-
1
-
-
0000179125
-
Huntington's disease
-
(Calne, D.B., ed.), W.B. Saunders
-
Greenamyre, J.T. and Shoulson, I. (1994) Huntington's disease, in Neurodegenerative Diseases (Calne, D.B., ed.), pp. 685-704, W.B. Saunders
-
(1994)
Neurodegenerative Diseases
, pp. 685-704
-
-
Greenamyre, J.T.1
Shoulson, I.2
-
2
-
-
0029991245
-
Neurobiology of Huntington's disease
-
Sharp, A.H. and Ross, C.A. (1996) Neurobiology of Huntington's disease, Neurobiol. Dis. 3, 3-15
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 3-15
-
-
Sharp, A.H.1
Ross, C.A.2
-
3
-
-
0029295607
-
Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat
-
Perischetti, F. et al. (1995) Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat, Mol. Med. 1, 374-383
-
(1995)
Mol. Med.
, vol.1
, pp. 374-383
-
-
Perischetti, F.1
-
4
-
-
0028989602
-
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
-
DiFiglia, M. et al. (1995) Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons, Neuron 14, 1075-1081
-
(1995)
Neuron
, vol.14
, pp. 1075-1081
-
-
DiFiglia, M.1
-
5
-
-
84993912315
-
Increased apoptosis and early embryonic lethality in mice nullizygousfor the Huntington's disease gene homologue
-
Zeitlin, S. et al. (1995) Increased apoptosis and early embryonic lethality in mice nullizygousfor the Huntington's disease gene homologue, Nat. Genet. 11, 155-163
-
(1995)
Nat. Genet.
, vol.11
, pp. 155-163
-
-
Zeitlin, S.1
-
6
-
-
0028829596
-
CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain
-
Aronin, N. et al. (1995) CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain, Neuron 15, 1193-1201
-
(1995)
Neuron
, vol.15
, pp. 1193-1201
-
-
Aronin, N.1
-
7
-
-
0027176364
-
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
-
Andrew, S.E. et al. (1993) The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease, Nat. Genet. 4, 398-403
-
(1993)
Nat. Genet.
, vol.4
, pp. 398-403
-
-
Andrew, S.E.1
-
8
-
-
0023115076
-
Homozygotes for Huntington's disease
-
Wexler, N.S. et al. (1987) Homozygotes for Huntington's disease, Nature 326, 194-197
-
(1987)
Nature
, vol.326
, pp. 194-197
-
-
Wexler, N.S.1
-
9
-
-
0027759564
-
Characterization and localization of the Huntington disease gene product
-
Hoogeveen, A.T. et al. (1993) Characterization and localization of the Huntington disease gene product, Hum. Mol. Genet. 2, 2069-2073
-
(1993)
Hum. Mol. Genet.
, vol.2
, pp. 2069-2073
-
-
Hoogeveen, A.T.1
-
10
-
-
0027484673
-
Huntington's disease gene (IT15) is widely expressed in human and rat tissues
-
Li, S-H. et al. (1993) Huntington's disease gene (IT15) is widely expressed in human and rat tissues, Neuron 11, 985-993
-
(1993)
Neuron
, vol.11
, pp. 985-993
-
-
Li, S.-H.1
-
11
-
-
0028292634
-
Mouse Huntington's disease gene homolog (HDh)
-
Barnes, G.T. et al. (1994) Mouse Huntington's disease gene homolog (HDh), Somat. Cell Mol. Genet. 20, 87-97
-
(1994)
Somat. Cell Mol. Genet.
, vol.20
, pp. 87-97
-
-
Barnes, G.T.1
-
12
-
-
0029085920
-
The identification of a functional nuclear localization signal in the Huntington disease protein
-
Bessert, D.A. et al. (1995) The identification of a functional nuclear localization signal in the Huntington disease protein. Mol. Brain Res. 33, 165-173
-
(1995)
Mol. Brain Res.
