PRODUCTION; HOST RESISTANCE; HUMAN; IMMUNOREGULATION; LIFESPAN; NUTRITIONAL STATUS; PROTEIN CALORIE MALNUTRITION; REVIEW; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; WEIGHT REDUCTION;

EID: 0031452304     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0749-0690(18)30145-9     Document Type: Review

References (87)

1. W. Alder J. Nagel Clinical immunology W. Hazzard E. Bierman J. Blass Principles of Geriatric Medicine and Gerontology 1994 McGraw-Hill New York 61 75
2. J.W. Alexander S.J. Grance P.W. Miskell A new model for studying nutrition in peritonitis: The adverse effect of overfeeding Ann Surg 209 1989 334 340
3. S. Antonaci E. Jirillo L. Bonomo Immunoregulation in aging Diag Clin Immunol 5 1987 55 61
4. S. Antonaci E. Jirillo M. Gallitelli Impairment of T immunoregulatory activities in the induction of antibody specific response in aged humans Mech Ageing Develop 30 1985 251 259
5. U. Babu M.L. Failla Respiratory burst and candidacidal activity of peripheral macrophages are impaired in copper deficient rats J Nutr 120 1990 1692 1699
6. R.L. Baehner L.A. Boxer J.M. Allen Autooxidation as a basis for altered function by polymorphonuclear leukocytes Blood 50 1977 327 335
7. S. Bala M.L. Failla J.K. Lunney T-cell numbers and functional alterations in peripheral blood mononuclear cells are decreased in copper deficient rats Nutr Res 10 1990 749 760
8. A.A. Beharka D. Wu S. Han Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by dietary antioxidant vitamin E Mech Ageing Dev 94 1997 157 165
9. W.R. Beisel R. Edelman K. Nauss Single-nutrient effects on immunologic functions: Report of a workshop sponsored by the Department of Food and Nutrition and its Nutrition Advisory Group of the American Medical Association JAMA 245 1981 53 58
10. B.S. Bender J.E. Nagel W.H. Adler Absolute peripheral blood lymphocyte count and subsequent mortality of elderly men: The Baltimore longitudinal study of aging J Am Geriatr Soc 34 1986 649 654
11. B.S. Bender J.E. Nagel W.H. Adler Absolute peripheral blood lymphocyte count and subsequent mortality of elderly men: The Baltimore longitudinal study of aging J Am Geriatr Soc 34 1986 649 654
12. L.E. Bermudez L.S. Young S. Gupta 1,25-Dihydroxy vitamin D3 dependent inhibition of growth or killing of Mycobacterium avium complex in human macrophages mediated by TNF and GM-CSF Cell Immunol 127 1990 432 441
13. J.D. Bogden Studies on micronutrient supplements and immunity in older people Nutr Rev 53 1995 S59 S65
14. J.D. Bogden A. Bendich F.W. Kemp Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people Am J Clin Nutr 60 1994 437 447
15. T.A. Bowman I.M. Goonewardene A.M.G. Pasatiempo Vitamin A deficiency decreases natural killer cell activity and interferon production in rats J Nutr 120 1990 1264 1273
16. P.B. Brevard Beta-carotene increases monocyte numbers in peripheral rat blood Int J Vitam Nutr Res 63 1993 21 26
17. J.D. Carver i.a: Dietary nucleotides: Cellular immune J Nutr 124 1994 1445 1485
18. R.K. Chandra Immune response in overnutrition Cancer Res 41 1981 3795 3796
19. R.K. Chandra Excessive intake of zinc impairs immune responses JAMA 252 1984 1443 1446
20. R.K. Chandra Nutritional regulation of immunity and risk of infection in old age Immunology 67 1989 141 147
21. R.K. Chandra Protein-energy malnutrition and immunological responses J Nutr 122 1992 597 600
22. R.K. Chandra Effect of vitamin and trace element supplementation on immune responses and infections in elderly subjects Lancet 340 1992 1124 1127
23. R.K. Chandra Nutrition and the immune system Proc Nutr Soc 52 1993 77 84
24. R.K. Chandra Nutrition and immunity in the elderly: clinical significance Nutr Rev 53 1995 S80 S85
25. R.K. Chandra Graying of the immune system: Can nutrient supplements improve immunity in the elderly? JAMA 277 1997 1398 1399
26. J.R. Cohn C.A. Hohl C.E. Buckley The relationship between cutaneous cellular immune responsiveness and mortality in a nursing home population J Am Geriatr Soc 31 1983 808 809
