Xanthines as a scaffold for molecular diversity

Molecular Diversity

Volumn 2, Issue 3, 1997, Pages 171-174

  Heizmann, Gerhard ^a   Eberle, Alex N ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Combinatorial chemistry; Diversity; Small molecules; Xanthines

Indexed keywords

XANTHINE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC CHEMISTRY; SYNTHESIS;

ALKYLATION; CHEMISTRY, ORGANIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; XANTHINES;

EID: 0031086320     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01682205     Document Type: Article

References (21)

1. a. Houghten, R.A., Combinatorial libraries. Finding the needle in the haystack, Curr. Biol., 4 (1994) 564-567.
2. b. Eichler, J., Appel, J.R., Blondelle, S.E., Dooley, CT., Dorner, B., Ostresh, J.M., Perez-Paya, E., Pinilla, C. and Houghten, R.A., Peptide, peptidominietic, and organic synthetic combinatorial libraries, Med. Res. Rev., 15 (1995) 481-496.
3. Gallop, M.A., Barrett, R.W., Dower, W.J., Fodor, S.P.A. and Gordon, E.M., Applications of combinatorial technologies to drug discovery. I. Background and peptide combinatorial libraries, J. Med. Chem., 37 (1994) 1233-1251.
4. Gordon, E.M., Barren, R.W., Dower, W.J., Fodor, S.P.A. and Gallop, M.A., Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions, J. Med. Chem., 37 (1994) 1385-1401.
5. e. Felder, E.R., The challenge of preparing and testing combinatorial "compound libraries in the fast lane, at the front edge of drug development, Chimia, 48 (1994) 531-541.
6. f. Terrett, N.K., Gardner, M., Gordon, D.W., Kbbylecki, R.J. and Steele, J., Combinatorial synthesis: The design of compound libraries and their application to drug discovery, Tetrahedron, 51 (1995) 8135-8173.
7. a. Bunin, B.A. and Ellman, J.A., A general and expedient method for the solid phase synthesis of l,4-bcn;odia:epine derivatives, J. Am. Chem. Soc., 114 (1992) 10997-10998.
8. b. DeWitt, S.H., Kiely, J.S., Stankovic, C.J., Schroeder, M.C., Cody, D.M.R. and Pavia, M.R., 'Diversomers': An approach to nonpeptide nonoligomeric chemical diversity, Proc. Natl. Acad. Sci. USA, 90 (1993) 6909-6913.
9. Goff, D.A. and Zuckermann, R.N., Solid-phase synthesis of highly substituted peptoid 1(2H)-isoquinolinones, J. Org. Chem., 60 (1995) 5748-5749.
10. Patek, M., Drake, B. and Lebl, M., Solid-phase synthesis of 'small' organic molecules based on thia:olidine scaffold, Tetrahedron Lett., 36 (1995) 2227-2230.
11. e. Marzinzik, A.L. and Felder, E.R., Solid support synthesis of highly functionaliied pyra:oles and isoxaiolcs; scaffolds for molecular diversity. Tetrahedron Lett., 37 (1996) 1003-1006.
12. f. MacDonald, A.A., DeWitt, S.H., Hogan, E.M. and Ramage, R.A., Solid phase approach to quinolones using the Diversomer technology. Tetrahedron Lett., 37 (1996) 4815-4818.
13. g. Dressman, B.A., Spangle, L.A. and Kaldor, S.W., Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclizationlcleavage step, Tetrahedron Lett., 37 (1996) 937-940.
14. h. Ruhland, B., Bhandari, A., Gordon, E.M. and Gallop, M.A., Solid-supported combinatorial synthesis of structurally diverse β-lactams, J. Am. Chem. Soc., 118 (1996) 253-254.
15. Mutschier, E. (Ed.), Arzneimittel-Wirkungen, Wissenschaftliche Verlagsgesellschaft, Stuttgart, Germany, 1986.
16. Hock, F.J., Therapeutic approaches for memory impairments, Behav. Brain Res., 66 (1995) 143-150.
17. a. Daly, J.W., Hide, L, Muller, C.E. and Shamim, M., Caffeine analogs: Structure-activity relationship at adenosine receptors, Pharmacology, 42 (1991) 309-321.
18. b. Olah, M.E. and Stiles, G.L., Adenosine receptor subtypes: Characterisation and therapeutic regulation, Annu. Rev. Pharmacol. Toxicol., 35 (1995) 581-606.
19. a. Goldner, H., Dietz, G. and Carstens, E., Die Oxydation von 5-Nitrosouracilen, Liebigs Ann. Chem., 699 (1966) 145-152, and references cited therein.
20. b. Fuchs, H., Gottlieb, M. and Pfleiderer, W, Uber die Cyclisierung von 4-Alkylamino-5-mtrosouracilen und die Synthese von 8-substituierlen Xanthinen und Bis(theophyllin-8-yl)alkan-Derivaten, Chem. Ber., 111 (1978) 982-995.
21. Rink, H., Solid-phase synthesis of protected peptide fragments using a trialkyloxy-diphenyl-methylester resin, Tetrahedron Lett., 28 (1987) 3787-3790.