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Volumn 7, Issue 6, 1997, Pages 805-811

A kinder, gentler genetic analysis of behavior: Dissection gives way to modulation

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; PROTEIN KINASE; TRANSCRIPTION FACTOR;

EID: 0031449525     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(97)80139-0     Document Type: Article
Times cited : (48)

References (59)
  • 1
    • 0000064419 scopus 로고
    • Behavioral mutants of Drosophila isolated by counter-current distribution
    • Benzer S: Behavioral mutants of Drosophila isolated by counter-current distribution. Proc Natl Acad Sci USA 1967, 58:1112-1119.
    • (1967) Proc Natl Acad Sci USA , vol.58 , pp. 1112-1119
    • Benzer, S.1
  • 4
    • 0005905302 scopus 로고
    • The emergence of neurogenetics
    • Greenspan RJ: The emergence of neurogenetics. Semin Neurosci 1990, 2:145-157.
    • (1990) Semin Neurosci , vol.2 , pp. 145-157
    • Greenspan, R.J.1
  • 5
    • 0030447141 scopus 로고    scopus 로고
    • Discovery of genes involved with learning and memory: An experimental synthesis of Hirschian and Benzerian perspectives
    • Tully T: Discovery of genes involved with learning and memory: • an experimental synthesis of Hirschian and Benzerian perspectives. Proc Natl Acad Sci USA 1996, 93:13460-13467. A comparison of the two dominant strands of research in behavioral genetics, with particular reference to the author's past work on sensitization in the blowfly and current work on memory phases in the fruit fly.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13460-13467
    • Tully, T.1
  • 6
    • 0001872499 scopus 로고
    • Pleiotropy of behavioral genes?
    • Edited by Greenspan RJ, Kyriacou CP. Berlin: Dahlem Konferenzen Publications
    • Hall JC: Pleiotropy of behavioral genes? In Flexibility and Constraint in Behavioral Systems. Edited by Greenspan RJ, Kyriacou CP. Berlin: Dahlem Konferenzen Publications; 1994:15-28.
    • (1994) Flexibility and Constraint in Behavioral Systems , pp. 15-28
    • Hall, J.C.1
  • 7
    • 0029940557 scopus 로고    scopus 로고
    • Gene-targeting studies of mammalian of mammalian behavior
    • Gerlai R: Gene-targeting studies of mammalian of mammalian • behavior. Trends Neurosci 1996, 19:177-181. A thoughtful warning on the potential pitfalls attributable the effects of genetic background on behavioral phenotypes in the mouse. The principles, which apply equally to any organism, are that effects assumed to be attributable to the single mutated gene may in fact be attributable to genetic variation already present in the strain. This 'genetic background' effect can be particularly problematic when strains have been mixed, as in mouse knock-out breeding.
    • (1996) Trends Neurosci , vol.19 , pp. 177-181
    • Gerlai, R.1
  • 8
    • 0029815737 scopus 로고    scopus 로고
    • Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: A case study of the mushroom body miniature gene (mbm)
    • De Belle J, Heisenberg M: Expression of Drosophila mushroom •• body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm). Proc Natl Acad Sci USA 1996, 93:9875-9880. One of the few intentional studies of the effect of genetic background on a neural and behavioral mutant. The severity of phenotype in mutations affecting various brain structures in the fly can be drastically affected over a wide range by the genetic background in which they are expressed. Specific attention is focused on the mushroom-body-miniature mutation and the separability of its anatomical and behavioral phenotypes depending on genetic background.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9875-9880
    • De Belle, J.1    Heisenberg, M.2
  • 10
    • 0017068081 scopus 로고
    • The behavior of cacophony, a courtship song mutant in Drosophila melanogaster
    • Schilcher FV: The behavior of cacophony, a courtship song mutant in Drosophila melanogaster. Behav Biol 1976, 17:187-196.
