V-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells

Cell Death and Differentiation

Volumn 4, Issue 1, 1997, Pages 82-93

  Glassman, Robert H ^a   Hempstead, Barbara L ^a   Staiano Coico, Lisa ^b   Steiner, Melissa G ^b   Hanafusa, Hldesaburo ^a   Birge, Raymond B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Bcl 2; MAP kinase; Nerve growth factor; Sh2 and SH3 containing adaptor proteins; TrkA receptor tyrosine kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; ONCOGENE SRC; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION;

EID: 0031032348     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400203     Document Type: Article

References (51)

1. Barde Y (1989) Trophic factors and neuronal survival. Neuron 2:1525-1534
2. Bertrand R, Solary E, O'Connor P, Kohn K and Pommier Y (1994) Induction of a common pathway of apootosis by sîaurosporme. Expérimentai Ce!-. Res. 211 : 314-321
3. Bissonnetts R, Echeverri F, Mahboudi A and Green D (1992) Apoptoîic cell dea:h induced oy c-myc is inhibited by bcl-2. Nature 359: 552-554
4. Borasio GD, Markus A, Wittingnofer A, Sarde YAand Heumann R (1993) Involvement of ras p21 in rteurotropan-induced response of sensory, but rot sympathetic neurons. J. Cell B,ol. 121: 665-672
5. cdc2 kinases ir. PCI2 pneocnromocytoma ceils. Molecular Biol. Cell 5:1225-1241
6. Cantley L, Auger K, Carpenter C, Duckworfh B, Graziani A, Kapeiler R and Soltoff S (1991 ) Oncogenes and signal transduction. Cell 64:281 -302
7. Estus S, Zaks WJ, Freeman RS, Gruca M, Bravo R and Johnson EM (1994) Altered gene expression in neurons during programmed ce! death: identification of c-X; ss necessary for neuronal apoptosis. Journal Cell. Bio-.. 127:1717-1727
8. Evan G, Wyliie A, Gilbert C, Littlewooa T, Lard H, Brooks M, Waters C, Penn L and Hancock D (1S92) l.ia.otion of apoptosis in fibrcblasts by c-nyc protein. Cell 69: 119-128
9. Path I, Schweighoffer F, fley I, Multon M-C, Boiziau J, Ducnesne M and Tocque B (1994) Cloning of a Grb2 isoforrn with apoptotic properties. Science 264: 971-974
10. Ferrari G, Anderson B, Stephens H, Kaplan D and Greene L (1995) Prevention of apoptotic neuronal death by GM1 ganglioside. J. Bio!. Cnem. 270:3074-3080
11. Ferrari G and Greene LA (1994) Proliferate inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 celis from apoptotic death. EMBOJ. 13:5922-5928
12. Freeman RS, Estus S and Johnson EM (1894) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin 01 during programmed ceil death. Neuron 12: 343-355
13. Garcia I, Martinou I, Tsujimoto Y and Martinou J (1992) Prevention of programmed ce,I death of sympathetic neurons by the bcl-2 proto-oncogsne. Science 258: 302-304
14. Geer Pvd and Pawson T (1995) The PTB: a new protein module implicated in signal transduciion. TIBS 20:277-280
15. Gomez-Piniila F, Knauer DJ and Kieto-Sampedro M (1988) Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization. Brain Res. 438:385-390
16. Gonzalex-Garcia M, Garcia I, Ding L, O'Shea S, Boise LH, Thompson CB and Nunez G {1995) bci-x is expressed in embryonic and postnatal tissues and functions to prevent neuronal cell death. Proc. Nati. Acad. Sei. USA 92:4304-4308
17. Greene L and Tischler A (1976) Establishment of a noradrenergic clonal line of rat adrenal phecchromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sei. USA 73:2424-2428
18. Greene L and Tischler A (1982) PC12 pneochromocytorna cultures in neurobiological research. Adv. Celi. Neurobio!. 3:373-414
19. Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M and Rubin LL (1995) A cJun dominant negative mutant protects sympathetic neurons againsi programmed cell death. Neuron 14:927-939
20. Hempstead BL, Birge RB, Fajardo JE, Glassman R, Mahaceo D, Kraemer R and Hanafusa H (1994) Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. Mol. Cell. Biol. 14:1964-1971
21. Hempstead BL, Rabin SJ, Kaplan L field S, Parada LF and Kaplan DR (1992) Overexpression of the irk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9:883-896
22. Johnson NL, Gardner AM, Diener KM, Lange-Carter C;A, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI and Johnson GL (1996) Signai transduction pathways regulated by mitogeri-actlvated/extracellular response kinase induced ceil deatn. J. Bici. Cnem. 271:3229-3237
23. Kaplan D, Hempstead B, Mariin-Zanca D, Chac M and Parada L (1991) The trk protooncogene product: a signal transducing receptor for nerve growth factor. Science 252: 554-558
24. Kaplan D and Stephens H (1994) Neurotrophin signal transduction ay the trk receptor. J. Neurobiol. 25:1404 -1417
25. Klein R, Jing S, Nanduri V, O'Rourke E and Barbacid M (1991) The trk protooncogene encodes a receptor for nerve growth factor. Celi 65:189-197
