Effects of prenatal ethanol exposure on brain region NMDA-mediated increase in intracellular calcium and the NMDAR1 subunit in forebrain

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 1, 1997, Pages 68-75

  Spuhler Phillips, Karen ^a,c   Lee, Young Hee ^a   Hughes, Peter ^b   Randoll, Lynne ^b   Leslie, Steven W ^c  

^a Division of Pharmacology and Toxicology   (United States)

^b Institute for Neuroscience   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Brain Regions; Dissociated Neurons; NMDA Receptor Complex; NMDAR1 Subunit; Prenatal Ethanol Exposure

Indexed keywords

GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CEREBELLUM; CONTROLLED STUDY; FEMALE; FOREBRAIN; HIPPOCAMPUS; MALE; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; WEIGHT GAIN;

ANIMALIA;

EID: 0031025890     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb03730.x     Document Type: Article

References (69)

1. Cotman CW, Kahle JS, Miller SE, Ulas J, Bridges RJ: Excitatoiy amino acid transmission, in Bloom FE, Kupfer DJ (eds): Psychopharmacology: The Fourth Generation of Progress. New York, Raven Press, 1995, pp 75-85
2. Daw NW: The role of NMDA receptors in information processing. Annu Rev Neurosci 16:207-222, 1993
3. Hollmann M, Heinemann S: Cloned glutamate receptors. Annu Rev Neurosci 17:31-108, 1994
4. Mori H, Mishina M: Structure and function of the NMDA receptor channel. Review: Neurotransmitter receptors VIII. Neuropharmacology 34:1219-1237, 1995
5. Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY: Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature (Lond) 368:144-147, 1994
6. Zhong J, Carrozza DP, Williams K, Pritchett DB, Molinoff PB: Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 64:531-539, 1995
7. Zukin RS, Bennett MVL: Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends Neurosci 18:306-313, 1995
8. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540, 1994
9. Farrant M, Feldmeyer D, Takahashi T, Cull-Candy SO: NMDAreceptor channel diversity in the developing cerebellum. Nature (Lend) 368:335-339, 1994
10. Wang Y-H, Bosy TZ, Yasuda RP, Grayson DR, Vicini S, Pizzorusso T, Wolfe BB: Characterization of NMDA receptor subunit-specific antibodies: Distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J Neurochem 65:176-183, 1995
11. Leslie SW, Weaver MS: Sensitivity of NMDA receptors to acute and in utero ethanol exposure, in Ailing C (ed): Alcohol, Cell Membranes, and Signal Transduction in Brain. New York, Plenum Press, 1993, pp 97-106
12. Dildy-Mayfield JE, Harris RA: Comparison of ethanol sensitivity of rat brain kainate, DL-a-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 262:487-494, 1992
13. Randoll LA, Wilson WR, Weaver MS, Spuhler-Phillips K, Leslie SW: N-methyl-D-aspartate-stimulated increases in intracellular calcium exhibit brain regional differences in sensitivity to inhibition by ethanol. Alcohol Clin Exp Res 20:197-200, 1996
14. Simson PE, Criswell HE, Breese GR: Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: Evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses. Brain Res 607:9-16, 1993
15. Follesa P, Ticku MK: Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Mol Brain Res 29:99-106, 1995
16. Lovinger DM: Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: Relation to the actions of ifenprodil. J Pharmacol Exp Ther 274:164-172, 1995
17. Masood K, Wu C, Brauneis U, Weight FF: Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 45:324-329, 1994
18. Mirshahi T, Woodward JJ: Ethanol sensitivity of heteromeric NMDA receptors: Effects of subunit assembly, glycine and NMDAR1 Mg2+-insensitive mutants. Neuropharmacology 34:347-355, 1995
19. Trevisan L, Fitzgerald LW, Brose N, Gasic GP, Heinemann SF, Duman RS, Nestler EJ: Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem 62:1635-1638, 1995
20. Michaelis EK: Fetal alcohol exposure: Cellular toxicity and molecular events involved in toxicity. Alcohol Clin Exp Res 14:819-826, 1990
