Vα3.2 Selection in MHC Class I Mutant Mice: Evidence for an Alternate Orientation of TCR-MHC Class I Interaction

Journal of Immunology

Volumn 159, Issue 7, 1997, Pages 3322-3329

  Sim, Bee Cheng ^a   Travers, Paul J ^b   Gascoigne, Nicholas R J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

H2 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; FEMALE; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; MULTIGENE FAMILY; THYMUS; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GENE REARRANGEMENT, T-LYMPHOCYTE; H-2 ANTIGENS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MODELS, MOLECULAR; MULTIGENE FAMILY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND;

EID: 0031253811     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Stern, L. J., and D. C. Wiley. 1994. Antigenic peptide binding by class I and class II histocompalibility antigens. Structure 2:245.
2. Bjorkman, P. J., and W. P. Burmeister. 1994. Structures of two classes of MHC molecules elucidated: crucial differences and similarities. Curr. Opin. Struct. Biol. 4:852.
3. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A Wilson. 1996. An αβ T cell receptor structure at 2.5Å and its orientation in the TCR-MHC complex. Science 274:209.
4. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
5. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
6. Chothia, C., D. R. Bothwell, and A. M. Lesk. 1988. The outline structure of the T-cell αβ receptor. EMBO J. 7:3745.
7. Claverie, J.-M., A. Prochnicka-Chalufour, and L. Bougueleret. 1989. Implications of a Fab-like structure for the T-cell receptor. Immunol. Today 10:10.
8. Hedrick, S. M., I. Engel, P. J. Fink, M.-L. Hsu, D. Hansburg, and L. A. Matis. 1988. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 239:1541.
9. Danska, J. S., A. M. Livingstone, V. Paragas, T. Ishihara, and C. G. Fathman. 1990. The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172:27.
10. Lai, M.-Z., Y. J. Jang, L.-K. Chen, and M. L. Gefter. 1990. Restricted V-(D)-J junctional regions in the T cell response to lambda-repressor: identification of residues critical for antigen recognition. J. Immunol. 144:4851.
11. Engel, I., and S. M. Hedrick. 1988. Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition. Cell 54:473.
12. Katayama, C. D., F. J. Eidelman, A. Duncan, F. Hooshmand, and S. M. Hedrick. 1995. Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J. 14:927.
13. Jorgensen, J. L., U. Esser, B. F. De St. Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355:224.
14. Kelly, J. M., S. J. Sterry, S. Cose, S. J. Turner, J. Fecondo, S. Rodda, P. J. Fink, and F. R. Carbone. 1993. Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant. Eur. J. Immunol. 23:3318.
15. Sant'Angelo, D. B., G. Waterbury, P. Preston-Hurlburt, S. T. Yoon, R. Medzhitov, S. Hong, and C. A. Janeway, Jr. 1996. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4:367.
16. b molecule. Immunity 3:573.
17. Utsunomiya, Y., J. Bill, E. Palmer, K. Gollob, Y. Takagaki, and O. Kanagawa. 1989. Analysis of a monoclonal rat antibody directed to the α-chain variable region (Vα3) of the mouse T cell antigen receptor. J. Immunol. 143:2602.
18. + cells. J. Immunol. 145:1324.
19. Jameson, S. C., P. B. Nakajima, J. L. Brooks, W. Heath, O. Kanagawa, and N. R. J. Gascoigne. 1991. The T cell receptor Vα11 gene family: analysis of allelic sequence polymorphism and demonstration of Jα-region dependent recognition by allele-specific antibodies. J. Immunol. 147:3185.
20. a haplotypes: determination with a Vα2-specific monoclonal antibody. Eur. J. Immunol. 22:399.
21. Saouaf, S. J., M. Katsumata, K. Yui, S. Thayu, N. R. J. Gascoigne, and M. I. Greene. 1994. Azobenzenearsonate hapten specific T cell receptor alpha chain transgenic mice. Transgenics 1:185.
22. Alam, S. M., B.-C. Sim, and N. R. J. Gascoigne. 1995. Selection of TCR Vα by MHC class II predicts superantigen reactivity. Int. Immunol. 7:1311.
23. + T cells by MHC class I molecules. Immunogenetics 35:291.
24. Hong, S., A. Chelouche, R. Lin, D. Shaywitz, N. S. Braunstein, L. Glimcher, and C. A. Janeway. Jr. 1992. An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell 69:999.
25. Sim, B.-C. L. Zerva, M. I. Greene, and N. R. J. Gascoigne. 1996. Control of MHC restriction by TCR Vα CDR1 and CDR2. Science 273:963.
26. Kaye, J., N. J. Vasquez, and S. M. Hedrick. 1992. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol 148:3342.
27. Casanova, J.-L., F. Martinon, H. Gournier, C. Barra, C. Pannetier, A. Regnault, P. Kourilsky, J.-C. Cerottini, and J. L. Maryanski. 1993. T cell receptor selection by and recognition of two class I major histocompatibility complex-restricted antigenic peptides that differ at a single position. J. Exp. Med. 177:811.
28. Nanda, N. K., K. K. Arzoo, H. M. Geysen, A. Sette, and E. E. Sercarz. 1995. Recognition of multiple peptide cores by a single T cell receptor. J. Exp. Med. 182:531.
29. Tang, X. X., N. Ikegaki, J. S. Danska, and H. Heber-Katz. 1995. An alternative view of T-cell receptor-MHC interaction: T-cell receptor binds transversally to the α-helices of the MHC molecule. Mol. Immunol. 32:661.
30. Wucherpfennig, K. W., D. A. Hafler, and J. L. Strominger. 1995. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2 peptide complexes. Proc. Natl. Acad. Sci. USA 92:8896.
31. Brawley, J. V., and P. Concannon. 1996. Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residues. J. Exp. Med. 183:2043.
32. k determinant: single conservative amino acid changes in the complementarity-determining region 3 dramatically alter antigen line specificity. J. Immunol. 157:2291.
33. Ehrich, E. W., B. Devaux, E. P. Rock, J. L. Jorgensen, M. M. Davis, and Y. Chien. 1993. T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J. Exp. Med. 178:713.
34. Davis, M. M., and Y. Chien. 1993. Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes. Curr. Opin. Immunol. 5:45.
35. 257-264 determinant. Int. Immunol. 4:861.
36. Ceredig, R., J. W. Lowenthal, M. Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nature 314:98.
37. Sarmiento, M., A. L. Glasebrook, and H. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants in the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
38. Dennert, G., R. Hyman, J. Lesley, and I. S. Trowbridge. 1980. Effects of cytotoxic monoclonal antibody specific for T200 glycoprotein on functional lymphpoid cell populations. Cell. Immunol. 53:350.
39. Coligan, J. E., A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and S. Strober. 1993. Current Protocols in Immunology. Wiley Interscience, New York.
40. b-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc. Natl. Acad. Sci. USA 92:2479.
41. Nathenson, S. G., J. Geliebter, G. M. Pfaffenbach, and R. A. Zeff. 1986. Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Annu. Rev. Immunol. 4:471.
42. Bjorkman, P. J., M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley. 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512.
43. b. Science 257:919.
44. b molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. Proc. Natl. Acad. Sci. USA 89:8403.
45. + T cells. Science 244:214.
46. + thymocytes. Nature 333:742.
47. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. J. Gascoigne. 1996. T cell receptor affinity and thymocyte positive selection. Nature 381:616.
48. Alam, S. M., I. N. Crispe, and N. R. J. Gascoigne. 1995. Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation. Immunity 3:449.