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Volumn 9, Issue 1, 1997, Pages 37-43

Pathways of spindle assembly

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN; TUBULIN;

EID: 0031052157     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80149-4     Document Type: Article
Times cited : (89)

References (60)
  • 1
    • 0000322130 scopus 로고
    • Morphogenesis of the mitotic and meiotic spindle: Conclusions from one system are not necessarily applicable to the other
    • Edited by Vig BK. Berlin, Heidelberg: Springer-Verlag; NATO series, vol H72
    • 1. Rieder CL, Ault JG, Eichenlaub-Ritter U, Sluder G: Morphogenesis of the mitotic and meiotic spindle: conclusions from one system are not necessarily applicable to the other. In Chromosome Segregation and Aneuploidy. Edited by Vig BK. Berlin, Heidelberg: Springer-Verlag; 1993:183-197. [NATO series, vol H72.]
    • (1993) Chromosome Segregation and Aneuploidy , pp. 183-197
    • Rieder, C.L.1    Ault, J.G.2    Eichenlaub-Ritter, U.3    Sluder, G.4
  • 2
    • 0029619833 scopus 로고
    • Chromosomal control of meiotic cell division
    • 2. McKim KS, Hawley RS: Chromosomal control of meiotic cell division. Science 1995, 270:1595-1601.
    • (1995) Science , vol.270 , pp. 1595-1601
    • McKim, K.S.1    Hawley, R.S.2
  • 3
    • 0030059247 scopus 로고    scopus 로고
    • Morphogenetic properties of microtubules and mitotic spindle assembly
    • 3. Hyman AA, Karsenti E: Morphogenetic properties of microtubules and mitotic spindle assembly. Cell 1996, 84:401-410.
    • (1996) Cell , vol.84 , pp. 401-410
    • Hyman, A.A.1    Karsenti, E.2
  • 4
    • 0000747860 scopus 로고    scopus 로고
    • The role of microtubule dependent motors in centrosome movements and spindle pole organization during mitosis
    • 4. Karsenti E, Haralabia B, Vernos I: The role of microtubule dependent motors in centrosome movements and spindle pole organization during mitosis. Semin Cell Dev Biol 1996, 7:367-378.
    • (1996) Semin Cell Dev Biol , vol.7 , pp. 367-378
    • Karsenti, E.1    Haralabia, B.2    Vernos, I.3
  • 5
    • 0030113626 scopus 로고    scopus 로고
    • A catastrophic kinesin
    • 5. Waters JC, Salmon ED: A catastrophic kinesin. Curr Biol 1996, 6:361-363.
    • (1996) Curr Biol , vol.6 , pp. 361-363
    • Waters, J.C.1    Salmon, E.D.2
  • 6
    • 0028955479 scopus 로고
    • Riding the polar winds: Chromosomes motor down east
    • 6. Fuller MT: Riding the polar winds: chromosomes motor down east. Cell 1995, 81:5-8.
    • (1995) Cell , vol.81 , pp. 5-8
    • Fuller, M.T.1
  • 7
    • 0029053823 scopus 로고
    • Chromosomes take the lead in spindle assembly
    • 7. Vernos I, Karsenti E: Chromosomes take the lead in spindle assembly. Trends Cell Biol 1995, 5:297-301.
    • (1995) Trends Cell Biol , vol.5 , pp. 297-301
    • Vernos, I.1    Karsenti, E.2
  • 8
    • 0029394870 scopus 로고
    • Chromosomes take an active role in spindle assembly
    • 8. Waters JC, Salmon ED: Chromosomes take an active role in spindle assembly. Bioessays 1995, 17:911-914.
    • (1995) Bioessays , vol.17 , pp. 911-914
    • Waters, J.C.1    Salmon, E.D.2
  • 9
    • 0028034333 scopus 로고
    • The spindle pole body of yeast
    • 9. Snyder M: The spindle pole body of yeast. Chromosoma 1994, 6:369-380.
