'Myocardial hibernation' - Questions and controversies

Cardiovascular Research

Volumn 36, Issue 3, 1997, Pages 301-309

  Heusch, Gerd ^a   Ferrari, Roberto ^b   Hearse, David J ^c   Ruigrok, Tom J C ^d   Schulz, Rainer ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF BRESCIA   (Italy)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d Heart Lung Institute Utrecht   (Netherlands)

Author keywords

Contractile function; Hibernation; Myocardial ischemia

Indexed keywords

DOBUTAMINE;

ADAPTATION; CORONARY ARTERY BLOOD FLOW; ECHOCARDIOGRAPHY; HEART CONTRACTION; HEART EJECTION FRACTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; HEART TRANSPLANTATION; ISCHEMIC HEART DISEASE; MYOCARDIAL HIBERNATION; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; REVIEW;

ANIMALS; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL REVASCULARIZATION; MYOCARDIAL STUNNING; PATIENT SELECTION; VENTRICULAR DYSFUNCTION;

EID: 0031439482     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00125-9     Document Type: Review

References (70)

1. Rahimtoola S.H. Coronary bypass surgery for chronic angina - 1981. Circulation. 65:1982;225-241.
2. Rahimtoola SH. A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 1985;72(suppl V):V-123-V-135.
3. Diamond G.A., Forrester J.S., de Luz P.L., Wyatt H.L., Swan H.J.C. Postextrasystolic potentiation of ischemic myocardium by atrial stimulation. Am Heart J. 95:1978;204-209.
4. Gallagher KP, Matsuzaki M, Osakada G, Kemper WS, Ross Jr J, Effect of exercise on the relationship between myocardial blood flow and systolic wall thickening in dogs with acute coronary stenosis. Circ Res 1983;52:716-729.
5. Matsuzaki M, Gallagher KP, Kemper WS, White F, Ross JrJ, Sustained regional dysfunction produced by prolonged coronary stenosis: gradual recovery after reperfusion. Circulation 1983;68:170-182.
6. Ross Jr J. Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 1991;83:1076-1083.
7. Fedele F.A., Gewirtz H., Capone R.J., Sharaf B., Most A.S. Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation. 78:1988;729-735.
8. Pantely G.A., Malone S.A., Rhen W.S.et al. Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res. 67:1990;1481-1493.
9. Schulz R., Guth B.D., Pieper K., Martin C., Heusch G. Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res. 70:1992;1282-1295.
10. Bolukoglu H., Liedtke A.J., Nellis S.H., Eggleston A.M., Subramanian R., Renstrom B. An animal model of chronic coronary stenosis resulting in hibernating myocardium. Am J Physiol. 263:1992;H20-H29.
11. Liedtke A.J., Renstrom B., Nellis S.H., Subramanian R. Myocardial function and metabolism in pig hearts after relief from chronic partial coronary stenosis. Am J Physiol. 267:1994;H1312-H1319.
12. Mills I., Fallon J.T., Wrenn D.et al. Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow. Am J Physiol. 266:1994;H447-H457.
13. Chen C., Li L., Chen L.L.et al. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 92:1995;756-766.
14. Liedtke A.J., Renstrom B., Nellis S.H., Hall J.L., Stanley W.C. Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Coll Cardiol. 26:1995;815-828.
15. Chen C., Chen L., Fallon J.T.et al. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation. 94:1996;507-516.
16. Canty JM, Klocke FJ. Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circ Res 1987;61(suppl II):107-116.
17. Shen Y.-T., Vatner S.F. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning. Circ Res. 76:1995;479-488.
18. Fallafollita JA, Perry BJ, Canty JM. 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium. Circulation 1997;95:1900-1909.
19. Iskandrian A.S., Hakki A.-H., Kane S.A.et al. Rest redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting. Am J Cardiol. 51:1983;1312-1316.
20. Tillisch J., Brunken R., Marshall R.et al. Reversibility of cardiac wall-motion abnormalities predicted by positron emission tomography. N Engl J Med. 314:1986;884-888.
21. Tamaki N., Yonekura Y., Yamashita K.et al. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol. 64:1989;860-865.
