Cloned glutamate receptors

Annual Review of Neuroscience

Volumn 17, Issue , 1994, Pages 31-108

  Hollmann, Michael ^a   Heinemann, Stephen ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

AMPA receptor; CPD receptor; ionotropic glutamate receptor; kainate receptor; metabotropic glutamate receptor; NMDA receptor

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT; RECEPTOR PROTEIN;

ANIMAL TISSUE; CLONING; NONHUMAN; PRIORITY JOURNAL; REVIEW; SNAIL; VERTEBRATE;

EID: 0028278560     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ne.17.030194.000335     Document Type: Review

References (204)

1. 2+ signal transduction. J. Biol. Chem. 267:13361-68
2. Advokat C, Pellegrin AI. 1992. Excitatory amino acids and memory - evidence from research on Alzheimer's disease and behavioral pharmacology. Neurosci. Biobehav. Rev. 16:13-24
3. Anantharam V, Panchal RG, Wilson A, et al. 1992. Combinatorial RNA splicing alters the surface charge on the NMDA receptor. FEBS Lett. 305:27-30
4. Appel SH. 1993. Excitotoxic neuronal cell death in amyotrophic lateral sclerosis. Trends Neurosci. 16:3-5
5. Aramori I, Nakanishi S. 1992. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron 8:757-65
6. Aroniadou VA, Teyler TJ. 1991. The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex. Brain Res. 562:136-43
7. Bahr BA, Godshall AC, Hall RA, Lynch G. 1992. Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers. Brain Res. 589:320-26
8. A receptor: The receptor/channel superfamily. Trends Neurosci. 10:502-8
9. Barnard EA, Henley JM. 1990. The non-NMDA receptors - types, protein structure and molecular biology. Trends Pharmacol. Sci. 11:500-7
10. Barnes JM, Henley JM. 1992. Molecular characteristics of excitatory amino acid receptors. Prog. Neurobiol. 39:113-33
11. Beal MF. 1992. Mechanisms of excitotoxicity in neurologic diseases. FASEB J. 6:3338-44
12. Ben-Ari Y, Aniksztejn L, Bregestovski P. 1992. Protein kinase-C modulation of NMDA currents - an important link for LTP induction. Trends Neurosci. 15:333-39
13. Ben-Ari Y, Gho M. 1988. Long-lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic acid. J. Physiol. 404:365-84
14. Bessho Y, Nawa H, Nakanishi S. 1993. Glutamate and quisqualate regulate expression of metabotropic glutamate receptor messenger RNA in cultured cerebellar granule cells. J. Neurochem. 60:253-59
15. Bettler B, Boulter J, Hermans-Borgmeyer I, et al. 1990. Cloning of a novel glutamate receptor subunit, GluR5 - expression in the nervous system during development. Neuron 5:583-95
16. Bettler B, Egebjerg J, Sharma G, et al. 1992. Cloning of a putative glutamate receptor - a low affinity kainate-binding subunit. Neuron 8:257-65
17. Betz H. 1990. Ligand gated channels in the brain: the amino acid receptor superfamily. Neuron 5:383-92
18. Blackstone CD, Levey AI, Martin LJ, et al. 1992a. Immunological detection of glutamate receptor subtypes in human central nervous system. Ann. Neurol. 31:680-83
19. Blackstone CD, Moss SJ, Martin LJ, et al. 1992b. Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. J. Neurochem. 58:1118-26
20. Blaschke M, Keller BU, Rivosecchi R, et al. 1993. A single amino-acid determines the subunit-specific spider toxin block of AMPA/kainate receptor channels. Proc. Natl. Acad. Sci. USA 90:6528-32
21. Bliss TVP, Collingridge GL. 1993. A synaptic model of memory - long-term potentiation in the hippocampus. Nature 361:31-39
22. Boulter J, Hollmann M, O'Shea-Greenfield A, et al. 1990. Molecular cloning and functional expression of glutamate receptor subunit genes. Science 249:1033-37
