Germline diversity within the mouse Igk-V9 gene family

Immunogenetics

Volumn 47, Issue 1, 1997, Pages 91-95

  Ulrich, Helle D ^a,b   Moore, Frederick L ^a   Schultz, Peter G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Catalytic antibody; Germline; Immunoglobin repertoire; Somatic hypermutation; VK9 gene family

Indexed keywords

CATALYTIC ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA CHAIN; MONOCLONAL ANTIBODY;

ARTICLE; DATA BASE; DNA FLANKING REGION; EVOLUTION; GENE LOCUS; GENE MAPPING; GENETIC VARIABILITY; GERM LINE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS; MICE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; VARIATION (GENETICS);

RODENTIA;

EID: 0031446562     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050331     Document Type: Article

References (29)

1. Berek, C., Griffiths, G.M., and Milstein, C. Molecular events during maturation of the immune response to oxazolone. Nature 316: 412-418, 1985
2. Bernard, O., Gough, N.M., and Adams, J.M. Plasmacytomas with more than one immunoglobulin κ mRNA: implications for allelic exclusion. Proc Natl Acad Sci USA 78: 5812-5816, 1981
3. b family of antibodies: somatic mutation evident in a γ2a variable region. Cell 24: 625-637, 1981
4. Clackson, T., Hoogenboom, H.R., Griffiths, A.D., and Winter, G. Making antibody fragments using phage display libraries. Nature 352: 624-628, 1991
5. Cook, G.P. and Tomlinson, I.M. The human immunoglobulin V repertoire. Immunol Today 16: 237-242, 1995
6. H gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell 25: 59-66, 1981
7. Darsley, M.J. and Rees, A.R. Nucleotide sequences of five antilysozyme monoclonal antibodies. EMBO J 4: 393-398, 1985
8. French, D.L., Laskov, R., and Scharff, M.D. The role of somatic hypermutation in the generation of antibody diversity. Science 244: 1152-1157, 1989
9. Frippiat, J.P., Williams, S.C., Tomlinson, I.M., Cook, G.P., Cherif, D., Le Paslier, D., Collins, J.E., Durham, I., Winter, G., and Lefranc, M.P. Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. Hum Mol Genet 4: 983-991, 1995
10. Giudicelli, V., Chaume, D., Bodmer, J., Muller, W., Busin, C., Marsh, S., Bontrop, R., Marc, L., Malik, A., and Lefranc, M.P. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res 25: 206-211, 1997
11. κ families. Immunogenetics 29: 65-74, 1989
12. Kofler, R., Strohal, R., Balderas, R.S., Johnson, M.E., Noonan, D.J., Duchosal, M.A., Dixon, F.J., and Theofilopoulos, A.N. Immunoglobulin κ light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice. J Clin Invest 82: 852-860, 1988
13. Matsuda, F., Shin, E.K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Taka-ishi, S., Imai, T., Riley, J.H., Anand, R., Soeda, E., and Honjo, T. Structure and physical map of 64 variable segments in the 3 0.8-megahase region of the human immunoglobulin heavy-chain locus. Nat Genet 3: 88-94, 1993
14. Max, E.E., Seidman, J.G., Miller, H., and Leder, P. Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence for a cryptic gene. Cell 21: 793-799, 1980
15. Ollier, P., Rocca-Serra, J., Sommé, G., Thèze, J., and Fougereau, M. The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system. EMBO J 4: 3681-3688, 1985
16. Patten, P.A., Gray, N.S., Yang, P.L., Marks, C.B., Wedemayer, G.J., Boniface, J.J., Stevens, R.C., and Schultz, P.C. The immunological evolution of catalysis. Science 271: 1086-1091, 1996
17. κ gene is in the leader intron. Eur J Immunol 24: 1453-1457, 1994
18. Rajewsky, K. Clonal selection and learning in the antibody system. Nature 181: 751-758, 1996
19. Rogerson, B.J. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol Immunol 31: 83-98, 1994
20. Rothenfluh, H.S., Blanden, R.V., and Steele, E.J. Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes. Immunogenetics 42: 159-171, 1995
21. Rothenfluh, H.S., Taylor, L., Bothwell, A.L.M., Both, G.W., and Steele, E.J. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions. Eur J Immunol 23: 2152-2159, 1993
22. Seidman, J.G., Max, E.E., and Leder, P. A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature 280: 370-375, 1979
23. Shlomchik, M.J., Marshak-Rothstein, A., Wolfowicz, C.B., Rothstein, T.L., and Weigert, M.G. The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805-811, 1987
24. Tsao, B.P., Ebling, F.M., Roman, C., Panosian-Sahakian, N., Calame, K., and Hahn, B.H. Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in mouse lupus. J Clin Invest 85: 530-540, 1990
25. Ulrich, H.D., Patten, P.A., Yang, P.L., Romesberg, F.E., and Schultz, P.G. Expression studies of catalytic antibodies. Proc Natl Acad Sci USA 92: 11907-11911, 1995
26. Ulrich, H.D., Mundorff, E., Santarsiero, B.D., Driggers, E.M., Stevens, R.C., and Schultz, P.G. The interplay between binding energy and catalysis in the evolution of a catalytic antibody. Nature, in press
27. Williams, S.C., Frippiat, J.P., Tomlinson, I.M., Ignatovich, O., Lefranc, M.P., and Winter, G. Sequence and evolution of the human germline V lambda repertoire. J Mol Biol 264: 220-232, 1996
28. Zachau, H.G. The immunoglobulin kappa locus - or - what has been learned from looking closely at one-tenth of a percent of the human genome. Gene 135: 167-173, 1993
29. Zemel, R., Schindler, D.G., Tawfik, D.S., Eshhar, Z., and Green, B.S. Differences in the biochemical properties of esterolytic antibodies correlate with structural diversity. Mol Immunol 31: 127-137, 1994