    • (1976) Behav Biol , vol.17 , pp. 187-196
    • Schilcher, F.V.1
  • 11
    • 0017397812 scopus 로고
    • A mutation which changes courtship song in Drosophila melanogaster
    • Schilcher FV: A mutation which changes courtship song in Drosophila melanogaster. Behav Genet 1977, 7:251-259.
    • (1977) Behav Genet , vol.7 , pp. 251-259
    • Schilcher, F.V.1
  • 12
    • 0023093954 scopus 로고
    • Behavioral and cytogenetic analysis of the cacophony courtship song mutant and interacting genetic variants in Drosophila melanogaster
    • Kulkarni SJ, Hall JC: Behavioral and cytogenetic analysis of the cacophony courtship song mutant and interacting genetic variants in Drosophila melanogaster. Genetics 1987, 115:461-475.
    • (1987) Genetics , vol.115 , pp. 461-475
    • Kulkarni, S.J.1    Hall, J.C.2
  • 13
    • 0016789624 scopus 로고
    • The use of mutations for the partial degradation of vision in Drosophila melanogaster
    • Heisenberg M, Goetz K: The use of mutations for the partial degradation of vision in Drosophila melanogaster. J Comp Physiol 1975, 98:217-241.
    • (1975) J Comp Physiol , vol.98 , pp. 217-241
    • Heisenberg, M.1    Goetz, K.2
  • 14
    • 0019722302 scopus 로고
    • The distribution of randomly recovered X-ray induced sex-linked genetic effects in Drosophila melanogaster
    • Lefevre G: The distribution of randomly recovered X-ray induced sex-linked genetic effects in Drosophila melanogaster. Genetics 1981, 99:461-480.
    • (1981) Genetics , vol.99 , pp. 461-480
    • Lefevre, G.1
  • 15
    • 0029808911 scopus 로고    scopus 로고
    • A Drosophila calcium channel α1 subunit gene maps to a genetic locus associated with behavioral and visual defects
    • Smith LA, Wang XJ, Peixoto AA, Neumann EK, Hall LM, Hall JC: • A Drosophila calcium channel α1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci 1996, 16:7868-7879. Demonstration that the cacophony gene, identified for its effect on courtship song, encodes a calcium channel and is the same gene independently isolated as nightblind-A affecting visual physiology and behavior. A classic case of genetic pleiotropy in behavioral mutants.
    • (1996) J Neurosci , vol.16 , pp. 7868-7879
    • Smith, L.A.1    Wang, X.J.2    Peixoto, A.A.3    Neumann, E.K.4    Hall, L.M.5    Hall, J.C.6
  • 16
    • 0030939869 scopus 로고    scopus 로고
    • Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene
    • Peixoto AA, Smith LA, Hall JC: Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene. Genetics 1997, 145:1003-1013.
    • (1997) Genetics , vol.145 , pp. 1003-1013
    • Peixoto, A.A.1    Smith, L.A.2    Hall, J.C.3
  • 17
    • 0026413976 scopus 로고
    • A component of calcium-activated potassium channels encoded by the Drosophila slo locus
    • Atkinson NS, Robertson GA, Ganetzky B: A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science 1991, 253:551-555.
    • (1991) Science , vol.253 , pp. 551-555
    • Atkinson, N.S.1    Robertson, G.A.2    Ganetzky, B.3
  • 18
    • 0031909086 scopus 로고    scopus 로고
    • Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila
    • in press
    • Peixoto AA, Hall JC: Analysis of temperature-sensitive • mutants reveals new genes involved in the courtship song of Drosophila. Genetics 1998, in press. Examination of a variety of mutations in ion channel genes (affecting potassium channels, calcium channels and sodium channels), and finding that mild mutations in several of them have selective effects on courtship song. Interactions between these mutations have even more pronounced effects.
    • (1998) Genetics
    • Peixoto, A.A.1    Hall, J.C.2
  • 19
    • 0003182589 scopus 로고
    • A mutation causing abnormal mating behavior
    • Gill KS: A mutation causing abnormal mating behavior. Drosophila Inform Serv 1963, 38:33.
