Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS

Journal of Medical Primatology

Volumn 26, Issue 1-2, 1997, Pages 11-18

  Villinger, Francois ^a,b   Brar, Sukhdev S ^a   Brice, Gary T ^a   Chikkala, Nathaniel F ^a   Novembre, Francis J ^b   Mayne, Ann E ^a   Bucur, Silvana ^a   Hillyer, Christopher D ^a   Ansari, Aftab A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

AIDS; Chemokines; Chimpanzee; Cytokines

Indexed keywords

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; PAN (APE); PAN TROGLODYTES;

CD34 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL; ANIMAL DISEASE; APE DISEASE; ARTICLE; BIOSYNTHESIS; CD4 LYMPHOCYTE COUNT; CELLULAR IMMUNITY; COMPARATIVE STUDY; DISEASE COURSE; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; PAN TROGLODYTES; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTIGENS, CD34; APE DISEASES; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; HEMATOPOIETIC STEM CELLS; HIV-1; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; PAN TROGLODYTES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL;

EID: 0031063679     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0684.1997.tb00314.x     Document Type: Article

References (37)

1. ALKHATIB G, COMBADIERE C, BRODER CC, FENG Y, KENNEDY PE, MURPHY PM: CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophagetropic HIV-1. Science 272:1955-1958, 1996.
2. AHMED-ANSARI A, BRODIE AR, FULTZ P, SELL KW, MCCLURE HM: Flow microfluorometric analysis of peripheral blood mononuclear cells from primates - correlation of phenotype with immune function. Am J Primatol 17:107-131, 1989.
3. ANSARI AA, MAYNE A, HUNT D, SUNDSTROM JB, VILLINGER F: TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates. J Med Primatol 23:102-107, 1994.
4. BENVENISTE O, VASLIN B, VILLINGER F, LE GRAND R, ANSARI AA, DORMONT D: Cytokine mRNA levels in unmanipulated (ex vivo) and in vitro stimulated monkey PBMCs using a semi-quantitative RT-PCR and high sensitivity fluorescence-based detection strategy. Cytokine 8:32-41, 1996.
5. BRUCK C, THIRIART C, FABRY L, FRANCOTTE M, PALA P, VAN OPSTAL O, ROSENBERG M, DE WILDE M, HEIDT P ET AL.: HIV-1 envelope-elicited neutralizing antibody titres correlate with protection and virus load in chimpanzees. Vaccine 12:1141-1148, 1994.
6. CASTRO BA, WALKER CM, EICHBERG JW, LEVY JA: Suppression of human immunodeficiency virus replication by CD8+ cells from infected and uninfected chimpanzees. Cell Immunol 132:246-255, 1991.
7. CHIRGWIN JM, PRZYBYLA AE, MACDONALD RJ, RUTTER WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochem 18:5294-5299, 1979.
8. CHOE H, FARZAN M, SUN Y, SULLIVAN N, ROLLINS B, PONATH PD, WU L, LAROSA G, NEWMAN W, GERARD N, GERARD C, SODROSKI J: The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-1148, 1996.
9. CLERICI M, SHEARER GM: A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 14:107-111, 1993.
10. CLERICI M, SHEARER GM: The Th1-Th2 hypothesis of HIV infection: New insights. Immunol Today 15:575-581, 1994.
11. CLERICI M, STOCKS NI, ZAJAC RA, BOSWELL RN, LUCEY DR, VIA CS, SHEARER GM: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus positive patients. J Clin Invest 84:1892-1899, 1989.
12. + T cells. Science 270:1811-1815, 1995.
13. DORANZ BJ, RUCKER J, YI Y, SMYTH RJ, SAMSON M, PEIPER SC, PARMENTIER M, COLLMAN RG, DOMS RW: A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-1158, 1996.
14. DRAGIC T, LITWIN V, ALLAWAY GP, MARTIN SR, HUANG Y, NAGASHIMA KA, MADDON PJ, KOUP RA, MOORE JP, PAXTON WA: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673, 1996.
15. FAN J, BASS HZ, FAHEY JL: Elevated IFN-γ and decreased IL-2 gene expression are associated with HIV infection. J Immunol 151:5031-5040, 1993.
16. FENG Y, BRODER CC, KENNEDY PE, BERGER EA: HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877, 1996.
17. FERRARI G, OTTINGER J, PLACE C, NIGIDA SM JR, ARTHUR LO, WEINHOLD KJ: The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees. AIDS Res Hum Retroviruses 9:647-656, 1993.