23. Burnashev N, Khodorova A, Jonas P, et al. 1992a. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science 256:1566-70
24. Burnashev N, Monyer H, Seeburg PH, Sakmann B. 1992b. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8:189-98
25. Burnashev N, Schoepfer R, Monyer H, et al. 1992c. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257: 1415-19
26. Cajal SR. 1911. Histologie du systeme nerveux de I'homme et des vertebres. Paris: Moloine
27. Carlsson M, Carlsson A. 1990. Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinsons disease. Trends Neurosci. 13:272-76
28. Chazot PL, Cik M, Stephenson FA. 1992. Immunological detection of the NMDAR1 glutamate receptor subunit expressed in human embryonic kidney-293 cells and in rat brain. J. Neurochem. 59:1176-78
29. Chen JW, Cunningham MD, Galton N, Michaelis EK. 1988. Immune labeling and purification of a 71-kDa glutamate-binding protein from brain synaptic membranes. J. Biol. Chem. 263:417-26
30. Choi DW. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-34
31. Choi DW, Rothman SM. 1990. The role of glutamate neurotoxicity in hypoxicischemic neuronal death. Annu. Rev. Neurol. 13:171-82
32. Collingridge GL, Blake JF, Brown MW, et al. 1991. Involvement of excitatory amino acid receptors in long-term potentiation in the Schaffer collateral commissural pathway of rat hippocampal slices. Can. J. Physiol. Pharmacol. 69:1084-90
33. Collingridge GL, Bliss TVP. 1987. NMDA receptors - their role in long-term potentiation. TINS 10:288-93
34. Collingridge GL, Lester RAJ. 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 41:143-210
35. Collingridge GL, Singer W. 1990. Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol. Sci. 11:290-96
36. Constantine-Paton M, Cline HT, Debski E. 1990. Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways. Annu. Rev. Neurosci. 13:129-54
37. Cooper E, Couturier S, Ballivet M. 1991. Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350:235-38
38. Cooper JA, Esch FS, Taylor SS, Hunter T. 1984. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine kinases in vivo and in vitro. J. Biol. Chem. 259:7835-41
39. Cotman CW, Monaghan DT, Ottersen OP, Storm-Mathisen J. 1987. Anatomical organization of excitatory amino acid receptors and their pathways. TINS 10:273-79
40. Cowburn RF, Hardy JA, Roberts PJ. 1990. Glutamatergic neurotransmission in Alzheimers disease. Biochem. Soc. Trans. 18: 390-92
41. Curutchet P, Bochet P, Decarvalho LP, et al. 1992. In the GluR1 glutamate receptor subunit a glutamine to histidine point mutation suppresses inward rectification but not calcium permeability. Biochem. Biophys. Res. Commun. 182:1089-93
42. Darlison MG. 1992. Invertebrate GABA and glutamate receptors - molecular biology reveals predictable structures but some unusual pharmacologies. Trends Neurosci. 15:469-74
43. Dawson TL, Nicholas RA, Dingledine R. 1990. Homomeric GluR1 excitatory amino acid receptors expressed in Xenopus oocytes. Mol. Pharmacol. 38:779-84
44. Devereux J, Haeberli P, Smithies O. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-95
45. Dingledine R, Hume RI, Heinemann SF. 1992. Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. J. Neurosci. 12: 4080-87
46. Dingledine R, McBain CJ, McNamara JO. 1990a. Excitatory amino acid receptors in epilepsy. Trends Pharmacol. Sci. 11:334-38
47. Dingledine R, Myers SJ, Nicholas RA. 1990b. Molecular biology of mammalian amino acid receptors. FASEB J. 4:2636-45
48. Durand GM, Gregor P, Zheng X, et al. 1992. Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Proc. Natl. Acad. Sci. USA 89:9359-63
