Enzyme-linked immunosorbent assay of autoantibodies against mitochondrial glycerophosphate dehydrogenase in insulin-dependent and non- insulin-dependent diabetic subjects

Biochemical and Molecular Medicine

Volumn 62, Issue 2, 1997, Pages 172-177

  Fabregat, M E ^a   Benito, C ^a   Gudayol, M ^a   Vidal, J ^a   Gallart, T ^a   Malaisse, W J ^b   Gomis, R ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Insulin dependent diabetes; Mitochondrial glycerophosphate dehydrogenase antibodies; Non insulin dependent diabetes

Indexed keywords

GLYCEROL 3 PHOSPHATE DEHYDROGENASE;

ADULT; ANTIBODY DETECTION; ANTIGENICITY; ARTICLE; CHILD; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE MUTATION; GENETIC RECOMBINATION; GLUCOSE METABOLISM; HUMAN; MALE; MITOCHONDRIAL MEMBRANE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL;

EID: 0031430967     PISSN: 10773150     EISSN: None     Source Type: Journal    
DOI: 10.1006/bmme.1997.2642     Document Type: Article

References (30)

1. 2+. Biochem J. 278:1991;335-340.
2. 2+. J Biol Chem. 267:1992;13251-13256.
3. Malaisse W J. Pancreatic B-cell FAD-glycerophosphate dehydrogenase deficiency in non-insulin-dependent diabetes: An up-dated review. Frontiers in insulin secretion and pancreatic B-cell research. 1994;Smith-Gordon, London. p. 445-452.
4. Fernandez-Alvarez J, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse W J. Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 37:1994;131-134.
5. Malaisse W J, Malaisse-Lagae F, Kukel S, Reinhold U, Sener A. Could non-insulin-dependent diabetes mellitus be attributable to a deficiency of FAD-linked glycerophosphate dehydrogenase? Biochem Med Metab Biol. 50:1993;226-232.
6. Vidal J, Rasschaert J, Sener A, Gomis R, Malaisse W J. FAD-glycerophosphate dehydrogenase activity in lymphocytes of type-2 diabetic patients and their relatives. Diabetes Res Clin Pract. 31:1996;17-25.
7. Vidal J, Corominola H, Cardona F, Levy I, Cararach V, Gomis R, Malaisse W J. Low mitochondrial glycerophosphate dehydrogenase activity in lymphocytes of women with gestational diabetes. Horm Metab Res. 29:1997;60-62.
8. Novials A, Vidal J, Franco C, Ribera F, Sener A, Malaisse W J, Gomis R. Mutation in the calcium-binding domain of the mitochondrial glycerophosphate dehydrogenase gene in a family of diabetic subjects. Biochem Biophys Res Commun. 231:1997;570-572.
9. Fabregat M E, Gasa R, Rodriguez C, Novials A, Gallart T, Malaisse W J, Gomis R. Autoantibodies against mitochondrial glycerophosphate dehydrogenase in patients with IDDM. Diabetes Res Clin Practice. 1997.
10. Novials A, Fabregat M E, Benito C, Fernandez-Alvarez J, Gallart T, Malaisse W J, Gomis R. Immunodetection of mitochondrial glycerophosphate dehydrogenase (mGDH) by a polyclonal antibody raised against a recombinant mGDH fragment product. Biochem Mol Med. 59:1996;187-191.
11. Gallart T, Bladé J, Martinez-Quesada J, Sierra J, Rozman C. Multiple myeloma with monoclonal IgG and IgD of lambda type exhibiting, under treatment, a shift from mainly IgG to mainly IgD. Immunology. 55:1985;45-57.
12. Diem K. Tables Scientifiques. 1963;Geigy, Basel. p. 109-123.
13. Nepom G T. Glutamic acid decarboxylase and other autoantigens in IDDM. Curr Opin Immunol. 7:1995;825-830.
14. Wegmann D R. The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus. Curr Opin Immunol. 8:1996;860-864.
15. Hagopian W A, Lernmark A. Islet cell autoantibodies. Peter J B, Shoenfeld Y. Autoantibodies. 1996;441-448 Elsevier, Amsterdam.
16. Verge C F, Gianini R, Kawasaki E, Liping Y, Pietropaolo M, Chase H P, Eisenbarth G S. Number of autoantibodies (against insulin, GAD or ICA 512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes. J Autoimmun. 9:1996;379-380.
17. Pietropaolo M, Castaño L, Babu S, Buelow R, Kuo Y-L S, Martin S, Martin A, Powers A C, Prochazka M, Noggert J, Leiter E H, Eisenbarth G S. Islet cell autoantigen 69 kD (ICA 69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest. 92:1993;359-371.
18. Nomura H, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R. Isolation of human cDNA clones of jun-related genes, jun-B, and jun-D. Nucleic Acid Res. 18:1996;3047-3048.
19. Honeyman M C, Cram D S, Harrison L C. Transcription factor jun-B is target of autoreactive T-cells in IDDM. Diabetes. 42:1993;626-630.
20. Rabin D U, Pleasic S M, Shapiro J A, Yoo-Warren H, Oles J, Hicks J M, Goldstein D E, Rae P MM. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol. 152:1994;3183-3188.
21. Christie M R, Hollands J A, Brown T J, Michelsen B K, Delovitch T L. Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J Clin Invest. 92:1993;240-248.
22. Rewers M, Hamman R F. Risk factors for non-insulin-dependent diabetes. Diabetes in America. 1995;NIH, Bethesda. p. 179-220.
23. Leslie R DG, Elliott R B. Early environmental events as a cause of IDDM. Diabetes. 43:1994;843-850.
24. Atkinson M A, Kaufman D L, Campbell L, Gibbs K A, Shah S C, Bu D-F, Erlander M G, Tobin A J, Maclaren N K. Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet. 339:1992;458-459.
25. Tisch R, Yang X D, Singer S M, Liblau R S, Fugger L, McDevitt H O. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (London). 366:1993;72-75.
26. Kaufman D, Clare-Salzler M, Tian J. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (London). 366:1993;69-72.
27. Diaz J-L, Ways J, Hammonds P. T-lymphocyte lines specific for glutamic acid decarboxylase (GAD) the 64Kβ-cell antigen of IDDM. Diabetes. 41:1992;118-121.
28. Arden S D, Roep B O, Neophytou P I, Usac E F, Duinkerken G, de Vries R RP, Hutton J C. Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T-cells from a newly diagnosed type 1 diabetic patient. J Clin Invest. 97:1996;551-561.
29. Müller S, Seitz H J. Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulations by thyroid hormones. Proc Natl Acad Sci USA. 91:1994;10581-10585.
30. Payton M A, Hawkes C J, Christie M R. Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest. 96:1995;1506-1511.