Pharmacokinetics of oligonucleotides in cell culture

CIBA Foundation Symposia

Volumn , Issue 209, 1997, Pages 47-59

  Lebleu, Bernard ^a   Robbins, Ian ^a   Bastide, Lionel ^a   Vives, Eric ^a   Gee, Jay E ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ANIMAL; CELL CULTURE; HUMAN; REVIEW; SYNTHESIS;

ANIMALS; CELLS, CULTURED; HUMANS; OLIGONUCLEOTIDES;

EID: 0031309625     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Behr JP 1994 Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjugate Chem 5:382-389
2. Bongartz JP, Aubertin AM, Milhaud PG, Lebleu B 1994 Improved biological activity of antisense oligonucleotides conjugated to fusogenic peptides. Nucleic Acids Res 22:4681-4688
3. Boussif O, Lezouala'h F, Zanta MA et al 1995 A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc Natl Acad Sci USA 92:7297-7301
4. Clarenc JP, Degols G, Leonetti JP, Milhaud P, Lebleu B 1993 Delivery of antisense oligonucleotides by poly (L-lysine) conjugation and liposome encapsulation. Anticancer Drug Des 8:81-94
5. Crooke ST, Lebleu B 1993 Antisense research and applications. CRC Press, Boca Raton, FL
6. Degols G, Devaux C, Lebleu B 1994 Oligonucleotide poly (L-lysine) heparin complexes: potent sequence-specific inhibitors of HIV-1 infection. Bioconjugate Chem 5:8-13
7. Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, Prochiantz A 1996 Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J Biol Chem 271:18188-18193
8. Fawell S, Seery J, Daikh Y et al 1994 TAT-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 91:664-668
9. Giles RV, Tidd DM 1992 Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures. Nucleic Acids Res 20:763-770
10. Gryaznov SM, Lloyd DH, Chen J-K et al 1995 Oligonucleotide N3′→P5′ phosphoramidates. Proc Natl Acad Sci USA 92:5798-5802
11. Krieg AM, Tonkinson J, Maison S et al 1993 Modification of antisense phosphodiester oligodeoxynucleotides by a 5′-cholesteryl moiety increases cellular association and improves efficacy. Proc Natl Acad Sci USA 90:1048-1052
12. Lebleu B, Bastide L, Bisbal C et al 1997 Poly (L-lysine)-mediated delivery of nucleic acids. In: Gregoriadis G, McCormack B (eds) Targeting of drugs: strategies for oligonucleotide and gene delivery in therapy. Plenum Press, New York, p 115-122
13. Lewis JG, Lin K-Y, Kothavale A et al 1996 A serum-resistant cytofectin for cellular delivery of antisense of oligodeoxynucleotides and plasmid DNA. Proc Natl Acad Sci USA 93:3176-3181
14. Mignet N, Tosquelas G, Barber I, Morvan F, Rayner B, Imbach JL 1997 The pro-oligonucleotide approach: synthesis and stability of chimeric pro-oligonucleotides in culture medium and in total cell extract. New Engl J Chem 21:73-79
15. Milhaud PG, Bongartz JP, Lebleu B, Philippot JR 1996 pH-sensitive liposomes and antisense oligonucleotide delivery. Drug Deliv 3:67-73
16. Nielsen PE 1995 DNA analogs with nonphosphodiester backbones. Annu Rev Biophys Biomol Struct 24:167-183
17. Planck C, Oberhauser B, Mechtler K, Koch C, Wagner E 1994 The influence of endosome disruptive peptides on gene transfer with synthetic virus like gene transfer systems. J Biol Chem 269:12918-12925
18. Sierakowska H, Sambade MJ, Agrawal S, Kole R 1997 Repair of thalassemic human beta globin mRNA in mammalian cells by antisense oligonucleotides. Proc Nad Acad Sci USA, in press
19. Stein CA, Cheng Y-C 1993 Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261:1004-1012
20. Vives E, Lebleu B 1997 Selective coupling of a highly basic peptide to an oligonucleotide. Tetrahedron Lett 38:1183-1186
21. Vives E, Brodin P, Lebleu B 1997 A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272:16010-16017
22. Wang G, Seidman MM, Glazer PM 1996 Mutagenesis in mammalian cells induced by triple-helix formation and transcription-coupled repair. Science 271:802-805
23. White JM 1992 Membrane fusion. Science 258:917-924
24. Wu GY, Wu CH 1992 Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J Biol Chem 267:12436-12439
25. Wu-Pong S, Weiss JL, Hunt CA 1994 Antisense c-myc oligonucleotide cellular uptake and activity. Antisense Res Dev 4:155-163
26. Yao GQ, Corrias S, Cheng YC 1996 Identification of two oligodeoxyribonucleotide-binding proteins on plasma membranes of human cell lines. Biochem Pharmacol 51:431-436
27. Yoon K, Cole-Strauss A, Kmiec EB, 1996 Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA-center-dot-DNA oligonucleotide. Proc Natl Acad Sci USA 93:2071-2076
28. Zelphati O, Zon G, Leserman L 1993 Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes. Antisense Res Dev 3:323-338