49. Egebjerg J, Bettler B, Hermans-Borgmeyer I, Heinemann S. 1991. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351:745-48
50. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proc. Natl. Acad. Sci. USA 90:755-59
51. Eshhar N, Hunter C, Wenthold RJ, Wada K. 1992. Structural characterization and expression of a brain specific gene encoding chick kainate binding protein. FEBS Lett. 297: 257-62
52. Etienne P, Baudry M. 1990. Role of excitatory amino acid neurotransmission in synaptic plasticity and pathology - an integrative hypothesis concerning the pathogenesis and evolutionary advantages of schizophrenia-related genes. J. Neural Transm. 39-48
53. Eubanks JH, Puranam RS, Kleckner NW, et al. 1993. The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 90: 178-82
54. Feng A-F, Doolittle RF. 1987. Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J. Mol. Evol. 25: 351-60
55. Fields RD, Yu C, Nelson PG. 1991. Calcium, network activity, and the role of NMDA channels in synaptic plasticity in vitro. J. Neurosci. 11:134-46
56. Gall C, Sumikawa K, Lynch G. 1990. Levels of mRNA for a putative kainate receptor are affected by seizures. Proc. Natl. Acad. Sci. USA 87:7643-47
57. Gallo V, Upson LM, Hayes WP, et al. 1992. Molecular cloning and developmental analysis of a new glutamate receptor subunit isoform in cerebellum. J. Neurosci. 12: 1010-23
58. Gasic GP, Heinemann S. 1991. Receptors coupled to ionic channels: the glutamate receptor family. Curr. Opin. Neurobiol. 1: 20-26
59. Gasic GP, Hollmann M. 1992. Molecular neurobiology of glutamate receptors. Annu. Rev. Physiol. 54:507-36
60. Gilbertson TA, Scobey R, Wilson M. 1991. Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells. Science 251:1613-15
61. Girault JA, Halpain S, Greengard P. 1990. Excitatory amino acid antagonists and Parkinsons disease. Trends Neurosci. 13:325-26
62. Gregor P, Eshhar N, Ortega A, Teichberg VI. 1988. Isolation, immunochemical characterization and localization of the kainate subclass of glutamate receptor from chick cerebellum. EMBO J. 7:2673-79
63. Gregor P, Mano I, Maoz I, et al. 1989. Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor. Nature 342:689
64. Gregor P, Yang XD, Mano I, et al. 1992. Organization and expression of the gene encoding chick kainate binding protein, a member of the glutamate receptor family. Mol. Brain Res. 16:179-86
65. Hampson DR, Huang XP, Oberdorfer MD, et al. 1992. Localization of AMPA receptors in the hippocampus and cerebellum of the rat using an anti-receptor monoclonal antibody. Neuroscience 50:11-22
66. Hansen JJ, Krogsgaard-Larsen P. 1990. Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors. Med. Res. Rev. 10:55-94
67. Harrison PJ, Barton AJL, Najlerahim A, Pearson RCA. 1990. Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain. NeuroReport 1:149-52
68. Harrison PJ, McLaughlin D, Kerwin RW. 1991. Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337:450-52
69. Hayashi Y, Tanabe Y, Aramori I, et al. 1992. Agonist analysis of 2-(carboxycyclopropyl) glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in chinese hamster ovary cells. Br. J. Pharmacol. 107:539-43
70. Hebb DO. 1949. The organization of behavior. New York: Wiley
71. Henley JM, Jenkins R, Hunt SP. 1993. Localisation of glutamate receptor binding sites and messenger RNAs to the dorsal horn of the rat spinal cord. Neuropharmacology 32:37-41
72. Henneberry RC. 1992. Cloning of the genes for excitatory amino acid receptors. Bioessays 14:465-71
73. Herb A, Burnashev N, Werner P, et al. 1992. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8:775-85
