Neuronal differentiation of PC12 cells as a result of prevention of cell death by bcl‐2

Journal of Neurobiology

Volumn 25, Issue 10, 1994, Pages 1227-1234

  Sato, Noboru ^a   Hotta, Kazuhiko ^a   Waguri, Satoshi ^a   Nitatori, Tohru ^a   Tohyama, Koujiro ^a   Tsujimoto, Yoshihide ^b   Uchiyama, Yasuo ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

bcl 2; cell death; neuronal differentiation; PC12; transfection

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; GENETIC TRANSFECTION; MESSENGER RNA SYNTHESIS; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0028048704     PISSN: 00223034     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/neu.480251005     Document Type: Article

References (35)

1. The proto‐oncogene bcl‐2 can selectively rescue neurotrophic factor ‐dependent neurons from apoptosis
2. Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
3. Microinjection of the rat oncogene protein into PC12 cells induces morphological differentiation
4. Aurinitricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity
5. Internucleosomal DNA cleavage and neuronal cell survival/death
6. Bcl‐2 affects survival but not neuronal differentiation of PC12 cells
7. High‐efficiency transformation of mammalian cells by plasmid DNA. Mol.
8. Single‐step method of RNA isolation by acid guanidinium thiocyanate‐phenol‐chloroform extraction
9. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
10. Bcl‐2 associates with the ras‐related protein R‐ras p23
11. Prevention of programmed cell death of sympathetic neurons by the bcl ‐2 proto‐oncogene
12. PC12 pheochromocytoma cultures in neurobiological research
13. Bcl‐2 function in an antioxidant pathway to prevent apoptosis
14. The slow component of axonal transport: identification of major structural polypeptides of the axon and their generality among mammalian neurons
15. Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation
16. Bcl‐2 bloks apoptosis in cells lacking mitochondrial DNA
17. Bcl‐2 inhibition of neural death: Decreased generation of reactive oxygen species
18. Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament protein in PC12 cells
19. Transcriptional and post‐transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC12 cells
20. The protooncogene bcl ‐2 inhibits apoptosis in PC12 cells
21. Inhibition of protein synthesis and RNA synthesis prevent neuronal cell death caused by nerve growth factor deprivation
22. Bcl‐2 protein expression is widespread in the developing nervous system and retained in the adult PNS
23. Nerve growth factor withdrawal‐induced cell death in neuronal PC12 cells resembles that in sympathetic neurons
24. Prorenin is sorted into the regulated secretory pathway independent of its processing to renin in mouse pituitary AtT‐20 cells
25. Sarcoma viruses carrying ras oncogenes induce differentiation‐associated properties in a neuronal cell line
26. Deregulated bcl ‐2 gene expression selectively prolongs survival of growth factor‐deprived hemopoietic cell lines
27. A system for characterizing cellular and molecular events in programmed neuronal cell death
28. Multiple agents rescue PC12 cells from serum‐free cell death by translation‐ and transcription‐independent mechanisms
29. bcl ‐2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
30. bcl ‐2 transgene inhibits T cell death and perturbs thymic self‐censorship
31. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
32. Stress‐resistance conferred by high level of bcl ‐2a protein in human B lymphoblastoid cells
33. Analysis of the structure, transcripts and protein product of bcl ‐2, the gene involved in human follicular lymphoma
34. bcl ‐2 gene promotes haemopoietic cell survival and co‐operates with c‐myc to immortalize pre‐B cells