    • (1994) Chromosoma , vol.6 , pp. 369-380
    • Snyder, M.1
  • 10
    • 0028973450 scopus 로고
    • Microtubule nucleation by γ-tubulin-containing rings in the centrosome
    • 10. Moritz M, Braunfeld MB, Sedat JW, Alberts B, Agard DA: Microtubule nucleation by γ-tubulin-containing rings in the centrosome. Nature 1995, 378:637-640.
    • (1995) Nature , vol.378 , pp. 637-640
    • Moritz, M.1    Braunfeld, M.B.2    Sedat, J.W.3    Alberts, B.4    Agard, D.A.5
  • 11
    • 0028879986 scopus 로고
    • Nucleation of microtubule assembly by a γ-tubulin-containing ring complex
    • 11. Zheng Y, Wong ML, Alberts B, Mitchison TJ: Nucleation of microtubule assembly by a γ-tubulin-containing ring complex. Nature 1995, 378:578-583.
    • (1995) Nature , vol.378 , pp. 578-583
    • Zheng, Y.1    Wong, M.L.2    Alberts, B.3    Mitchison, T.J.4
  • 12
    • 0029005392 scopus 로고
    • The impact of chromosomes and centrosomes on spindle assembly as observed in living cells
    • 12. Zhang D, Nicklas RB: The impact of chromosomes and centrosomes on spindle assembly as observed in living cells. J Cell Biol 1995, 129:1287-1300. Micromanipulation techniques are used to show that chromosomes, not kinetochores, modify spindle assembly dynamics to cause a local increase in microtubule mass. Centrosomes are also shown to be necessary for spindle assembly.
    • (1995) J Cell Biol , vol.129 , pp. 1287-1300
    • Zhang, D.1    Nicklas, R.B.2
  • 13
    • 0028889363 scopus 로고
    • Chromosomes initiate spindle assembly upon experimental dissolution of the nuclear envelope in grasshopper spermatocytes
    • 13. Zhang D, Nicklas RB: Chromosomes initiate spindle assembly upon experimental dissolution of the nuclear envelope in grasshopper spermatocytes. J Cell Biol 1995, 131:1125-1131. When the micromanipulation techniques that this laboratory is famous for are used to rupture the nucleus during early prophase (mid-diakinesis), chromosomes induce the centrosomes to form a bipolar spindle prematurely. In addition, removal of the centrosomes from prophase cells was shown to inhibit spindle assembly after nuclear envelope dissolution.
    • (1995) J Cell Biol , vol.131 , pp. 1125-1131
    • Zhang, D.1    Nicklas, R.B.2
  • 14
    • 0027172190 scopus 로고
    • The force producing mechanism for centrosome separation in vertebrate cells is intrinsic to each aster
    • 14. Waters JC, Cole RW, Rieder CL: The force producing mechanism for centrosome separation in vertebrate cells is intrinsic to each aster. J Cell Biol 1993, 122:361-372.
    • (1993) J Cell Biol , vol.122 , pp. 361-372
    • Waters, J.C.1    Cole, R.W.2    Rieder, C.L.3
  • 15
    • 0025168692 scopus 로고
    • Antiparallel microtubule interactions: Spindle formation and anaphase B
    • 15. Hogan CJ, Cande WZ: Antiparallel microtubule interactions: spindle formation and anaphase B. Cell Motil Cytoskeleton 1990, 16:99-103.
    • (1990) Cell Motil Cytoskeleton , vol.16 , pp. 99-103
    • Hogan, C.J.1    Cande, W.Z.2
  • 16
    • 0030070110 scopus 로고    scopus 로고
    • XKLP2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis
    • 16. Bolenti H, Karsenti E, Vernos I: XKLP2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis. Cell 1996, 84:49-59. XKLP2 is shown to be a slow plus-end-directed kinesin-like microtubule motor protein. XKLP2 localizes to centrosomes and spindle poles. Immunodepletion of XKLP2 prior to spindle assembly, and antibody addition after spindle assembly, demonstrates that XKLP2 is necessary for both centrosome separation and spindle maintenance in Xenopus egg M-phase extracts.