74. Hollmann M, Boulter J, Maron C, et al. 1993. Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 10:943-54
75. 2+ permeability of KA-AMPA gated glutamate receptor channels depends on subunit composition. Science 252:851-53
76. Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S. 1989. Cloning by functional expression of a member of the glutamate receptor family. Nature 342:643-48
77. Hollmann M, Rogers SW, O'Shea-Greenfield A, et al. 1990. The glutamate receptor GluR-K1 - structure, function, and expression in the brain. Cold Spring Harbor Symp. Quant. Biol. 55:41-55
78. Holmes WR, Levy WB. 1990. Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes. J. Neurophysiol. 63: 1148-68
79. Honore T. 1989. Excitatory amino acid receptor subtypes and specific antagonists. Med. Res. Rev. 9:1-23
80. Honore T, Drejer J, Nielsen EO, et al. 1989. Molecular target size analyses of the NMDA-receptor complex in rat cortex. Eur. J. Pharmacol. 172:239-47
81. Hopfield JJ. 1982. Neural networks and physical systems with emergent collective computational abilities. Proc. Natl. Acad. Sci. USA 79:2554-58
82. Houamed KM, Kuijper JL, Gilbert TL, et al. 1991. Cloning, expression, and gene structure of a G-protein-coupled glutamate receptor from rat brain. Science 252:1318-21
83. Huettner JE. 1990. Glutamate receptor channels in rat DRG neurons - activation by kainate and quisqualate and blockade of desensitization by Con-A. Neuron 5:255-66
84. Hughes TE, Hermans-Borgmeyer I, Heinemann S. 1992. Differential expression of glutamate receptor genes (GluR1-5) in the rat retina. Visual Neurosci. 8:49-55
85. Hullebroeck MF, Hampson DR. 1992. Characterization of the oligosaccharide side chains on kainate binding proteins and AMPA receptors. Brain Res. 590:187-92
86. Hume RI, Dingledine R, Heinemann SF. 1991. Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253:1028-31
87. Hutton ML, Harvey RJ, Barnard EA, Darlison MG. 1991. Cloning of a cDNA that encodes an invertebrate glutamate receptor subunit. FEBS Lett. 292:111-14
88. Iino M, Ozawa S, Tsuzuki K. 1990. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. (London) 424: 151-65
89. Ikeda K, Nagasawa M, Mori H, et al. 1992. Cloning and expression of the epsilon4 subunit of the NMDA receptor channel. FEBS Lett. 313:34-38
90. Ishii T, Moriyoshi K, Sugihara H, et al. 1993. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunit. J. Biol. Chem. 268:2836-43
91. Izquierdo I. 1991. Role of NMDA receptors in memory. Trends Pharmacol. Sci. 12:128-29
92. Kamboj RK, Schoepp DD, Nutt S, et al. 1992. Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. Mol. Pharmacol. 42:10-15
93. Kamphuis W, Monyer H, Derijk TC, Dasilva FHL. 1992. Hippocampal kindling increases the expression of glutamate receptor-A flip and receptor-B flip messenger RNA in dentate granule cells. Neurosci. Lett. 148:51-54
94. Karp SJ, Masu M, Eki T, et al. 1993. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor. J. Biol. Chem. 268: 3728-33
95. Kawamoto S, Onishi H, Hattori S, et al. 1991. Functional expression of the alpha1 subunit of the AMPA-selective glutamate receptor channel, using a baculovirus system. Biochem. Biophys. Res. Commun. 181:756-63
96. Keinänen K, Wisden W, Sommer B, et al. 1990. A family of AMPA-selective glutamate receptors. Science 249:556-60
97. Keller BU, Blaschke M, Rivosecchi R, et al. 1993. Identification of a subunit-specific antagonist of α-amino-3-hydroxy-5-methyl-4-isoazolepropionate/kainate receptor channels. Proc. Natl. Acad. Sci. USA 90:605-9
98. Keller BU, Hollmann M, Heinemann S, Konnerth A. 1992. Calcium influx through subunits GluR1/GluR3 of kainate/AMPA receptor channels is regulated by cAMP dependent protein kinase. EMBO J. 11:891-96