27. A.J. Duits W. Dimjoti J.G.J. Van der Winkel Synergism of interleukin 6 and 1,25-dehydroxy vitamin D3 indication of myeloid differentiation of human leukemic cell line J Leuk Biol 51 1992 237 243
28. W.B. Ershler W.H. Sun N. Binkley Interleuken-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction Lymphokine Cytokine Res 12 1993 225 230
29. R.H. Fiser J.C. Denniston V.G. McGann Altered immune function in hypercholesterolemic monkeys Infect Immun 8 1973 105 109
30. A. Flynn Control of in vitro lymphocyte proliferation by copper, magnesium, and zinc deficiencies J Nutr 114 1984 2034 2042
31. J.M. Friedman G.L. Jensen H. Smiciklas-Wright Predicting early nonelective hospital readmission in nutritionally compromised older adults Am J Clin Nutr 65 1997 1714 1720
32. J.S. Goodwin Decreased immunity and increased morbidity in the elderly Nutr Rev 53 1995 S41 S46
33. J.S. Goodwin R.P. Series K.S. Tung Immunological responses of a healthy elderly population Clin Exp Immunol 48 1982 403 410
34. R.F. Grimble Nutrition and cytokine action Nutr Res Rev 3 1990 193 210
35. R.F. Grimble Dietary manipulation of the inflammatory response Proc Nutr Soc 51 1992 285 294
36. R.F. Grimble Malnutrition and the immune response: Impact of nutrients on cytokine biology in infection Trans R Soc Trop Med Hyg 88 1994 615 619
37. B.M. Hannigan Diet and immune function Br J Biomed Sci 51 1994 252 259
38. M.D. Heuser F.J. Chrest W.H. Adler T-cell activation and cell cycle progression are impaired in healthy and frail older adults Gerontologist 36 1996 233
39. M.D. Heuser R.S. Pyle M.M. Schoonmaker Alterations of lymphocyte phenotypes are associated with age and ethnicity Gerontologist 36 1996 170
40. N. Hirase Y. Abe S. Sadamura Anemia and neutropenia in a case of copper deficiency: Role of copper in normal hemopoiesis Acta Haematol 87 1992 195 197
41. H. Jyonouchi Nucleotide actions on humoural immune responses J Nutr 15 1994 1385 1435
42. R.A. Keenan L.L. Moldawer R.D. Yang An altered response by peripheral leukocytes to synthesize or to release leukocyte endogenous mediator in critically ill protein-malnourished patients J Lab Clin Med 100 1982 844 857
43. J. Dupont B.J. Holub H.R. Knapp Fatty acid-related functions Am J Clin Nutr 63 1996 991S 993S
44. Y.T. Kim G.W. Siskind M.E. Weksler Plaque-forming cell response of human blood lymphocytes: Cellular basis of the reduced immune response in the elderly Isr J Med Sci 21 1985 317 322
45. A.B. Lehmann Review: Undernutrition in elderly people Age Ageing 18 1989 339 353
46. B. Lesourd Protein undernutrition as the major cause of decreased immune function in the elderly: Clinical and functional implications Nutr Rev 53 1995 S86 S91
47. G.J. Ligthart J.X. Corberand C. Fournier Admission criteria for immunological studies in man: The SENIEUR protocol Mech Ageing Dev 28 1984 47 55
48. P.A. Maki P.M. Newberne Dietary lipids and immune function J Nutr 122 1992 610 614
49. T. Makinodan Patterns of age-related immunologic changes Nutr Rev 53 1995 S27 S31
50. T. Makinodan T. Hahn S. McDougall Cellular immunosenescence: An overview Exper Geront 26 1991 281 288
51. T. Makinodan M. Kay Age influence on the immune system Adv Immunology 29 1980 287 330
52. A. Martin T. Foxall J.B. Blumberg Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aotic endothelial cells in vitro Arteriosclerosis, Thrombosis, and Vascular Biology 17 1997 429 436
53. H. McDonald S. Stamford H.D. McGarthy Acute effect of peripheral interleukin-1-beta administration on macronutrient selection in the rat Proc Nutr Soc 52 1993 358A
54. S.N. Meydani Vitamins and mineral supplementation, the aging response and risk of infection Nutr Rev 51 1993 106 112
55. S.N. Meydani Effect of (n-3) polyunsaturated fatty acids on cytokine production and their biologic function Nutr 12 1996 S8 S14
56. S.N. Meydani Vitamin E enhancement of T cell-mediated function in healthy elderly: Mechanisms of action Nutr Rev 53 1995 S52 S58
57. S.N. Meydani M.P. Barklund S. Liu Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects Am J Clin Nutr 52 1990 557 563
