Pilot study of low dose oral methotrexate treatment for primary biliary cirrhosis

American Journal of Gastroenterology

Volumn 91, Issue 2, 1996, Pages 295-299

  Bergasa, Nora Valeria ^a   Anthony Jones, E ^c   Kleiner, David E ^c   Rabin, Lionel ^c   Park, Yoon ^c   Wells, Mary C ^c   Hoofnagle, Jay H ^b  

^a BETH ISRAEL MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; DOSE RESPONSE; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; LIVER DISEASE; LYMPHADENOPATHY; MALE; ORAL DRUG ADMINISTRATION; PNEUMONIA; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PRURITUS;

ADULT; AGED; ALKALINE PHOSPHATASE; ANALYSIS OF VARIANCE; BILIRUBIN; ENZYME TESTS; EVALUATION STUDIES; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENTS; LIVER; LIVER CIRRHOSIS, BILIARY; MALE; METHOTREXATE; MIDDLE AGED; PILOT PROJECTS; TIME FACTORS; TRANSAMINASES;

EID: 0030021559     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. James SP, Hoofnagle JH, Strober W, et al. Primary biliary cirrhosis. A model autoimmune disease. Ann Intern Med 1983;99:500-12.
2. Gershwin M, Mackay I. Primary biliary cirrhosis: Paradigm or paradox for autoimmunity. Gastroenterology 1991;100:822-33.
3. Mitchinson HC, Palmer JM, Bassendine MF, et al. A controlled trial of prednisolone treatment in primary biliary cirrhosis: Three-year results. J Hepatol 1992;15:336-44.
4. Heathcote J, Ross A, Sherlock S. A prospective controlled trial of azathioprine in primary biliary cirrhosis. Gastroenterology 1976;70: 656-60.
5. Crowe J, Christensen E, Smith M, et al. Azathioprine in primary biliary cirrhosis: A preliminary report of an international trial. Gastroenterology 1980;78:1005-10.
6. Mitchinson HC, Bassendine MF, Malcolm AJ, et al. A pilot double-blind controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis. Hepatic improvement but greater bone loss. Hepatology 1989;10:420-9.
7. Hoofnagle JH, Bergasa NV. Methotrexate therapy of primary biliary cirrhosis: Promising but worrisome. Gastroenterology 1991;101: 1440-2.
8. Lombard M, Portman B, Neuberger J, et al. Cyclosporine: A treatment in primary biliary cirrhosis. Results of a long-term placebo controlled trial. Gastroenterology 1993;104:519-26.
9. Kaplan MM, Knox TA. Treatment of primary biliary cirrhosis with low-dose weekly methotrexate. Gastroenterology 1991;101:1332-8.
10. Wiesner RH, Ludwig J, Lindor KD, et al. A controlled trial of cyclosporine in the treatment of primary biliary cirrhosis. N Engl J Med 1990;322:1419-24.
11. Weinstein GD. Methotrexate. Ann Intern Med 1977;86:198-204.
12. Berlin NI, Rail D, Mead JAR, et al. Folic acid antagonists. Ann Intern Med 1963;59:931-56.
13. Jolivet J, Cowan KH, Curt GA, et al. The pharmacology and clinical use of methotrexate. N Engl J Med 1983;3:1094-104.
14. Weinblatt ME, Coblyn JS, Fox DA, et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med 1985;312:818-23.
15. Metzger AL, Bohan A, Golberg LS, et al. Polymyositis and dermatomyositis: Combined methotrexate and corticosteroid therapy. Ann Intern Med 1974;81:182-9.
16. Ferrara JLM, Deeg HJ. Graft-versus-host disease. N Engl J Med 1991;324:667-74.
17. Scheuer PJ. Primary biliary cirrhosis. Proc R Soc Med 1967;60:1257-60.
18. Weinstein GD, Roenick H, Maibach H, et al. Psoriasis-liver-methotrexate interactions. Arch Dermatol 1973;108:36-42.
19. Locke RG, Therneau TM, Ludwig J, Dickson ER, Lindor KD. Time course of histological progression in primary biliary cirrhosis. Hepatology 1996;23:52-56
20. Lloyd-Thomas HGL, Sherlock S. Testosterone therapy for the pruritus of obstructive jaundice. Br Med J 1952;2:1289-91.
21. Bergasa NV, Sabol SL, Young SW, et al. Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver. Am J Physiol 1995;268:346-54.
22. Bergasa NV, Mukerjee E, Kleiner D, et al. Methotrexate (MTX) therapy is associated with decreased bile ductular proliferation in cholestatic rat livers from bile duct resection. Implication on heaptic endogenous opioids. Hepatology 1993;18:295A (abstract).
23. Searales G, Mckendry RJ. Methotrexate pneumonitis in rheumatoid arthritis: Potential risks factors. Four case reports and review of the literature. J Rheumatol 1987;14:1164-71.
24. Zachariae H, Sogaard H. Methotrexate-liver cirrhosis. Dermatologica 1987;175:178-82.
25. Olsen NJ, Callahan LF, Pincus T. Immunologic studies of patients treated with methotrexate. Arth Rheum 1987;30:481-8.
26. Olsen NJ, Murray LM. Antiproliferative effects of methotrexate on peripheral blood mononuclear cells. Arth Rheum 1989;32:378-85.
27. Segal R, Mozes E, Yaron M, et al. The effects of methotrexate on the production and activity of interleukin-1. Arth Rheum 1989;32:370-7.
28. Bergasa NV, Newman W, Rothlein R, et al. Serum levels of soluble adhesion molecules (I-CAM-1, V-CAM1 and E-selectin) are markedly elevated in primary biliary cirrhosis (PBC) and unaffected by low oral methotrexate therapy. Gastroenterology 1993;104:A877 (abstract).