99. Kennelly PJ, Krebs EG. 1991. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266:15555-58
100. Kiskin NI, Krishtal OA, Tsyndrenko AY. 1990. Cross-desensitization reveals pharmacological specificity of excitatory amino acid receptors in isolated hippocampal neurons. Eur. J. Neurosci. 2:461
101. Klockgether T, Turski L. 1989. Excitatory amino acids and the basal ganglia - implications for the therapy of Parkinsons disease. Trends Neurol. 12:285-86
102. Koerner JF, Johnson RL. 1992. Excitatory amino acid receptors: design of agonists and antagonists. In L-AP4 Receptor Ligands, ed. P. Krogsgaard-Larsen JJ Hansen, pp. 308-330. West Sussex, UK: Ellis Horwood
103. 2+ permeability in both TM1 and TM2 of high-affinity kainate receptor channels: Diversity by RNA editing. Neuron 10:495-500
104. Kumar KN, Tilakaratne N, Johnson PS, et al. 1991. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. Nature 354:70-73
105. Kutsuwada T, Kashiwabuchi N, Mori H, et al. 1992. Molecular diversity of the NMDA receptor channel. Nature 358:36-41
106. Lambolez B, Audinat E, Bochet P, et al. 1992. AMPA receptor subunits expressed by single Purkinje cells. Neuron 9:247-58
107. Lambolez B, Curutchet P, Stinnakre J, et al. 1991. Electrophysiological and pharmacological properties of GluR1, a subunit of a glutamate receptor-channel expressed in Xenopus oocytes. Neurosci. Lett. 123:69-72
108. Langosch D, Thomas L, Betz H. 1988. Conserved quaternary structure of ligand gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc. Natl. Acad. Sci. USA 85:7394-98
109. Liman ER, Knapp AG, Dowling JE. 1989. Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase. Brain Res. 481:399-402
110. Lindstrom J, Criado M, Hochschwender S, et al. 1984. Immunochemical tests of acetylcholine receptor subunit models. Nature 311: 573-75
111. Lodge D, Johnson KM. 1990. Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol. 11:81-86
112. Lomeli H, Sprengel R, Laurie DJ, et al. 1993. The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family. FEBS Lett. 315:318-22
113. Lomeli H, Wisden W, Köhler M, et al. 1992. High-affinity kainate and domoate receptors in rat brain. FEBS Lett. 307:139-43
114. Ly AM, Michaelis EK. 1991. Solubilization, partial purification, and reconstitution of glutamate-activated and N-methyl-D-aspartate-activated cation channels from brain synaptic membranes. Biochemistry 30:4307-16
115. MacDonald JF, Nowak LM. 1990. Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmacol. 11: 167-72
116. Maragos WF, Greenamyre JT, Penney JB, Young AB. 1987. Glutamate dysfunction in Alzheimer's disease: an hypothesis. TINS 10:65-68
117. Marshall RD. 1972. Glycoproteins. Annu. Rev. Biochem. 41:673-702
118. Martin LJ, Blackstone CD, Huganir RL, Price DL. 1992. Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 9:259-70
119. Martin LJ, Blackstone CD, Huganir RL, Price DL. 1993. The striatal mosaic in primates: striosomes and matrix are differentially enriched in ionotropic glutamate receptor subunits. J. Neurosci. 13:782-92
120. Masu M, Tanabe Y, Tsuchida K, et al. 1991. Sequence and expression of a metabotropic glutamate receptor. Nature 349:760-65
121. Masu Y, Kazuhisa N, Tamaki H, et al. 1987. cDNA cloning of bovine substance-K receptor through oocyte expression system. Nature 329:836-38
122. Mayer ML, Vyklicky L Jr. 1989. Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors. Proc. Natl. Acad. Sci. USA 86:1411-15
123. Mayer ML, Westbrook GL. 1987. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28:197-276
