Cytotoxic Activities of Recombinant Soluble Murine Lymphotoxin-α and Lymphotoxin-αβ Complexes

Journal of Immunology

Volumn 159, Issue 7, 1997, Pages 3299-3310

  Mackay, Fabienne ^a   Bourdon, Paul R ^a   Griffiths, David A ^a   Lawton, Pornsri ^a   Zafari, Mohammad ^a   Sizing, Irene Dougas ^a   Miatkowski, Konrad ^a   Ngam ek, Apinya ^a   Benjamin, Christopher D ^a   Hession, Catherine ^a   Ambrose, Christine M ^a   Meier, Werner ^a   Browning, Jeffrey L ^a,b  

^a BIOGEN   (United States)

^b 12 Cambridge Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LTB PROTEIN, HUMAN; LTB PROTEIN, MOUSE; LYMPHOTOXIN; LYMPHOTOXIN BETA; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; CYTOTOXICITY TEST; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; SECRETION; SOLUBILITY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOTOXIN-ALPHA; LYMPHOTOXIN-BETA; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; SOLUBILITY; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031253958     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Browning, J. L., A. Ngam-ek, P. Lawton, J DeMarinis, R. Tizard, E. P. Chow, C. Hession, G. B. O'Brine, S. F. Foley, and C. F. Ware. 1993. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72:847.
2. Ware, C. F., T. L. VanArsdale, P. D. Crowe, and J. L. Browning. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175.
3. Browning, J. L., K. Miatkowski, D. A. Griffiths, P. R. Bourdon, C. Hession, C. M. Ambrose, and W. Meier. 1996. Preparation and characterization of soluble recombinant heterotrimeric complexes of human lymphotoxins alpha and beta. J. Biol. Chem. 271:8618.
4. Aggarwal, B. B., and K. Natarajan. 1996. Tumor necrosis factors: developments during the last decade. Eur. Cytokine Netw. 7:93.
5. Crowe, P. D., T. L. VanArsdale, B. N. Walter, C. F. Ware, C. Hession, B. Ehrenfels, J. L. Browning, W. S. Din, R. G. Goodwin, and C. A. Smith. 1994. A lymphotoxin-beta-specific receptor. Science 264:707.
6. Millet, I., and N. H. Ruddle. 1994. Differential regulation of lymphotoxin (LT), lymphotoxin-β (LT-β), and TNF-α in murine T cell clones activated through the TCR. J. Immunol. 152:4336.
7. Pokholok, D. K., I. G. Maroulakou, D. V. Kuprash, M. B. Alimzhanov, S. V. Kozlov, T. I. Novobrantseva, R. L. Turetskaya, J. E. Green, and S. A. Nedospasov. 1995. Cloning and expression analysis of the murine lymphotoxin beta gene. Proc. Natl. Acad. Sci. USA 92:674.
8. Lawton, P., J. Nelson, R. Tizard, and J. L. Browning. 1995. Characterization of the mouse lymphotoxin-β gene. J. Immunol. 154:239.
9. Fashena, S. J., W. L. Tang, T. Sarr, and N. H. Ruddle. 1990. The murine lymphotoxin gene promoter: characterization and negative regulation. J. Immunol. 145:177.
10. Kuprash, D. V., O. A. Osipovich, D. K. Pokholok, M. B. Alimzhanov, A. Biragyn, R. L. Turetskaya, and S. A. Nedospasov. 1996. Functional analysis of the lymphotoxin-β promoter: sequence requirements for PMA activation. J. Immunol. 156:2465.
11. Laskov, R., G. Lancz, N. H. Ruddle, K. M. McGrath, S. Specter, T. Klein, J Y. Djeu, and H. Friedman. 1990. Production of tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β) by murine pre-B and B cell lymphomas. J. Immunol. 144:3424.
12. Weil, D., and F. Dautry. 1988. Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines. Onrogene Res. 3:409.
13. Matsumoto, M., Y.-X. Fu, H. Molina, and D. D. Chaplin. 1997. Lymphotoxin-α-deficient mice and TNF receptor-1-deficient mice define developmental and functional characteristics of germinal centers. Immunol. Rev. 156:137.
14. Koni, P. A., R. Sacca, P. Lawton, J. L. Browning, N. H. Ruddle, and R. A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin-beta deficient mice. Immunity 6:491.
15. Hochman, P. S., G. R. Majeau, F. Mackay, and J. L. Browning. 1996. Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. J. Inflamm. 46:220.
16. Browning, J. L., K. Miatkowski, I. Sizing, D. A. Griffiths, M. Zafari, C. D. Benjamin, W. Meier, and F. Mackay. 1996. Signaling through the lymphotoxin-beta receptor induces the death of some adenocarcinoma tumor lines. J. Exp. Med. 183:867.
17. Browning, J. L., I. Dougas, A. Ngam-ek, P. R. Bourdon, B. N. Ehrenfels, K. Miatkowski, M. Zafari, A. M. Yampaglia, P. Lawton, W. Meier, C. P. Benjamin, and C. Hession. 1995. Characterization of surface lymphotoxin forms: use of specific monoclonal antibodies and soluble receptors. J. Immunol. 154:33.
18. 17a. Browning, J. L., I. Dougas-Sizing, P. Lawton, P. Bourdon, P. D. Rennert, G. R. Majeau, C. M. Ambrose, C. Hession, K. Miatkowski, D. A. Griffiths, A. Ngamek, W. Meier, C. D. Benjamin, and P. S. Houchman. 1997. Characterization of lymphotoxin-αβ complexes on the surface of mouse lymphocytes. J. Immunol. In press this issue.
19. Browning, J., and A. Ribolini. 1989. Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines. J. Immunol. 143:1859.
