Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH

EMBO Journal

Volumn 16, Issue 5, 1997, Pages 1093-1102

  Marinoni, Jean Christophe ^c   Roy, Richard ^c   Vermeulen, Wim ^a   Miniou, Pierre ^b   Lutz, Yves ^c   Weeda, Geert ^a   Seroz, Thierry ^c   Gomez, Denise Molina ^b   Hoeijmakers, Jan H J ^a   Egly, Jean Marc ^c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c NONE

Author keywords

DNA repair; p52; TFIIH; TFIIH subunits localization; Transcription

Indexed keywords

PROTEIN SUBUNIT; TRANSCRIPTION FACTOR;

ARTICLE; COCKAYNE SYNDROME; CONTROLLED STUDY; DNA REPAIR; DNA TRANSCRIPTION; EXCISION REPAIR; GENE STRUCTURE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRICHOTHIODYSTROPHY; XERODERMA PIGMENTOSUM;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; CLONING, MOLECULAR; DNA REPAIR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FUNGAL PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRANSCRIPTION FACTOR TFIID; TRANSCRIPTION FACTOR TFIIH; TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS, TFII; TRANSCRIPTION, GENETIC;

EID: 0031048846     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.5.1093     Document Type: Article

References (37)

1. Adamczewski, J., Rossignol, M., Tassan, J.P., Nigg, E., Moncollin, V. and Egly, J.M. (1996) MAT1, cdk7 and cyclin H form a kinase complex which is UV light sensitive upon association with TFIIH. EMBO J., 15, 1877-1884.
2. Bhatia, P., Wang, Z. and Friedberg, E.C. (1996) DNA repair and transcription. Curr. Opin. Genet. Dev., 6, 146-150.
3. Bootsma, D. and Hoeijmakers, J.H.J. (1993) DNA repair. Engagement with transcription. Nature, 363, 114-115.
4. Boulikas, T. (1994) Putative nuclear localization signals (NLS) in protein transcription factors. J. Cell Biochem., 55, 32-58.
5. Broughton, B.C. et al. (1995) Molecular and cellular analysis of the DNA repair defect in a patient with xeroderma pigmentosum complementation group D with the clinical features of xeroderma pigmentosum and Cockayne syndrome. Am. J. Hum. Genet., 56, 167-174.
6. Chalut, C., Gallois, Y., Poterszman, A., Moncollin, V. and Egly, J.M. (1995) Genomic structure of the human TATA-box binding protein. Gene, 61, 277-282.
7. Mo15 catalytic subunit of cdk-activating kinase. Oncogene, 9, 3127-3138.
8. Devault, A., Martinez, A., Fesquet, D., Labbé, J., Morin, N., Tassan, J.P., Nigg, E., Cavadore, J.C. and Dorée, M. (1995) MAT1 ('ménage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J., 14, 5027-5036
9. Drapkin, R., Reardon, J.T., Ansari, A., Huang, J.C., Zawel, L., Ahn, K.J., Sancar, A. and Reinberg, D. (1994) Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature, 368, 769-772.
10. Feaver, W.J., Svejstrup, J.Q., Henry, N.L. and Kornberg, R.D. (1994) Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK. Cell, 79, 1103-1109.
11. Fischer, L., Gérard, M., Chalut, C., Lutz, Y. Humbert, S., Kanno, M., Chambon, P. and Egly, J.M. (1992) Cloning of the 62-kilodalton component of basic transcription factor BTF2. Science, 257, 1392-1395.
12. Fisher, R. and Morgan, D. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell, 78, 713-724.
13. Gardiner-Garden, M. and Frommer, M. (1987) CpG islands in vertebrate genomes. J. Mol. Biol. 196, 261-282.
14. Gérard, M., Fisher, L., Moncollin, V., Chipoulet, J.M., Chambon, P. and Egly, J.M. (1991) Purification and interaction properties of the human RNA polymerase B (II) general transcription factor BTF2. J. Biol. Cell., 266, 20940-20945.
15. Hansson, J. and Wood, R.D. (1989) Repair synthesis by human cell extracts in DNA damaged by cis- and trans-diamminedichloroplatinum(II). Nucleic Acids Res., 17, 8073-8091.