    • (1996) Cell , vol.84 , pp. 49-59
    • Bolenti, H.1    Karsenti, E.2    Vernos, I.3
  • 17
    • 0030604718 scopus 로고    scopus 로고
    • Kinesin-related proteins at mitotic spindle poles: Function and regulation
    • 17. Walczak CL, Mitchison TJ: Kinesin-related proteins at mitotic spindle poles: function and regulation. Cell 1996, 85:943-946.
    • (1996) Cell , vol.85 , pp. 943-946
    • Walczak, C.L.1    Mitchison, T.J.2
  • 18
    • 0026739078 scopus 로고
    • Mitotic spindle organization by a plus-end-directed microtubule motor
    • 18. Sawin KE, LeGuellec K, Philippe M, Mitchison TJ: Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 1992, 359:540-543.
    • (1992) Nature , vol.359 , pp. 540-543
    • Sawin, K.E.1    LeGuellec, K.2    Philippe, M.3    Mitchison, T.J.4
  • 19
    • 0027420391 scopus 로고
    • Cytoplasmic dynein plays a role in mammalian mitotic spindle formation
    • 19. Vaisberg EA, Koonce MP, McIntosh JR: Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. J Cell Biol 1993, 123:849-858.
    • (1993) J Cell Biol , vol.123 , pp. 849-858
    • Vaisberg, E.A.1    Koonce, M.P.2    McIntosh, J.R.3
  • 20
    • 0028799957 scopus 로고
    • Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis
    • 20. Gunsalus KC, Bonaccorsi S, Williams E, Verni F, Gatti M, Goldberg M: Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J Cell Biol 1995, 131:1243-1259. Twinstar encodes an essential 17 kDa actin-severing protein. Twinstar mutants show defects in cytokinesis in both mitotic and meiotic systems. In meiotic spermatocytes, twinstar mutants also show defects in centrosome separation. This suggests that centrosome motility may depend on interactions with the actin cytoskeleton.
    • (1995) J Cell Biol , vol.131 , pp. 1243-1259
    • Gunsalus, K.C.1    Bonaccorsi, S.2    Williams, E.3    Verni, F.4    Gatti, M.5    Goldberg, M.6
  • 21
    • 0030004472 scopus 로고    scopus 로고
    • Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos
    • 21. Paddy MR, Saumweber H, Agard DA, Sedat JW: Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. J Cell Sci 1996, 109:591-607.
    • (1996) J Cell Sci , vol.109 , pp. 591-607
    • Paddy, M.R.1    Saumweber, H.2    Agard, D.A.3    Sedat, J.W.4
  • 22
    • 0028938482 scopus 로고
    • Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
    • 22. Glover DM, Leibowitz MH, McLean DA, Parry H: Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 1995, 81:95-105. Aurora encodes a 47 kDa protein with carboxy-terminal serine - threonine protein kinase domains. Mutants in aurora arrest in mitosis with unseparated centrosomes and monopolar spindles.
    • (1995) Cell , vol.81 , pp. 95-105
    • Glover, D.M.1    Leibowitz, M.H.2    McLean, D.A.3    Parry, H.4
  • 23
    • 0029417238 scopus 로고
    • cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
    • cdc2 phosphorylation site during mitosis, and this phosphorylation is necessary for localization of HsEg5 to spindles.
    • (1995) Cell , vol.83 , pp. 1159-1169
    • Blangy, A.1    Lane, H.A.2    D'Herin, P.3    Harper, M.4    Kress, M.5    Nigg, E.6
  • 24
    • 0026722242 scopus 로고
    • Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis
    • 24. Mitchison TJ, Salmon ED: Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J Cell Biol 1992, 119:569-582.