, vol.33
, pp. 165-173
-
-
Bessert, D.A.1
-
13
-
-
0029039238
-
Transcription of the Huntington disease gene during the quinolinic acid excitotoxic cascade
-
Carlock, L. et al. (1995) Transcription of the Huntington disease gene during the quinolinic acid excitotoxic cascade, NeuroReport 6, 1121-1124
-
(1995)
NeuroReport
, vol.6
, pp. 1121-1124
-
-
Carlock, L.1
-
14
-
-
0029072690
-
Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
-
Portera-Cailliau, C., Hedreen, J.C., Price, D.L. and Koliatsos, V.E. (1995) Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models, J. Neurosci. 15, 3775-3787
-
(1995)
J. Neurosci.
, vol.15
, pp. 3775-3787
-
-
Portera-Cailliau, C.1
Hedreen, J.C.2
Price, D.L.3
Koliatsos, V.E.4
-
15
-
-
0029066045
-
Effects of striatal excitotoxicity on huntingtin-like immunoreactivity
-
Tatter, S.B. et al. (1995) Effects of striatal excitotoxicity on huntingtin-like immunoreactivity, NeuroReport 6, 1125-1129
-
(1995)
NeuroReport
, vol.6
, pp. 1125-1129
-
-
Tatter, S.B.1
-
16
-
-
0029150526
-
2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
-
2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons, J. Neurochem. 65, 1740-1751
-
(1995)
J. Neurochem.
, vol.65
, pp. 1740-1751
-
-
Mattson, M.P.1
-
18
-
-
0027289605
-
Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum
-
Simpson, J.R. and Isacson, O. (1993) Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum, Exp. Neurol. 121, 57-64
-
(1993)
Exp. Neurol.
, vol.121
, pp. 57-64
-
-
Simpson, J.R.1
Isacson, O.2
-
19
-
-
0029875381
-
Mitochondrial defect in Huntington's disease caudate nucleus
-
Gu, M. et al. (1996) Mitochondrial defect in Huntington's disease caudate nucleus, Ann. Neurol. 39, 385-389
-
(1996)
Ann. Neurol.
, vol.39
, pp. 385-389
-
-
Gu, M.1
-
20
-
-
0029040355
-
In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
-
Dragunow, M. et al. (1995) In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes, NeuroReport 6, 1053-1057
-
(1995)
NeuroReport
, vol.6
, pp. 1053-1057
-
-
Dragunow, M.1
-
21
-
-
0029664992
-
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
-
Burke, J.R. et al. (1996) Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH, Nat. Med. 2, 347-350
-
(1996)
Nat. Med.
, vol.2
, pp. 347-350
-
-
Burke, J.R.1
-
22
-
-
0030045251
-
Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture
-
Ishitani, R. et al. (1996) Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture, J. Neurochem. 66, 928-935
-
(1996)
J. Neurochem.
, vol.66
, pp. 928-935
-
-
Ishitani, R.1
-
23
-
-
9344227302
-
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
-
Goldberg, Y.P. et al. (1996) Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract, Nat. Genet. 13, 442-449
-
(1996)
Nat. Genet.
, vol.13
, pp. 442-449
-
-
Goldberg, Y.P.1
-
24
-
-
0028260436
-
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
-
Ambrose, C.M. et al. (1994) Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat, Somatic Cell Mol. Genet. 20, 27-38
-
(1994)
Somatic Cell Mol. Genet.
, vol.20
, pp. 27-38
-
-
Ambrose, C.M.1
-
25
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini, L. et al. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice, Cell 87, 493-506
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
-
26
-
-
0029082383
-
Inactivation of the mouse Huntington's disease gene homolog HDh
-
Duyao, M.P. et al. (1995) Inactivation of the mouse Huntington's disease gene homolog HDh, Science 269, 407-410
-
(1995)
Science
, vol.269
, pp. 407-410
-
-
Duyao, M.P.1
-
27
-
-
0029055717
-
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
-
Nasir, J. et al. (1995) Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes, Cell 81, 811-823
-
(1995)
Cell
, vol.81
, pp. 811-823
-
-
Nasir, J.1
-
28
-
-
0028901802
-
Therapeutic antisense and ribozymes
-
Rossi, J.J. (1995) Therapeutic antisense and ribozymes, Br. Med. Bull. 51, 217-225
-
(1995)
Br. Med. Bull.
, vol.51
, pp. 217-225
-
-
Rossi, J.J.1
-
29
-
-
0031105341
-
Antisense gene therapy for neurodegenerative disease?
-
in press
-
Haque, N.S.K. and Isacson, O. Antisense gene therapy for neurodegenerative disease? Exp. Neurol. (in press)
-
Exp. Neurol.
