Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome

Journal of Neurochemistry

Volumn 66, Issue 1, 1996, Pages 296-302

  Sei, Yoshitatsu ^a   Paul, Ian A ^a,e   Saito, Kuniaki ^b   Layar, Richard ^b   Hartley, Janet W ^c   Morse III, Herbert C ^c   Skolnick, Phil ^a   Heyes, Melvyn P ^b,d  

^a Laboratory of Neuroscience   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Azidothymidine; Blood; Brain; LP BM5 murine leukemia virus; Macrophages; Quinolinic acid; Zidovudine

Indexed keywords

QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; HELPER CELL; IMMUNE DEFICIENCY; MACROPHAGE FUNCTION; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; VIRUS INFECTION;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0030032840     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66010296.x     Document Type: Article

References (45)

1. Aylward E. H., Henderer J. D., McArthur J. C., Brettschneider P. D., Harris G. J., Barta P. E., and Pearlson G. D. (1993) Reduced basal ganglia volume in HIV-1-associated dementia. Neurology 43, 2099-2104.
2. Beal M. F., Kowall N. W., Ellison D. W., Mazurek M. F., Swartz K. J., and Martin J. B. (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168-171.
3. Block F., Kunkel M., and Schwarz M. (1993) Quinolinic acid lesion of the striatum induces impairment in spatial learning and motor performance in rats. Neurosci. Lett. 149, 126-128.
4. Brenneman D. E., Westbrook G. L., Fitzgerald S. P., Ennist D. L., Elkins K. L., Ruff M. R., and Pert C. B. (1988) Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 335, 639-642.
5. Brouwers P., Heyes M. P., Moss H., Wolters P., El-Amin D., Poplack D., Markey S. P., and Pizzo P. (1993) Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type-1 disease: relationships to clinical status and therapeutic response. J. Infect. Dis. 168, 1380-1386.
6. Chattopadhyay S. K., Morse H. C. I., Makino M., Ruscetti S. K., and Hartley J. W. (1989) A defective virus is associated with induction of a murine retrovirus-induced immunodeficiency syndrome, MAIDS. Proc. Natl. Acad. Sci. USA 86, 3862-3866.
7. Dreyer E. B., Kaiser P. K., Offermann J. T., and Lipton S. A. (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248, 364-367.
8. Eiseman J. L., Yetter R. A., Fredrickson T. N., Shapiro S. G., MacAuley C., and Bilello J. A. (1991) Effect of 3′ azidothymidine administered in drinking water or by continuous infusion on the development of MAIDS. Antiviral Res. 16, 307-326.
9. Gazzinelli R. T., Makino M., Chattopadhyay S. K., Snapper C. M., Sher A., Hugin A. W., and Morse H. C. I. (1992) CD4+ subset regulation in viral infection - preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J. Immunol. 148, 182-188.
10. Genis P., Jett M., Bernton E. W., Boyle T., Gelbard H. A., Dzenko K., Keane R. W., Resnick L., Mizrachi Y., Volsky D. J., Epstein L. G., and Gendelman H. E. (1992) Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astrocyte interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703-1718.
11. Giulian D., Vaca K., and Noonan C. A. (1990) Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250, 1593-1596.
12. Ha J.-H., Sei Y., and Basile A. S. (1995) Striatal Met-enkephalin and substance P levels are decreased in mice infected with the LP-BM5-murine leukemia virus. J. Neurochem. 64, 1896-1898.
13. Heyes M. P. (1994) Potential mechanisms of neurologic disease in HIV infection, in Psychopharmacology: The Fourth Generation of Progress (Bloom F. E. and Kupfer D. J., eds), pp. 1559-1566. Raven Press, New York.
14. Heyes M. P. and Markey S. P. (1988) Quantification of quinolinic acid in rat brain, whole blood and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations. Anal. Biochem. 174, 349-359.
15. Heyes M. P., Rubinow D., Lane C., and Markey S. P. (1989) Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Ann. Neurol. 26, 275-277.
16. Heyes M. P., Brew B. J., Martin A., Price R. W., Salazar A. M., Sidtis J. J., Yergey J. A., Mouradian M. M., Sadler A. E., Keilp J., Rubinow D., and Markey S. P. (1991) Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurologic status. Ann. Neurol. 29, 202-209.
17. Heyes M. P., Jordan E. K., Lee K., Saito K., Frank J. A., Snoy P. J., Markey S. P., and Gravell M. (1992a) Relationship of neurologic status in macaques infected with the simian immuno-deficiency virus to cerebrospinal fluid and serum quinolinic acid and kynurenic acid. Brain Res. 570, 237-250.
18. Heyes M. P., Saito K., Jacobowitz D., Takikawa O., Markey S. P., and Vickers J. (1992b) Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain. FASEB J. 6, 2977-2989.
19. Heyes M. P., Saito K., and Markey S. P. (1992c) Human macrophages convert L-tryptophan to the neurotoxin quinolinic acid. Biochem. J. 283, 633-635.
20. Heyes M. P., Saito K., Major E. O., Milstein S., Markey S. P., and Vickers J. H. (1993) A mechanism of quinolinic acid formation by brain in inflammatory neurologic disease: attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 116, 1425-1450.