26. Kranenburg O, v a Eb AJ and Zantema A (1996) Cyclin D is an essentiai mediator of apoptotic neuronal cell deatn. EMBO J. 15:46-54
27. Llndenboim L, Diamond R, Rothenberg E and Stein R (1995) Apoptosis induced by serum deprivation of PC12 cells ;S not proceeded dy growth arrest and can occ j,r at each phase of the cell cycle. Cancer Res. 55:1242 -1247
28. Loeb DM and Greene LA (1993) ; ransfection with trk restores 'slow' MGF binding, efficient NGF uptake, sndrnJtipieNGFrespo rises TO NGF-nor.respcnsive PCI 2 ceii mutants. J. Neuroscience 13:2919-2929
29. Lowe SW, Ruley HE, Jacks T and Nous DE 0993) p53-dependent apoptosis mocuates the cy;ctcxici;y of anticancer agents. Celi 74: S57 -967
30. Mah S, Zhong LT, Liu Y, Roghani A, Edwards R and Bredesen D (1993) The protooncogene bcl-2 innibits apoptosis in PC12 ceils. J. Nearochem. SO: 1163-1136
31. Matsuda M, Hashimoto Y, Muroya K, Hasegawa H, Kurafe T, Tanaka S, Nakamura S and rlattori S (1994) CRK proiein binds tc tv/o guanine nucleotide-re.easing proteins forthe Ras family and modulates nerve growth factor-induced activation of Ras ir. PC12 cells. Mol. Cell. B;cl. 14: 5495-550C
32. Mayer B Hamaguchi M and hanafusa H (1988) A novel virai cncoçene with structural similarity to pnospholipase C. Nature 332: 272-275
33. Meikrantz W, Gisseibracht S; Tarn SW anc Schlegel R (1994) Activation of cyclin A-dependent protein xhases auring apoptosis. ?roc. Nati. Acad. Sei. USA 91: 3754-3758
34. Mesner P, Winters T and Green S (1992) Nerve growth factorwiihdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J. Cell. Biol. 119:1669-1680
35. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K-i, Nakayama K, Negishi I, Senju S, Zhsng Q, Fuji S and Lon DY (1995) Massive ceil Death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267: 1505-1510
36. Nicholson DW, Aii A, Thcrnberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin P, Labella M, Lazebnik YA, Munday MA, Raju SM, Smulson ME, Yarrun T-T, Yu VL and Milier DK (1995) Identification ana inhibiiicn of ;he ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37 - 43
37. Ooermeier A, Sradshaw H, Seedorf K, Choedas A, Schlessinger J and Ullrich A (1994) Neuronal differentiation signals are controlled by nerve growth iactor receptor/Trk binding sites for SHC and PLC-gamma. EMBOJ. 13:1585-1590
38. Park D and Rhee S (1992) Phosphoryiauon of Nek in response to a variety of receptors, phorbo' myristate acetaie and cyclic AMP. Mol. Cell. Biol. 12:5816-5823
39. Reichman C, Mayer B, Keshav S and Hanafusa H (1992) The product of the cellular crk gene consists primarily of SH2 and SH3 regions. Celi Growth Differ. 3:451-460
40. Ren R, Mayer BJ, Cicchetti P and Baltimore D (1993; identification of a 10-amino acia proline-rich SH3 binding site. Science 259:1157-1161
41. Rozakis-Adcock M, McGlade J, Mbamalu B, Peiicci G, Daiy R, Li W, Batzer A, Thomas S, Brugge J, PeJcci P, Schlessinger J and PawscnT (1992) Association or the She and Grb2/Sem5 Sh2-conlaining proteins is implicated in activation of the Ras patnway by tyrosine kirases. Nature 360:669-692
42. Rubin L Philpott K and Brooks S (1993; The cell cycle ana cell death. Current 3ioi. 3: 391-394
43. Rudkin SB, Lazarovici P, Levi B, Abe Y, Fujita K and Guroff G (1989) Ceil cydespscific action, of nerve growth factor in PCI 2 ce.Is: differentiation without proliferation. EMBO J. 8: 3319-3325
44. Rukensteh A, Rydel R and Greeie L (1991} Multiple agents rescue PC12 cells from serum-free ceil deatn by translation- and transcription-independent mechanisms. J. Neuroscience 11:2552 - 2563
45. Sato N, Hotta K, Waguri S, Nitatori T, Tonyarna K, Tsujimoto Y and Uchiyama Y (199) Neuronal differentiation of PC12 cells as a result of prevention of ceil death by ocl-2. J. Neurobiol.25:1227-1234
46. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA and Kaplan DR (1994) Trk receptors use redundant signai transduction pathways involving SHC and PLC-gammato mediate NGF responses. Neuron. 12:691 -705
47. Teng KK, tanaers M, Fajardo J E, Hanafusa H, Hempstead BL and Birge RB (1995) vCrk modulation of grew th factor-induced PC12 cell differentiation invcives the src nomoiogy 2 domain of v-Crk and sustained activation of the Ras/Mitogenactivated protein kinase pathway. J. Biol. Charn. 270: 20677-20685
48. Thoenen H and Barde YA (198C) Physiology of nerve growth factor. Physiology Rev. 60:1284-1335
49. Tucker M, Eves EM, Wainer BH and Rosner MR (1994) Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines. J. of Neurochem. 61:1376-1387
50. XiaZ, Dicksrs M, Raingeaud J, Davis R and Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosls. Science 270:1326-1331
51. Yao R and Cooper GM (1995) Requirement for phosphatitiylmositoi-3 kinase in prevention of apoptosis oy NGF. Science 267:2003-2006