    • (1963) Drosophila Inform Serv , vol.38 , pp. 33
    • Gill, K.S.1
  • 20
    • 0024654703 scopus 로고
    • Behavior and cytogenetics of fruitless in Drosophila melanogaster: Different courtship defects caused by separate, closely linked lesions
    • Gailey DA, Hall JC: Behavior and cytogenetics of fruitless in Drosophila melanogaster: different courtship defects caused by separate, closely linked lesions. Genetics 1989, 121:773-785.
    • (1989) Genetics , vol.121 , pp. 773-785
    • Gailey, D.A.1    Hall, J.C.2
  • 21
    • 0029793003 scopus 로고    scopus 로고
    • Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain
    • Ito H, Fujitani K, Usui K, Shimizu-Nishikawa K, Tanaka S, Yamamoto D: Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain. Proc Natl Acad Sci USA 1996, 93:9687-9692.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9687-9692
    • Ito, H.1    Fujitani, K.2    Usui, K.3    Shimizu-Nishikawa, K.4    Tanaka, S.5    Yamamoto, D.6
  • 22
    • 0030582732 scopus 로고    scopus 로고
    • Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene
    • Ryner LC, Goodwin SF, Castrillon DH, Anand A, Villella A, •• Baker BS, Hall JC, Taylor BJ, Wasserman SA: Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 1996, 87:1079-1089. Comprehensive molecular characterization of the fruitless locus, its sequence, pattern of transcription, splicing and spatial expression, its interactions with other genes involved in sex determination, and some of its behavioral phenotypes. The gene encodes a transcription factor, and the various alleles affect all steps in courtship, including song production.
    • (1996) Cell , vol.87 , pp. 1079-1089
    • Ryner, L.C.1    Goodwin, S.F.2    Castrillon, D.H.3    Anand, A.4    Villella, A.5    Baker, B.S.6    Hall, J.C.7    Taylor, B.J.8    Wasserman, S.A.9
  • 23
    • 0030666543 scopus 로고    scopus 로고
    • Extended reproductive roles of the fruitless gene in Drosophila melanogaster revealed by behavioral analysis of new fru mutants
    • Villella A, Gailey DA, Berwald B, Ohshima S, Barnes PT, Hall JC: •• Extended reproductive roles of the fruitless gene in Drosophila melanogaster revealed by behavioral analysis of new fru mutants. Genetics 1997, 147:1107-1130. Comprehensive characterization of the behavioral complexity of the various alleles of the fruitless locus: the specific courtship phenotypes of each allele individually and their interactions with each other. Illustrates all of the different ways one gene can affect courtship behavior, in some cases exerting selective effects on some steps as opposed to others.
    • (1997) Genetics , vol.147 , pp. 1107-1130
    • Villella, A.1    Gailey, D.A.2    Berwald, B.3    Ohshima, S.4    Barnes, P.T.5    Hall, J.C.6
  • 24
    • 0027214152 scopus 로고
    • Preferential expression in the mushroom bodies of the catalytic subunit of protein kinase a and its role in learning and memory
    • Skoulakis EMC, Kalderon D, Davis RL: Preferential expression in the mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory. Neuron 1993, 11:197-208.
    • (1993) Neuron , vol.11 , pp. 197-208
    • Emc, S.1    Kalderon, D.2    Davis, R.L.3
  • 25
    • 0029677221 scopus 로고    scopus 로고
    • Effects of a conditional Drosophila PKa mutant on olfactory learning and memory
    • Li W, Tully T, Kalderon D: Effects of a conditional Drosophila • PKA mutant on olfactory learning and memory. Learn Mem 1996, 2:320-333. Behavioral analysis of a cold-sensitive mutation in the catalytic subunit of Drosophila PKA. Demonstrates a role for PKA in medium-term memory as well as in initial learning based on analysis of the retention curve.