    • (1992) J Cell Biol , vol.119 , pp. 569-582
    • Mitchison, T.J.1    Salmon, E.D.2
  • 25
    • 0029910131 scopus 로고    scopus 로고
    • Real time observation of anaphase in vitro
    • 25. Murray AW, Desai AB, Salmon ED: Real time observation of anaphase in vitro. Proc Natl Acad Sci USA 1996, 93:12327-12332. Digital-fluorescence microscopy was used to make the first real-time observations of anaphase in vitro. Spindles and mitotic chromosomes were assembled in Xenopus M-phase egg extracts. Anaphase poleward movement was shown to occur at normal velocities when the inactivation of Cdc2-cyclin B complexes was prevented by the addition of a nondegradable cyclin B. Spindle poles were not disrupted when centrosomes migrated away, but microtubule assembly depended on the relative positions of chromosomes and poles.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12327-12332
    • Murray, A.W.1    Desai, A.B.2    Salmon, E.D.3
  • 26
    • 0024311160 scopus 로고
    • Mechanically cut mitotic spindles: Clean cuts and stable microtubules
    • 26. Nicklas RB, Lee GM, Rieder CL, Rupp G: Mechanically cut mitotic spindles: clean cuts and stable microtubules. J Cell Sci 1989, 94:415-423.
    • (1989) J Cell Sci , vol.94 , pp. 415-423
    • Nicklas, R.B.1    Lee, G.M.2    Rieder, C.L.3    Rupp, G.4
  • 28
    • 0028786819 scopus 로고
    • Kinetochore microtubule dynamics and the metaphase-anaphase transition
    • 28. Zhai Y, Kronebusch PJ, Borisy GG: Kinetochore microtubule dynamics and the metaphase-anaphase transition. J Cell Biol 1995, 131:721-734.
    • (1995) J Cell Biol , vol.131 , pp. 721-734
    • Zhai, Y.1    Kronebusch, P.J.2    Borisy, G.G.3
  • 29
    • 0028009012 scopus 로고
    • Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle
    • 29. Rieder CL, Salmon ED: Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle. J Cell Biol 1995, 124:223-233.
    • (1995) J Cell Biol , vol.124 , pp. 223-233
    • Rieder, C.L.1    Salmon, E.D.2
  • 31
    • 0021963766 scopus 로고
    • Experimental separation of pronuclei in fertilized sea urchin eggs - Chromosomes do not organize a spindle in the absence of centrosomes
    • 31. Sluder G, Rieder CL: Experimental separation of pronuclei in fertilized sea urchin eggs - chromosomes do not organize a spindle in the absence of centrosomes. J Cell Biol 1985, 100:897-903.
    • (1985) J Cell Biol , vol.100 , pp. 897-903
    • Sluder, G.1    Rieder, C.L.2
  • 32
    • 0025098191 scopus 로고
    • Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells
    • 32. Rieder CL, Alexander SP: Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J Cell Biol 1990, 110:81-95.
    • (1990) J Cell Biol , vol.110 , pp. 81-95
    • Rieder, C.L.1    Alexander, S.P.2
  • 33
    • 0029890528 scopus 로고    scopus 로고
    • Kinetochore function: Molecular motors, switches and gates
    • 33. Yen TJ, Schaar BT: Kinetochore function: molecular motors, switches and gates. Curr Opin Cell Biol 1996, 8:381-388.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 381-388
    • Yen, T.J.1    Schaar, B.T.2
  • 34
    • 0029913484 scopus 로고    scopus 로고
    • Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
    • 34. Echeverri CJ, Paschal BM, Vaughan KT, Valle RB: Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol 1996, 132:617-633. The p50 subunit of the dynactin complex is shown to localize to kinetochores. Overexpression of p50 resulted in cells arrested with misaligned chromosomes and aberrant spindles.
    • (1996) J Cell Biol , vol.132 , pp. 617-633
    • Echeverri, C.J.1    Paschal, B.M.2    Vaughan, K.T.3    Valle, R.B.4
  • 35
    • 0021274367 scopus 로고
    • Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs
    • 35. Karsenti E, Newport J, Hubble R, Kirschner M: Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs. J Cell Biol 1984, 98:1730-1745.
    • (1984) J Cell Biol , vol.98 , pp. 1730-1745
    • Karsenti, E.1    Newport, J.2    Hubble, R.3    Kirschner, M.4
  • 36
    • 0021276314 scopus 로고
    • Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase
    • 36. Karsenti E, Newport J, Kirschner M: Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase. J Cell Biol 1984, 99:47-54.