22. vanOverschelde J.L.J., Wijns W., Depré C.et al. Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulation. 87:1993;1513-1523.
23. Shivalkar B., Maes A., Borgers M.et al. Only hibernating myocardium invariably shows early recovery after coronary revascularization. Circulation. 94:1996;308-315.
24. Gerber BL, Vanoverschelde JL, Bol A, et al. Myocardial blood flow, glucose uptake, and recruitment of inotropic reserve in chronic left ventricular ischemic dysfunction. Circulation 1996;94:651-659.
25. Sun KT, Czernin J, Krivokapich J, et al. Effects of dobutamine stimulation on myocardial blood flow, glucose metabolism, and wall motion in normal and dysfunctional myocardium. Circulation 1996;94:3146-3154.
26. De Silva R., Yamamoto Y., Rhodes C.G.et al. Preoperative prediction of the outcome of coronary revascularization using positron emission tomography. Circulation. 86:1992;1738-1742.
27. Marinho N.V.S., Keogh B.E., Costa D.C., Lammerstma A.A., Ell P.J., Camici P.G. Pathophysiology of chronic left ventricular dysfunction. New insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation. 93:1996;737-744.
28. Mäki M, Luatolahti M, Nuutila P, et al. Glucose uptake in the chronically dysfunctional but viable myocardium. Circulation 1996;93:1658-1666.
29. Conversano A, Walsh JF, Geltman EM, Perez JE, Bergmann SR, Gropler RJ. Delineation of myocardial stunning and hibernation by positron emission tomography in advanced coronary artery disease. Am. Heart J 1996;131:440-450.
30. Rahimtoola SH. Hibernating myocardium has reduced blood flow at rest that increases with low-dose dobutamine. Circulation 1996;94:3055-3061.
31. Gallagher KP, Matsuzaki M, Koziol JA, Kemper WS, Ross Jr J. Regional myocardial perfusion and wall thickening during ischemia in conscious dogs. Am J Physiol 1984;247:H727-H738.
32. Hearse D.J. Myocardial ischemia: can we agree on a definition for the 21st century? Cardiovasc Res. 28:1994;1737-1744.
33. Ferrari R., Cargnoni A., Bernocchi P.et al. Metabolic adaptation during a sequence of no-flow and low-flow ischaemia: a possible trigger for hibernation. Circulation. 94:1996;2587-2596.
34. 31P MRS study in rat hearts. J Mol Cell Cardiol 1996;28:2373-2381.
35. Schulz R., Post H., Sakka S., Wallbridge D.R., Heusch G. Intraischemic preconditioning. Increase tolerance to sustained low-flow ischemia by a brief episode of no-flow ischemia without intermittent reperfusion. Circ Res. 76:1995;942-950.
36. Koning M.M.G., Simonis L.A.J., deZeeuw S., Nieukoop S., Post S., Verdouw P.D. Ischaemic preconditioning by partial occlusion without intermittent reperfusion. Cardiovasc Res. 28:1994;1146-1151.
37. Schulz R., Heusch G. Ischemic preconditioning and myocardial hibernation: is there a common mechanism? Basic Res Cardiol. 91:1996;50-52.
38. Arai A.E., Grauer S.E., Anselone C.G., Pantely G.A., Bristow J.D. Metabolic adaptation to grandual reduction in myocardial blood flow. Circulation. 92:1995;244-252.
39. Ito B.R. Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation. Circulation. 91:1995;2058-2070.
40. Schelbert HR. Positron emission tomography for the assessment of myocardial viability. Circulation 1991; 84(suppl I):I-122-I-131.
41. Camici P.G., Rosen S.D. Does positron emission tomography contribute to the management of clinical cardiac problems? Eur Heart J. 17:1996;174-181.
42. La Canna G., Alfieri O., Giubbini R., Gargano M., Ferrari R., Visioli O. Echocardiography during infusion of dobutamine for identification of reversible dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol. 23:1994;617-626.
43. Perrone-Filardi P., Pace L., Prastaro M.et al. Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease. Circulation. 91:1995;2556-2565.
44. Dilsizian V., Rocco T.P., Freedman N.M.T., Leon M.B., Bonow R.O. Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging. N Engl J Med. 323:1990;141-146.
45. Dilsizian V., Bonow R.O. Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium. Circulation. 87:1993;1-20.
46. Panza J.A., Dilsizian V., Laurienzo J.M., Curiel R.V., Katsiyiannis P.T. Relation between thallium uptake and contractile response to dobutamine. Implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation. 91:1995;990-998.
