The potential roles of cytokines, IL-5 and IL-8, and plasma cortisol in the anti-inflammatory actions of phosphodiesterase inhibitors in sensitized guinea-pig airways

Pulmonary Pharmacology and Therapeutics

Volumn 10, Issue 5-6, 1997, Pages 277-285

  Danahay, Henry ^a   Broadley, Kenneth J ^a   McCabe, Patrick J ^b   Nials, Anthony T ^b   Sanjar, Shahin ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Dexamethasone; Eosinophilia; IL 5; IL 8; Inhibitors; Ovalbumin challenge; PDE; Plasma cortisol; Sensitized guinea pigs

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; AMINOPHYLLINE; CORTICOTROPIN; CYTOKINE; DEXAMETHASONE; HYDROCORTISONE; INTERLEUKIN 5; INTERLEUKIN 8; OVALBUMIN; PHOSPHODIESTERASE INHIBITOR; SIGUAZODAN;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; EOSINOPHILIA; GUINEA PIG; HYDROCORTISONE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; LOEFFLER PNEUMONIA; LUNG LAVAGE; MALE; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

EID: 0031260626     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0105     Document Type: Article

References (36)

1. 1. Costello J F, Piper P J. Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease. London: Parthenon, 1995.
2. 2. Souness J E, Maslen C, Webber S, Foster M, Raeburn D, Palfreyman M N, Ashton M J, Karlsson A. Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram. Br J Pharmacol 1995; 115: 39-46.
3. 4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol 1996; 118: 1727-1735.
4. 4. Turner C R, Andresen C J, Smith W B, Watson J W. Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am J Respir Crit Care Med 1994; 149: 1153-1159.
5. 5. Banner K H, Page C P. Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs. Br J Pharmacol 1995; 114: 93-98.
6. 6. Teixeira M M, Rossi A G, Williams T J, Hellewell P G. Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig. Br J Pharmacol 1994; 112: 332-340.
7. 7. Sanjar S, Aoki S, Kristersson A, Smith D, Morley J. Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs. Br J Pharmacol 1990; 99: 679-686.
8. 8. Howell R E, Sickels B D, Woeppel S L. Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors. J Pharmacol Exp Ther 1993; 264: 609-615.
9. 9. Danahay H, Broadley K J. Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitised guinea-pigs and airway leukocyte infiltration. Br J Pharmacol 1997; 120: 289-297.
10. 10. Lagente V, Pruniaux M P, Junien J L, Moodley I. Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors. Am J Respir Crit Care Med 1995; 151: 1720-1724.
11. 11. Hadley A J, Kumari M, Cover P O, Osbourne J, Poyser R, Flack J D, Buckingham J C. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline. Br J Pharmacol 1996; 119: 463-470.
12. 12. Danahay H, Broadley K J, McCabe P J, Nials A T, Sanjar S. Temporal relationships between inflammatory and functional changes in lungs after antigen challenge. Inflammation Res (submitted).
13. 13. Danahay H, Broadley K J, McCabe P J, Nials A T, Sanjar S. A simple, rapid and sensitive scintillation proximity assay for the determination of levels of guinea-pig interleukin-5 in bronchoalveolar lavage samples. J Pharmacol Toxicol Meth 1997; 37: 161-166.
14. 14. Walker C, Virchow J C, Bruijnzeel P L B, Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma. J Immunol 1991; 146: 1829-1835.
15. 15. Kline J N, Hunninghake G W. T-lymphocyte dysregulation in asthma. Proc Soc Exp Biol Med 1994; 207: 243-253.
16. 16. Teixeira M M, Williams T J, Hellewell P G. Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo. Trends Pharmacol Sci 1995; 16: 418-423.