16. Heng, H., Xiao, H., Shi, X.M., Greenblatt, J. and Tsui, L.C. (1993) Genes encoding general initiation factors for RNA polymerase II are dispersed in the human genome. Hum. Mol. Genet., 3, 61-64.
17. Hoeijmakers, J.H.J., Egly, J.M. and Vermeulen, W. (1996) TFIIH: a key component in multiple DNA transactions. Curr. Opin. Genet. Dev., 6, 26-33.
18. Humbert, S., van Vuuren, H., Lutz, Y., Hoeijmakers, J.H.J., Egly, J.M. and Moncollin, V. (1994) p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. EMBO J., 13, 2393-2398.
19. Kozak, M. (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell, 44, 283-292.
20. Lefebvre, S. et al. (1995) Identification and characterization of spinal muscular atrophy-determining gene. Cell, 80, 155-165.
21. Mohrenweiser, H.W., Carrano, A.V. Fertitta, A., Perry, B., Thompson, L.H., Tucker, J.D. and Weber, C.A. (1989) Refined mapping of the three DNA repair genes ERCC1, ERCC2, and XRCC1, on chromosome 19. Cytogenet. Cell Genet., 52, 11-14.
22. Morgan, D.O. (1995) Principles of CDK regulation. Nature, 374, 131-134.
23. Nigg, E. (1996) Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? Curr. Opin. Cell Biol., 8, 312-317
24. Otevrel, T. and Stamato, T.D. (1995) Regional localization of the XRCC4 human radiation repair gene. Genomics, 27, 211-214.
25. Roy, R., Schaeffer, L., Humbert, S., Vermeulen, W., Weeda, G. and Egly, J.M. (1993) The DNA-dependent ATPase activity associated with the class II transcription factor BTF2/TFIIH. J. Biol. Chem., 269, 9826-9832.
26. Roy, R., Adamczewski, J., Seroz, T., Vermeulen, W., Tassan, J.P., Schaeffer, L., Hoeijmakers, J.H.J. and Egly, J.M. (1994) The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell, 79, 1093-1101.
27. Schaeffer, L. Moncollin, V., Roy, R., Staub, A., Mezzina, M., Sarasin, A., Weeda, G., Hoeijmakers, J.H.J. and Egly, J.M. (1994) The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. EMBO J., 13, 2388-2392.
28. Stefanini, M. et al. (1993) A new nucleotide-excision repair gene associated with the disorder trichothiodystrophy. Am. J. Hum. Genet., 53, 817-821.
29. Sung, P., Bailly, V., Weber, C., Thompson, L., Prakash, L., and Prakash, S. (1993) Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature, 365, 852-855.
30. Svejstrup, J.Q., Vichi, P. and Egly, J.M. (1996a) The multiple roles of transcription/repair factor TFIIH. Trends Biol. Sci., 249, 346-350.
31. Svejstrup, J.Q., Feaver, W.J. and Kornberg, R.D. (1996b) Subunits of yeast RNA polymerase II transcription factor TFIIH encoded by the CCL1 gene. J. Biol. Chem., 271, 643-645.
32. Tassan, J.P., Jaquenoud, M., Fry, A., Frutiger, S., Hughes, G. and Nigg, E. (1995) In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J., 14, 5608-5617.
33. Vermeulen, W. et al. (1994a) Three unusual repair deficiencies associated with transcription factor BTF2 (TFIIH). Evidence for the existence of a transcription syndrome. Cold Spring Harbor Symp. Quant. Biol., 59, 317-329.
34. Vermeulen, W. et al. (1994b) Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3. Am. J. Hum. Genet., 54, 191-200.
35. Viegas-Péquignot, E., Dutrillaux, B., Magdelenat, H. and Coppey-Moisan, M. (1989) Mapping of single-copy DNA sequences on human chromosomes by in situ hybridization with biotinylated probes: enhancement of detection sensitivity by intensified-fluorescence digital imaging microscope. Proc. Natl Acad. Sc. USA, 86, 582-586.
36. Wang, Z., Buratowski, S., Svejstrup, J.Q., Feaver, W.J., Wu, X., Kornberg, R.D., Donahue, T.F. and Friedberg, E.C. (1995) The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and polymerase II transcription. Mol. Cell. Biol., 15, 2288-2293.
37. Weeda, G., Wiegant, J., van der Ploeg, M., Geurts van Kessel, A., van der Eb, A. and Hoeijmakers, J.H.J. (1991) Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21. Genomics, 10, 1035-1040.