Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: Identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis

Neurogenetics

Volumn 1, Issue 1, 1997, Pages 65-71

  Zu, James S ^a   Deng, Han Xiang ^a   Lo, Terence P ^d   Mitsumoto, Hiroshi ^c   Ahmed, Mohamed S ^a   Hung, Wu Yen ^a   Cai, Zi Jian ^b   Tainer, John A ^d   Siddique, Teepu ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); Cu; Zn superoxide dismutase (SOD1)

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; RECOMBINANT PROTEIN; SUPEROXIDE DISMUTASE;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING SITE; CASE REPORT; CHEMICAL STRUCTURE; ENZYMOLOGY; EXON; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CRYSTALLOGRAPHY, X-RAY; EXONS; HUMANS; MALE; MIDDLE AGED; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDE DISMUTASE;

EID: 0031128772     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480050010     Document Type: Article

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