    • (1996) Learn Mem , vol.2 , pp. 320-333
    • Li, W.1    Tully, T.2    Kalderon, D.3
  • 26
    • 0027199816 scopus 로고
    • Genetic investigation of cAMP-dependent protein kinase function in Drosophila development
    • Lane ME, Kalderon D: Genetic investigation of cAMP-dependent protein kinase function in Drosophila development Genes Dev 1993, 7:1229-1243.
    • (1993) Genes Dev , vol.7 , pp. 1229-1243
    • Lane, M.E.1    Kalderon, D.2
  • 27
    • 0025970781 scopus 로고
    • cAMP-dependent protein kinase and the disruption of learning in transgenic flies
    • Drain P, Folkers E, Quinn WG: cAMP-dependent protein kinase and the disruption of learning in transgenic flies. Neuron 1991, 6:71-82.
    • (1991) Neuron , vol.6 , pp. 71-82
    • Drain, P.1    Folkers, E.2    Quinn, W.G.3
  • 28
    • 0030840137 scopus 로고    scopus 로고
    • Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase
    • Goodwin SF, Del Vecchio M, Velinzon K, Hogel C, Russell SRH, Tully T, Kaiser K: Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase. J Neurosci 1997, 17:8817-8827.
    • (1997) J Neurosci , vol.17 , pp. 8817-8827
    • Goodwin, S.F.1    Del Vecchio, M.2    Velinzon, K.3    Hogel, C.4    Russell, S.5    Tully, T.6    Kaiser, K.7
  • 29
    • 0018413205 scopus 로고
    • Conditioned responses in courtship behavior of normal and mutant Drosophila
    • Siegel RW, Hall JC: Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc Natl Acad Sci USA 1979, 76:3430-3434.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 3430-3434
    • Siegel, R.W.1    Hall, J.C.2
  • 30
    • 0020852539 scopus 로고
    • Conditioned courtship in Drosophila and its mediation by association of chemical cues
    • Tompkins L, Siegel RW, Gailey DA, Hall JC: Conditioned courtship in Drosophila and its mediation by association of chemical cues. Behav Genet 1983, 13:565-578.
    • (1983) Behav Genet , vol.13 , pp. 565-578
    • Tompkins, L.1    Siegel, R.W.2    Gailey, D.A.3    Hall, J.C.4
  • 31
    • 0030722123 scopus 로고    scopus 로고
    • CaM kinase II and visual input modulate memory formation in the neuronal circuit controlling courtship conditioning
    • Joiner MA, Griffith LC: CaM kinase II and visual input modulate memory formation in the neuronal circuit controlling courtship conditioning. J Neurosci 1997, 17:9384-9391.
    • (1997) J Neurosci , vol.17 , pp. 9384-9391
    • Joiner, M.A.1    Griffith, L.C.2
  • 32
    • 0027538509 scopus 로고
    • Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity
    • Griffith LC, Verselis L, Aitkin KM, Kyriacou CP, Danho W, Greenspan RJ: Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity. Neuron 1993, 10:501-509.
    • (1993) Neuron , vol.10 , pp. 501-509
    • Griffith, L.C.1    Verselis, L.2    Aitkin, K.M.3    Kyriacou, C.P.4    Danho, W.5    Greenspan, R.J.6
  • 33
    • 0027971438 scopus 로고
    • Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila
    • Griffith LC, Wang J, Renger J, Wu CF, Greenspan RJ: Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila. Proc Natl Acad Sci USA 1994, 91:10044-10048.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10044-10048
    • Griffith, L.C.1    Wang, J.2    Renger, J.3    Wu, C.F.4    Greenspan, R.J.5
  • 34
    • 0031054874 scopus 로고    scopus 로고
    • Learning without performance in PKC-deficient Drosophila
    • Kane NS, Robichon A, Dickinson JA, Greenspan RJ: Learning • without performance in PKC-deficient Drosophila. Neuron 1997, 18:307-314. Demonstration of a selective effect of PKC on courtship conditioning that dissociates the immediate expression of conditioning from its acquisition and retention. A transgenic strain of flies expressing a specific peptide inhibitor of PKC shows normal courtship conditioning in all respects except that there is no decrement in the male's courtship during the training period.