18. FULTZ PN, SIEGEL RL, BRODIE A, MAWLE AC, STRICKER RB, SWENSOV RB, MCCLURE HM: Prolonged CD4+ lymphocytopenia and thrombocytopenia in a chimpanzee persistently infected with human immunodeficiency virus type 1. J Infect Dis 163:441-447, 1991.
19. FULTZ PN, NARA P, BARRE-SINOUSSI F, CHAPUT A, GREENBERG ML, MUCHMORE E, KIENY MP, GIRARD M: Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells. Science 256:1687-1690, 1992.
20. GIBBS CJ JR, PETERS R, GRAVELL M, JOHNSON BK, JENSEN FC, CARLO DJ: Observations after human immunodeficiency virus immunization and challenge of human immunodeficiency virus seropositive and seronegative chimpanzees. Proc Natl Acad Sci USA 88:3348-3352, 1991.
21. HUSCH B, EIBL MM, MANNHALTER JW: CD3, CD8 double-positive cells from HIV-1-infected chimpanzees show group-specific inhibition of HIV-1 replication. AIDS Res Hum Retroviruses 9:405-413, 1993.
22. JOHNSON BK, STONE GA, GODEC MS, ASHER DM, GAJDUSEK DC, GIBBS CJ JR: Long-term observations of human immunodeficiency virus-infected chimpanzees. AIDS Res Hum Retroviruses 9:375-378, 1993.
23. NEAL TF, HOLLAND HK, BAUM CM, VILLINGER F, ANSARI AA, SARAL R, FLEMING WH: CD34+ progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1. Blood 86:1749-1756, 1995.
24. NEHETE PN, MURTHY KK, SATTERFIELD WC, ARLINGHAUS RB, SASTRY KJ: Studies on V3-specific cross-reactive T-cell responses in chimpanzees chronically infected with HIV-1IIIB. AIDS 9:567-572, 1995.
25. NIEDRIG M, GREGERSEN JP, FULTZ PN, BROKER M, MEHDI S, HILFENHAUS J: Immune response of chimpanzees after immunization with the inactivated whole immunodeficiency virus (HIV-1), three different adjuvants and challenge. Vaccine 11:67-74, 1993.
26. NOVEMBRE F, SAUCIER M, ANDERSON DC, KLUMPP SA, O'NEIL SP, BROWN CR, HART CE, GUENTHNER PC, SWENSON RB, MCCLURE HM: J. Virol 71:4086-4091, 1997.
27. OU CY, KWOK S, MITCHELL SW, MACK DH, SNINSKY JJ, KREBS JW, FEORINO P, WARFIELD D, SCHOCHETMAN G: DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science 239:295-297, 1988.
28. PEETERS M, NKENGASONG J, WILLEMS B, KARITA E, DELAPORTE E, VAN DENHAESEVELDE M, PIOT P, VAN DER GROEN G: Antibodies to V3 loop peptides derived from chimpanzee lentiviruses and the divergent HIV-1 ANT-70 isolate in human sera from different geographic regions. AIDS 8:1657-1661, 1994.
29. PRINCE AM, REESINK H, PASCUAL D, HOROWITZ B, HEWLETT I, MURTHY KK, EICHBERG JW: Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res Hum Retroviruses 7:971-973, 1991.
30. SAKSELA K, MUCHMORE E, GIRARD M, FULTZ P, BALTIMORE D: High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1-infected chimpanzees. J Virol 67:7423-7427, 1993.
31. SCHLEIF WA, MURTHY KK, SARDANA W, SCHNEIDER CL, BYRNES VW, COBB KE, WOLFGANG JA, HOFFMAN JM, SMITH AM ET AL.: Attempted prophylaxis of human immunodeficiency virus type 1 infection in chimpanzees with a nonnucleoside reverse transcriptase inhibitor. AIDS Res Hum Retroviruses 10:107-110, 1994.
32. SCHRUM S, PROBST P, FLEISCHER B, ZIPFEL PF: Synthesis of the CC-chemokines MIP-1α. MIP-1β and RANTES is associated with a type 1 immune response. J Immunol 157:3598-3604, 1996.
33. SCHUITEMAKER H, MEYAARD L, KOOTSTRA NA, DUBBES R, OTTO SA, TERSMETTE M, HEENEY JL, MIEDEMA F: Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants. J Infect Dis 168:1140-1147, 1993.
34. SHIBATA R, SEIMON C, CHO MW, ARTHUR LO, NIGIDA SM JR, MATTHEWS T, SCHULTZ A, MURTHY KK, ISRAEL Z, JAVADIAN A, FROST P, LANE HC, MARTIN MA: Resistance of previously infected chimpanzees to successive challenges with a heterologous intraclade B strain of human immunodeficiency virus type I. J Virol 70:4361-4369, 1996.
35. VILLINGER F, HUNT D, MAYNE A, VUCHETICH M, FINDLEY H, ANSARI AA: Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells. Cytokine 5:469-479, 1993.
36. VILLINGER F, BRAR SS, MAYNE A, CHIKKALA N, ANSARI AA: Comparative sequence analysis of cytokine genes from human and nonhuman primates. J Immunol 155:3946-3954, 1995.
37. ZARLING JM, LEDBETTER JA, SIAS J, FULTZ P, EICHBERG J, GJERSET G: HIV-infected humans, but not chimpanzees, have circulating cytotoxic T lymphocytes that lyse uninfected CD4+ cells. J Immunol 144:2992-2998, 1990.