Spermine modulation of specific [(3H)]-gabapentin binding to the detergent-solubilized porcine cerebral cortex α2δ calcium channel subunit

British Journal of Pharmacology

Volumn 120, Issue 5, 1997, Pages 833-840

  Dissanayake, V U K ^a   Gee, N S ^a   Brown, J P ^a   Woodruff, G N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

2 subunit; Anticonvulsant; Calcium channels; Endogenous ligand; Gabapentin; N methyl D aspartate (NMDA); Neurontin; Polyamines; Spermine; Spermine modulation

Indexed keywords

1,10 DECANEDIAMINE; ANTICONVULSIVE AGENT; CALCIUM CHANNEL; DETERGENT; DRUG BINDING PROTEIN; GABAPENTIN; MAGNESIUM ION; MEMBRANE PROTEIN; RADIOLIGAND; SPERMIDINE; SPERMINE; ZINC;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIALYSATE; DRUG BINDING; GEL FILTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SWINE;

ACETIC ACIDS; AMINES; ANIMALS; ANTICONVULSANTS; CALCIUM CHANNELS; CATIONS, DIVALENT; CEREBRAL CORTEX; CHROMATOGRAPHY, GEL; CYCLOHEXANECARBOXYLIC ACIDS; DETERGENTS; DIALYSIS; GAMMA-AMINOBUTYRIC ACID; MEMBRANE PROTEINS; POLYSORBATES; PROTEIN BINDING; RADIOLIGAND ASSAY; SPERMINE; SWINE; TRITIUM;

EID: 0031000945     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700988     Document Type: Article

References (28)

1. CALLEWAERT, G., HANBAUER, I & MORAD, M. (1989). Modulation of calcium channels in cardiac and neuronal cells by an endogenous peptide. Science, 243, 663 - 666.
2. COSTA, E. & GUIDOTTI, A. (1979). Molecular mechanisms in the receptor action of benzodiazepines. Ann. Rev. Pharmacol. Toxicol., 19, 531 - 545.
3. DELEAN, A., MUNSON, P.J. & RODBARD, D. (1978). Simultaneous analysis of families of sigmoidal curves: application to bioassays, radioligand assays and physiological dose-response curves. Am. J. Physiol., 235, E97 - E102.
4. DOOLEY, D.J. BARTOSZYK, G.D., HARTENSEIN, J., REIMANN, W., ROCK, D.M. & SATZINGER, G. (1986). Preclinical pharmacology of gabapentin. Golden Jubilee Conference and Northern Europe Meeting, 8, (Abstract). U.K.: University of York.
5. 3H]nitrendipine in extracts of rat brain. J. Pharmacol. Exp. Ther., 244, 971 - 976.
6. EBERSOLE, B.J. & MOLINOFF, P.B. (1992). Identification of ascorbate as an endogenous substance that irreversibly inhibits binding of dihydropyridine calcium channel blockers. J. Neurochem., 58, 1300 - 1307.
7. 2δ subunit of a calcium channel. J. Biol. Chem., 271, 5768 - 5776.
8. A-benzodiazepine receptor ligands in membranes from the rat forebrain. Neuropharmacology, 31, 895 - 898.
9. GOTZ, E., FEUERSTEIN, T.J., LAIS, A. & MEYER, D.K. (1993). Effects of gabapentin on release of gamma-aminobutyric acid from slices or rat neostriatum. Arzneimittelforschung., 43, 636 - 638.
10. 3H]gabapentin to a novel site in rat brain: autoradiographic studies. Eur. J. Pharmacol., 244, 303 - 309.
11. 3H]dihydropyridine binding and L-type calcium channel current. FEBS Lett., 239, 233 - 236.
12. LOSCHER, W., HONACK, D. & TAYLOR, C.P. (1991). Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci. Lett., 128, 150 - 154.
13. MCLEAN, M.J. (1995). Gabapentin. Epilepsia, 36, S73 - S86.
14. MUNSON, P.J. & RODBARD, D. (1980). LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem., 107, 220 - 239.
15. OLES, R.J., SINGH, L., HUGHES, J. & WOODRUFF, G.N. (1990). The anticonvulsant action of gabapentin involves the glycine/NMDA receptor. Soc. Neurosci.. 16, 783(Abstract)
16. 3H]3-PPP binding to sigma receptors. Eur. J. Pharmacol., 184, 203 - 204.
17. PULLAN, L.M., KEITH, R.A., LAMONTE, D., STUMPO, R.J. & SALAMA, A.I. (1990). The polyamine spermine affects w-conotoxin binding and function at N-type voltage-sensitive calcium channels. J. Auton. Pharmacol., 10, 213.
18. 3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J. Neurochem., 51, 830 - 836.
19. REYNOLDS, I.J. & MILLER, R.J. (1989). Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol. Pharmacol., 36, 758 - 765.
20. ROCK, D.M., KELLY, K.M. & MACDONALD, R.L. (1993). Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons. Epilepsy Res., 16, 89 - 98.
21. ROGAWSKI, M.A. & PORTER, R.J. (1990). Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev., 42, 223 - 286.
22. 3H]nitrendipine binding to the voltage-sensitive calcium channel in rat brain. Eur. J. Pharmacol.. 225, 167 - 169.
23. SINGH, L., FIELD, M.J., FERRIS, P., HUNTER, J.C., OLES, R.J., WILLIAMS, R.G. & WOODRUFF, G.N. (1996). The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-Serine Psychopharmacology, 127, 1 - 9.
24. 3H]gabapentin binding to a novel site in rat brain: homogenate binding studies. Eur. J. Pharmacol., 244, 293 - 301.
25. TAYLOR, C.P. (1993). Mechanism of action of new anti-epileptic drugs. In New Trends in Epilepsy Management: The Role of Gabapentin. ed. Chadwick, D. pp. 13 - 40. London: Royal Society of Medicine Services Limited.
26. 3H]-gabapentin may label a system-L-like neutral amino acid carrier in brain. Eur. J. Pharmacol. Mol. Pharmacol., 247, 341 - 345.
27. WASSERKORT, R., HOPPE, E., REDDINGTON, M. & SCHUBERT, P. (1991). Modulation of A1 adenosine receptor function in rat brain by the polyamine, spermine. Neurosci. Lett., 124, 183 - 186.
28. 3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol. Pharmacol., 36, 575 - 581.