58. S.N. Meydani M.G. Hayek Vitamin E and aging immune response Clin Geriatr Med 11 1995 567 576
59. S.N. Meydani M. Meydani J.B. Blumberg Vitamin E supplementation and in vivo immune response in healthy elderly subjects JAMA 277 1997 1380 1386
60. S.N. Meydani M. Meydani C.P. Verdon Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice Mech Ageing Dev 34 1986 191 201
61. R.A. Miller The aging immune system: Primer and Prospectus Science 273 1996 70 74
62. D. Murasko B. Nelson D. Matour Heterogeneity of changes in lymphoproliferative ability with increasing age Exper Gerontology 26 1991 269 279
63. D. Murasko B. Nelson R. Silver Immunologic response in an elderly population with a mean age of 85 Am J Med 81 1986 612 618
64. M.J. Murray A.B. Murray Cachexia: A “last ditch” mechanism of host defence? J Royal Coll Phys London 14 1980 197 199
65. Q.N. Myrvik Nutrition and immunology M.E. Shils V.R. Young Modern Nutrition in Health and Disease 1990 Lea and Febiger Philadelphia 251 259
66. C. Nicoletti X. Yang J. Cerny Repertoire diversity of antibody response to bacterial antigens in aged mice: Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae J Immunol 150 1993 543
67. D.C. Nieman S.I. Nehlsen-Cannarella D.A. Henson Immune response to obesity and moderate weight loss Intern J Obes Relat Metab Disord 20 1996 353 360
68. B.L. O’Dell Interleuken-2 production is altered by copper deficiency Nutr Rev 51 1993 307 309
69. J.D. O’Leary D. Jackola C. Mehta Enhancement of mitogen response and surface marker analysis of lymphocytes from young and old donors after preliminary incubation in vitro Mech Ageing Dev 29 1985 239 253
70. N.D. Penn L. Purkins J. Kelleher The effect of dietary supplementation with vitamins A, C, and E on cell-mediated immunity function in elderly long-stay patients: a randomized controlled trial Age Ageing 20 1991 169 174
71. M.J. Pertschuk L.O. Crosby L. Bardot Immunocompetence in anorexia nervosa Am J Clin Nutr 35 1982 968 972
72. J.S. Prasad Effect of vitamin E supplementation on leukocyte function Am J Clin Nutr 33 1980 606 608
73. J.R. Prohaska Changes in Cu-Zn superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper deficient mice and rats J Nutr 121 1991 355 363
74. I.H. Rosenberg Nutrition and aging W. Hazzard E. Bierman J. Blass Principles of Geriatric Medicine and Gerontology 1994 McGraw-Hill New York 49 59
75. M.S. Santos S.N. Meydani L. Leka Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation Am J Clin Nutr 64 1996 772 777
76. C.B. Scanga T.J. Verde A.M. Paolone Effects of weight loss and exercise training on natural killer cell activity in obese women Med Sci Sports Exerc 27 1995 S68
77. A.R. Sherman Zinc, copper, and iron nutriture and immunity J Nutr 122 1992 604 609
78. R. Simons H. Reynolds Altered immune status in the elderly Semin Resp Infect 5 1990 251 259
79. R.S. Sohal R. Weindruch Oxidative stress, caloric restriction, and aging Science 273 1996 59 63
80. M.C. Talbot L.T. Miler N.I. Kerkvliet Pyridoxine supplementation effect on lymphocyte responses in elderly persons Am J Clin Nutr 46 1987 659 664
81. M.C. Talbott L.T. Miller N.I. Kerkvliet Pyridoxine supplementation: Effect on lymphocyte, responses in elderly persons Am J Clin Nutr 46 1987 659 664
82. K.K. Tong J.J. Strain B.M. Hannigan Characteristics of human lymphoid cells under in vitro copper deficiency Ir J Med Sci 161 1992 471 472
83. S.J. Wayne R.L. Rhyne P.J. Garry Cell-mediated immunity as a predictor of morbidity and mortality in the aged J Gerontol 45 1990 M45 M48
84. D.J. Weber W.A. Rutala G.P. Samsa Obesity as a predictor of poor antibody response to Hepatitis B plasma vaccine JAMA 254 1985 3187 3189
85. R. Weindruch Immunogerontologic outcomes of dietary restriction started in adulthood Nutr Rev 53 1995 S66 S71
86. M.E. Weksler Immune senescence: Deficiency or dysregulation Nutr Rev 53 1995 S3 S7
87. D. Wu S.N. Meydani M. Meydani Immunologic effects of marine- and plantderived n-3 polyunsaturated fatty acids in nonhuman primates Am J Clin Nutr 63 1996 273 280