Telomeres, not the end of the story

BioEssays

Volumn 19, Issue 5, 1997, Pages 367-370

  Gotta, Monica ^a   Cockell, Moira ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031150015     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.950190503     Document Type: Review

References (34)

1. Hecht, A., Strahl-Bolsinger, S. and Grunstein, M. (1996). Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature 383, 92-6.
2. Strahl-Bolsinger, S., Hecht, A., Kunheng, L. and Grunstein, M. (1997). SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev. 11, 83-93.
3. Henikoff, S. (1992). Position effect and related phenomena. Curr. Opin. Gen. Dev. 2, 907-12.
4. Palladino, F. and Gasser, S. M. (1994). Telomere maintenance and gene repression: a common end? Curr. Opin. Cell Biol. 6, 373-379.
5. Thompson, J.S., Hecht, A. and Grunstein, M. (1993). Histones and the regulation of heterochromatin in yeast. Cold Spring Harbor Symp. Quant. Biol. 58, 247-56.
6. Laurenson, P. and Rine, J. (1992). Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56, 543-60.
7. Kayne, P.S., Kim, U.J., Han, M., Mullen, J.R., Yoshizaki, F. and Grunstein, M. (1988). Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55, 27-39.
8. Johnson, L.M., Kayne, P.S., Kahn, E.S. and Grunstein, M. (1990). Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 87, 6286-90.
9. Hecht, A., Laroche, T., Strahl-Bolsinger, S., Gasser, S.M. and Grunstein, M. (1995) Histone H3 and H4 N-termini interact with SIRS and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80, 583-92.
10. Moretti, P., Freeman, K., Coodly, L. and Shore, D. (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev. 8, 2257-69.
11. Cockell, M. et al. (1995). The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J. Cell Biol. 129, 909-24.
12. Liu, C., Mao, X. and Lustig, A.J. (1994). Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae. Genetics 138, 1025-40.
13. Brachmann, C.B., Sherman, J.M., Devine, S.E., Kameron, E.E., Pillus, L. and Boeke, J.D. (1995). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9, 2888-902.
14. Moazed, D. and Johnson, D. (1996). A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Cell 86, 667-77.
15. Renauld, H. et al. (1993). Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev. 7, 1133-45.
16. Lustig, A.J., Liu, C., Zhang, C. and Hanish, J.P. (1996) Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 2483-95.
17. Marcand, S., Buck, S.W., Moretti, P., Gilson, E. and Shore, D. (1996). Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein. Genes Dev. 10, 1297-309.
18. Gottlieb, S. and Esposito, R.E. (1989). A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56, 771-6.
19. Byrk, M. et al. (1997). Transcriptional silencing of Ty elements in the RDN1 locus of yeast. Genes Dev. 11, 255-269.
20. Smith, J.S. & Boeke, J.D. (1997). An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev. 11, 241-254.
21. Gotta, M. et al. (1997). Sir2p localization: the nucleolus as a compartment of Silent Information Regulators. EMBO J. (in press).
22. Kennedy, B.K., Austriaco, N.R., Jr., Zhang, J. and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96.
23. Buchman, A.R., Kimmerly, W.J., Rine, J. and Kornberg, R.D. (1988). Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 210-25.
24. Gilson, E., Roberge, M., Giraldo, R., Rhodes, D. and Gasser, S.M. (1993). Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J. Mol. Biol. 231, 293-310.
25. Longtine, M.S., Wilson, N.M., Petracek, M.E. and Berman, J. (1989). A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1. Curr. Genet. 16, 225-39.
26. Gotta, M., Laroche, T., Formenton, A., Maillet, L., Scherthan, H. and Gasser, S.M. (1996). The clustering of telomeres and colocalization with Rap1, Sir3 and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell Biol. 134, 1349-1363.
27. Marcand, S., Gilson, E. and Shore, D. (1997). A protein counting mechanism for telomere length regulation in yeast. Science (in press).
28. Wooton, D. and Shore, D. (1997).A novel Rap1p interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in S. cerevisiae. Genes Dev. (in press).
29. Krauskopf, A. and Blackburn, E.H. (1996). Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383, 354-7.
30. Hardy, C.F., Sussel, L. and Shore, D. (1992). A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6, 801-14.
31. Kyrion, G., Liu, C., Cheng, L. and Lustig, A.J. (1993). RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev. 7, 1146-59.
32. Palladino, F., Laroche, T., Gilson, E., Axelrod, A., Pillus, L. and Gasser, S.M. (1993). SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75, 531-42.
33. Singer, M.S. and Gottschling, D.E. (1994). TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Genetics 266, 404-9.
34. Wiley, E.A. and Zakian, V.A. (1994). Extra telomeres but not internal tract of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres. Genetics 139, 67-79.