47. 99mTc sestamibi in patients undergoing cardiac transplantation. A scintigraphic/pathological study. Circulation. 94:1996;1010-1017.
48. Adams J.N., Norton M., Trent R.J., Mikecz P., Walton S., Evans N. Incidence of hibernating myocardium after acute myocardial infarction treated with thrombolysis. Heart. 75:1996;442-446.
49. Galli M., Marcassa C., Bolli R.et al. Spontaneous delayed recovery of perfusion and contraction after the first 5 weeks after anterior infarction. Evidence for the presence of hibernating myocardium in the infarcted area. Circulation. 90:1994;1386-1397.
50. Louie HW, Laks H, Milgalter E. Ischemic cardiomyopathy criteria for coronary revascularization and cardiac transplantation. Circulation 1991; 84(suppl III):III-290-III-295.
51. Rahimtoola S.H. Hibernating myocardium. A brief article. Basic Res Cardiol. 90:1995;38-40.
52. Schulz R., Rose J., Martin C., Brodde O.E., Heusch G. Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation. 88:1993;684-695.
53. ATP channels. Am J Physiol. 268:1995;H2294-H3201.
54. Kitakaze M., Marban E. Cellular mechanism of the modulation of contractile function by coronary perfusion pressure in ferret hearts. J Physiol. 414:1989;455-472.
55. Heusch G., Rose J., Skyschally A., Post H., Schulz R. Calcium responsiveness in regional myocardial short-term hibernation and stunning in the in situ porcine heart - inotropic responses to postextrasystolic potentiation and intracoronary calcium. Circulation. 93:1996;1556-1566.
56. Camici PG, Wijns W, Borgers M, et al. Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (hibernating myocardium). Circulation 1997;in press.
57. Vanoverschelde JL, Wijns W, Borgers M, et al. Chronic myocardial hibernation in humans. Circulation 1997;95:1961-1971.
58. Flameng W, Suy R, Schwarz F, et al. Ultrastructural correlates of left ventricular contraction abnormalities in patients with chronic ischemic heart disease: Determinants of reversible segmental asynergy postrevascularization surgery. Am Heart J;102:846-857.
59. Elsässer A., Schaper J. Hibernating myocardium: adaptation or degeneration? Basic Res Cardiol. 90:1995;47-48.
60. Borgers M., Ausma J. Structural aspects of the chronic hibernating myocardium in man. Basic Res Cardiol. 90:1995;44-46.
61. Rahimtoola S.H. From coronary artery disease to heart failure: role of the hibernating myocardium. Am J Cardiol. 75:1995;16E-22E.
62. Topol E.J., Weiss J.L., Guzman P.A.et al. Immediate improvement of dysfunctional myocardial segments after coronary revascularization: Detection by intraoperative transesophageal echocardiography. J Am Coll Cardiol. 4:1984;1123-1134.
63. Takeishi Y., Tono-oka I., Kubota I.et al. Functional recovery of hibernating myocardium after coronary bypass surgery: does it coincide with improvement in perfusion? Am Heart J. 122:1991;665-670.
64. Bolli R., Zhu W.-X., Thornby J.I., O'Neill P.G., Roberts R. Time course and determinants of recovery of function after reversible ischemia in conscious dogs. Am J Physiol. 254:1988;H102-H114.
65. Schulz R., Guth B.D., Heusch G. No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs: Evidence against the Gregg phenomenon. Circulation. 83:1991;1390-1403.
66. Kriett J.M., Kaye M.P. The registry of the International Society for Heart Transplantation. J Heart Transplant. 9:1990;323-330.
67. Primo G., Le Clerc J.L., Goldstein J.P., De Smet J.M., Joris M.P. Cardiac transplantation for the treatment of endstage ischemic cardiomyopathy. Adv Cardiol. 36:1988;293-297.
68. Franciosa J.A., Wilen M. Ziesvival in men with severe chronic left ventricular failure due to either coronary heart disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 51:1983;831-836.
69. Wechsler A.S., Junod F.L. Coronary bypass grafting in patients with chronic congestive heart failure. Circulation. 79:1989;I92-I96.
70. Kron I.L., Flanagan T.L., Blackbourne L.H., Schroeder R.A., Nolan S.P. Coronary revascularisation rather than cardiac transplantation for chronic ischemic cardiomyopathy. Ann Surg. 210:1989;348-352.