-
-
Haque, N.S.K.1
Isacson, O.2
-
30
-
-
0030001072
-
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin
-
Bao, J. et al. (1996) Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin, Proc. Natl. Acad. Sci. U. S. A. 93, 5037-5042
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 5037-5042
-
-
Bao, J.1
-
31
-
-
0028803757
-
A huntingtin-associated protein enriched in brain with implications for pathology
-
Li, X-J. et al. (1995) A Huntingtin-associated protein enriched in brain with implications for pathology, Nature 378, 398-402
-
(1995)
Nature
, vol.378
, pp. 398-402
-
-
Li, X.-J.1
-
32
-
-
0029670049
-
The p21 (RAS) farnesyltransferase α subunit in TGF-β and activin signaling
-
Wang, T. et al. (1996) The p21 (RAS) farnesyltransferase α subunit in TGF-β and activin signaling, Science 271, 1120-1122
-
(1996)
Science
, vol.271
, pp. 1120-1122
-
-
Wang, T.1
-
33
-
-
0029008993
-
Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra
-
Isacson, O. et al. (1995) Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra, Restor. Neurol. Neurosci. 8, 59-61
-
(1995)
Restor. Neurol. Neurosci.
, vol.8
, pp. 59-61
-
-
Isacson, O.1
-
34
-
-
0028856571
-
Trial of D-α-tocopherol in Huntington's disease
-
Peyser, C.E. et al. (1995) Trial of D-α-tocopherol in Huntington's disease, Am. J. Psychiatry 152, 1771-1775
-
(1995)
Am. J. Psychiatry
, vol.152
, pp. 1771-1775
-
-
Peyser, C.E.1
-
35
-
-
0028868574
-
Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
-
Isacson, O. et al. (1995) Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres, Nat. Med. 1, 1189-1194
-
(1995)
Nat. Med.
, vol.1
, pp. 1189-1194
-
-
Isacson, O.1
-
36
-
-
0027487866
-
Huntington's disease: Animal models and transplantation repair
-
Dunnett, S.B. and Svendson, C.N. (1993) Huntington's disease: animal models and transplantation repair, Curr. Opin. Neurobiol. 3, 790-796
-
(1993)
Curr. Opin. Neurobiol.
, vol.3
, pp. 790-796
-
-
Dunnett, S.B.1
Svendson, C.N.2
-
37
-
-
0030062296
-
Human gene therapy - An immature genie, but certainly out of the bottle
-
Friedmann, T. (1996) Human gene therapy - an immature genie, but certainly out of the bottle, Nat. Med. 2, 144-147
-
(1996)
Nat. Med.
, vol.2
, pp. 144-147
-
-
Friedmann, T.1
-
38
-
-
0028168783
-
Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain
-
Pakzaban, P., Geller, A.I. and Isacson, O. (1994) Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain, Hum. Gene Ther. 5, 987-995
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 987-995
-
-
Pakzaban, P.1
Geller, A.I.2
Isacson, O.3
-
39
-
-
0029031496
-
Virus vectors for gene delivery to the nervous system
-
Smith, F., Jacoby, D. and Breakefield, X.O. (1995) Virus vectors for gene delivery to the nervous system, Restor. Neurol. Neurosci. 8, 21-34
-
(1995)
Restor. Neurol. Neurosci.
, vol.8
, pp. 21-34
-
-
Smith, F.1
Jacoby, D.2
Breakefield, X.O.3
-
40
-
-
0025231388
-
Direct gene transfer into mouse muscle in vivo
-
Wolff, J.A. et al. (1990) Direct gene transfer into mouse muscle in vivo, Science 247, 1465-1468
-
(1990)
Science
, vol.247
, pp. 1465-1468
-
-
Wolff, J.A.1
-
41
-
-
0026505305
-
Persistence of plasmid DNA and expression in rat brain cells in vivo
-
Jiao, S. et al. (1992) Persistence of plasmid DNA and expression in rat brain cells in vivo, Exp. Neurol. 115, 400-413
-
(1992)
Exp. Neurol.
, vol.115
, pp. 400-413
-
-
Jiao, S.1
-
42
-
-
0028015996
-
IT15 gene expression in fetal human brain
-
Dure, L.S. et al. (1994) IT15 gene expression in fetal human brain, Brain Res. 659, 33-41
-
(1994)
Brain Res.
, vol.659
, pp. 33-41
-
-
Dure, L.S.1
-
43
-
-
0029392854
-
HEAT repeats in the Huntington's disease protein
-
Andrade, M.A. and Bork, P. (1995) HEAT repeats in the Huntington's disease protein, Nat. Genet. 11, 115-116
-
(1995)
Nat. Genet.
, vol.11
, pp. 115-116
-
-
Andrade, M.A.1
Bork, P.2
-
44
-
-
0029586383
-
Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients
-
Richfield, E.K. et al. (1995) Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients, Ann. Neurol. 38, 852-861
-
(1995)
Ann. Neurol.
, vol.38
, pp. 852-861
-
-
Richfield, E.K.1
|