Structure and function of the NMDA receptor channel

Neuropharmacology

Volumn 34, Issue 10, 1995, Pages 1219-1237

  Mori, H ^a   Mishina, M ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; MESSENGER RNA;

AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; ANIMAL TISSUE; BRAIN REGION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; ION CHANNELS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0028810883     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00109-J     Document Type: Review

References (140)

1. Selective modulation of NMDA responses by reduction and oxidation
2. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
3. Combinational RNA splicing alters the surface charge on the NMDA receptor
4. Calcium permeability of the channels activated by N-ethyl-D-aspartate (NMDA) in isolated mouse central neurones
5. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture
6. N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture
7. +-induced depolarization selectively promote the expression of an NMDA-preferring class of the ionotropic glutamate receptors in cerebellar granule neurones
8. Protein kinase C modulation of NMDA currents: an important link for LTP induction
9. +-induced depolarization and NMDA treatment
10. AMPA and kainate receptors
11. A synaptic model of memory: long-term potentiation in the hippocampus
12. Two calcium-activated chloride conductances in Xenopus laevis oocytes permeabilized with the ionophore A23187
13. Membrane fusion takes excitatory turn: syntaxin, vesicle docking protein, or glutamate receptor?
14. Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1
15. The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition
16. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor
17. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex
18. Immunological detection of the NMDAR1 glutamate receptor subunit expressed in human embryonic kidney 293 cells and in rat brain
19. Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule
20. Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid
21. 2+ block of NMDA-receptor channels as a mechanism of modulation
22. Glutamate neurotoxicity and diseases of the nervous system
23. -methyl-D-aspartate receptor antagonist desegregates eye-specific stripes
24. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
25. Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons
26. Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos
27. 2-amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
28. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
29. Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C
30. Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C
31. NMDA-receptor channel diversity in the developing cerebellum
32. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
33. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
34. Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings
35. Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus
36. Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans
37. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
38. Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse
39. Cloned glutamate receptors
40. Cloning by functional expression of a member of the glutamate receptor family
41. Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor
42. N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
43. Identification of a site in glutamate receptor subunits that controls calcium permeability
44. Cloning and expression of the ϵ4 subunit of the NMDA receptor channel
45. Reduced spontaneous activity of mice defective in the ϵ4 subunit of the NMDA receptor channel
46. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits
47. Glycine potentiates the NMDA response in cultured mouse brain neurons
48. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
49. Impairment of motor coordination, Purkinje cell synapse formation and cerebellar long-term depression in GluRδ2 mutant mice
50. Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes
51. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
52. Blockade of “NMDA” receptors disrupts experience-dependent plasticity of kitten striate cortex
53. Modulation of neuronal migration by NMDA receptors
54. NMDA receptor channels: subunit-specific potentiation by reducing agents
55. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex
56. Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus)
57. Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins
58. Molecular diversity of the NMDA receptor channel
59. Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA
60. Reduction of disulfide bonds activates NMDA-sensitive glutamate receptors in primary cultures of cerebellar granule cells
61. Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current
62. NMDA channel behavior depends on agonist affinity
63. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
64. 2+-dependent phosphatase
65. NMDA receptor activation and early olfactory learning
66. Ethanol inhibits NMDA-activated ion current in hippocampal neurons
67. Alternatively spliced isoforms of the N-methyl-D-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord
68. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
69. NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
70. Nitric oxide-induced blockade of NMDA receptors
71. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits
72. Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons
73. 2+ of NMDA responses in spinal cord neurones
74. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
75. Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes
76. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs
77. 2+ permeability of AMPA-selective glutamate receptor channels
78. Molecular and functional diversity of the NMDA receptor channel
79. Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine
80. Heteromeric NMDA receptors: molecular and functional distinction of subtypes
81. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
82. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B
83. 2+-block site of the NMDA receptor channel
84. Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel
85. Molecular cloning and characterization of the rat NMDA receptor
86. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
87. Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors
88. Molecular diversity and functions of glutamate receptors
89. Structural homology of Torpedo californica acetylcholine receptor subunits
90. Magnesium gates glutamate-activated channels in mouse central neurones
91. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
92. Excitotoxic amino acids and neuropsychiatric disorders
93. Excitatory Synaptic Currents in Purkinje Cells
94. The metabotropic glutamate receptors: structure and functions
95. Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids
96. Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development
97. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ϵ 1 subunit
98. 2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor
99. The role of NMDA receptors in the development of binocular maps in Xenopus tectum
100. A receptor shows a ligand-gated receptor super-family
101. The molecular biology of mammalian glutamate receptor channels
102. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
103. N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map
104. Characterization of a presynaptic glutamate receptor
105. Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat
106. Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors
107. Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes
108. Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing
109. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
110. Chromosomal localization of the ϵ1, ϵ3 and ζ1 subunit genes of the human NMDA receptor channel
111. Generation of antibodies specific for phosphorylated NMDA receptors
112. Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain
113. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
114. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
115. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
116. Ion permeation properties of the cloned mouse ϵ2/ζ1 NMDA receptor channel
117. Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in Xenopus oocytes injected with rat brain RNA
118. Membrane depolarization and the expression of glutamate receptors in cerebellar granule cells
119. Structural determinants of ion flow through recombinant glutamate receptor channels
120. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions
121. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A
122. Regulation of NMDA receptors by tyrosine kinases and phosphatases
123. Developmental changes in distribution of NMDA receptor channel subunit mRNAs
124. Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain
125. Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum
126. Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem
127. Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord
128. The synthesis of some acidic amino acids possessing neuropharmacological activity
129. 2+ antagonize NMDA and GABA responses of hippocampal neurons
130. Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the ϵ4 (NR2D) subunit
131. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor
132. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits
133. Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation
134. A topological analysis of goldfish kainate receptors predicts three transmembrane segments
135. Unraveling the modular design of glutamate-gated ion channels
136. Modulation of glutamate receptors: molecular mechanisms and functional implications
137. Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists
138. Phosphorylation of the carboxyl-terminal domain of the ζ 1 subunit is not responsible for potentiation by TPA of the NMDA receptor channel
139. Cloning, expression and modulation of a mouse NMDA receptor subunit
140. Spermine potentiation of recombinant N-methyl-D-aspartate receptors is affected by subunit composition