21. Charness ME, Safran RM, Perides G: Ethanol inhibits neural cell-cell adhesion. J Biol Chem 269:9304-9309, 1994
22. Marcussen BL, Goodlett CR, Mahoney JC, West JR: Developing rat Purkinje cells are more vulnerable to alcohol-induced depletion during differentiation than during neurogenesis. Alcohol 11:147-156, 1994
23. Miller MW: Generation of neurons in the rat dentate gyrus an'hippocampus: Effects of prenatal and postnatal treatment with ethanol. Alcohol Clin Exp Res 19:1500-1515, 1995
24. Miller MW, Kühn PE: Cell cycle kinetics in fetal rat cerebral cortex: Effects of prenatal treatment with ethanol assessed by a cumulative labeling technique with flow cytometry. Alcohol Clin E\p Res 19:233-237,1995
25. Miller MW, Robertson S: Prenatal exposure to ethanol alters the postnatal development and transformat' n of radial glia to astrocytes in the cortex. J Comp Neurol 337:253 .66, 1993
26. 26. Saunders DE, Zajac CS, Wappler NL: Alcohol inhibits neurite extension and increases N-myc and c-myc proteins. Alcohol 12:475-483, 1995
27. Smith DE, Davies DL: Effect of perinatal administration of ethanol on the CA1 pyramidal cell of the hippocampus and Purkinje cell of the cerebellum: an ultrastructural survey. J Neurocytol 19:708-717, 1990
28. Druse MJ: Effect of in utero ethanol exposure on the development of neurotransmitter systems, in Miller MW (ed): Development of the Central Nervous System Effects of Alcohol and Opiates. New York, Wiley-Liss, 1992, pp 139-167
29. Kater SB, Mills LR: Regulation of growth cone behavior by calcium. J Neurosci 11:891-899, 1991
30. Spitzer NC: Development of voltage-dependent and ligand-gated channels in excitable membranes, in van Pelt J, Corner MA, Uylings HBH, Lopes da Suva FH (eds): Progress in Brain Research, vol 102. New York, Elsevier, 1994, pp 169-179
31. Blanton MG, Kriegstein AR: Properties of amino acid neurotransmitter receptors of embryonic cortical neurons when activated by exogenous and endogenous agonists. J Neurophysiol 67:1185-1200, 1992
32. Hofer M, Constantine-Paton M: Regulation of N-methyl-D-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections, in van Pelt J, Corner MA, Uylings HBH, Lopes da Suva FH (eds): Progress in Brain Research, vol 102. New York, Elsevier, 1994, pp 277-285
33. Lee H, Choi BH: Density and distribution of excitatory amino acid receptors in the developing human fetal brain: A quantitative autoradiographie study. Exp Neurol 118:284-290, 1992
34. Rakic P, Komuro H: The role of receptor/channel activity in neuronal cell migration. J Neurobiol 26:299-315, 1995 f
35. Vogel MW, Prittie J: Purkinje cell dendritic arbors in chick embryos following chronic treatment with an N-methyl-D-aspartate receptor antagonist. J Neurobiol 26:537-552, 1995
36. Gould E, Cameron HA, McEwen BS: Blockade of NMDA receptors increases cell death and birth in developing rat dentate gyrus. J Comp Neurol 340:551-565, 1994
37. Rabacchi S, Bailly Y, Delhaye-Bouchaud N, Mariani J: Involvement of the N-methyl-D-aspartate (NMDA) receptor in synapse elimination during cerebellar development. Science (Washington, DC) 256:18231825, 1992
38. Aoki C, Venkatesan C, Go C-G, Mong JA, Dawson TM: Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats. J Neurosci 14:5202-5222, 1994
39. Savage DD, Montano CY, Otero MA, Paxton LL: Prenatal ethanol exposure decreases hippocampal NMDA-ser.sitive [3H]-glutamate binding site density in 45-day-old rats. Alcohol 8:i93-201, 1991
40. Savage DD, Queen SA, Sanchez CF, Paxton LL, Mahoney JC, Goodlett CR, West JR: Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring. Alcohol 9:37-41, 1992
41. Abdollah S, Brien JF: Effect of chronic maternal ethanol administration on glutamate and N-methyl-D-aspartate binding sites in the hippocampus of the near-term fetal guinea pig. Alcohol 12:377-382, 1995
42. Morrisett RA, Martin P, Wilson WA, Savage DD, Swartzwelder HS: Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate. Alcohol 6:415-420, 1989
