Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients

Pediatric Hematology and Oncology

Volumn 13, Issue 6, 1996, Pages 545-548

  Erttmann, Rudolf ^a   Schmitt, Caroline ^a   Ollert, Markus W ^b   David, Kerstin ^b   Bredehorst, Reinhard ^b   Vogel, Carl Wilhelm ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

cytotoxic immunoglobulins; natural immunity; neuroblastoma

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; PROPIDIUM IODIDE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; HUMAN; HUMORAL IMMUNITY; NEUROBLASTOMA; SERUM;

EID: 0029856919     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.3109/08880019609030870     Document Type: Article

References (6)

1. Sawada T, Shikata T, Matsumara T, et al. Analysis of 598 cases of neuroblastoma (NB) detected by screening and changes in the age distribution and incidence of NB patients after mass screening in infants in Japan. Prog Clin Biol Res. 1994;385:371-375.
2. Nishi M, Miyake H, Takeda T, et al. Cases of spontaneous regression and true patients detected in mass screening for neuroblastoma. Int J Pediatr Hematol Oncol. 1995;1:557-563.
3. Ollert MW, David K, Schmitt G, et al. Normal human serum contains a natural IgM antibody cytotoxic for human neuroblastoma cells. Proc Natl Acad Sci USA. 1996;93:4498-1503.
4. Ollert MW, Kadlec JV, David K, et al. Antibody-mediated complement activation on nucleated cells: a quantitative analysis of the individual reaction steps. J Immunol. 1994;153:2213-2221.
5. Beck D, De Bernardi B, Michon J, et al. Phase II clinical trial of surgery as the only treatment for INSS stage 2 neuroblastoma (94.01 trial and study of the localized neuroblastoma European study group; SIOP 95-01 Study). Med Pediatr Oncol. 1995;25:278.
6. David K, Ollert MW, Juhl H, et al. Growth arrest of large solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans. Proc Am Assoc Cancer Res. 1996;37:487.