    • (1997) Neuron , vol.18 , pp. 307-314
    • Kane, N.S.1    Robichon, A.2    Dickinson, J.A.3    Greenspan, R.J.4
  • 35
    • 0015119210 scopus 로고
    • Clock mutants of Drosophila melanogaster
    • Konopka R, Benzer S: Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci USA 1971, 68:2112-2116.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 2112-2116
    • Konopka, R.1    Benzer, S.2
  • 36
    • 0028946238 scopus 로고
    • Tripping along the trail to the molecular mechanisms of biological clocks
    • Hall JC: Tripping along the trail to the molecular mechanisms of biological clocks. Trends Neurosci 1995, 18:230-240.
    • (1995) Trends Neurosci , vol.18 , pp. 230-240
    • Hall, J.C.1
  • 37
    • 0000364235 scopus 로고
    • Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song
    • Kyriacou CP, Hall JC: Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc Natl Acad Sci USA 1980, 77:6729-6733.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6729-6733
    • Kyriacou, C.P.1    Hall, J.C.2
  • 38
    • 0032126945 scopus 로고    scopus 로고
    • The period gene controls courtship song cycles in Drosophila melanogaster
    • in press
    • Alt S, Ringo J, Talyn B, Bray W, Dowse H: The period gene • controls courtship song cycles in Drosophila melanogaster. Anim Behav 1998, in press. Independent confirmation of the song phenotypes in long-day, short-day and arrhythmic alleles of the period gene, employing analytical techniques completely different from those used in [37], thus demonstrating the robustness and reproducibility (which had been questioned) of the original findings.
    • (1998) Anim Behav
    • Alt, S.1    Ringo, J.2    Talyn, B.3    Bray, W.4    Dowse, H.5
  • 39
    • 0025520773 scopus 로고
    • Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginai Drosophila melanogaster
    • Ewer J, Hamblen-Coyle M, Rosbash M, Hall JC: Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginai Drosophila melanogaster. J Neurogenet 1990, 7:31-73.
    • (1990) J Neurogenet , vol.7 , pp. 31-73
    • Ewer, J.1    Hamblen-Coyle, M.2    Rosbash, M.3    Hall, J.C.4
  • 40
    • 0023140125 scopus 로고
    • Changes in abundance and structure of the per gene product can alter periodicity of the Drosophila clock
    • Baylies MK, Bargiello TA, Jackson FR, Young MW: Changes in abundance and structure of the per gene product can alter periodicity of the Drosophila clock. Nature 1987, 326:390-392.
    • (1987) Nature , vol.326 , pp. 390-392
    • Baylies, M.K.1    Bargiello, T.A.2    Jackson, F.R.3    Young, M.W.4
  • 41
    • 0023152057 scopus 로고
    • Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster
    • Yu Q, Jacquier AC, Citri Y, Hamblen M, Hall JC, Rosbash M: Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc Natl Acad Sci USA 1987, 84:784-788.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 784-788
    • Yu, Q.1    Jacquier, A.C.2    Citri, Y.3    Hamblen, M.4    Hall, J.C.5    Rosbash, M.6
  • 42
    • 0025903643 scopus 로고
    • Length polymorphism in the threonine-glycine-encoding repeat region of the period gene in Drosophila
    • Costa R, Peixoto AA, Thackeray JR, Dalgleish R, Kyriacou CP: Length polymorphism in the threonine-glycine-encoding repeat region of the period gene in Drosophila. J Mol Evol 1991, 32:238-246.