20. Chai, H., S. G. Vasudevan, A. G. Porter, K. L. Chua, S. Oh, and M. Yap. 1993. Glycosylation and high-level secretion of human tumour necrosis factor-beta in recombinant baculovirus-infected insect cells. Biotechnol. Appl. Biochem. 18: 259.
21. Crowe, P. D., T. L. VanArsdale, B. N. Walter, K. M. Dahms, and C. F. Ware. 1994. Production of lymphotoxin (LT alpha) and a soluble dimeric form of its receptor using the baculovirus expression system. J. Immunol. Methods 168: 79.
22. Sheehan, K. C. F., N. H. Ruddle, and R. D. Schreiber. 1989. Generation and characterization of hamster monoclonal antibodies that neutralize tumor necrosis factors. J. Immunol. 142:3884.
23. Aggarwal, B. B., W. J. Henzel, B. Moffat, W. J. Kohr, and R. N. Harkins. 1985. Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line. J. Biol. Chem. 260:2334.
24. Schoenfeld, H. J., B. Poeschl, J. R. Frey, H. Loetscher, W. Hunziker, A. Lustig, and M. Zulauf. 1991. Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors. J. Biol. Chem. 266: 3863.
25. Hains, J. M., and B. B. Aggarwal. 1989. Characterization of recombinant human lymphotoxin (tumor necrosis factor-beta) produced by a mammalian cell line. Arch. Biochem. Biophys. 274:417.
26. Medvedev, A. E., T. Espevik, G. Ranges, and A. Sundan. 1996. Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. J. Biol. Chem. 271:9778.
27. Medvedev, A. E., A. Laegreid, A. Sundan, and T. Espevik. 1996. A non-competitive P55 TNF receptor antibody enhances the specific activity of lymphotoxin-alpha. Scand. J. Immunol. 43:439.
28. Laster, S. M., J. G. Wood, and L. R. Gooding. 1988. Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J. Immunol. 141:2629.
29. Nedwin, G. E., L. P. Svedersky, T. S. Bringman, M. A. Palladino, and D. V. Goeddel. 1985. Effect of interleukin-2, interferon-γ and mitogens on the production of tumor necrosis factors of and β. J. Immunol. 135:2492.
30. Hackett, S. P., and D. L. Stevens. 1993. Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis. J. Infect. Dis. 168:232.
31. Steffen, M., O. G. Ottmann, and M. A. Moore. 1988. Simultaneous production of tumor necrosis factor-α and lymphotoxin by normal T cells after induction with IL-2 and anti-T3. J. Immunol. 140:2621.
32. Ruddle, N. H., C. M. Bergman, K. M. McGrath, E. G. Lingenheld, M. L. Grunnet, S. J. Padula, and R. B. Clark. 1990. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172:1193.
33. Yang, X. D., R. Tisch, S. M. Singer, Z. A. Cao, R. S. Liblau, R. D. Schreiber, and H. O. McDevitt. 1994. Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med. 180:995.
34. Smith, C. A., F.-Q. Hu, T. D. Smith, C. L. Richards, P. Smolak, R. G. Goodwin, and D. J. Pickup. 1996. Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors distinct from CrmB. that binds TNF and not LTα. Virology 223:132.
35. Banner, D. W., A. D'Arcy, W. Janes, R. Gentz, H. J. Schoenfeld, C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 73:431.
36. Mackay, F., G. R. Majeau, P. S. Hochman, and J. L. Browning. 1996. Lymphotoxin-β receptor triggering induces the activation of NF-κB transcription factor in some cell types. J. Biol. Chem. 271:24934.
37. Schuchmann, M., S. Hess, P. Bufler, C. Brakebusch, D. Wallach, A. Porter, G. Riethmuller, and H. Engelmann. 1995. Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions. Eur. J. Immunol. 25:2183.
38. Estrov, Z., R. Kurzrock, E. Pocsik, S. Pathak, H. M. Kantarjian, T. F. Zipf, D. Harris, M. Talpaz, and B. B. Aggarwal. 1993. Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines. J. Exp. Med. 177: 763.
39. De Togni, P., J. Goellner, N. H. Ruddle, P. R. Streeter, A. Fick, S. Mariathasan, S. C. Smith, R. Carlson, L. P. Shornick, J. Strauss-Schoenberger, J. H. Russell, R. Karr, and D. D. Chaplin. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264:703.
40. Banks, T. A., B. T. Rouse, M. K. Kerley, P. J. Blair, V. L. Godfrey, N. A. Kuklin, D. M. Bouley, J. Thomas, S. Kanangat, and M. L. Mucenski. 1995. Lymphotoxin-α-deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1685.
41. Eugster, H.-P., M. Mueller, U. Karrer, B. D. Car, B. Schnyder, V. M. Eng, G. Woerly, M. Le Hir, F. di Padova, M. Aguet, R. Zinkernagel, H. Bluethmann, and B. Ryffel. 1996. Multiple abnormalities in tumor necrosis factor and lymphotoxin-α double deficient mice. Int. Immunol. 8:23.
42. Neumann, B., A. Luz, K. Pfeffer, and B. Holzmann. 1996. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184:259.
43. Pasparakis, M., L. Alexopoulou, V. Episkopou, and G. Kollias. 1996. Immune and inflammatory responses in TNF-α deficient mice: a critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers and in the maturation of the humoral immune response. J. Exp. Med. 184:1397.
44. Rennert, P. D., J. L. Browning, R. Mebius, F. Mackay, and P. S. Hochman. 1996. Surface lymphotoxin alpha/beta complex is required for the development for peripheral lymphoid organs. J. Exp. Med. 184:1999.
45. Rennert, P. D., J. L. Browning, and P. S. Hochman. 1997. Lymphotoxin ligands selectively function to generate and organize secondary lymphoid tissue. Int. Immunol. In press.