124. McDonald JW, Johnston MV. 1990. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res. Rev. 15:41-70
125. McNamara JO, Eubanks JH, McPherson JD, et al. 1992. Chromosomal localization of human glutamate receptor genes. J. Neurosci. 12:2555-62
126. Meguro H, Mori H, Araki K, et al. 1992. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357:70-74
127. Meldrum B. 1985. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clin. Sci. 68:113-22
128. Meldrum B, Garthwaite J. 1990. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:379-87
129. Michaelis EK, Michaelis ML, Kumar KN, et al. 1992. Purification, reconstitution, and cloning of an NMDA receptor-ion channel complex from rat brain synaptic membranes - implications for neurobiological changes in alcoholism. In Neurobiology of Drug and Alcohol Addiction, ed. PW Kalivas, HH Samson, pp. 7-18. New York: N. Y. Acad. Sciences
130. Molnar E, Baude A, Richmond SA, et al. 1993. Biochemical and immunocytochemical characterisation of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit - cellular and subcellular distribution in the rat forebrain. Neuroscience 53:307-26
131. Monaghan DT, Bridges RJ, Cotman CW. 1989. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:365
132. Monyer H, Seeburg P. 1992. Developmental expression of NMDA receptor subtypes. Soc. Neurosci. Abstr. 18:#172.1
133. Monyer H, Seeburg PH, Wisden W. 1991. Glutamate-operated channels - developmentally early and mature forms arise by alternative splicing. Neuron 6:799-810
134. Monyer H, Sprengel R, Schoepfer R, et al. 1992. Heteromeric NMDA receptors - molecular and functional distinction of subtypes. Science 256:1217-21
135. 2+-block site of the NMDA receptor channel. Nature 358:673-75
136. Morita T, Sakimura K, Kushiya E, et al. 1992. Cloning and functional expression of a cDNA encoding the mouse beta2 subunit of the kainate-selective glutamate receptor channel. Mol. Brain Res. 14:143-46
137. Moriyoshi K, Masu M, Ishii T, et al. 1991. Molecular cloning and characterization of the rat NMDA receptor. Nature 354:31-37
138. Morris RGM. 1989. Synaptic plasticity and learning: selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9:3040-57
139. Moss SJ, Blackstone CD, Huganir RL. 1993. Phosphorylation of recombinant non-NMDA glutamate receptors on serine and tyrosine residues. Neurochem. Res. 18:105-10
140. Müller F, Greferath U, Wässle H, et al. 1992. Glutamate receptor expression in the rat retina. Neurosci. Lett. 138:179-82
141. Murphy SN, Thayer SA, Miller RJ. 1987. The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons. J. Neurosci. 7:4145-58
142. Nakanishi N, Axel R, Shneider NA. 1992. Alternative splicing generates functionally distinct N-methyl-D-asparte receptors. Proc. Natl. Acad. Sci. USA 89:8552-56
143. Nakanishi N, Shneider NA, Axel R. 1990. A family of glutamate receptor genes - evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 5:569-81
144. Nakanishi S. 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603
145. Olney JS. 1989a. Excitotoxicity and N-methyl-D-aspartate receptors. Drug Dev. Res. 17: 299
146. Olney JW. 1989b. Excitatory amino acids and neuropsychiatrie disorders. Biol. Psychiatry 26:505-25
147. Ortega A, Eshhar N, Teichberg VI. 1991a. Properties of kainate receptor/channels on cultured Bergmann glia. Neuroscience 41: 335-49
148. Ortega A, Lamed Y, Gregor P, Teichberg VI. 1991b. The chick cerebellar kainate binding protein - structure and function. In Excitatory Amino Acids, ed. BS Meldrum, F Moroni, RP Simon, JH Woods, 5:97-103. New York: Raven. 780 pp.