    • (1991) J Mol Evol , vol.32 , pp. 238-246
    • Costa, R.1    Peixoto, A.A.2    Thackeray, J.R.3    Dalgleish, R.4    Kyriacou, C.P.5
  • 44
    • 0030737642 scopus 로고    scopus 로고
    • Linkage disequilibrium, mutational analysis and natural selection in the repetitive region of the clock gene, period, in Drosophila melanogaster
    • Rosato E, Peixoto AA, Costa R, Kyriacou CP: Linkage •• disequilibrium, mutational analysis and natural selection in the repetitive region of the clock gene, period, in Drosophila melanogaster. Genet Res Camb 1997, 69:89-99. Mathematical treatment of sequence variation in the Thr-Gly region of the period gene, demonstrating that the Thr-Gly repeats themselves, rather than some other nearby sequences, correlate most strongly with the latitudinal cline previously demonstrated for natural variants of this gene. This finding is significant because these repeats have a subtle, functional impact on the courtship song and on temperature compensation of circadian oscillations.
    • (1997) Genet Res Camb , vol.69 , pp. 89-99
    • Rosato, E.1    Peixoto, A.A.2    Costa, R.3    Kyriacou, C.P.4
  • 45
    • 0001757026 scopus 로고
    • On temperature independence in the clock system controlling emergence time in Drosophila
    • Pittendrigh CS: On temperature independence in the clock system controlling emergence time in Drosophila. Proc Natl Acad Sci USA 1954, 40:1018-1029.
    • (1954) Proc Natl Acad Sci USA , vol.40 , pp. 1018-1029
    • Pittendrigh, C.S.1
  • 46
    • 0031442734 scopus 로고    scopus 로고
    • Natural variation in a Drosophila clock gene and temperature compensation
    • in press
    • Sawyer LA, Hennessy JM, Peixoto AA, Rosato E, Parkinson H, •• Costa R, Kyriacou CP: Natural variation in a Drosophila clock gene and temperature compensation. Science 1998, in press. A very significant report showing that the naturally occurring variants in the period gene produce subtle alterations in the flies' temperature compensation of circadian rhythms. The predominant allele in cold climates is better at temperature compensation over a wide range of temperatures than is the predominant allele in warm climates. Construction of transgenic strains expressing the different alleles confirms that the difference in temperature compensation is attributable to the polymorphic Thr-Gly repeat region of the gene.
    • (1998) Science
    • Sawyer, L.A.1    Hennessy, J.M.2    Peixoto, A.A.3    Rosato, E.4    Parkinson, H.5    Costa, R.6    Kyriacou, C.P.7
  • 47
    • 0026129061 scopus 로고
    • Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster
    • Wheeler DA, Kyriacou CP, Greenacre ML, Yu Q, Rutila JE, Rosbash M, Hall JC: Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science 1991, 251:1082-1085.
    • (1991) Science , vol.251 , pp. 1082-1085
    • Wheeler, D.A.1    Kyriacou, C.P.2    Greenacre, M.L.3    Yu, Q.4    Rutila, J.E.5    Rosbash, M.6    Hall, J.C.7
  • 49
    • 0018968051 scopus 로고
    • Foraging strategies of Drosophila melanogaster: A chromosomal analysis
    • Sokolowski MB: Foraging strategies of Drosophila melanogaster: a chromosomal analysis. Behav Genet 1980, 10:291-302.
    • (1980) Behav Genet , vol.10 , pp. 291-302
    • Sokolowski, M.B.1
  • 50
    • 0013409132 scopus 로고
    • A genetic analysis of path length and pupation height in a natural population of Drosophila melanogaster
    • Bauer SJ, Sokolowski MB: A genetic analysis of path length and pupation height in a natural population of Drosophila melanogaster. Can J Genet Cytol 1985, 27:334-340.
