Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymatic deamination with adenosine deaminase

Canadian Journal of Chemistry

Volumn 75, Issue 6, 1997, Pages 762-767

  Robins, Morris J ^a   Zou, Ruiming ^b   Hansske, Fritz ^c   Wnuk, Stanislaw F ^d  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

^b GILEAD SCIENCES   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

2,6 Diaminopurine nucleosides; Adenosine deaminase; Deoxygenation; Guanine nucleosides; Nucleosides

Indexed keywords

AMINO ACIDS; ENZYMES; HYDROGENATION; REDUCTION; SUGARS; SYNTHESIS (CHEMICAL);

DEAMINATION; DEOXYGENATION; NUCLEOSIDES;

NUCLEIC ACIDS;

2,6 DIAMINOPURINE; ADENOSINE DEAMINASE; GUANOSINE;

ARTICLE; DEAMINATION; ENZYME ACTIVITY; ENZYME MECHANISM; HYDROLYSIS; NUCLEOTIDE METABOLISM; SYNTHESIS;

EID: 0031171046     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v97-092     Document Type: Article

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