149. Ortega A, Teichberg VI. 1990. Phosphorylation of the 49-kDa putative subunit of the chick cerebellar kainate receptor and its regulation by kainatergic ligands. J. Biol. Chem. 265:21404-6
150. 2+-permeable kainate/AMPA receptors more abundant in immature brain? Neurosci. Lett. 144:65-69
151. Pellegrini-Giampietro DE, Zukin RS, Bennett MVL, et al. 1993. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats. Proc. Natl. Acad. Sci. USA 89:10499-503
152. Penney JB, Maragos WF, Greenamyre JT, et al. 1990. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. J. Neurol. Neurosurg. Psychiatry 53:314-20
153. Petralia RS, Wenthold RJ. 1992. Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J. Comp. Neurol. 318:329-54
154. Pin J-P, Fagni L, Bockaert J. 1993. Metabotropic glutamate receptors: targets for new neuropharmacologically active drugs. Curr. Drugs In press
155. Pin JP, Waeber C, Prezeau L, et al. 1992. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in xenopus oocytes. Proc. Natl. Acad. Sci. USA 89:10331-35
156. Potier M-C, Dutriaux A, Lambolez B, et al. 1993. Assignment of the human glutamate receptor gene GluR5 to 21q22 by screening a chromosome 21 YAC library. Genomics 15:696-97
157. Potier M-C, Spillantini MG, Carter NP. 1992. The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq. 2:211-18
158. Puckett C, Gomez CM, Korenberg JR, et al. 1991. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc. Natl. Acad. Sci. USA 88:7557-61
159. Racine RJ, Moore KA Wicks S. 1991. Activation of the NMDA receptor - a correlate in the dentate gyrus field potential and its relationship to long-term potentiation and kindling. Brain Res. 556:226-39
160. Ratnam M, Lindstrom J. 1984. Structural features of the nicotinic acetylcholine receptor revealed by antibodies to synthetic peptides. Biochem. Biophys. Res. Commun. 122: 1225-33
161. Raymond LA, Blackstone CD, Huganir RL. 1993. Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase. Nature 361:637-41
162. Reid IC, Morris RGM. 1991. N-methyl-D-aspartate receptors and learning - a framework for classifying some recent studies. In Excitatory Amino Acids, ed. B. S. Meldrum F Moroni RP Simon JH Woods, 5:521-32. New York: Raven. 780 pp.
163. Represa A, Tremblay E, Ben-Ari Y. 1987. Kainate binding sites in the hippocampal mossy fibres: localization and plasticity. Neuroscience 20:739-48
164. Reynolds IJ, Miller RJ. 1990. Allosteric modulation of N-methyl-D-aspartate receptors. Adv. Pharmacol. 21:101-26
165. Robinson JH, Deadwyler SA. 1981. Kainic acid produces depolarization of CA3 pyramidal cells in the in vitro hippocampal slice. Brain Res. 221:117-27
166. Rogers SW, Hughes TE, Hollmann M, et al. 1991. The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain. J. Neurosci. 11:2713-24
167. Sakimura K, Bujo H, Kushiya E, et al. 1990. Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 272:73-80
168. Sakimura K, Morita T, Kushiya E, Mishina M. 1992. Primary structure and expression of the gamma2 subunit of the glutamate receptor channel selective for kainate. Neuron 8:267-74
169. 2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor. J. Biol. Chem. 268:410-15
170. Sansom MSP, Usherwood PNR. 1990. Single channel studies of glutamate receptors. Int. Rev. Neurobiol. 32:51-106
171. Schoepp D, Bockaert J, Sladeczek F. 1990. Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol. Sci. 11:508-15
172. Schuster CM, Ultsch A, Schloss P, et al. 1991. Molecular cloning of an invertebrate glutamate receptor subunit expressed in drosophila muscle. Science 254:112-14
173. Sekiguchi M, Wada K, Wenthold RJ. 1992. N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes. FEBS Lett. 311:285-89
174. Shigemoto R, Nakanishi S, Mizuno N. 1992a. Distribution of the messenger RNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system - an in situ hybridization study in adult and developing rat. J. Comp. Neurol. 322:121-35
175. Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992b. Expression of the messenger RNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomie ganglion neurons Neurosci. Lett. 144:229-32