    • (1985) Can J Genet Cytol , vol.27 , pp. 334-340
    • Bauer, S.J.1    Sokolowski, M.B.2
  • 51
    • 0030788576 scopus 로고    scopus 로고
    • Evolution of foraging behaviour in Drosophila by density-dependent selection
    • Sokolowski MB, Pereira HS, Huges K: Evolution of foraging •• behaviour in Drosophila by density-dependent selection. Proc Natl Acad Sci USA 1997, 94:7373-7377. Long-term breeding experiments under conditions of high versus low population density result in selection for the rover behavioral type of the foraging locus at high density and the sitter form at low density. Provides a mechanistic explanation for the maintenance of the two naturally occurring forms of this behavior.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7373-7377
    • Sokolowski, M.B.1    Pereira, H.S.2    Huges, K.3
  • 52
    • 0024730135 scopus 로고
    • Genetic localization of the foraging (for): A major gene for larval behavior in Drosophila melanogaster
    • De Belle JS, Hilliker AJ, Sokolowski MB: Genetic localization of the foraging (for): a major gene for larval behavior in Drosophila melanogaster. Genetics 1989, 123:157-163.
    • (1989) Genetics , vol.123 , pp. 157-163
    • De Belle, J.S.1    Hilliker, A.J.2    Sokolowski, M.B.3
  • 53
    • 0030771199 scopus 로고    scopus 로고
    • Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
    • Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, • Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB: Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science 1997, 277:834-836. Molecular identification of the foraging locus as the previously identified dg2 locus for PKG, demonstrating that sitters have lower levels of enzyme activity, PKG protein and mRNA than rovers, and that sitters can be converted to rovers by increased expression of a dg2 cDNA. Shows that natural behavioral variation can be attributable to mild differences in a widely acting gene.
    • (1997) Science , vol.277 , pp. 834-836
    • Osborne, K.A.1    Robichon, A.2    Burgess, E.3    Butland, S.4    Shaw, R.A.5    Coulthard, A.6    Pereira, H.S.7    Greenspan, R.J.8    Sokolowski, M.B.9
  • 54
    • 0024328705 scopus 로고
    • cGMP-dependent protein kinase genes in Drosophila
    • Kalderon D, Rubin GM: cGMP-dependent protein kinase genes in Drosophila. J Biol Chem 1989, 264:10738-10748.
    • (1989) J Biol Chem , vol.264 , pp. 10738-10748
    • Kalderon, D.1    Rubin, G.M.2
  • 56
    • 0028287255 scopus 로고
    • Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase
    • Lincoln TM, Komalavilas P, Cornwell TL: Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase. Hypertension 1994, 23:1141-1147.
    • (1994) Hypertension , vol.23 , pp. 1141-1147
    • Lincoln, T.M.1    Komalavilas, P.2    Cornwell, T.L.3
  • 57
    • 0030452310 scopus 로고    scopus 로고
    • Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
    • Pfeifer A, Aszodi A, Seidler U, Ruth P, Hofmann F, Faessler R: Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 1996, 274:2082-2086.
    • (1996) Science , vol.274 , pp. 2082-2086
    • Pfeifer, A.1    Aszodi, A.2    Seidler, U.3    Ruth, P.4    Hofmann, F.5    Faessler, R.6
  • 58
    • 0345260455 scopus 로고
    • How do genes set up behavior?
    • Edited by Greenspan RJ, Kyriacou CP. Berlin: Dahlem Konferenzen Publications
    • Greenspan RJ, Tully T: How do genes set up behavior? In Flexibility and Constraint in Behavioral Systems. Edited by Greenspan RJ, Kyriacou CP. Berlin: Dahlem Konferenzen Publications; 1994:65-80.
    • (1994) Flexibility and Constraint in Behavioral Systems , pp. 65-80
    • Greenspan, R.J.1    Tully, T.2
  • 59
    • 0032167859 scopus 로고    scopus 로고
    • Genetic lesions in Drosophila behavioural mutants
    • in press
    • Pflugfelder GO: Genetic lesions in Drosophila behavioural • mutants. Behav Brain Res 1998, in press. Discussion of the preponderance of pleiotropic mutants among those isolated for their effects on behavior, and its implication for gene identification strategies.
    • (1998) Behav Brain Res
    • Pflugfelder, G.O.1


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