21. Huang M., Simard C., and Jolicoeur P. (1989) Immunodeficiency and clonal growth of target cells induced by helper-free defective retrovirus. Science 246, 1614-1617.
22. Hugin A. W., Vacchio M. S., and Morse H. C. I. (1991) A virus-encoded 'superantigen' in a retrovirus-induced immunodeficiency syndrome. MAIDS. Science 252, 424-427.
23. Klinken S. P., Fredrickson T. N., Hartley J. W., Yetter R. A., and Morse H. C. I. (1988) Evolution of B-cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS. J. Immunol. 140, 1123-1131.
24. Klinman D. M. and Morse H. C. I. (1989) Characterization of B-cell proliferation and activation in murine AIDS. J. Immunol. 142, 1144-1149.
25. Klinman D. M., Kreig A., Conover J., Ussery M. A., and Black P. L. (1992) Effect of cyclophosphamide, total body irradiation, and zidovudine on retrovirus proliferation and disease progression in murine AIDS. AIDS Res. Hum. Retroviruses 8, 101-106.
26. Lipton S. A., Sucher N. J., and Kaiser P. K. (1991) Synergistic effects of HIV coat protein and NMDA-receptor mediated neurotoxicity. Neuron 7, 111-118.
27. Makino M., Sei Y., Arora P. K., Morse H. C. I., and Hartley J. W. (1992) Impaired calcium mobilization in CD4+ and CD8+ T cells in a retrovirus-induced immunodeficiency syndrome, murine AIDS. J. Immunol. 149, 1707-1713.
28. Martin A., Heyes M. P., Salazar A. M., Law W. A., and Williams J. (1993) Impaired motor-skill learning, slowed reaction time, and elevated cerebrospinal fluid quinolinic acid in a sub-group of HIV-infected individuals. Neuropsychology 7, 149-147.
29. Masliah E., Ge N., Morey M., DeTeresa R., Terry R. D., and Wiley C. A. (1992) Cortical dendritic pathology in human immunodeficiency virus encephalitis. Lab. Invest. 66, 285-291.
30. Miller R., La Grone J., Skolnick P., and Boje K. M. (1992) High-performance liquid chromatographic assay for 1-aminocyclopropanecarboxylic acid from plasma and brain. J. Chromatogr. 578, 103-108.
31. Morse H. C. I., Chattopadhyay S. K., Makino M., Fredrickson T. N., Hugin A. W., and Hartley J. W. (1992) Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 6, 607-621.
32. Nagra R. M., Heyes M. P., and Wiley C. A. (1994) Viral load and its relationship to quinolinic acid, TNF-α and IL-6 levels in the CNS of retrovirus infected mice. Mol. Chem. Neuropathol. 22, 143-160.
33. Ohnota H., Okada Y., Ushijima H., Kitamura T., Komuro K., and Mizuochi T. (1990) 3′-Azido-3′-deoxythymidine prevents induction of murine acquired immunodeficiency syndrome in C57BL/10 mice infected with LP-BM5 murine leukemia viruses, a possible animal model for antiretroviral drug screening. Antimicrob. Agents Chemother. 34, 605-609.
34. Portnoi D., Stall A. M., Schwartz D., Merigan T. C., Herzenberg L. A., and Basham T. (1990) Zidovudine (azido dideoxythymidine) inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. J. Immunol. 144, 1705-1710.
35. Rausch D. M., Heyes M. P., Murray E. A., Lendvay J., Sharer L. R., Ward J. M., Rehm S., Nohr D., Weihe E., and Eiden L. E. (1994) Cytopathologic and neurochemical correlates to motor/cognitive impairments in SIV-infected rhesus monkeys. J. Neuropathol. Exp. Neurol. 53, 165-175.
36. Rausch D. M., Heyes M. P., Murray E. A., and Eiden L. E. (1995) AZT treatment decreases viral load and prolongs survival in rhesus macaques infected perinatally with SIV. J. Infect. Dis. 172, 59-69.
37. Rowe W. P., Pugh W. E., and Hartley J. W. (1970) Plaque assay techniques for murine leukemia viruses. Virology 42, 1136-1139.
38. Saito K., Markey S. P., and Heyes M. P. (1992) Effects of immune activation on quinolinic acid and kynurenine pathway metabolism in the mouse. Neuroscience 51, 25-39.
39. Saito K., Chen C. Y., Masana M., Crowley J., Markey S. P., and Heyes M. P. (1993a) 4-Chloro-3-hydroxyanthranilic acid, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ stimulated monocytes (THP-1) cells. Biochem. J. 291, 11-14.
40. Saito K., Crowley J. S., Markey S. P., and Heyes M. P. (1993b) A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. J. Biol. Chem. 268, 15496-15503.
41. Saito K., Nowak T. S. Jr., Markey S. P., and Heyes M. P. (1993c) Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. J. Neurochem. 60, 180-192.
42. Saito K., Nowak T. S. Jr., Suyama K., Quearry B. J., Saito M , Crowley J. S., Markey S. P., and Heyes M. P. (1993d) Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. J. Neurochem. 61, 2061-2070.
43. Sei Y., Arora P. K., Skolnick P., and Paul I. A. (1992a) Spatial learning impairment in a murine model of AIDS. FASEB J. 6, 3008-3013.
44. Sei Y., Makino M., Vitkovic L., Chattopadhyay S. K., Hartley J. W., and Arora P. K. (1992b) Central nervous system infection in a murine retrovirus-induced immunodeficiency syndrome. J. Neuroimmunol. 37, 131-140.
45. Tyor W. R., Glass J. D., Griffin J. W., Becker P. S., McArthur J. C., Bezman L., and Griffin D. E. (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31, 349-360.