In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 24, Issue 1, 1996, Pages 1-18

  Upton, Richard N ^a   Ludbrook, Guy L ^a   Grant, Cliff ^a   Gray, Elke C ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

brain; cerebral blood flow; pharmacodynamics; pharmacokinetics; thiopentone

Indexed keywords

THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; DOPPLER FLOWMETRY; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; SHEEP; SUPERIOR SAGITTAL SINUS;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMODYNAMIC PROCESSES; SHEEP; THIOPENTAL;

EID: 0029902146     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02353508     Document Type: Article

References (33)

1. D. R. Stanski, R. J. Hudson, T. D. Homer, L. J. Saidman, and E. Meathe. Pharmacodynamic modeling of thiopental anaesthesia. J. Pharmacokin. Biopharm. 12:223-240 (1984).
2. C. A. Shanks, M. J. Avram, T. C. Krejcie, T. K. Henthorn, and W. B. Gentry. A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental. J. Pharmacokin. Biopharm. 21:309-321 (1993).
3. W. B. Gentry, T. C. Krejcie, T. K. Henthorn, C. A. Shanks, K. A. Howard, D. K. Gupta, and M. J. Avram. Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology 81:316-324 (1994).
4. M. J. Avram, T. C. Krejcie, and T. K. Henthorn. The relationship of age to the pharmacokinetics of early drug distribution. The concurrent disposition of thiopental and indocyanine green. Anesthesiology 72:399-402 (1990).
5. K. B. Bischoff and R. L. Dedrick. Thiopental pharmacokinetics. J. Pharm. Sci. 57:1346-1351 (1968).
6. P. P. Gillis, R. J. DeAngelis, and R. L. Wynn. Nonlinear pharmacokinetic model of intravenous anesthesia. J. Pharm. Sci. 65:1001-1006 (1976).
7. T. Igari, Y. Sugiyama, S. Awazu, and M. Hanono. Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the rat. J. Pharmacokin. Biopharm. 10:53-75 (1982).
8. W. F. Ebling, D. R. Wada, and D. R. Stanski. From piecewise to full physiologic modeling. Applied to thiopentone disposition in the rat. J. Pharmacokin. Biopharm. 22:259-292 (1994).
9. J. D. Michenfelder. Cerebral blood flow and metabolism. In R. F. Cucchiara and J. D. Michenfelder (eds.). Clinical Neuroanesthesia, Churchill Livingstone, New York, 1990, pp. 1-40.
10. G. L. Ludbrook, R. N. Upton, C. Grant, and E. Gray. The cerebral pharmacokinetics and pharmacodynamics of propofol. Anaesth. Intens. Care 22:494 (1994).
11. R. N. Upton, C. Grant, and G. L. Ludbrook. An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. J. Cerebral. Blood Flow Metab. 14:680-688 (1994).
12. D. B. Lindsay and B. P. Setchell. Cannulation of the sagittal sinus for the determination of cerebral ketone body metabolism in sheep. J Physiol. 226:51P (1972).
13. J. R. S. Hales. Chronic catheterization for sampling venous blood from the brain of sheep. Pflugers Arch. 337:81-85 (1972).
14. W. B. Runciman, A. H. Ilsley, L. E. Mather, R. J. Carapetis, and M. M. Rao. A sheep preparation for studying interactions between blood flow and drug disposition 1: Physiological profile. Br. J. Anaesth. 56:1015-1028 (1984).
15. J. R. Haywood, R. A. Shaffer, C. Fastenow, G. D. Fink, and M. J. Brody. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am. J. Physiol. 241H:273-278 (1981).
16. G. L. Ludbrook, C. Grant, R. N. Upton, and C. Penhall. A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus. J. Pharmacol. Toxicol. Meth. 33:17-22 (1995).
17. R. N. Upton, L. E. Mather, W. B. Runciman, C. Nancarrow, and R. J. Carapetis. The use of mass balance principles to describe regional drug distribution and elimination. J. Pharmacokin. Biopharm. 16:13-29 (1988).
18. R. N. Upton. An analysis of errors arising from the direct use of mass balance principles to describe regional drug uptake and elution. J. Pharmacokin. Biopharm. 22:309-321 (1994).
19. R. A. Shipley and R. E. Clark. Tracer Methods for In Vivo Kinetics. Theory and Applications, Academic Press, New York, 1972, pp. 1-20.
20. L. B. Sheiner, D. R. Stanski, S. Vozeh, R. D. Miller, and J. Ham. Simultaneous modelling of pharmacokinetics and pharacodynamics: Application to d-tubocurarine Clin. Pharmacol. Ther. 25:358-372 (1979).
21. G. G. McDowall. Cerebral blood flow. In T. C. Gray, J. F. Nunn. and J. E. Utting (eds.), General Anaesthesia, 4th ed., Vol. 1., Butterworths, London, 1980, pp. 657-684.
22. W. B. Runciman and R. N. Upton. Pharmacokinetics and pharmacodynamics - what is of value to anaethetists? Anaesth. Pharmacol Rev. 2:280-293 (1994).
23. J. W. Dundee and R. S. J. Clarke. Non-inhalational anaesthetics. In T. C. Gray, J. F. Nunn, and J. E. Utting (eds.), General Anaesthesia, 4th ed., Vol, I., Butterworths, London, 1980, pp. 217-255.
24. C. Drummond, C. A. Brann, D. E. Perkins, and D. E. Wolfe. A comparison of median frequency, spectral edge frequency, a frequency band power ratio, total power and dominance shift in the determination of the depth of anaesthesia. Acta. Anaesthesiol. Scand. 35:693-699 (1991).
25. P. L. Bailey, J. D. Port, S. McJames, L. Reinersman, and T. H. Stanley. Is fentanyl an anesthetic in the dog? Anesth. Analg. 66:542-548 (1987).
26. E. I. Egar, L. J. Saidman, and B. Brandstater. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 26: 756-763 (1965).
27. M. A. Salonen and M. Maze. Molecular mechanism of action for hyponotic and sedative agents. In S. Feldmann, C. F. Scurr, and W. Paton (eds. ), Mechanisms of Drugs in Anaesthesia, Edward Arnold, London, 1993, pp. 201-210.
28. Y. F. Huang, R. N. Upton, and W. B. Runciman. Intravenous bolus administration of subconvulsive doses of Iignocaine to conscious sheep. II. Myocardial pharmacokinetics Br. J. Anaesth. 70:326-332 (1993).
29. B. B. Brodie, H. Kurz, and L. S. Schanker. The importance of dissociation constant and lipid solubility in influencing the passage of drugs into the cerebrospinal fluid. J. Pharmacol. Exp. Ther. 130:20-25 (1960).
30. G. R. Wilkinson. Plasma and tissue binding considerations in drug disposition. Drug Metab. Rev. 4:427-465 (1983).
31. S. Björkman, J. Akeson, F. Nilsson, K. Messeter, and B. Roth. Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: An application of mass balance pharmacokinetics with a changing regional flow. J. Pharmacokin. Biopharm. 20:637-652 (1992).
32. M. N. Ashmann, W. B. Blesser, and R. M. Epstein. A nonlinear model for the uptake and distribution of halothane in man. Anesthesiology 33:419-429 (1970).
33. R. N. Upton. An "indicator dilution" model of the initial distribution of drugs after intravenous bolus injection. Proc. Aust. Soc. Clin. Exp. Pharmacol. Toxicol. 1:119 (1994).