Inefficient termination of antigen responses in NF-ATp-deficient mice

Immunobiology

Volumn 198, Issue 1-3, 1997, Pages 162-169

  Heyer, Jörg ^a   Kneitz, Burkhard ^b   Schuh, Kai ^a   Jankevics, Eriks ^c   Siebelt, Friederike ^a   Schimpl, Anneliese ^b   Serfling, Edgar ^a,b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF LATVIA   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOKINE; MESSENGER RNA; NUCLEAR FACTOR; PADGEM PROTEIN; SUPERANTIGEN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION TERMINATION;

EID: 0031437835     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(97)80037-X     Document Type: Article

References (19)

1. SHAW, J.-P., P. J. UTZ, D. B. DURAND, J. J. TOOLE, E. A. EMMEL, and G. R. CRABTREE. 1988. Identification of a putative regulator of early T cell activation genes. Science 241: 202.
2. RAO, A. 1994. NF-ATp: a transcription factor required for the coordinate induction of several cytokine genes. Immunol. Today 15: 274.
3. SERFLING, E., A. AVOTS, and M. NEUMANN. 1995. The architecture of the Interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta 1263: 181.
4. LIU, J. 1993. FK 506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immunol. Today 14: 290.
5. MCCAFFREY, P. G., C. LUO, T. K. KERPPOLA, J. JAIN, T. M. BADALIAN, A. M. HO, E. BURGEON, W. S. LANE, J. N. LAMBERT, T. CURRAN, G. L. VERDINE, A. RAO, and P. G. HOGAN. 1993. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262: 750.
6. NORTHROP, J. P., S. N. HO, L. CHEN, D. J. THOMAS, L. A. TIMMERMAN, G. J. NOLAN, A. ADMON, and G. R. CRABTREE. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369: 497.
7. HOEY, T. K., Y. L. SUN, K. WILLIAMSON, and X. XU. 1995. Isolation of two new members of the NFAT gene family and functional characterization of NFAT proteins. Immunity 2: 461.
8. MASUDA, E., Y. NAITO, H. TOKUMITSU, B. CAMPBELL, F. SAITO, C. HANNUM, K. I. ARAI, and N. ARAI. 1995. NFATx: a novel member of the NFAT family that is predominantly expressed in the thymus. Mol. Cell. Biol. 15: 2697.
9. TSITSIKOV, E. N., N. RAMESH, and R. S. GEHE. 1994. Structure of the CD40 ligand gene. Mol. Immunol. 16: 5232.
10. BRUNNER, T., N. J. YOO, D. LAFACE, C. F. WARE, and D. R. GREEN. Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol. 8: 1017-1026.
11. COCKERILL, P. N., M. F. SHANNON, A. G. BERT, G. R. RYAN, and M. A. VADAS. 1993. The granulocyte-macrophage stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl. Acad. Sci. USA 90: 2466.
12. CHUVPILO, S., C. SCHOMBERG, R. GERWIG, A. HEINFLING, R. REEVES, F. GRUMMT, and E. SERFLING. 1993. Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucl. Acids Res. 21: 5694.
13. ROONEY, J. W., Y. L. SUN, L. H. GLIMCHER, and T. HOEY. 1995. Novel NF-AT sites that mediate activation of the Interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15: 6299.
14. TSAI, E. Y., J. JAIN, P. A. PESAVENTO, A. RAO, and A. E. GOLDFELD. 1996. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol. Cell. Biol. 16: 459.
15. PARK, J. A. TAKEUCHI, and S. SHARMA. 1996. Characterization of a new isoform of the NFAT (Nuclear Factor of Activated T cells) gene family member NFATc. J. Biol. Chem. 271: 20914.
16. KNEITZ, B., T. HERRMANN, S. YONEHARA, and A. SCHIMPL. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2 deficient mice. Eur. J. Immunol. 25: 2572.
17. WILLERFORD, D. M., J. CHEN, J. A. FERRY, L. DAVIDSON, A. MA, and F. W. ALT. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid department. Immunity 3: 521.
18. HODGE, M. R., A. M. RANGER, F. C. DE LA BROUSSE, T. HOEY, M. J. GRUSBY, and L. H. GLIMCHER. 1996. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4: 397.
19. XANTHOUDAKIS, S., J. P. B. VIOLA, K. T. Y. SHAW, C. LUO, J. D. WALLACE, P. T. BOZZA, T. CURRAN, and A. RAO. 1996. An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272: 892.