    • (1984) J Cell Biol , vol.99 , pp. 47-54
    • Karsenti, E.1    Newport, J.2    Kirschner, M.3
  • 37
    • 0029869434 scopus 로고    scopus 로고
    • Influence of M-phase chromatin on the anisotropy of microtubule asters
    • 37. Dogterom M, Felix MA, Guet CC, Leibler S: Influence of M-phase chromatin on the anisotropy of microtubule asters. J Cell Biol 1996, 133:125-140. The stabilizing effect of chromatin on individual microtubule dynamics is observed in M-phase Xenopus egg extracts. Microtubules in the vicinity of salmon sperm chromatin undergo fewer catastrophes and more rescues, and have a slower growth rate.
    • (1996) J Cell Biol , vol.133 , pp. 125-140
    • Dogterom, M.1    Felix, M.A.2    Guet, C.C.3    Leibler, S.4
  • 38
    • 0029836330 scopus 로고    scopus 로고
    • Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
    • 38. Heald R, Tournebize R, Blank T, Sandaltzopoulos R, Becker P, Hyman A, Karsenti E: Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 1996, 382:420-425. Magnetic beads coated with DNA were added to Xenopus egg extracts. In interphase, a nuclear envelope with functional nuclear pores formed around the beads. In M phase, the DNA-coated beads induced elongation and organization of microtubules into bipolar spindles. Immunodepletion of the minus-end-directed motor protein cytoplasmic dynein resulted in less focused spindle poles in these in vitro spindles.
    • (1996) Nature , vol.382 , pp. 420-425
    • Heald, R.1    Tournebize, R.2    Blank, T.3    Sandaltzopoulos, R.4    Becker, P.5    Hyman, A.6    Karsenti, E.7
  • 39
    • 0025147718 scopus 로고
    • A kinesin-like protein required for distributive chromosome segregation in Drosophila
    • 39. Zhang P, Knowles BA, Goldstein LSB, Hawley RS: A kinesin-like protein required for distributive chromosome segregation in Drosophila. Cell 1990, 62:1053-1062.
    • (1990) Cell , vol.62 , pp. 1053-1062
    • Zhang, P.1    Knowles, B.A.2    Goldstein, L.S.B.3    Hawley, R.S.4
  • 40
    • 0028988361 scopus 로고
    • Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning
    • 40. Vernos I, Raats J, Hirano T, Heasman J, Karsenti E, Wylie C: Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning. Cell 1995, 81:117-127. XKLP1 is a predicted plus-end-directed kinesin-like microtubule motor protein that binds to DNA and localizes to chromosomes and the spindle midzone during mitosis. Microinjection of anti-sense XKLP1 mRNA into Xenopus oocytes results in aberrant spindle morphology, whereas immunodepletion of XKLP1 from Xenopus egg M-phase extracts results in a decrease in spindle microtubule density and defects in chromosome congression.
    • (1995) Cell , vol.81 , pp. 117-127
    • Vernos, I.1    Raats, J.2    Hirano, T.3    Heasman, J.4    Karsenti, E.5    Wylie, C.6
  • 41
    • 0028925221 scopus 로고
    • Chromokinesin: A DNA-binding, kinesin-like nuclear protein
    • 41. Wang SZ, Adler R: Chromokinesin: a DNA-binding, kinesin-like nuclear protein. J Cell Biol 1995, 128:761-768.
    • (1995) J Cell Biol , vol.128 , pp. 761-768
    • Wang, S.Z.1    Adler, R.2
  • 43
    • 0022452232 scopus 로고
    • Oscillatory movements of mono-oriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle
    • 43. Rieder CL, Davison EA, Jensen LCW, Cassimeris L, Salmon ED: Oscillatory movements of mono-oriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle. J Cell Biol 1986, 103:581-591.
    • (1986) J Cell Biol , vol.103 , pp. 581-591
    • Rieder, C.L.1    Davison, E.A.2    Jensen, L.C.W.3    Cassimeris, L.4    Salmon, E.D.5
  • 44
    • 0028231705 scopus 로고
    • Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis
    • 44. Endow SA, Chandra R, Komma DJ, Yamamoto AH, Salmon ED: Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. J Cell Sci 1994, 107:859-867.
