Stereoselective disposition and chiral inversion of KE-298, a new antirheumatic drug, in rats

Chirality

Volumn 9, Issue 1, 1997, Pages 22-28

  Yoshida, H ^a   Kohno, Y ^a   Endo, H ^a   Ohmi, N ^a   Fukushima, K ^a   Suwa, T ^a   Hayashi, M ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

binding site; chiral HPLC; displacement; metabolic chiral inversion; metabolism; pharmacokinetics; protein binding; stereoselectivity

Indexed keywords

2 ACETHYLTHIOMETHYL 4 (4 METHYLPHENYL) 4 OXOBUTANOIC ACID; ANTIRHEUMATIC AGENT; DRUG METABOLITE; NEW DRUG; PLASMA PROTEIN; SERUM ALBUMIN; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENANTIOMER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY;

ANIMALS; ANTIRHEUMATIC AGENTS; BLOOD PROTEINS; MALE; PHENYLPROPIONATES; PROTEIN BINDING; RATS; RATS, WISTAR; STEREOISOMERISM;

EID: 0030994718     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:1<22::AID-CHIR5>3.0.CO;2-I     Document Type: Article

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