The effects of short intravenous infusions of thiopentone on myocardial function, blood flow and oxygen consumption in sheep

Anaesthesia and Intensive Care

Volumn 25, Issue 6, 1997, Pages 627-633

  Huang, Y F ^a,b   Upton, R N ^a,c   Gray, E C ^a,c   Grant, C ^a,c   Zheng, D ^a,c   Ludbrook, G L ^a,c  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Anaesthetics, intravenous: thiopentone; Heart: mean arterial pressure, heart rate, cardiac output, myocardial contractility, left coronary blood flow, myocardial oxygen consumption

Indexed keywords

THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE WORK; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; LEFT CORONARY ARTERY; MEAN ARTERIAL PRESSURE; NONHUMAN; SHEEP;

EID: 0031434768     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x9702500605     Document Type: Article

References (25)

1. Conway CM, Ellis DB. The haemodynamic effects of short-acting barbiturates. A review. Br J Anaesth 1969; 41:534-542.
2. Reilly CS. Intravenous anaesthetic agents: Pharmacology. In: Nimmo WS, Rowbotham DJ, Smith G, eds. Anaesthesia. Blackwell Scientific Publications, Oxford, 1994; 87-105.
3. Turner DM, Ilkiw JE. Cardiovascular and respiratory effects of three rapidly acting barbiturates in dogs. Am J Vet Res 1990; 51:598-604.
4. Runciman WB, Mather LE, Selby DG. Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. Br J Anaesth 1990; 65:353-359.
5. Aun CS, Sung RY, O'Meara ME, Short TG, Oh TE. Cardiovascular effects of i.v. induction in children: comparison between propofol and thiopentone. Br J Anaesth 1993; 70:647-653.
6. Mouren S, Baron JF, Albo C, Szekely B, Arthaud M, Vaiars P. Effects of propofol and thiopentone on coronary blood flow and myocardial performance in an isolated rabbit heart. Anesthesiology 1994; 80:634-641.
7. Patschke D, Bruckner JB, Gethman JW, Tarnow J, Weymar A. Comparison of the immediate effects of etomidate, propandid and thiopentone on haemodynamics, coronary bloodflow and myocardial oxygen consumption. An experimental study. Acta Anaesth Belg 1975; 26:112-119.
8. Chamberlain JH, Seed RGFL, Chung DCW. Effect of thiopentone on myocardial function. Br J Anaesth 1977; 49:865-870.
9. McGrath JC, Mackenzie JE. The effects of intravenous anaesthetics on the cardiovascular system of the rabbit. Br J Pharmacol 1977; 61:199-212.
10. Carlon GC, Kahn RC, Goldiner PL, Howland WS, Turnbull A. Long-term infusion of sodium thiopental: hemodynamic and respiratory effects. Crit Care Med 1978; 6:311-316.
11. Gaudy JH, Dauthier C, Galliot M. Ventilatory effects produced by the IV administration of incremental doses of thiopentone in the dog. Br J Anaesth 1983; 55:977-984.
12. Seltzer JL, Gerwon JI, Allen FB. Comparison of the cardiovascular effects of bolus vs incremental administration of thiopentone. Br J Anaesth 1980; 52:527-529.
13. Upton RN, Huang YF, Grant C, Gray EC, Ludbrook GL. The myocardial pharmacokinetics of thiopental in sheep after short term administration - Relationship to thiopental induced reductions in myocardial contractility. J Pharm Sci 1996; 85:863-867.
14. Huang YF, Upton RN, Rutten AJ, Runciman WB. Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. Effect on circulatory function. Br J Anaesth 1992; 69:368-374.
15. Huang YF, Upton RN, Runciman WB. Intravenous bolus administration of subconvulsive doses of lignocaine to conscious sheep. Myocardial pharmacokinetics. Br J Anaesth 1993; 70:326-332.
16. Runciman WB, Ilsley AH, Mather LE, Carapetis RJ, Rao MM. A sheep preparation for studying interactions between blood flow and drug disposition I: Physiological profile. Br J Anaesth 1984; 56:1015-1028.
17. Langston PG, Jarvis DA, Lewis G, Osborne GA, Russell WJ. The determination of absorption coefficients for measurement of carboxyhaemoglobin, oxyhaemoglobin, reduced haemoglobin, and methaemoglobin in sheep using the IL 482 CO-Oximeter. J Anal Toxicol 1993; 17:278-283.
18. Upton RN, Ludbrook GL, Grant C, Gray EC. In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration. J Pharmacokin Biopharm 1996; 24:1-18.
19. Mason DT. Usefulness and limitations of the rate of rise of intraventricular pressure (dp/dt) in the evaluation of myocardial contractility in man. Am J Cardiology 1969; 23:516-527.
20. Strobeck JE, Sonnenblick EH. Myocardial contractile properties and ventricular performance. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, eds. The Heart and Cardiovascular System, Raven Press, New York, 1986; 31-49.
21. Davidson DM, Covell JW, Malloch CI, Ross J. Factors influencing indices of left ventricle contractility in the conscious dog. Cardiovasc Res 1974; 8:299-312.
22. Davies AE, McCans JL. Effect of barbiturate anesthetics and ketamine on the force-frequency relation of cardiac muscle. Eur J Pharmacol 1979; 59:65-73.
23. Kavanagh BP, Ryan MP, Cunningham AJ. Myocardial contractility and ischaemia in the isolated perfused rat heart with propofol and thiopental. Can J Anaesth 1991; 38:634-639.
24. Huang YF, Upton RN, Mather LE. The hemodynamic effects of intravenous bolus doses of meperidine in conscious sheep. Anesth Analg 1994; 78:442-449.
25. Guyton AC, Hall JE. Circulatory Physiology IV. University Press, Baltimore, 1982.