17. 17. Mauser P J, Pitman A, Witt A, Fernandez X, Zurcher J, Kung T, Jones H, Watnick A S, Egan R W, Kreutner W. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am Rev Resp Dis 1993; 148: 1623-1627.
18. 18. Van Oosterhout A J, Ladenius A R, Savelkoul H F, Van Ark I, Delsman K C, Nijkamp F P. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am Rev Resp Dis 1993; 147: 548-552.
19. 19. Mauser P J, Pitman A, Fernandez X, Foran S K, Adams G K, Kreutner W, Egan R W, Chapman R W. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am J Respir Crit Care Med 1995; 152: 467-472.
20. 20. Xiu Q, Fujimura M, Nomura M, Saito M, Matsuda T, Akao N, Kondo K, Matsushima K. Bronchial hyperresponsiveness and airway neutrophil accumulation induced by interleukin-8 and the effect of the thromboxane A2 antagonist S-1452 in guinea-pigs. Clin Exp All 1995; 25: 51-59.
21. 21. Howell R E, Jenkins L P, Howell D E. Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs. J Pharmacol Exp Ther 1995; 275: 703-709.
22. 22. Bradding P, Okayama Y, Howarth P H, Church M K, Holgate S T. Heterogeneity of human mast cells based on cytokine content. J Immunol 1995; 155: 297-307.
23. 23. Bazzoni F, Cassatella M A, Rossi F, Ceska M, Dewald B, Baggiolini M. Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/ interleukin 8. J Exp Med 1991; 173: 771-774.
24. 24. Averill L E, Kammer G M. Inhibition of interleukin-2 production is mediated by a cyclic adenosine monophosphate (cAMP)-dependent pathway. Clin Res 1985; 33: 839A.
25. 25. Mary D, Aussel C, Ferrua B, Fehlmann M. Regulation of interleukin 2 synthesis by cAMP in human T cells. J Immunol 1987; 139: 1179-1184.
26. 26. Barnes P J. Molecular mechanisms of steroid action in asthma. J Allergy Clin Immunol 1996; 97: 159-168.
27. 27. Wardlaw A J, Kay A B. The role of the eosinophil in the pathogenesis of asthma. Allergy 1987; 42: 321-335.
28. 28. Romagnani S, Mosmann T. Human T(H)1 and T(H)2 subsets: doubt no more. Immunol Today 1991; 12: 256-257.
29. 29. Anderson G P, Coyle A J. TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. TiPS 1994; 15: 324-332.
30. 30. Undem B J, Peachell P T, Lichtenstein L M. Isoproterenol-induced inhibition if immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. J Pharmacol Exp Ther 1988; 247: 209-217.
31. 31. Raeburn D, Karlsson A. Comparison of the effects of isoenzyme-selective phosphodiesterase inhibitors and theophylline on PAF-induced plasma leak in the guinea-pig airways in vivo. Am Rev Resp Dis 1992; 145: A612.
32. 32. Town G I, Holgate S T. The role of inflammation in airways disease. In Mediators of Pulmonary Inflammation. Eds Bray MA, Anderson WH. New York: Marcel Dekker, INC, 1991: 35-79.
33. 33. Sturm R J, Osbourne M C, Heaslip R J. The effect of phosphodiesterase inhibitors on pulmonary inflammatory cell influx in ovalbumin sensitised guinea-pigs. J Cell Biochem 1990; 14: 337.
34. 34. Hadley A J, Flack J D, Buckingham J C. Effects of selective phosphodiesterase inhibitors on the release of ACTH and LH from the rat anterior pituitary gland in vitro. Pharmacol Comms 1993; 3: 283-295.
35. 35. Buckingham J C, Loxley H D, Taylor A D, Flower R J. Cytokines, glucocorticoids and neuroendocrine function. Pharmacol Res 1994; 30: 35-42.
36. 36. Anand-Srivastava M B, Contin M, Gutkowska J. Adenosine regulates the release of adrenocorticotrophic hormone (ACTH) from cultured pituitary cells. Mol Cell Biochem 1989; 89: 21-28.