Immunochemical and immunohistochemical localization of Bcl-x protein in the rat central nervous system

Brain Research

Volumn 712, Issue 2, 1996, Pages 281-286

  Mizuguchi, Masashi ^a,b   Sohma, Osamu ^a   Takashima, Sachio ^a   Ikeda, Kazuhiko ^b   Yamada, Mitsunori ^c   Shiraiwa, Nobuko ^d   Ohta, Shigeo ^d,e  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

^e NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

apoptosis; development; glial cell; immunohistochemistry; neuron; Western blotting

Indexed keywords

BRAIN PROTEIN;

ADOLESCENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; EMBRYO; FETUS; GLIA CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029966521     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01453-5     Document Type: Article

References (31)

1. Abe-Dohmae, S., Harada, N., Yamada, K. and Tanaka, R., bcl-2 gene is highly expressed during neurogenesis in the central nervous system, Biochem. Biophys. Res. Commun., 191 (1993) 915-921.
2. Boise, L.H., González-García, M., Postema, C.E., Ding, L., Lindsen, T., Turka, L.A., Mao, X., Nuñez, G. and Thompson, C.B., bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death, Cell, 74 (1994) 597-608.
3. Chittenden, T., Harrington, E.A., O'Conner, R., Flemington, C., Lutz, R.J., Evan, G.I. and Guild, B.C., Induction of apoptosis by the Bcl-2 homologue Bak, Nature, 374 (1995) 733-736.
4. Fang, W., Rivard, J.J., Mueller, D.L. and Behrens, T.W., Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes, J. Immunol., 153 (1994) 4388-4398.
5. Farrow, S.N., White, J.H.M., Martinou, I., Raven, T., Pun, K.-T., Grinham, C.J., Martinou, J.-C. and Brown, R., Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K, Nature, 374 (1995) 731-733.
6. Ferrer, I., Tortosa, A., Condom, E., Blanco, R., Macaya, A. and Planas, A., Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat, Neurosci. Lett., 179 (1994) 13-16.
7. L is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria, Development, 120 (1994) 3033-3042.
8. Gottschlak, A.R., Boise, L.H., Thompson, C.B. and Quintans, J., Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not by bcl-2, Proc. Natl. Acad. Sci. USA, 91 (1994) 7530-7534.
9. Halder, S., Jena, N. and Croce, C.M., Inactivation of Bcl-2 by phosphorylation, Proc. Natl. Acad. Sci. USA, 92 (1995) 4507-4511.
10. Hockenbery, D.M., Zutter, M., Hickey, W., Nahm, M. and Korsmeyer, S.J., BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death, Proc. Natl. Acad. Sci. USA, 88 (1991) 6961-6965.
11. Kiefer, M.C., Brauer, M.J., Powers, V.C., Wu, J.J., Umansky, S.R., Tomei, L.D. and Barr, P.J., Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak, Nature, 374 (1995) 736-739.
12. Kozopas, K.M., Yang, T., Buchan, H.L., Zhou, P. and Craig, R.W., MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence homology to BCL2, Proc. Natl. Acad. Sci. USA, 90 (1993) 3516-3520.
13. Krajewski, S., Krajewska, M., Shabaik, A., Wang, H.-G., Irie, S., Fong, L. and Reed, J.C., Immunohistochemical analysis of in vivo patterns of Bcl-x expression, Cancer Res., 54 (1994) 5501-5507.
14. LeBrun, D.P., Warnke, R.A. and Cleary, M.L., Expression of bcl-2 in fetal tissues suggests a role in morphogenesis, Am. J. Pathol., 142 (1993) 743-753.
15. Lin, E.Y., Orlofsky, A., Berger, M.S. and Prystowsky, M.B., Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2, J. Immunol., 151 (1993) 1979-1988.
16. Merry, D.E., Veis, D.J., Hickey, W.F. and Korsmeyer, S.J., bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS, Development, 120 (1994) 301-311.
17. Mizuguchi, M., Ikeda, K., Asada, M., Mizutani, S. and Kamoshita, S., Expression of Bcl-2 protein in murine glial cells in culture, Brain Res., 649 (1994) 197-202.
18. Mizuguchi, M., Ikeda, K., Kim, S.U., Differential distribution of cellular forms of β-amyloid precursor protein in murine glial cell cultures, Brain Res., 584 (1992) 219-225.
19. Mizuguchi, M., Ikeda, K., Namba, Y. and Kim, S.U., Alzheimer's disease β-amyloid precursor protein in rat neural cells in culture, Gerontology, 38 (1992) S15-S23.
20. Mizuguchi, M., Yamada, M., Kim, S.U. and Rhee, S.G., Phospholipase C isozymes in neurons and glial cells in culture: an immunocytochemical and immunochemical study, Brain Res., 548 (1991) 35-40.
21. Motoyama, N., Wang, F., Roth, K.A., Sawa, H., Nakayama, K.-I., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S. and Loh, D.Y., Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice, Science, 267 (1995) 1506-1510.
22. Nakayama, K., Nakayama, K.-I., Negishi, I., Kuida, K., Sawa, H. and Loh, D.Y., Targeted disruption of Bcl-2αβ in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia, Proc. Natl. Acad. Sci. USA, 91 (1994) 3700-3704.
23. Novack, D.V. and Korsmeyer, S.J., Bcl-2 protein expression during murine development, Am. J. Pathol., 145 (1994) 61-73.
24. Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolg, Bax, that accelerates programmed cell death, Cell, 74 (1993) 609-619.
25. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L.H., Thompson, C.B., Golemis, E., Fong, L., Wang, H.-G. and Reed, J.C., Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system, Proc. Natl. Acad. Sci. USA, 91 (1994) 9238-9242.
26. Selkoe, D.J., Podlinski, M.B., Joachim, C.L., Vickers, E.A., Lee, G., Fritz, L.C. and Oltersdorf, T., β-Amyloid precursor protein of Alzheimer's disease occurs as 110-to 135-kilodalton membrane associated proteins in neural and nonneural tissues, Proc. Natl. Acad. Sci. USA, 85 (1988) 7341-7345.
27. Shiraiwa, N., Mizusawa, H., Shoji, S., Yuzaki, M., Inohara, N. and Ohta, S., Cloning of genes related to apotosis-inhibiting bcl-2 gene (Abstr.), In: Proceeding for the 35th Annual Meeting of the Japanese Neurologic Society, Japanese Neurologic Society, Fukuoka, 1994, p. 247.
28. Sohma, O., Mizuguchi, M., Takashima, S., Yamada, M. Ikeda, K. and Ohta, S., High expression of Bcl-x protein in the developing human cerebellar cortex, J. Neurosci. Res., in press.
29. Veis, D.J., Sorenson, C.M., Shutter, J.R., Korsmeyer, S.J., Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair, Cell, 75 (1993) 229-240.
30. L and Bcl-2, displaces Bax and promotes cell death, Cell, 80 (1995) 285-291.
31. Yin, X.-M., Oltvai, Z.N. and Korsmeyer, S.J., BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax, Nature, 369 (1994) 321-323.