176. Sommer B, Burnashev N, Verdoorn TA, et al. 1992. A glutamate receptor channel with high affinity for domoate and kainate EMBO J. 11:1651-56
177. Sommer B, Keinänen K, Verdoorn TA, et al. 1990. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science 249:1580-85
178. Sommer B, Kohler M, Sprengel R, Seeburg PH. 1991. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67:11-19
179. Sommer B, Seeburg PH. 1992. Glutamate receptor channels - novel properties and new clones. Trends Pharmacol. Sci. 13:291-96
180. Stein E, Cox JA, Seeburg PH, Verdoorn TA. 1992. Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes. Mol. Pharmacol. 42:864-71
181. Stern P, Behe P, Schoepfer R, Colquhoun D. 1992. Single-channel conductances of NMDA receptors expressed from cloned cDNAs - comparison with native receptors. Proc. R. Soc. London Ser. B 250:271-77
182. Storey E, Kowall NW, Finn SF, et al. 1992. The cortical lesion of Huntington's disease - further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex. Ann. Neurol. 32:526-34
183. Sugihara H, Moriyoshi K, Ishii T, et al. 1992. Structures and properties of 7 isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185:826-32
184. Sugiyama H, Ito I, Hirono C. 1987. A new type of glutamate receptor linked to inositol phospholipid metabolism. Nature 325:531-33
185. Sun W, Ferrer-Montiel AV, Schinder AF, et al. 1992. Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. Proc. Natl. Acad. Sci. USA 89:1443-47
186. Tanabe Y, Masu M, Ishii T, et al. 1992. A family of metabotropic glutamate receptors. Neuron 8:169-79
187. Uchino S, Sakimura K, Nagahari K, Mishina M. 1992. Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel. FEBS Lett. 308: 253-57
188. Ultsch A, Schuster CM, Laube B, et al. 1992. Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system. Proc. Natl. Acad. Sci. USA 89: 10484-88
189. Vanderklish P, Neve R, Bahr BA, et al. 1992. Translational suppression of a glutamate receptor subunit impairs long-term potentiation. Synapse 12:333-37
190. Verdoorn TA, Burnashev N, Monyer H, et al. 1991. Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252:1715-18
191. Wachtel H, Turski L. 1990. Glutamate - a new target in schizophrenia. Trends Pharmacol. 11:219-20
192. Wada K, Dechesne CJ, Shimasaki S, et al. 1989. Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein. Nature 342:684
193. Wang L-Y, Taverna FA, Huang X-P, et al. 1993. Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase. Science 259:1173-75
194. Watkins JC, Krogsgaard-Larsen P, Honore T. 1990. Structure activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol. 11:25-33
195. Wenthold RJ, Hampson DR, Wada K, et al. 1990a. Isolation, localization, and cloning of a kainic acid binding protein from frog brain. J. Histochem. Cytochem. 38:1717-23
196. Wenthold RJ, Hunter C, Wada K, Dechesne CJ. 1990b. Antibodies to a C-terminal peptide of the rat brain glutamate receptor subunit, GluR-A, recognize a subpopulation of AMPA binding sites but not kainate sites. FEBS Lett. 276:147-50
197. Wenthold RJ, Yokotani N, Doi K, Wada K. 1992. Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies - evidence for a hetero-oligomeric structure in rat brain. J. Biol. Chem. 267:501-7
198. Werner P, Voigt M, Keinänen K, et al. 1991. Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells. Nature 351:742-44
199. Wroblewski JT, Danysz W. 1989. Modulation of glutamate receptors: molecular mechanisms and functional implications. Annu. Rev. Pharmacol. Toxicol. 29:441-74
200. Yamazaki M, Araki K, Shibata A, Mishina M. 1992a. Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. Biochem. Biophys. Res. Commun. 183:886-92
201. Yamazaki M, Mori H, Araki K, et al. 1992b. Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300:39-45
202. Yoneda Y, Ogita K. 1991. Neurochemical aspects of the N-methyl-D-aspartate receptor complex. Neurosci. Res. 10:1-33
203. Young EF, Ralston E, Blake J, et al. 1985. Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide. Proc. Natl. Acad. Sci. USA 82:626-30
204. Zorumski CF, Thio LL. 1992. Properties of vertebrate glutamate receptors - calcium mobilization and desensitization. Prog. Neurobiol. 39:295-336