    • (1994) J Cell Sci , vol.107 , pp. 859-867
    • Endow, S.A.1    Chandra, R.2    Komma, D.J.3    Yamamoto, A.H.4    Salmon, E.D.5
  • 45
    • 0029897393 scopus 로고    scopus 로고
    • Anastral meiotic spindle morphogenesis: Role of nonclaret disjunctional kinesin-like protein
    • 45. Matthies HJG, McDonald HB, Goldstein LSB, Theurkauf WE: Anastral meiotic spindle morphogenesis: role of nonclaret disjunctional kinesin-like protein. J Cell Biol 1996, 134:455-464. Time-lapsed confocal imaging of Drosophila embryos injected with fluorescently labeled tubulin was used to visualize spindle dynamics. The minus-end-directed kinesin-like microtubule motor protein Ncd was shown to be necessary for maintaining focused spindle poles.
    • (1996) J Cell Biol , vol.134 , pp. 455-464
    • Matthies, H.J.G.1    McDonald, H.B.2    Goldstein, L.S.B.3    Theurkauf, W.E.4
  • 46
    • 0028877327 scopus 로고
    • NuMA is required for the organization of microtubules into aster-like mitotic arrays
    • 46. Gaglio T, Saredi A, Compton D: NuMA is required for the organization of microtubules into aster-like mitotic arrays. J Cell Biol 1995, 131:693-708. Immunodepletion of the protein NuMA inhibits aster formation in mitotic HeLa extracts.
    • (1995) J Cell Biol , vol.131 , pp. 693-708
    • Gaglio, T.1    Saredi, A.2    Compton, D.3
  • 47
    • 0030298137 scopus 로고    scopus 로고
    • A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
    • 47. Merdes A, Ramyar K, Vechio JD, Cleveland DW: A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 1996, 87:447-458. Immunodepletion of NuMA, dynein and dynactin from Xenopus M-phase extracts was used to show that these proteins form a complex that is necessary for in vitro spindle assembly.
    • (1996) Cell , vol.87 , pp. 447-458
    • Merdes, A.1    Ramyar, K.2    Vechio, J.D.3    Cleveland, D.W.4
  • 48
    • 0029862190 scopus 로고    scopus 로고
    • Opposing motor activities are required for the organization of the mammalian mitotic spindle pole
    • 48. Gaglio T, Saredi A, Bingham JB, Hasbani J, Gill SR, Schroer TA, Compton DA: Opposing motor activities are required for the organization of the mammalian mitotic spindle pole. J Cell Biol 1996, 135:399-414. Single, double and triple immunodepletions of the proteins NuMA, Eg5, cytoplasmic dynein and dynactin from mitotic HeLa extracts demonstrate that, during aster formation, minus-end-directed forces generated by dynein and in association with NuMA oppose the plus-end-directed forces of Eg5.
    • (1996) J Cell Biol , vol.135 , pp. 399-414
    • Gaglio, T.1    Saredi, A.2    Bingham, J.B.3    Hasbani, J.4    Gill, S.R.5    Schroer, T.A.6    Compton, D.A.7
  • 49
    • 0029905303 scopus 로고    scopus 로고
    • Mammalian-cells express 3 distinct dynein heavy-chains that are localized to different cytoplasmic organelles
    • 49. Vaisberg EA, Grissom PM, McIntosh JR: Mammalian-cells express 3 distinct dynein heavy-chains that are localized to different cytoplasmic organelles. J Cell Biol 1996, 133:831-842.
    • (1996) J Cell Biol , vol.133 , pp. 831-842
    • Vaisberg, E.A.1    Grissom, P.M.2    McIntosh, J.R.3
  • 51
    • 0027385963 scopus 로고
    • How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: Analysis using a Monte Carlo computer simulation
    • 51. Gliksman NR, Skibbens RV, Salmon ED: How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation. Mol Biol Cell 1993, 4:1035-1050.