43. Noble EP, Ritchie T: Prenatal ethanol exposure reduces the effects of excitatory amino acids in the rat hippocampus. Life Sei 45:803-810, 1989
44. Savage DD, Swartzwelder HS: Effects of perinatal ethanol exposure on hippocampal formation, in Watson RR (ed): Alcohol and Neurobiology: Brain Development and Hormone Regulation. New York, CRC Press, 1992, pp 171-200
45. Lee Y-H, Spuhler-Phillips K, Randall PK, Leslie SW: Effects of prenatal ethanol exposure on NMDA-mediated calcium entry into dissociated neurons. J Pharmacol Exp Ther 271:1291-1298, 1994
46. Weaver MS, Lee Y-H, Morris JL, Randall PK, Schauert T, Leslie SW: Effects of in vitro ethanol and fetal ethanol exposure on glutathione stimulation of N-methyl-D-aspartate receptor function. Alcohol Clin Exp Res 17:643-650, 1993
47. Diaz-Granados JL, Spuhler-Phillips K, Lilliquist MW, Amsel AA, Leslie SW: Comparisons of prenatal and/or early postnatal ethanol exposure effect on [3H]MK-801 binding in rat cortex and hippocampus. Alcohol Clin Exp Res 18:469, 1994
48. Vallès S, Felipo V, Montoliu C, Guerri C: Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus. Life Sei 56:1373-1383, 1995
49. Lieber CS, DeCarli LM: The feeding of alcohol in liquid diets: Two decades of applications and 1982 update. Alcohol Clin Exp Res 6:523-531, 1982
50. Lieber CS, DeCarli LM: Liquid diet technique of ethanol administration: 1989 update. Alcohol 24:197-211, 1989
51. Raizada MK, Morse CA, Gonzales RA, Crews FT, Summers C: Receptors for phorbol esters are primarily localized in neurons: Comparison of neuronal and glial culture. Neurochem Res 13:51-56, 1988
52. Dildy JE, Leslie SW: Ethanol inhibits NMDA-induced increase in free intracellular Ca2+ in dissociated brain cells. Brain Res 499:383-387, 1989
53. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450, 1985
54. Javitt DC, Zukin SR: Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain. Proc Natl Acad Sei USA 86:740-744, 1989
55. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Polin phenol reagent. J Biol Chem 193:265-275, 1951
56. Siegal SJ, Brose N, Janssen WG, Gasic GP, Jahn R, Heinemann SF, Morrison JH: Regional, cellular and ultrastructural distribution of Nmethyl-D-aspartate receptor 1 in monkey hippocampus. Proc Natl Acad Sei USA 91:564-568, 1994
57. Laemmli UK: Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685, 1970
58. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sei USA 76:4350-4354, 1979
59. Rogers SW, Hughes TE, Hollmann M, Gasic GP, Deneris ES, Heinemann SS: The characterization and localization of the glutamate receptor subunit GIuRl in the rat brain. J Neurosci 11:2713-2724, 1991
60. DeLean A, Munson PJ, Rodbard D: Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235:E97-E102,1978
61. Ratkowsky DA: Nonlinear Regression Modeling. A Unified Practical Approach. New York, Marcel Dekker, 1983
62. Constantine-Paton M: Effects of NMDA receptor antagonists on the developing brain. Psychopharmacol Bull 30:561-565, 1994
63. Koltchine V, Anantharam V, Wilson A, Bayley H, Treistman SN: Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci Lett 152:13-16, 1993
64. Kuner T, Schoepfer R, Korpi ER: Ethanol inhibits glutamateinduced currents in heteromeric NMDA receptor subtypes. NeuroReport 5:297-300, 1993
65. Chu B, Anantharam V, Treistman SN: Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem 65:140-148, 1995
66. Buller AL, Larson HC, Morrisett RA, Monaghan DT: Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol 48:717-723, 1995
67. Williams K, Russell SL, Shen YM, Molinoff PB: Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10:267-278, 1993
68. , 68. Laurie DJ, Seeburg PH: Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J Neurosci 14:31803194, 1994b
69. Senke D, Wenzel A, Scheuer L, Fritschy JM, Mohler H: Immunobiochemical characterization of the NMDA-receptor subunit NR1 in the developing and adult rat brain. J Recep Signal Transduc Res 15:393-411, 1995