    • (1993) Mol Biol Cell , vol.4 , pp. 1035-1050
    • Gliksman, N.R.1    Skibbens, R.V.2    Salmon, E.D.3
  • 52
    • 0027372852 scopus 로고
    • Regulation of microtubule dynamics
    • 52. Cassimeris LU: Regulation of microtubule dynamics. Cell Motil Cytoskeleton 1993, 26:275-281.
    • (1993) Cell Motil Cytoskeleton , vol.26 , pp. 275-281
    • Cassimeris, L.U.1
  • 53
    • 0030031999 scopus 로고    scopus 로고
    • XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
    • 53. Walczak CE, Mitchison TJ, Desai A: XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 1996, 84:37-47. XKCM1 was the first endogenous regulator of catastrophe to be identified, and is a kinesin-related protein. Immunodepletion of XKCM1 from cell extracts inhibits spindle assembly and results in the formation of dense asters with longer microtubules than in control extracts. Analysis of single microtubule dynamics shows that immunodepletion of XKCM1 reduces the number of catastrophes in M-phase extracts fourfold.
    • (1996) Cell , vol.84 , pp. 37-47
    • Walczak, C.E.1    Mitchison, T.J.2    Desai, A.3
  • 54
    • 0030048731 scopus 로고    scopus 로고
    • Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules
    • 54. Belmont LD, Mitchison TJ: Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell 1996, 84:623-631. A protein was identified in a screen for heat-stable proteins that induce microtubule catastrophe in vitro. Cloning revealed that the isolated catastrophe factor is Op18/stathmin, a protein that is found at increased concentrations in some types of cancer cells.
    • (1996) Cell , vol.84 , pp. 623-631
    • Belmont, L.D.1    Mitchison, T.J.2
  • 55
  • 56
    • 0024369644 scopus 로고
    • Polewards microtubule flux in the mitotic spindle: Evidence from photoactivation of fluorescence
    • 56. Mitchison TJ: Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. J Cell Biol 1989, 109:637-652.
    • (1989) J Cell Biol , vol.109 , pp. 637-652
    • Mitchison, T.J.1
  • 57
    • 0026722242 scopus 로고
    • Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis
    • 57. Mitchison TJ, Salmon ED: Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J Cell Biol 1992, 119:569-582.
    • (1992) J Cell Biol , vol.119 , pp. 569-582
    • Mitchison, T.J.1    Salmon, E.D.2
  • 58
    • 0028278804 scopus 로고
    • Microtubule flux in mitosis is independent of chromosomes, centrosomes and antiparallel microtubules
    • 58. Sawin KE, Mitchison TJ: Microtubule flux in mitosis is independent of chromosomes, centrosomes and antiparallel microtubules. Mol Biol Cell 1994, 5:217-226.
    • (1994) Mol Biol Cell , vol.5 , pp. 217-226
    • Sawin, K.E.1    Mitchison, T.J.2
  • 59
    • 0029836707 scopus 로고    scopus 로고
    • The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
    • 59. Waters JC, Mitchison TJ, Rieder CL, Salmon ED: The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol Biol Cell 1996, 7:1547-1558. During both metaphase and anaphase, the drug taxol is shown to preferentially stabilize microtubule plus ends at the kinetochore, whereas minus-end depolymerization persists. Under these conditions, in which microtubule poleward flux continues but sister kinetochore motility is inhibited, the centromeres are stretched to the same extent as in control cells.
    • (1996) Mol Biol Cell , vol.7 , pp. 1547-1558
    • Waters, J.C.1    Mitchison, T.J.2    Rieder, C.L.3    Salmon, E.D.4
  • 60
    • 0014594112 scopus 로고
    • Chromosome micromanipulation III. Spindle fiber tension and the reorientation of mal-oriented chromosomes
    • 60. Nicklas RB, Koch CA: Chromosome micromanipulation III. Spindle fiber tension and the reorientation of mal-oriented chromosomes. J Cell Biol 1969, 43:40-50.
    • (1969) J Cell Biol , vol.43 , pp. 40-50
    • Nicklas, R.B.1    Koch, C.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.